Cited by 526Gastrointestinal motility and disordersIon Channels and ReceptorsPain Mechanisms and Treatments

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Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain

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Akbar, A, Yiangou, Y, Facer, P, Walters, J R F, Anand, P, Ghosh, S·2008·Gut

DOI 10.1136/gut.2007.138982PMC PMC2564830

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Abstract

OBJECTIVE: The capsaicin receptor TRPV1 (transient receptor potential vanilloid type-1) may play an important role in visceral pain and hypersensitivity states. In irritable bowel syndrome (IBS), abdominal pain is a common and distressing symptom where the pathophysiology is still not clearly defined. TRPV1-immunoreactive nerve fibres were investigated in colonic biopsies from patients with IBS, and this was related to abdominal pain. METHODS: Rectosigmoid biopsies were collected from 23 IBS patients fulfilling Rome II criteria, and from 22 controls. Abdominal pain scores were recorded using a validated questionnaire. TRPV1-, substance P- and neuronal marker protein gene product (PGP) 9.5-expressing nerve fibres, mast cells (c-kit) and lymphocytes (CD3 and CD4) were quantified, following immunohistochemistry with specific antibodies. The biopsy findings were related to the abdominal pain scores. RESULTS: A significant 3.5-fold increase in median numbers of TRPV1-immunoreactive fibres was found in biopsies from IBS patients compared with controls (p<0.0001). Substance P-immunoreactive fibres (p = 0.01), total nerve fibres (PGP9.5) (p = 0.002), mast cells (c-kit) (p = 0.02) and lymphocytes (CD3) (p = 0.03) were also significantly increased in the IBS group. In multivariate regression analysis, only TRPV1-immuno-reactive fibres (p = 0.005) and mast cells (p = 0.008) were significantly related to the abdominal pain score. CONCLUSIONS: Increased TRPV1 nerve fibres are observed in IBS, together with a low-grade inflammatory response. The increased TRPV1 nerve fibres may contribute to visceral hypersensitivity and pain in IBS, and provide a novel therapeutic target.

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The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139
An inventory for measuring depression
BECK, A. T. (1961) · Archives of General Psychiatry · doi:10.1001/archpsyc.1961.01710120031004 · Cited by 38,032
The capsaicin receptor: a heat-activated ion channel in the pain pathway
Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. J. (1997) · Nature · doi:10.1038/39807 · Cited by 9,132
The short-form McGill pain questionnaire
Melzack, R. (1987) · Pain · doi:10.1016/0304-3959(87)91074-8 · Cited by 4,368
Vanilloid (Capsaicin) Receptors and Mechanisms
SZALLASI, A., & Blumberg, P. M. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01403-0 · Cited by 1,903
Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome
Barbara, G., Stanghellini, V., De Giorgio, R., Cremon, C., Cottrell, G. S., Santini, D., Pasquinelli, G., Morselli-Labate, A. M., Grady, E. F., Bunnett, N. W., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.055 · Cited by 1,475
Lactobacillus and bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles
O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448
p38 MAPK Activation by NGF in Primary Sensory Neurons after Inflammation Increases TRPV1 Levels and Maintains Heat Hyperalgesia
Ji, R., Samad, T. A., Jin, S., Schmoll, R., & Woolf, C. J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00908-x · Cited by 1,239
Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome
Spiller, R. C., Jenkins, D., Thornley, J. P., Hebden, J. M., Wright, T., Skinner, M., & Neal, K. R. (2000) · Gut · doi:10.1136/gut.47.6.804 · Cited by 1,155
Postinfectious Irritable Bowel Syndrome
Spiller, R., & Garsed, K. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.074 · Cited by 1,024

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Boyer, J., Saint‐Paul, M., Dadone‐Montaudié, B., Patouraux, S., Vivinus, M., Ouvrier, D., Michiels, J., Piche, T., & Tulić, M. K. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13223 · Cited by 35
Tolerance to Morphine-Induced Inhibition of TTX-R Sodium Channels in Dorsal Root Ganglia Neurons Is Modulated by Gut-Derived Mediators
Mischel, R. A., Dewey, W. L., & Akbarali, H. I. (2018) · iScience · doi:10.1016/j.isci.2018.03.003 · Cited by 38
“This innovative approach has arisen as a powerful paradigm for investigating the mechanisms of peripheral nociception in both mice and human patients (Barbara et al., 2004; Cenac et al., 2007; Akbar et al., 2008).”
