Cited by 526Gastrointestinal motility and disordersIon Channels and ReceptorsPain Mechanisms and Treatments

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Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain

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Akbar, A, Yiangou, Y, Facer, P, Walters, J R F, Anand, P, Ghosh, S·2008·Gut

DOI 10.1136/gut.2007.138982PMC PMC2564830

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Abstract

OBJECTIVE: The capsaicin receptor TRPV1 (transient receptor potential vanilloid type-1) may play an important role in visceral pain and hypersensitivity states. In irritable bowel syndrome (IBS), abdominal pain is a common and distressing symptom where the pathophysiology is still not clearly defined. TRPV1-immunoreactive nerve fibres were investigated in colonic biopsies from patients with IBS, and this was related to abdominal pain. METHODS: Rectosigmoid biopsies were collected from 23 IBS patients fulfilling Rome II criteria, and from 22 controls. Abdominal pain scores were recorded using a validated questionnaire. TRPV1-, substance P- and neuronal marker protein gene product (PGP) 9.5-expressing nerve fibres, mast cells (c-kit) and lymphocytes (CD3 and CD4) were quantified, following immunohistochemistry with specific antibodies. The biopsy findings were related to the abdominal pain scores. RESULTS: A significant 3.5-fold increase in median numbers of TRPV1-immunoreactive fibres was found in biopsies from IBS patients compared with controls (p<0.0001). Substance P-immunoreactive fibres (p = 0.01), total nerve fibres (PGP9.5) (p = 0.002), mast cells (c-kit) (p = 0.02) and lymphocytes (CD3) (p = 0.03) were also significantly increased in the IBS group. In multivariate regression analysis, only TRPV1-immuno-reactive fibres (p = 0.005) and mast cells (p = 0.008) were significantly related to the abdominal pain score. CONCLUSIONS: Increased TRPV1 nerve fibres are observed in IBS, together with a low-grade inflammatory response. The increased TRPV1 nerve fibres may contribute to visceral hypersensitivity and pain in IBS, and provide a novel therapeutic target.

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The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139
An inventory for measuring depression
BECK, A. T. (1961) · Archives of General Psychiatry · doi:10.1001/archpsyc.1961.01710120031004 · Cited by 38,032
The capsaicin receptor: a heat-activated ion channel in the pain pathway
Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. J. (1997) · Nature · doi:10.1038/39807 · Cited by 9,132
The short-form McGill pain questionnaire
Melzack, R. (1987) · Pain · doi:10.1016/0304-3959(87)91074-8 · Cited by 4,368
Vanilloid (Capsaicin) Receptors and Mechanisms
SZALLASI, A., & Blumberg, P. M. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01403-0 · Cited by 1,903
Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome
Barbara, G., Stanghellini, V., De Giorgio, R., Cremon, C., Cottrell, G. S., Santini, D., Pasquinelli, G., Morselli-Labate, A. M., Grady, E. F., Bunnett, N. W., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.055 · Cited by 1,475
Lactobacillus and bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles
O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448
p38 MAPK Activation by NGF in Primary Sensory Neurons after Inflammation Increases TRPV1 Levels and Maintains Heat Hyperalgesia
Ji, R., Samad, T. A., Jin, S., Schmoll, R., & Woolf, C. J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00908-x · Cited by 1,239
Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome
Spiller, R. C., Jenkins, D., Thornley, J. P., Hebden, J. M., Wright, T., Skinner, M., & Neal, K. R. (2000) · Gut · doi:10.1136/gut.47.6.804 · Cited by 1,155
Postinfectious Irritable Bowel Syndrome
Spiller, R., & Garsed, K. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.074 · Cited by 1,024

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Neural signalling of gut mechanosensation in ingestive and digestive processes
Kim, M., Heo, G., & Kim, S. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00544-7 · Cited by 83
Visceral pain hypersensitivity in functional gastrointestinal disorders
