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Dysbiosis of the faecal microbiota in patients with Crohn’s disease and their unaffected relatives
Abstract
BACKGROUND AND AIMS: A general dysbiosis of the intestinal microbiota has been established in patients with Crohn's disease (CD), but a systematic characterisation of this dysbiosis is lacking. Therefore the composition of the predominant faecal microbiota of patients with CD was studied in comparison with the predominant composition in unaffected controls. Whether dysbiosis is present in relatives of patients CD was also examined. METHODS: Focusing on families with at least three members affected with CD, faecal samples of 68 patients with CD, 84 of their unaffected relatives and 55 matched controls were subjected to community fingerprinting of the predominant microbiota using denaturing gradient gel electrophoresis (DGGE). To analyse the DGGE profiles, BioNumerics software and non-parametric statistical analyses (SPSS V.17.0) were used. Observed differences in the predominant microbiota were subsequently confirmed and quantified with real-time PCR. RESULTS: Five bacterial species characterised dysbiosis in CD, namely a decrease in Dialister invisus (p=0.04), an uncharacterised species of Clostridium cluster XIVa (p = 0.03), Faecalibacterium prausnitzii (p < 1.3 × 10⁻⁵) and Bifidobacterium adolescentis (p = 5.4 × 10⁻⁶), and an increase in Ruminococcus gnavus (p = 2.1 × 10⁻⁷). Unaffected relatives of patients with CD had less Collinsella aerofaciens (p = 0.004) and a member of the Escherichia coli-Shigella group (p = 0.01) and more Ruminococcus torques (p = 0.02) in their predominant microbiota as compared with healthy subjects. CONCLUSION: Unaffected relatives of patients with CD have a different composition of their microbiota compared with healthy controls. This dysbiosis is not characterised by lack of butyrate producing-bacteria as observed in CD but suggests a role for microorganisms with mucin degradation capacity.
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“Although dysbiosis is associated with chronic inflammation and production of carcinogenic metabolites, 175, 176 there is limited evidence to support a direct link between specific intestinal bacteria, their virulence factors, and sporadic CRC.”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [175]
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Cites
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030
Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611
Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413
Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach
Manichanh, C., Rigottier-Gois, L., Bonnaud, E., Gloux, K., Pelletier, E., Frangeul, L., Nalin, R., Jarrin, C., Chardon, P., Marteau, P., et al. (2006) · Gut · doi:10.1136/gut.2005.073817 · Cited by 2,277
Hampe, J., Franke, A., Rosenstiel, P. C., Till, A., Teuber, M., Huse, K., Albrecht, M., Mayr, G., Vega, F. M. D. L., Briggs, J. C., et al. (2006) · Nature Genetics · doi:10.1038/ng1954 · Cited by 1,948
Microbial Influences in Inflammatory Bowel Diseases
Sartor, R. B. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.059 · Cited by 1,927
Low counts of Faecalibacterium prausnitzii in colitis microbiota
Sokol, H., Seksik, P., Furet, J. P., Firmesse, O., Nion-Larmurier, I., Beaugerie, L., Cosnes, J., Corthier, G., Marteau, P., & Doré, J. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20903 · Cited by 1,275
Parkes, M., Barrett, J. C., Prescott, N. J., Tremelling, M., Anderson, C. A., Fisher, S. A., Roberts, R. G., Nimmo, E. R., Cummings, F. J. R., Soars, D., et al. (2007) · Nature Genetics · doi:10.1038/ng2061 · Cited by 1,175