Targeted therapy of irritable bowel syndrome with anti-inflammatory cytokines
Kumar, S., Singh, P., & Kumar, A. (2021) · Clinical Journal of Gastroenterology · doi:10.1007/s12328-021-01555-8 · Cited by 36
Nerve growth factor and diarrhea-predominant irritable bowel syndrome (IBS-D): a potential therapeutic target?
Xu, X., Liu, L., & Yao, S. (2016) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1500181 · Cited by 35
Combined genetic and pharmacological inhibition of TRPV1 and P2X3 attenuates colorectal hypersensitivity and afferent sensitization
Kiyatkin, M. E., Feng, B., Schwartz, E. S., & Gebhart, G. F. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00180.2013 · Cited by 34
“Expression of TRPV1 in colorectal afferents is increased in patients with IBS, and the magnitude of channel expression often positively correlates with the severity of sensory symptoms (1).”
Novel therapeutics in the field of capsaicin and pain
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Editorial: Abnormal Immune Regulation and Low-Grade Inflammation in IBS: Does One Size Fit All?
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Effects of Chili Treatment on Gastrointestinal and Rectal Sensation in Diarrhea-predominant Irritable Bowel Syndrome: A Randomized, Double-blinded, Crossover Study
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Glucagon-like peptide 1 receptor (GLP-1R) expression by nerve fibres in inflammatory bowel disease and functional effects in cultured neurons
Anand, U., Yiangou, Y., Akbar, A., Quick, T., MacQuillan, A. H. F., Fox, M., Sinisi, M., Korchev, Y. E., Jones, B. J., Bloom, S. R., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198024 · Cited by 33
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Alaimo, A., & Rubert, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215277 · Cited by 33
Post-inflammatory Abdominal Pain in Patients with Inflammatory Bowel Disease During Remission: A Comprehensive Review
Takahashi, K., Khwaja, I., Schreyer, J. R., Bulmer, D. C., Peiris, M., Terai, S., & Aziz, Q. (2021) · Crohn s & Colitis 360 · doi:10.1093/crocol/otab073 · Cited by 33
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“This finding is of importance for the human gut, which shows an increased density of TRPV1-immunoreactive fibres in patients with IBS (66).”
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Wang, S., Yang, H.-Y., & Xu, G. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/483123 · Cited by 33
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Anand, P., Anand, U., Ottó, Sinisi, M., Fox, Birch, Foster, K., Mukerji, Akbar, A., Agarwal, et al. (2011) · Journal of Pain Research · doi:10.2147/jpr.s25189 · Cited by 33
“0 [range 25–77] years) was diagnosed according to Rome II criteria, and the subjects were further classified according to Rome II criteria, as described eleswhere.(10,19) Controls (n = 13, mean age 60.”
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Role of transient receptor potential melastatin 2 (TRPM2) channels in visceral nociception and hypersensitivity
Matsumoto, K., Takagi, K., Kato, A., Ishibashi, T., Mori, Y., Tashima, K., Mitsumoto, A., Kato, S., & Horie, S. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.09.001 · Cited by 33
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Cheung, C., Lan, L. L., Kyaw, M. H., Mak, A. D. P., Chan, A., Chan, Y., & Wu, J. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13176 · Cited by 32
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Background
Role of palmitoylethanolamide (PEA) in depression: Translational evidence
Gregorio, D. D., Manchia, M., Carpiniello, B., Valtorta, F., Nobile, M., Gobbi, G., & Comai, S. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.10.117 · Cited by 34
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Lee, J. Y., Kim, N., Park, J. H., Nam, R. H., Lee, S. M., Song, C., Kim, G., Na, H. Y., Choi, Y. J., Kim, J. J., et al. (2019) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm19099 · Cited by 31
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Hungin, A. P. S., Becher, A., Cayley, B., Heidelbaugh, J. J., Muris, J. W. M., Rubin, G. P., Seifert, B., Russell, A., & de Wit, N. J. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12524 · Cited by 33
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Self-citation
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Winter, B. Y. D., Deiteren, A., & Man, J. G. D. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12785 · Cited by 30
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Lucarini, E., Seguella, L., Vincenzi, M., Parisio, C., Micheli, L., Toti, A., Corpetti, C., Re, A., Squillace, S., Maftei, D., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9111671 · Cited by 28
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Upregulation of the transient receptor potential vanilloid 1 in colonic epithelium of patients with active inflammatory bowel disease.