Farmer, A. D., & Aziz, Q. (2009) · British Medical Bulletin · doi:10.1093/bmb/ldp026 · Cited by 74
BDNF contributes to IBS-like colonic hypersensitivity via activating the enteroglia-nerve unit
Wang, P., Du, C., Chen, F.-X., Li, C., Yu, Y.-B., Han, T., Akhtar, S., Zuo, X.-L., Tan, X., & Li, Y. (2016) · Scientific Reports · doi:10.1038/srep20320 · Cited by 72
Effect of Red Pepper on Symptoms of Irritable Bowel Syndrome: Preliminary Study
Bortolotti, M., & Porta, S. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-011-1740-9 · Cited by 73
Nasal hyperreactivity in rhinitis: A diagnostic and therapeutic challenge
Gerven, L. V., Steelant, B., & Hellings, P. W. (2018) · Allergy · doi:10.1111/all.13453 · Cited by 74
Colonic mucosal mediators from patients with irritable bowel syndrome excite enteric cholinergic motor neurons
Balestra, B., Vicini, R., Cremon, C., Zecchi, L., Dothel, G., Vasina, V. I., GIORGIO, R. D., Paccapelo, A., Pastoris, O., Stanghellini, V., et al. (2012) · Neurogastroenterology & Motility · doi:10.1111/nmo.12000 · Cited by 72
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Shinoda, M., Feng, B., & Gebhart, G. F. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.06.048 · Cited by 70
Mast cell number, substance P and vasoactive intestinal peptide in irritable bowel syndrome with diarrhea
Sohn, W., Lee, O. Y., Lee, S. P., Lee, K. N., Jun, D. W., Lee, H. L., Yoon, B. C., Choi, H. S., Sim, J., & Jang, K.-S. (2013) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2013.857712 · Cited by 68
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Diagnosis of IBS: symptoms, symptom-based criteria, biomarkers or 'psychomarkers'?
Sood, R., Law, G. R., & Ford, A. C. (2014) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2014.127 · Cited by 69
Distribution of transient receptor potential vanilloid 1 channel-expressing nerve fibers in mouse rectal and colonic enteric nervous system: relationship to peptidergic and nitrergic neurons
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Pasteurized Akkermansia muciniphila improves irritable bowel syndrome-like symptoms and related behavioral disorders in mice
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“The development of a colonic hypersensitivity in animals or humans can involve the activation of pro-nociceptive neuronal receptors such as TRPV1 46,47 or GPCRs, such as serotonin 48 , bradykinin, 49 and histamine 50 receptors.”
Pharmacological activity of capsaicin: Mechanisms and controversies (Review)
Zhang, W., Zhang, Y., Fan, J., Feng, Z., & Song, X. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13162 · Cited by 65
“Whether the hydrophobic side chain is a saturated or unsaturated alkyl chain, substituted naphthyl group, or something else can influence the activity of capsaicin (8,9).”
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Neuroimmune interactions at different intestinal sites are related to abdominal pain symptoms in children with IBS
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Role of the transient receptor potential vanilloid 1 in inflammation and sepsis
Montiel, A. V. F., Devesa, Planells-Cases, Fernandez-Ballester, G. J., González-Ros, J. M., & Montiel, A. V. F. (2011) · Journal of Inflammation Research · doi:10.2147/jir.s12978 · Cited by 62
“85 This process is also mediated by fast mobilization from a subcellular vesicular reservoir located near the plasma membrane that is recruited by SNARE-dependent exocytosis.”
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Muscatello, M. R. A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i24.7570 · Cited by 61
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“Patients suffering from chronic pelvic pain syndromes, particularly IBS, IC, and vulvodynia, commonly report that stress initiates or exacerbates existing symptoms (Arnold et al., 2006; Larauche et al., 2012; Bullones Rodriguez et al., 2013).”
Influential
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Nasser, Y., Boeckxstaens, G. E., Wouters, M. M., Schemann, M., & Vanner, S. J. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12316 · Cited by 53
Alterations in mucosal neuropeptides in patients with irritable bowel syndrome and ulcerative colitis in remission: A role in pain symptom generation?