D’Haens, G., Geboes, K., Peeters, M., Baert, F., PENNINCKX, F. M., & Rutgeerts, P. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70476-7 · Cited by 866
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Role of gut microbiota in infectious and inflammatory diseases
Maciel-Fiuza, M. F., Müller, G. C., Campos, D. M. S., Costa, P. D. S. S., Peruzzo, J., Bonamigo, R. R., Veit, T. D., & Vianna, F. S. L. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1098386 · Cited by 263
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Valdés, L., Cuervo, A. J. V., Salazar, N., Ruas‐Madiedo, P., Gueimonde, M., & González, S. (2015) · Food & Function · doi:10.1039/c5fo00322a · Cited by 243
Yu, S., Balasubramanian, I., Laubitz, D., Tong, K., Bandyopadhyay, S., Lin, X., Flores, J., Singh, R., Liu, Y., Macazana, C., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.07.010 · Cited by 240
Zuo, K., Li, J., Li, K., Hu, C., Gao, Y., Chen, M., Hu, R., Liu, Y., Chi, H., Wang, H., et al. (2019) · GigaScience · doi:10.1093/gigascience/giz058 · Cited by 237
Wu, T., Zhang, Z., Liu, B., Hou, D., Liang, Y., Zhang, J., & Shi, P. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-669 · Cited by 234
Spatial heterogeneity and co-occurrence patterns of human mucosal-associated intestinal microbiota
Zhang, Z., Geng, J., Tang, X., Fan, H., Xu, J., Wen, X., Ma, Z. S., & Shi, P. (2013) · The ISME Journal · doi:10.1038/ismej.2013.185 · Cited by 234
Chua, H.-H., Chou, H.-C., Tung, Y.-L., Chiang, B.-L., Liao, C.-C., Liu, H.-H., & Ni, Y.-H. (2018) · Gastroenterology · doi:10.1053/j.gastro.2017.09.006 · Cited by 229
Host immunoglobulin G selectively identifies pathobionts in pediatric inflammatory bowel diseases
Armstrong, H., Alipour, M., Valcheva, R. S., Bording‐Jorgensen, M., Jovel, J., Zaidi, D., Shah, P., Lou, Y., Ebeling, C., Mason, A. L., et al. (2019) · Microbiome · doi:10.1186/s40168-018-0604-3 · Cited by 228
Gilliland, A., Chan, J. J., Wolfe, T. J. D., Yang, H., & Vallance, B. A. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.09.019 · Cited by 237
Role of the enteric microbiota in intestinal homeostasis and inflammation
Koboziev, I., Webb, C. R., Furr, K. L., & Grisham, M. B. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.11.008 · Cited by 235
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Meijers, B. K. I., Evenepoel, P., & Anders, H. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0172-1 · Cited by 228
Fuentes, S., Rossen, N., van der Spek, M. J., Hartman, J., Huuskonen, L., Korpela, K., Salojärvi, J., Aalvink, S., de Vos, W. M., D’Haens, G., et al. (2017) · The ISME Journal · doi:10.1038/ismej.2017.44 · Cited by 220
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Carlsson, A. H., Yakymenko, O., Olivier, I., Håkansson, F., Postma, E., Keita, Å. V., & Söderholm, J. D. (2013) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2013.828773 · Cited by 219
The intestinal microbiota: its role in health and disease
Biedermann, L., & Rogler, G. (2015) · European Journal of Pediatrics · doi:10.1007/s00431-014-2476-2 · Cited by 227
López‐Siles, M., Enrich-Capó, N., Aldeguer, X., Sàbat, M., Duncan, S. H., Garcia-Gil, L. J., & Martínez-Medina, M. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00281 · Cited by 222
Halmos, E. P., Christophersen, C. T., Bird, A. R., Shepherd, S., Muir, J. G., & Gibson, P. R. (2016) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2016.22 · Cited by 212
Nagata, N., Nishijima, S., Kojima, Y., Hisada, Y., Imbe, K., Miyoshi-Akiyama, T., Suda, W., Kimura, M., Aoki, R., Sekine, K., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.03.054 · Cited by 209
Frémont, M., Coomans, D. H., Massart, S., & Meirleir, K. D. (2013) · Anaerobe · doi:10.1016/j.anaerobe.2013.06.002 · Cited by 208