Luo, C., Wang, Z., Mu, J., Zhu, M., Yu, Z., & Zhang, H. (2017) · PubMed Central · Cited by 28
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Paltser, G., Liu, X. J., Yantha, J., Winer, S., Tsui, H., Wu, P., Maezawa, Y., Cahill, L. S., Laliberté, C. L., Ramagopalan, S. V., et al. (2013) · Molecular Medicine · doi:10.2119/molmed.2012.00329 · Cited by 26
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Barbara, G., Stanghellini, V., Cremon, C., GIORGIO, R. D., Fronzoni, L., Serra, M., & Corinaldesi, R. (2009) · Digestive Diseases · doi:10.1159/000268131 · Cited by 27
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Naitou, K., Nakamori, H., Horii, K., Kato, K., Horii, Y., Shimaoka, H., Shiina, T., & Shimizu, Y. (2018) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00178.2018 · Cited by 25
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Pei, L., Chen, H., Guo, J., Lu, C., Wu, X., Xu, W., Weng, S., Yang, E., Hammer, T., & Sun, J. (2018) · Medicine · doi:10.1097/md.0000000000010877 · Cited by 25
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van Boxel, O. S., Linde, J. J. M. T., Siersema, P. D., & Smout, A. J. P. M. (2010) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.100 · Cited by 25
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Reddy, C. S., Mashozhera, N. T., Rashrash, B., Flores‐Iga, G., Nimmakayala, P., Hankins, G. R., Harris, R. T., & Reddy, U. K. (2024) · Molecules · doi:10.3390/molecules29194729 · Cited by 24
“TRPV1 influences pain management and immune modulation in cancer, making it a promising therapeutic target in conditions like irritable bowel syndrome, where TRPV1-expressing sensory fibers correlate with heightened pain perception [45].”
Background
Neonatal maternal separation increases susceptibility to experimental colitis and acute stress exposure in male mice
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BackgroundInfluential
Recurrent infections drive persistent bladder dysfunction and pain via sensory nerve sprouting and mast cell activity
Hayes, B. W., Choi, H., Rathore, A. P. S., Bao, C., Shi, J.-L., Huh, Y., Kim, M. W., Mencarelli, A., Bist, P., Ng, L., et al. (2024) · Science immunology · doi:10.1126/sciimmunol.adi5578 · Cited by 24
“…growth but also sensitizes sensory fibers by lowering the nociceptive activation threshold and increasing the relative expression of receptors ( 14 – 16 ), including transient receptor potential vanilloid (TRPV) receptors, which are suggested to mediate peripheral and visceral pain ( 17 – 21 ).”
Background
Abdominal Pain and the Neurotrophic System in Ulcerative Colitis
DeBerry, J. J., Bielefeldt, K., Davis, B. M., Szigethy, E., Hartman, D. J., & Coates, M. D. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000207 · Cited by 25
Mucosal mast cells mediate motor response induced by chronic oral exposure to ovalbumin in the rat gastrointestinal tract
Traver, E., Torres, R., de Mora, F., & Vergara, P. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01377.x · Cited by 24
Presence of intramucosal neuroglial cells in normal and aganglionic human colon
Badizadegan, K., Thomas, A. R., Nagy, N., Ndishabandi, D., Miller, S., Alessandrini, A., Belkind‐Gerson, J., & Goldstein, A. M. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00164.2014 · Cited by 24
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Neonatal vaginal irritation results in long-term visceral and somatic hypersensitivity and increased hypothalamic–pituitary–adrenal axis output in female mice
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“SP + neurone density is altered in gut pathologies including in IBS patients where density in colonic mucosa is threefold higher compared to healthy controls [61] with similar findings in IBS subtypes [62, 63].”