Keszthelyi, D., Troost, F. J., Jonkers, D. M. A. E., Helyes, Z., Hamer, H. M., Ludidi, S., Vanhoutvin, S. A. L. W., Venema, K., Dekker, J. P., Szolcsányi, J., et al. (2013) · European Journal of Pain · doi:10.1002/j.1532-2149.2013.00309.x · Cited by 53
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Chu, X., Zhuang, H., Liu, Y., Li, J., Wang, Y., Jiang, Y., Zhang, H., Zhao, P., Chen, Y., Jiang, X., et al. (2022) · Advanced Materials · doi:10.1002/adma.202108653 · Cited by 51
Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells
Wang, P., Kljavin, N. M., Nguyen, T. T. T., Storm, E. E., Marsh, B., Jiang, J. W., Lin, W., Menon, H., Piskol, R., & de Sauvage, F. J. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.07.013 · Cited by 55
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Keszthelyi, D., Troost, F., Simrén, M., Ludidi, S., Kruimel, J., Conchillo, J., & Masclee, A. (2012) · European Journal of Pain · doi:10.1002/j.1532-2149.2012.00147.x · Cited by 44
“TRPV1 receptors have in fact been shown to be up-regulated in mucosal biopsy specimens of IBS patients (Akbar et al., 2008).”
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You, X., Zhang, H., Han, X., Wang, F., Zhuang, P., & Zhang, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.659716 · Cited by 52
Baizhu shaoyao decoction restores the intestinal barrier and brain–gut axis balance to alleviate diarrhea-predominant irritable bowel syndrome via FoxO1/FoxO3a
Wei, Y., Fan, Y., Huang, S., Lv, J., Zhang, Y., & Hao, Z. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155163 · Cited by 53
CT-guided injection of a TRPV1 agonist around dorsal root ganglia decreases pain transmission in swine
Brown, J. D., Saeed, M. M., Do, L., Braz, J. M., Basbaum, A. I., Iadarola, M. J., Wilson, D. M., & Dillon, W. P. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac6589 · Cited by 50
Pelvic organ cross-sensitization to enhance bladder and urethral pain behaviors in rats with experimental colitis
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Substance P, obesity, and gut inflammation
Karagiannides, I., & Pothoulakis, C. (2009) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e328321306c · Cited by 52
Temperature Sensing by Thermal TRP Channels
Qin, F. (2014) · Current topics in membranes · doi:10.1016/b978-0-12-800181-3.00002-6 · Cited by 47
σ1Receptors Are Involved in the Visceral Pain Induced by Intracolonic Administration of Capsaicin in Mice
González‐Cano, R., Merlos, M., Baeyens, J. M., & Cendán, C. M. (2013) · Anesthesiology · doi:10.1097/aln.0b013e318280a60a · Cited by 48
The Pharmacology of Visceral Pain
Johnson, A. C., & Meerveld, B. G. (2016) · Advances in pharmacology · doi:10.1016/bs.apha.2015.11.002 · Cited by 48
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Correlation between anxiety-depression status and cytokines in diarrhea-predominant irritable bowel syndrome
GAO, J. (2013) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2013.1101 · Cited by 46
The gut–brain axis and pain signalling mechanisms in the gastrointestinal tract
Meerschaert, K. A., & Chiu, I. M. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-01017-9 · Cited by 57
“In patients with IBS, mast cell numbers increased and mast cells in close proximity to nerves were correlated with increased severity and frequency of abdominal pain scores in patients as compared with healthy individuals as controls 98–100 .”
Traditional Thoughts on the Pathophysiology of Irritable Bowel Syndrome
Hasler, W. L. (2011) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2010.12.004 · Cited by 46
What does irritable bowel syndrome share with non-alcoholic fatty liver disease?