Filippis, F. D., Paparo, L., Nocerino, R., Gatta, G. D., Carucci, L. R., Russo, R., Pasolli, E., Ercolini, D., & Canani, R. B. (2021) · Nature Communications · doi:10.1038/s41467-021-26266-z · Cited by 209
Gut Microbial Flora, Prebiotics, and Probiotics in IBD: Their Current Usage and Utility
Scaldaferri, F., Gerardi, V., Lopetuso, L. R., Zompo, F. D., Mangiola, F., Boškoski, I., Bruno, G., Petito, V., Laterza, L., Cammarota, G., et al. (2013) · BioMed Research International · doi:10.1155/2013/435268 · Cited by 207
Valcheva, R. S., Koleva, P. T., Martínez, I., Walter, J., Gänzle, M. G., & Dieleman, L. A. (2018) · Gut Microbes · doi:10.1080/19490976.2018.1526583 · Cited by 212
Russo, E., Giudici, F., Fiorindi, C., Ficari, F., Scaringi, S., & Amedei, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02754 · Cited by 204
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Wright, E. K., Kamm, M. A., Teo, S. M., Inouye, M., Wagner, J., & Kirkwood, C. D. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000382 · Cited by 219
Morgan, X. C., Kabakchiev, B., Waldron, L., Tyler, A. D., Tickle, T. L., Milgrom, R., Stempak, J. M., Gevers, D., Xavier, R. J., Silverberg, M. S., et al. (2015) · Genome biology · doi:10.1186/s13059-015-0637-x · Cited by 198
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Walker, A. W., & Lawley, T. D. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.09.008 · Cited by 209
Lahti, L., Salonen, A., Kekkonen, R. A., Salojärvi, J., Jalanka, J., Palva, A., Orešič, M., & de Vos, W. M. (2013) · PeerJ · doi:10.7717/peerj.32 · Cited by 198
Eppinga, H., Weiland, C. J. S., Thio, H. B., van der Woude, C. J., Nijsten, T. E. C., Peppelenbosch, M. P., & Konstantinov, S. R. (2016) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjw070 · Cited by 199
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Falony, G., Vieira-Silva, S., & Raes, J. (2015) · Annual Review of Microbiology · doi:10.1146/annurev-micro-091014-104422 · Cited by 187
Schoultz, I., & Keita, Å. V. (2019) · Cells · doi:10.3390/cells8020193 · Cited by 193
Zhang, X., Fang, Z., Zhang, C., Xia, H., Jie, Z., Han, X., Chen, Y., & Ji, L. (2017) · Diabetes Therapy · doi:10.1007/s13300-017-0226-y · Cited by 187
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Ladau, J., & Eloe‐Fadrosh, E. A. (2019) · Trends in Microbiology · doi:10.1016/j.tim.2019.03.003 · Cited by 185
von Martels, J. Z. H., Sadabad, M. S., Bourgonje, A. R., Blokzijl, T., Dijkstra, G. D. H., Faber, K. N., & Harmsen, H. J. M. (2017) · Anaerobe · doi:10.1016/j.anaerobe.2017.01.001 · Cited by 186
Zhao, Y., & Jiang, Q. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa104 · Cited by 191
Tailford, L. E., Owen, C. D., Walshaw, J., Crost, E. H., Hardy-Goddard, J., Le Gall, G., de Vos, W. M., Taylor, G. L., & Juge, N. (2015) · Nature Communications · doi:10.1038/ncomms8624 · Cited by 183
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Nagao‐Kitamoto, H., & Kamada, N. (2017) · Immune Network · doi:10.4110/in.2017.17.1.1 · Cited by 185
The involvement of gut microbiota in inflammatory bowel disease pathogenesis: Potential for therapy
Cammarota, G., Ianiro, G., Cianci, R., Bibbò, S., Gasbarrini, A., & Currò, D. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.12.006 · Cited by 184
Recent advances in the therapeutic application of short-chain fatty acids (SCFAs): An updated review
Rauf, A., Khalil, A. A., Rahman, U.-U., Khalid, A., Naz, S., Shariati, M. A., Ребезов, М. Б., Zavala, E., de Albuquerque, R. D. D. G., Anwar, S., et al. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1895064 · Cited by 190
