Cited by 1,063Gut microbiota and healthInflammatory Bowel DiseaseClostridium difficile and Clostridium perfringens research

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Dysbiosis of the faecal microbiota in patients with Crohn’s disease and their unaffected relatives

Joossens, M., Huys, G., Cnockaert, M., De Preter, V., Verbeke, K., Rutgeerts, P., Vandamme, P., Vermeire, S.·2011·Gut

DOI 10.1136/gut.2010.223263

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Abstract

BACKGROUND AND AIMS: A general dysbiosis of the intestinal microbiota has been established in patients with Crohn's disease (CD), but a systematic characterisation of this dysbiosis is lacking. Therefore the composition of the predominant faecal microbiota of patients with CD was studied in comparison with the predominant composition in unaffected controls. Whether dysbiosis is present in relatives of patients CD was also examined. METHODS: Focusing on families with at least three members affected with CD, faecal samples of 68 patients with CD, 84 of their unaffected relatives and 55 matched controls were subjected to community fingerprinting of the predominant microbiota using denaturing gradient gel electrophoresis (DGGE). To analyse the DGGE profiles, BioNumerics software and non-parametric statistical analyses (SPSS V.17.0) were used. Observed differences in the predominant microbiota were subsequently confirmed and quantified with real-time PCR. RESULTS: Five bacterial species characterised dysbiosis in CD, namely a decrease in Dialister invisus (p=0.04), an uncharacterised species of Clostridium cluster XIVa (p = 0.03), Faecalibacterium prausnitzii (p < 1.3 × 10⁻⁵) and Bifidobacterium adolescentis (p = 5.4 × 10⁻⁶), and an increase in Ruminococcus gnavus (p = 2.1 × 10⁻⁷). Unaffected relatives of patients with CD had less Collinsella aerofaciens (p = 0.004) and a member of the Escherichia coli-Shigella group (p = 0.01) and more Ruminococcus torques (p = 0.02) in their predominant microbiota as compared with healthy subjects. CONCLUSION: Unaffected relatives of patients with CD have a different composition of their microbiota compared with healthy controls. This dysbiosis is not characterised by lack of butyrate producing-bacteria as observed in CD but suggests a role for microorganisms with mucin degradation capacity.

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Authors: Joossens, M., Huys, G., Cnockaert, M., De Preter, V., Verbeke, K., Rutgeerts, P., Vandamme, P., & Vermeire, S.
Affiliations: Universitair Ziekenhuis Leuven (BE)
Ghent University (BE)
ORCID: Joossens, M.
Huys, G.
Cnockaert, M.
Verbeke, K.
Vandamme, P.
Vermeire, S.
Venue: Gut
Publisher: BMJ
Published: 2011-01-05
Volume: 60
Issue: 5
Pages: 631-637
ISSN: 0017-5749 (ISSN-L)
DOI: 10.1136/gut.2010.223263
OpenAlex: W2139327060
Semantic Scholar: 3c76b951197740ae02ffa2ef816767ede9de1b85
Cited by: 1,063
References: 47
Citations by year: 2026: 30 · 2025: 67 · 2024: 88 · 2023: 91 · 2022: 73 · 2021: 103 · 2020: 95 · 2019: 81 · 2018: 65 · 2017: 60 · 2016: 74 · 2015: 56 · 2014: 68 · 2013: 57 · 2012: 34
FWCI: 23.48
Type: journal article
Language: en
Open access: closed
Locations: Gut (publishedVersion)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
HighWire Press Open Archive (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Keywords: Crohn's disease, fecal microbiota, dysbiosis, gut microbiota composition, unaffected relatives, Dialister invisus, Faecalibacterium prausnitzii, Bifidobacterium adolescentis, Ruminococcus gnavus, Ruminococcus torques, Collinsella aerofaciens, Clostridium cluster XIVa, mucin degradation, butyrate-producing bacteria, familial aggregation
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Bacteria, Crohn Disease, DNA, Bacterial, Feces, Female, Humans, Male, Middle Aged, Symbiosis, Case-Control Studies, Reverse Transcriptase Polymerase Chain Reaction, Metagenome, Young Adult, Denaturing Gradient Gel Electrophoresis

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Dysbiosis of the faecal microbiota in patients with Crohn’s disease and their unaffected relatives

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