Scalera, A. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i33.5402 · Cited by 48
Saccharomyces boulardii CNCM I-745 supplementation reduces gastrointestinal dysfunction in an animal model of IBS
Brun, P., Scarpa, M., Marchiori, C., Sarasin, G., Caputi, V., Porzionato, A., Giron, M. C., Palù, G., & Castagliuolo, I. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181863 · Cited by 48
Diagnosis and management of functional symptoms in inflammatory bowel disease in remission
Teruel, C. (2016) · World Journal of Gastrointestinal Pharmacology and Therapeutics · doi:10.4292/wjgpt.v7.i1.78 · Cited by 47
Visceral and somatic sensory function in functional dyspepsia
Li, X., Cao, Y., Wong, R. K. M., Ho, K. Y., & Wilder‐Smith, C. H. (2012) · Neurogastroenterology & Motility · doi:10.1111/nmo.12044 · Cited by 45
Review article: transient receptor potential channels as possible therapeutic targets in irritable bowel syndrome
Beckers, A. B., Weerts, Z. Z. R. M., Helyes, Z., Masclee, A., & Keszthelyi, D. (2017) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14294 · Cited by 45
Evidence for neurotrophic factors associating with TRPV1 gene expression in the inflamed human esophagus
Shieh, K.-R., Yi, C., Liu, T. T., Tseng, H.-L., Ho, H., Hsieh, H. T., & Chen, C. L. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01530.x · Cited by 45
Potential Roles of Enterochromaffin Cells in Early Life Stress-Induced Irritable Bowel Syndrome
Tao, E., Zhu, Z., Hu, C., Long, G., Chen, B., Guo, R. C., Fang, M., & Jiang, M. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.837166 · Cited by 47
Burning Mouth Syndrome: An Update on Diagnosis and Treatment Methods
Suarez‐Durall, P., & Clark, G. T. (2012) · Wiley eBooks · doi:10.1002/9781118704851.ch14 · Cited by 44
The neurochemical changes in the innervation of human colonic mesenteric and submucosal blood vessels in U lcerative colitis and C rohn's disease
de Fontgalland, D., Brookes, S. J., Gibbins, I. L., Sia, T. C., & Wattchow, D. A. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12327 · Cited by 43
Peripheral contribution of NGF and ASIC 1a to colonic hypersensitivity in a rat model of irritable bowel syndrome
Matricon, J., Muller, E., Accarie, A., Méleine, M., Etienne, M., Voilley, N., Busserolles, J., Eschalier, A., Lazdunski, M., Bourdu, S., et al. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12199 · Cited by 43
Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction
Shi, H. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i16.4852 · Cited by 43
NaV1.1 inhibition can reduce visceral hypersensitivity
Salvatierra, J., Castro, J., Erickson, A., Li, Q., Bráz, J. M., Gilchrist, J. M., Grundy, L., Rychkov, G. Y., Deiteren, A., Rais, R., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.121000 · Cited by 40
The extracellular matrix glycoprotein tenascin‐X regulates peripheral sensory and motor neurones
Aktar, R., Peiris, M., Fikree, A., Cibert‐Goton, V., Walmsley, M., Tough, I. R., Watanabe, P. D. S., Araújo, E. J. D. A., Mohammed, S. D., Delalande, J., et al. (2018) · The Journal of Physiology · doi:10.1113/jp276300 · Cited by 43
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7-tert-Butyl-6-(4-Chloro-Phenyl)-2-Thioxo-2,3-Dihydro-1H-Pyrido[2,3-d]Pyrimidin-4-One, a Classic Polymodal Inhibitor of Transient Receptor Potential Vanilloid Type 1 with a Reduced Liability for Hyperthermia, Is Analgesic and Ameliorates Visceral Hypersensitivity
Nash, M. S., McIntyre, P., Groarke, A., Lilley, E. J., Culshaw, A. J., Hallett, A., Panesar, M., Fox, A., & Bevan, S. (2012) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.191932 · Cited by 42
“, 2003; Geppetti and Trevisani, 2004), and mucosal biopsy samples from patients with irritable bowel syndrome (IBS) show elevated TRPV1 expression that correlates with the degree of reported pain (Akbar et al., 2008).”