Jia, L., Li, D., Feng, N., Shamoon, M., Sun, Z., Ding, L., Zhang, H., Chen, W., Sun, J., & Chen, Y. Q. (2017) · Scientific Reports · doi:10.1038/s41598-017-07335-0 · Cited by 179
Biedermann, L., Brülisauer, K., Zeitz, J., Frei, P., Scharl, M., Vavricka, S. R., Fried, M., Loessner, M. J., Rogler, G., & Schuppler, M. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000129 · Cited by 178
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Raftery, A. L., Tsantikos, E., Harris, N. L., & Hibbs, M. L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02144 · Cited by 179
Tong, M., Li, X., Parfrey, L. W., Roth, B. E., Ippoliti, A., Wei, B., Borneman, J., McGovern, D. P. B., Frank, D. N., Li, E., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080702 · Cited by 184
Role of commensal gut bacteria in inflammatory bowel diseases
Loh, G., & Blaut, M. (2012) · Gut Microbes · doi:10.4161/gmic.22156 · Cited by 186
Lamas, B., Breyner, N. M., & Houdeau, É. (2020) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-00349-z · Cited by 182
Aldars‐García, L., Chaparro, M., & Gisbert, J. P. (2021) · Microorganisms · doi:10.3390/microorganisms9050977 · Cited by 181
López‐Siles, M., Martínez-Medina, M., Busquets, D., Sàbat, M., Duncan, S. H., Flint, H. J., Aldeguer, X., & Garcia-Gil, L. J. (2014) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2014.02.009 · Cited by 174
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Yang, J., Summanen, P. H., Henning, S. M., Hsu, M., Lam, H., Huang, J., Tseng, C., Dowd, S. E., Finegold, S. M., Heber, D., et al. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00216 · Cited by 175
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Zheng, H., Liang, H., Wang, Y., Miao, M., Shi, T., Yang, F., Liu, E., Yuan, W., Ji, Z., & Li, D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166026 · Cited by 172
Harsch, I. A., & Konturek, P. C. (2018) · Medical Sciences · doi:10.3390/medsci6020032 · Cited by 173
Celiberto, L. S., Graef, F. A., Healey, G. R., Bosman, E. S., Jacobson, K., Sly, L. M., & Vallance, B. A. (2018) · Immunology · doi:10.1111/imm.12939 · Cited by 167
Gut Microbiota Is a Potential Biomarker in Inflammatory Bowel Disease
Guo, X., Huang, C., Xu, J., Xu, H., Liu, L., Zhao, H., Wang, J., Huang, W., Wu, P., Chen, Y., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2021.818902 · Cited by 167
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Turpin, W., Goethel, A., Bedrani, L., & Croitoru, M. K. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy085 · Cited by 170
Wang, H., Lü, M., Deng, Y., Liu, Y., Wei, X., Liu, M., Zhou, J., Ma, H., Zheng, P., Yuan, J., et al. (2018) · Nutrition · doi:10.1016/j.nut.2018.11.018 · Cited by 167
Mondot, S., Lepage, P., Seksik, P., Allez, M., Tréton, X., Bouhnik, Y., Colombel, J., Leclerc, M., Pochart, P., Dore, J. M., et al. (2015) · Gut · doi:10.1136/gutjnl-2015-309184 · Cited by 163
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Halsey, T. M., Thomas, A. S., Hayase, T., Ma, W., Abu-Sbeih, H., Sun, B., Parra, E. R., Jiang, Z.-D., DuPont, H. L., Sanchez, C., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.abq4006 · Cited by 161
Gut Microbiota Dysbiosis and Increased Plasma LPS and TMAO Levels in Patients With Preeclampsia
Wang, J., Gu, X., Yang, J., Wei, Y., & Zhao, Y. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00409 · Cited by 161
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Nardone, O. M., de Sire, R., Petito, V., Testa, A., Villani, G., Scaldaferri, F., & Castiglione, F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.694217 · Cited by 159
Interaction of obesity and inflammatory bowel disease
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Metabolic Influences of Gut Microbiota Dysbiosis on Inflammatory Bowel Disease