Result
CGRP-related neuropeptide adrenomedullin 2 promotes tissue-protective ILC2 responses and limits intestinal inflammation
Uddin, J., Yano, H., Parkhurst, C. N., Zhang, W., Ahmed, A., de Godoy, V. R., Wei, Q., Panchakshari, R. A., Henninot, A., Dasgupta, S., et al. (2025) · Nature Immunology · doi:10.1038/s41590-025-02243-2 · Cited by 23
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Aberrant Gut-To-Brain Signaling in Irritable Bowel Syndrome - The Role of Bile Acids
Dhonnabháín, R. N., Xiao, Q., & O’Malley, D. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.745190 · Cited by 25
Role of TRPV1 in high-threshold rat colonic splanchnic afferents is revealed by inflammation
Phillis, B. D., Martin, C. M., Kang, D., Larsson, H., Lindström, E., Martı́nez, V., & Blackshaw, L. A. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.04.051 · Cited by 22
Visceral analgesics: drugs with a great potential in functional disorders?☆
Bradesi, S., HERMAN, J., & Mayer, E. A. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.08.009 · Cited by 22
NHE3 inhibitor tenapanor maintains intestinal barrier function, decreases visceral hypersensitivity, and attenuates TRPV1 signaling in colonic sensory neurons
King, A. J., Chang, L., Li, Q., Liu, L., Zhu, Y., Pasricha, P. J., Wang, J., Siegel, M., Caldwell, J. S., Edelstein, S. A., et al. (2024) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00233.2023 · Cited by 22
Upregulation of Vanilloid Receptor-1 in Functional Dyspepsia With or Without Helicobacter pylori Infection
Choi, Y. J., Kim, N., Kim, J., Lee, D. H., Park, J. H., & Jung, H. C. (2016) · Medicine · doi:10.1097/md.0000000000003410 · Cited by 21
4,5‐Di‐O‐Caffeoylquinic Acid from Ligularia fischeri Suppresses Inflammatory Responses Through TRPV1 Activation
Kim, Y., Kim, J. T., Park, J., Son, H. J., Kim, E., Lee, Y., & Rhyu, M. (2017) · Phytotherapy Research · doi:10.1002/ptr.5885 · Cited by 21
“Several recent studies have indicated a relationship between TRPV1 and inflammation (Engler et al., 2007; Akbar et al., 2008; Cho and Valtschanoff, 2008).”
Background
Glioplasticity in irritable bowel syndrome
Lilli, N. L., Quénéhervé, L., Haddara, S., Brochard, C., Aubert, P., Rolli‐Derkinderen, M., Durand, T., Naveilhan, P., Hardouin, J.-B., GIORGIO, R. D., et al. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13232 · Cited by 21
Achieving translation in models of visceral pain
Bulmer, D. C., & Grundy, D. (2011) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2011.09.008 · Cited by 20
Gut‐derived cholecystokinin contributes to visceral hypersensitivity via nerve growth factor‐dependent neurite outgrowth
Hsu, L., Hung, K., Wu, H., Liu, W., She, M., Lee, T., Sun, C., Yu, W., Buret, A. G., & Yu, L. C. (2016) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.13296 · Cited by 20
Mechanisms involved in abdominal nociception induced by either TRPV1 or TRPA1 stimulation of rat peritoneum
Trevisan, G., Rossato, M. F., Hoffmeister, C., Oliveira, S. M., Silva, C. R., MATHEUS, F. C., de Mello, G. C., Antunes, E., Prediger, R. D., & Ferreira, J. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.07.029 · Cited by 20
Erratum to: P2Y1, P2Y2, and TRPV1 Receptors Are Increased in Diarrhea-Predominant Irritable Bowel Syndrome and P2Y2 Correlates with Abdominal Pain
Luo, Y., Feng, C., Wu, J., Wu, Y., Liu, D., Wu, J., Dai, F., & Zhang, J. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4320-1 · Cited by 20
Acute colonic inflammation triggers detrusor instability via activation of TRPV1 receptors in a rat model of pelvic organ cross-sensitization
Asfaw, T. S., HYPOLITE, J. A., Northington, G. M., Arya, L. A., Wein, A. J., & Malykhina, A. P. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00804.2010 · Cited by 19
Expression of TRP Channels in Colonic Mucosa of IBS-D Patients and Its Correlation with the Severity of the Disease
Cheng, L., Luo, Q., & Chen, S. (2022) · Gastroenterology Research and Practice · doi:10.1155/2022/7294775 · Cited by 19
Inhibitory effect of Iboga-type indole alkaloids on capsaicin-induced contraction in isolated mouse rectum
Lo, M. W., Matsumoto, K., Iwai, M., Tashima, K., Kitajima, M., Horie, S., & Takayama, H. (2010) · Journal of Natural Medicines · doi:10.1007/s11418-010-0478-6 · Cited by 19
“Elevated numbers of TRPV1 channels are implicated in various gastrointestinal diseases, such as rectal hypersensitivity, fecal urgency [14], and irritable bowel syndrome [15].”