Background
Neural control of gut homeostasis
Abdullah, N., Defaye, M., & Altier, C. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00293.2020 · Cited by 44
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Duo, L., Wu, T., Ke, Z., Hu, L., Wang, C., Teng, G., Zhang, W., Wang, W., Ge, Q., Yang, Y., et al. (2020) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2020.10.006 · Cited by 42
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Salvo‐Romero, E., Martínez, C., Lobo, B., Rodiño‐Janeiro, B. K., Pigrau, M., Sánchez‐Chardi, A., González-Castro, A. M., Fortea, M., Pardo‐Camacho, C., Nieto, A., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-77176-x · Cited by 42
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Xiang, Y., Xu, X.-L., Zhang, T., Wu, X., Fan, D., Hu, Y., Ding, J., Yang, X., Lou, J. Q., Du, Q., et al. (2022) · Experimental Cell Research · doi:10.1016/j.yexcr.2022.113227 · Cited by 46
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Brierley, S. M., Meerveld, B. G., Sarnelli, G., Sharkey, K. A., Storr, M., & Tack, J. F. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00682-y · Cited by 41
Irritable bowel syndrome: new insights into symptom mechanisms and advances in treatment
Spiller, R. (2016) · F1000Research · doi:10.12688/f1000research.7992.1 · Cited by 38
TLR4 mediates upregulation and sensitization of TRPV1 in primary afferent neurons in 2,4,6-trinitrobenzene sulfate-induced colitis
Wu, Y., Wang, Y., Wang, J., Fan, Q. W., Zhu, J., Liu, Y., & Rong, W. (2019) · Molecular Pain · doi:10.1177/1744806919830018 · Cited by 41
A placebo‐controlled trial of an oral capsaicin load in patients with functional dyspepsia
Führer, M., Vogelsang, H., & Hammer, J. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01766.x · Cited by 41
Multiple chemical sensitivity: It's time to catch up to the science
Molot, J., Sears, M., & Anisman, H. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105227 · Cited by 40
Comparative effect of electroacupuncture and moxibustion on the expression of substance P and vasoactive intestinal peptide in patients with irritable bowel syndrome
Lu, Z., Xiaojun, Y., Teng, W., Yue-hua, C., Jie, S., Jimeng, Z., Anqi, W., Bao, C., & Shi, Y. (2015) · 中医杂志：英文版 · doi:10.1016/s0254-6272(15)30116-3 · Cited by 40
Putative mechanisms of kiwifruit on maintenance of normal gastrointestinal function
Bayer, S. B., Gearry, R. B., & Drummond, L. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1327841 · Cited by 40
“ENS in modulation of the immune system (Akbar et al., 2008).”
Background
Contribution of membrane receptor signalling to chronic visceral pain
Sadeghi, M., Erickson, A., Castro, J., Deiteren, A., Harrington, A. M., Grundy, L., Adams, D. J., & Brierley, S. M. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2018.02.017 · Cited by 40
Vinpocetine Ameliorates Acetic Acid-Induced Colitis by Inhibiting NF-κB Activation in Mice
Colombo, B. B., Fattori, V., Guazelli, C. F. S., Zaninelli, T. H., de Carvalho, T. T., Ferraz, C. R., Bussmann, A. J. C., Ruiz-Miyazawa, K. W., Baracat, M. M., Casagrande, R., et al. (2018) · Inflammation · doi:10.1007/s10753-018-0776-9 · Cited by 40
“Therefore, the inhibition of acetic acid-induced visceral mechanical hyperalgesia is an important finding, given that abdominal pain is a symptom inherent of patients with IBD [71].”
Background
Chronic colitis-induced visceral pain is associated with increased anxiety during quiescent phase
Salameh, É., Méleine, M., Gourcerol, G., do-Rego, J.-C., do Rego, J. L., Legrand, R., Breton, J., Aziz, M., Guérin, C., Coëffier, M., et al. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00248.2018 · Cited by 40
Cryosurgery of the prostate: techniques and indications.