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Chumpitazi, B. P., Hollister, E. B., Oezguen, N., Tsai, C. M., McMeans, A. R., Luna, R. A., Savidge, T. C., Versalovic, J., & Shulman, R. J. (2014) · Gut Microbes · doi:10.4161/gmic.27923 · Cited by 156
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Berry, D., & Reinisch, W. (2013) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2013.03.005 · Cited by 154
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Deng, Y., Wang, H., Zhou, J. W., Mou, Y., Wang, G., & Xiong, X. (2018) · Acta Dermato Venereologica · doi:10.2340/00015555-2968 · Cited by 166
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Nemoto, H., Kataoka, K., Ishikawa, H., Ikata, K., Arimochi, H., Iwasaki, T., Ohnishi, Y., Kuwahara, T., & Yasutomo, K. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2236-y · Cited by 152
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Banfi, D., Moro, E., Bosi, A., Bistoletti, M., Cerantola, S., Crema, F., Maggi, F., Giron, M. C., Giaroni, C., & Baj, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041623 · Cited by 160
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Frolkis, A. D., Dieleman, L. A., Barkema, H. W., Panaccione, R., Ghosh, S. K., Fedorak, R. N., Madsen, K., & Kaplan, G. G. (2013) · Canadian Journal of Gastroenterology · doi:10.1155/2013/102859 · Cited by 153
Li, D., Achkar, J., Haritunians, T., Jacobs, J. P., Hui, K. Y., D’Amato, M., Brand, S., Radford‐Smith, G. L., Halfvarson, J., Niess, J. H., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.06.051 · Cited by 153
Xu, Z., Takizawa, F., Casadei, E., Shibasaki, Y., Ding, Y., Sauters, T. J. C., Yu, Y., Salinas, I., & Sunyer, J. O. (2020) · Science Immunology · doi:10.1126/sciimmunol.aay3254 · Cited by 154
Moens, F., Weckx, S., & Vuyst, L. D. (2016) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2016.05.015 · Cited by 160
Kowalska‐Duplaga, K., Gosiewski, T., Kapusta, P., Sroka-Oleksiak, A., Wędrychowicz, A., Pieczarkowski, S., Ludwig‐Słomczyńska, A. H., Wołkow, P. P., & Fyderek, K. (2019) · Scientific Reports · doi:10.1038/s41598-019-55290-9 · Cited by 160
Kabeerdoss, J., Vijayalakshmi, S. P., Pugazhendhi, S., & Ramakrishna, B. (2013) · BMC Gastroenterology · doi:10.1186/1471-230x-13-20 · Cited by 156
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Yan, Y., Nguyen, L. H., Franzosa, E. A., & Huttenhower, C. (2020) · Genome Medicine · doi:10.1186/s13073-020-00765-y · Cited by 152
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Metwaly, A., Dunkel, A., Waldschmitt, N., Raj, A. C. D., Lagkouvardos, I., Corraliza, A. M., Mayorgas, A., Martínez-Medina, M., Reiter, S., Schloter, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17956-1 · Cited by 146
Hedin, C. R. H., McCarthy, N. E., Louis, P., Farquharson, F. M., McCartney, S. A., Taylor, K. M., Prescott, N. J., Murrells, T., Stagg, A. J., Whelan, K., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-306226 · Cited by 147
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Stange, E. F., & Schroeder, B. O. (2019) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2019.1671822 · Cited by 154
Ramakrishna, B., Jayakanthan, P., Pugazhendhi, S., & Kabeerdoss, J. (2015) · The Indian Journal of Medical Research · doi:10.4103/0971-5916.162091 · Cited by 144
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Navab-Moghadam, F., Sedighi, M., Khamseh, M. E., Alaei-Shahmiri, F., Talebi, M., Razavi, S., & Amirmozafari, N. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2017.07.034 · Cited by 149
Machiels, K., Sabino, J. P. G., Vandermosten, L., Joossens, M., Arijs, I., de Bruyn, M., Eeckhaut, V., Assche, G. V., Ferrante, M., Verhaegen, J., et al. (2015) · Gut · doi:10.1136/gutjnl-2015-309398 · Cited by 143