Background
Possible role for TRPV1 in neomycin‐induced inhibition of visceral hypersensitivity in rat
van den Wijngaard, R. M., Welting, O., Bulmer, D. C., Wouters, M. M., Lee, K., de Jonge, W. J., & Boeckxstaens, G. E. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01287.x · Cited by 19
Mast cells drive mesenteric afferent signalling during acute intestinal ischaemia
Jiang, W. Y., Kirkup, A. J., & Grundy, D. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.209478 · Cited by 19
Targeting the endocannabinoid system for gastrointestinal diseases: future therapeutic strategies
Schicho, R., & Storr, M. (2010) · Expert Review of Clinical Pharmacology · doi:10.1586/ecp.09.62 · Cited by 19
Focus on irritable bowel syndrome.
Scalera, A., & Loguercio, C. (2012) · PubMed · Cited by 19
Effect of TRPV1 combined with lidocaine on cell state and apoptosis of U87-MG glioma cell lines
Lu, J., Ju, Y., Li, C., Hua, F., Xu, G., & Hu, Y.-H. (2016) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/j.apjtm.2016.01.030 · Cited by 18
Influence of Dietary Restriction on Irritable Bowel Syndrome
Kamal, A., & Pimentel, M. (2018) · The American Journal of Gastroenterology · doi:10.1038/s41395-018-0241-2 · Cited by 19
Pharmacodynamics of TRPV1 Agonists in a Bioassay Using Human PC-3 Cells
Álvarez-Berdugo, D., Jiménez, M., Clavé, P., & Rofes, L. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/184526 · Cited by 18
A Novel Ileocolonic Release Peppermint Oil Capsule for Treatment of Irritable Bowel Syndrome: A Phase I Study in Healthy Volunteers
Weerts, Z. Z. R. M., Keszthelyi, D., Vork, L., Aendekerk, N. C. P., Frijlink, H. W., Brouwers, J. R. B. J., Neef, C., Jonkers, D. M. A. E., & Masclee, A. (2018) · Advances in Therapy · doi:10.1007/s12325-018-0802-1 · Cited by 19
Sensory Phenotype of the Oesophageal Mucosa in Gastro-Oesophageal Reflux Disease
Ustaoglu, A., & Woodland, P. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032502 · Cited by 19
Serine proteases: new players in diarrhoea-predominant irritable bowel syndrome
Barbara, G., & Cremon, C. (2008) · Gut · doi:10.1136/gut.2008.150821 · Cited by 17
An Update on the Assessment and Management of Pediatric Abdominal Pain
Friesen, C. A., Colombo, J. M., Deacy, A. D., & Schurman, J. V. (2021) · Pediatric Health Medicine and Therapeutics · doi:10.2147/phmt.s287719 · Cited by 21
S3-Leitlinie Reizdarmsyndrom: Definition, Pathophysiologie, Diagnostik und Therapie. Gemeinsame Leitlinie der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Neurogastroenterologie und Motilität (DGNM) 1 AWMF-Registriernummer: 021/016 Irritable Bowel Syndrome: German Consensus Guidelines on Definition, Pathophysiology and Management. German Society of Digestive and Metabolic Diseases (DGVS) and German Society of Neurogastroenterology …
Andresen, V., Pehl, C., Allescher, H. ‐., Bischoff, S. C., Enck, P., Frieling, T., Haag, S., Holtmann, G., Karaus, M., Keller, J., et al. (2011) · Cited by 17
Irritable bowel syndrome: When food is a pain in the gut
Hussein, H., Remoortel, S. V., & Boeckxstaens, G. E. (2024) · Immunological Reviews · doi:10.1111/imr.13374 · Cited by 16
“89 Mechanistically, increased receptor expression could result from increased receptor translocation to the membrane.”