Cohen, J. (2004) · Europe PMC (PubMed Central) · Cited by 40
Involvement of afferent neurons in the pathogenesis of endotoxin-induced ileus in mice: role of CGRP and TRPV1 receptors.
Winter, B. D., Bredenoord, A., van Nassauw, L., Man, J. G. D., Schepper, H. D. D., Timmermans, J., & Pelckmans, P. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.04.055 · Cited by 15
“In human rectosigmoid biopsies from IBS patients an increased expression of TRPV1 nerve fibers was reported (Akbar et al., 2008).”
Background
Capsaicin Receptor as Target of Calcitonin Gene-Related Peptide in the Gut
Evangelista, S. (2014) · Springer eBooks · doi:10.1007/978-3-0348-0828-6_10 · Cited by 40
Attenuation of TRPV1 and TRPV4 Expression and Function in Mouse Inflammatory Pain Models Using Electroacupuncture
Chen, W., Tzen, J. T. C., Hsieh, C. L., Chen, Y., Lin, T.-J., Chen, S., & Lin, Y. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/636848 · Cited by 39
Mechanisms of Stress‐Induced Visceral Pain: Implications in Irritable Bowel Syndrome
Meerveld, B. G., Moloney, R. D., Johnson, A. C., & Vicario, M. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12361 · Cited by 39
To learn, to remember, to forget—How smart is the gut?
Schemann, M., Frieling, T., & Enck, P. (2019) · Acta Physiologica · doi:10.1111/apha.13296 · Cited by 39
Saccharomyces boulardii CNCM I‐745 modulates the microbiota–gut–brain axis in a humanized mouse model of Irritable Bowel Syndrome
Constante, M., Palma, G. D., Lu, J., Jury, J., Rondeau, L. E., Caminero, A., Collins, S. M., Verdu, E. F., & Berčík, P. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.13985 · Cited by 41
Involvement of peripheral artemin signaling in tongue pain
Shinoda, M., Takeda, M., Honda, K., Maruno, M., Katagiri, A., Satoh‐Kuriwada, S., Shoji, N., Tsuchiya, M., & Iwata, K. (2015) · Pain · doi:10.1097/j.pain.0000000000000322 · Cited by 39
Irritable bowel syndrome immune hypothesis: the role of lymphocytes and mast cells
Lucas, M. O., Peiró, P. S., & Domingo, J. J. S. (2010) · Revista Española de Enfermedades Digestivas · doi:10.4321/s1130-01082010001100004 · Cited by 38
Chili Peppers, Curcumins, and Prebiotics in Gastrointestinal Health and Disease
Patcharatrakul, T., & Gonlachanvit, S. (2016) · Current Gastroenterology Reports · doi:10.1007/s11894-016-0494-0 · Cited by 39
Latest Insights on the Pathogenesis of Irritable Bowel Syndrome
Videlock, E. J., & Chang, L. (2021) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2021.04.002 · Cited by 38
Therapeutic Effects of Berberine Hydrochloride on Stress-Induced Diarrhea-Predominant Irritable Bowel Syndrome Rats by Inhibiting Neurotransmission in Colonic Smooth Muscle
Lu, Y.-L., Huang, J., Zhang, Y., Huang, Z., Yan, W., Zhou, T., Wang, Z., Liao, L., Cao, H., & Tan, B. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.596686 · Cited by 38
The shifting interface between IBS and IBD
Spiller, R. E., & Lam, C. (2011) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2011.09.009 · Cited by 38
Peripheral analgesia: Hitting pain where it hurts
McDougall, J. J. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.12.011 · Cited by 38
Visceral hypersensitivity induced by activation of transient receptor potential vanilloid type 1 is mediated through the serotonin pathway in rat colon
Qin, H., Luo, J., Qi, S., Xu, H., Sung, J. J. �., & Bian, Z. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.08.019 · Cited by 37
Involvement of the transient receptor potential vanilloid 1 (TRPV1) in the development of acute visceral hyperalgesia during colorectal distension in rats
Ravnefjord, A., Brusberg, M., Kang, D., Bauer, U., Larsson, H., Lindström, E., & Martı́nez, V. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.03.058 · Cited by 37
Physiology of Visceral Pain
Gebhart, G. F., & Bielefeldt, K. (2016) · Comprehensive physiology · doi:10.1002/j.2040-4603.2016.tb00725.x · Cited by 36
“Further, animal models of visceral inflammation as well as various human disorders from GERD, painful bladder syndrome (PBS) to rectal urgency have all been associated with increases in TRPV1 expression (4, 5, 23, 45, 149).”