Self-citationLi, H., Christman, L. M., Li, R., & Gu, L. (2020) · Food & Function · doi:10.1039/d0fo00713g · Cited by 145
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Li, P., Luo, H., Ji, B., & Nielsen, J. (2022) · Microbial Cell Factories · doi:10.1186/s12934-022-01973-4 · Cited by 155
Pigneur, B., Lepage, P., Mondot, S., Schmitz, J., Goulet, O., Dore, J. M., & Ruemmele, F. M. (2018) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjy207 · Cited by 139
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Hoffmann, T. W., Pham, H., Bridonneau, C., Aubry, C., Lamas, B., Martin‐Gallausiaux, C., Moroldo, M., Rainteau, D. P., Lapaque, N., Six, A., et al. (2015) · The ISME Journal · doi:10.1038/ismej.2015.127 · Cited by 144
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Bell, A., Brunt, J., Crost, E. H., Vaux, L., Nepravishta, R., Owen, C. D., Latousakis, D., Xiao, A., Li, W., Chen, X., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0590-7 · Cited by 137
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Henke, M. T., Brown, E., Cassilly, C. D., Vlamakis, H. C., Xavier, R. J., & Clardy, J. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2007595118 · Cited by 134
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Ravcheev, D. A., & Thiele, I. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00111 · Cited by 139
Yin, J., Sternes, P. R., Wang, M., Morrison, M., Song, J., Li, T., Zhou, L., Wu, X., He, F., Zhu, J., et al. (2019) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2019-215763 · Cited by 135
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Prince, A., Chu, D. M., Seferovic, M., Antony, K. M., Ma, J., & Aagaard, K. M. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a023051 · Cited by 141
Schäffler, H., Herlemann, D. P. R., Klinitzke, P., Berlin, P., Kreikemeyer, B., Jaster, R., & Lamprecht, G. (2018) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12591 · Cited by 134
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Toya, T., Corban, M., Marietta, E. V., Horwath, I. E., Lerman, L. O., Murray, J. A., & Lerman, A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227147 · Cited by 131
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Metadata
- Authors
- Joossens, M., Huys, G., Cnockaert, M., De Preter, V., Verbeke, K., Rutgeerts, P., Vandamme, P., & Vermeire, S.
- Affiliations
- Universitair Ziekenhuis Leuven (BE)
- Ghent University (BE)
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2011-01-05
- Volume
- 60
- Issue
- 5
- Pages
- 631-637
- ISSN
- 0017-5749 (ISSN-L)
- OpenAlex
- W2139327060
- Semantic Scholar
- 3c76b951197740ae02ffa2ef816767ede9de1b85
- Cited by
- 1,063
- References
- 47
- Citations by year
- 2026: 30 · 2025: 67 · 2024: 88 · 2023: 91 · 2022: 73 · 2021: 103 · 2020: 95 · 2019: 81 · 2018: 65 · 2017: 60 · 2016: 74 · 2015: 56 · 2014: 68 · 2013: 57 · 2012: 34
- FWCI
- 23.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gut (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Keywords
- Crohn's disease, fecal microbiota, dysbiosis, gut microbiota composition, unaffected relatives, Dialister invisus, Faecalibacterium prausnitzii, Bifidobacterium adolescentis, Ruminococcus gnavus, Ruminococcus torques, Collinsella aerofaciens, Clostridium cluster XIVa, mucin degradation, butyrate-producing bacteria, familial aggregation
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Bacteria, Crohn Disease, DNA, Bacterial, Feces, Female, Humans, Male, Middle Aged, Symbiosis, Case-Control Studies, Reverse Transcriptase Polymerase Chain Reaction, Metagenome, Young Adult, Denaturing Gradient Gel Electrophoresis
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