Tongxie Anchang Decoction Relieves Visceral Hypersensitivity in Diarrhea-Predominant Irritable Bowel Syndrome Rats by Regulating the NGF/TrkA Signaling Pathway
Tan, X., Pei, W., Xie, C., Wang, Z., Liu, J., Cheng, Y., Mao, T., Shi, L., Zhao, X., Lu, Q., et al. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/6679348 · Cited by 16
Mucosal Plasma Cell Activation and Proximity to Nerve Fibres Are Associated with Glycocalyx Reduction in Diarrhoea-Predominant Irritable Bowel Syndrome: Jejunal Barrier Alterations Underlying Clinical Manifestations
Pardo‐Camacho, C., Mall, J. G., Martínez, C., Pigrau, M., Expósito, E., Albert-Bayo, M., Melón-Ardanaz, E., Nieto, A., Rodiño‐Janeiro, B. K., Fortea, M., et al. (2022) · Cells · doi:10.3390/cells11132046 · Cited by 16
Irritable Bowel Syndrome: Manipulating the Endocannabinoid System as First-Line Treatment
Brugnatelli, V., Turco, F., Freo, U., & Zanette, G. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00371 · Cited by 16
Magnolol and honokiol target TRPC4 to regulate extracellular calcium influx and relax intestinal smooth muscle
Niu, L., Wang, J., Shen, F., Gao, J., Jiang, M., & Bai, G. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115105 · Cited by 16
The severity of inflammation at onset of ulcerative colitis is not associated with IBS-like symptoms during clinical remission
Jonefjäll, B., Simrén, M., Öhman, L., Lasson, A., Svedlund, J., & Strid, H. (2015) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjv107 · Cited by 16
Painful neurotrophins and their role in visceral pain
López-Pérez, A. E., Nurgali, K., & Abalo, R. (2018) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000386 · Cited by 17
The Endocannabinoid System: Implications in Gastrointestinal Physiology and Pathology
Caruso, E. A., Nunzio, V. D., Tutino, V., & Notarnicola, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031306 · Cited by 15
“However, further research is needed to refine treatment protocols and explore their full therapeutic potential.”
Gut–brain communication: types of sensory nerves and mechanisms of activation
Spencer, N. J., Hibberd, T. J., & Hu, H. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01132-1 · Cited by 20
“Den-ervation and retrograde tracing studies later provided the structural evidence for VFNs.”
The Ion Channels Involved in Oxidative Stress-Related Gastrointestinal Diseases
Miranda, M. R., Vestuto, V., Moltedo, O., Manfra, M., Campiglia, P., & Pepe, G. (2023) · Oxygen · doi:10.3390/oxygen3030022 · Cited by 18

Authors: Akbar, A., Yiangou, Y., Facer, P., Walters, J. R. F., Anand, P., & Ghosh, S.
Affiliations: Imperial College London (GB)
Hammersmith Hospital (GB)
Corresponding author: Ghosh, S
ORCID: Akbar, A
Yiangou, Y
Walters, J R F
Anand, P
Ghosh, S
Venue: Gut
Publisher: BMJ
Published: 2008-02-27
Volume: 57
Issue: 7
Pages: 923-929
ISSN: 0017-5749 (ISSN-L)
DOI: 10.1136/gut.2007.138982
PMC: PMC2564830
OpenAlex: W2165979101
Cited by: 526
References: 49
Citations by year: 2026: 19 · 2025: 16 · 2024: 34 · 2023: 25 · 2022: 21 · 2021: 36 · 2020: 28 · 2019: 27 · 2018: 30 · 2017: 30 · 2016: 41 · 2015: 25 · 2014: 36 · 2013: 39 · 2012: 26
FWCI: 29.02
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Gut (publishedVersion)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Spiral (Imperial College London) (submittedVersion)
Funders: GlaxoSmithKline
London School of Hygiene and Tropical Medicine
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Keywords: irritable bowel syndrome, TRPV1, capsaicin receptor, visceral pain, visceral hypersensitivity, abdominal pain, sensory nerve fibers, substance P, mast cells, lymphocytes, colonic mucosa, low-grade inflammation
MeSH terms: Adult, Aged, Anxiety, Depression, Female, Humans, Immunoenzyme Techniques, Intestinal Mucosa, Male, Middle Aged, Nerve Fibers, Neurons, Afferent, Pain Measurement, Abdominal Pain, Inflammation Mediators, Irritable Bowel Syndrome, TRPV Cation Channels

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Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain

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