Effect of repeated, long term capsaicin ingestion on intestinal chemo‐ and mechanosensation in healthy volunteers
Führer, M., & Hammer, J. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01227.x · Cited by 36
Mechanisms of visceral pain in health and functional gastrointestinal disorders
Farmer, A. D., & Aziz, Q. (2014) · Scandinavian Journal of Pain · doi:10.1016/j.sjpain.2014.01.002 · Cited by 38
“[26] Akbar A, Yiangou Y, Facer P,Walters JR, Anand P, Ghosh S.”
Background
5-HT7 receptor-dependent intestinal neurite outgrowth contributes to visceral hypersensitivity in irritable bowel syndrome
Chang, W.-Y., Yang, Y.-T., She, M., Tu, C., Lee, T., Wu, M., Sun, C., Hsin, L., & Yu, L. C. (2022) · Laboratory Investigation · doi:10.1038/s41374-022-00800-z · Cited by 37
Multi-omics for biomarker approaches in the diagnostic evaluation and management of abdominal pain and irritable bowel syndrome: what lies ahead
Shin, A., & Kashyap, P. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2195792 · Cited by 34
3-Iodothyronamine, a Novel Endogenous Modulator of Transient Receptor Potential Melastatin 8?
Khajavi, N., Mergler, S., & Biebermann, H. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00198 · Cited by 35

Authors: Akbar, A., Yiangou, Y., Facer, P., Walters, J. R. F., Anand, P., & Ghosh, S.
Affiliations: Imperial College London (GB)
Hammersmith Hospital (GB)
Corresponding author: Ghosh, S
ORCID: Akbar, A
Yiangou, Y
Walters, J R F
Anand, P
Ghosh, S
Venue: Gut
Publisher: BMJ
Published: 2008-02-27
Volume: 57
Issue: 7
Pages: 923-929
ISSN: 0017-5749 (ISSN-L)
DOI: 10.1136/gut.2007.138982
PMC: PMC2564830
OpenAlex: W2165979101
Cited by: 526
References: 49
Citations by year: 2026: 19 · 2025: 16 · 2024: 34 · 2023: 25 · 2022: 21 · 2021: 36 · 2020: 28 · 2019: 27 · 2018: 30 · 2017: 30 · 2016: 41 · 2015: 25 · 2014: 36 · 2013: 39 · 2012: 26
FWCI: 29.02
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Gut (publishedVersion)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Spiral (Imperial College London) (submittedVersion)
Funders: GlaxoSmithKline
London School of Hygiene and Tropical Medicine
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Keywords: irritable bowel syndrome, TRPV1, capsaicin receptor, visceral pain, visceral hypersensitivity, abdominal pain, sensory nerve fibers, substance P, mast cells, lymphocytes, colonic mucosa, low-grade inflammation
MeSH terms: Adult, Aged, Anxiety, Depression, Female, Humans, Immunoenzyme Techniques, Intestinal Mucosa, Male, Middle Aged, Nerve Fibers, Neurons, Afferent, Pain Measurement, Abdominal Pain, Inflammation Mediators, Irritable Bowel Syndrome, TRPV Cation Channels

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Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain

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