The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide
Abstract
BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) has been linked to a loss of tolerance towards the resident microflora. Therapeutic use of probiotics is known to be strain specific, but precise mechanisms remain unclear. The role of NOD2 signalling and the protective effect of Lactobacillus peptidoglycan (PGN) and derived muropeptides in experimental colitis were evaluated. METHODS: The anti-inflammatory capacity of lactobacilli and derived bacterial compounds was evaluated using the 2,4,6-trinitrobenzene sulfonic acid (TNBS) colitis model. The role of NOD2, MyD88 and interleukin 10 (IL-10) in this protection was studied using Nod2(-/-), MyD88(-/-) and Il10-deficient mice, while induction of regulatory dendritic cells (DCs) was monitored through the expansion of CD103(+) DCs in mesenteric lymph nodes or after adoptive transfer of bone marrow-derived DCs. The development of regulatory T cells was investigated by following the expansion of CD4(+)FoxP3(+) cells. High-performance liquid chromatography and mass spectrometry were used to analyse the PGN structural differences. RESULTS: The protective capacity of strain Lactobacillus salivarius Ls33 was correlated with a local IL-10 production and was abolished in Nod2-deficient mice. PGN purified from Ls33 rescued mice from colitis in an IL-10-dependent manner and favoured the development of CD103(+) DCs and CD4(+)Foxp3(+) regulatory T cells. In vitro Ls33 PGN induced IL-10-producing DCs able to achieve in vivo protection after adoptive transfer in a NOD2-dependent way. This protection was also correlated with an upregulation of the indoleamine 2,3-dioxygenase immunosuppressive pathway. The protective capacity was not obtained with PGN purified from a non-anti-inflammatory strain. Structural analysis of PGNs highlighted in Ls33 the presence of an additional muropeptide, M-tri-Lys. The synthesised ligand protected mice from colitis in a NOD2-dependent but MyD88-independent manner. CONCLUSIONS: The results indicated that PGN and derived muropeptides are active compounds in probiotic functionality and might represent a useful therapeutic strategy in IBD.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Furthermore, muramyl dipeptide or peptidoglycan mediated activation of NOD2 is reported to negatively regulate TLR signaling and provide protection of wildtype mice against colitis.175,176”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [176]
In the citing paper
“The absence of NOD protein–mediated microbial sensing leads to a loss of gut barrier homeostasis and leads to increased susceptibility to gut inflammatory diseases.176”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [176]
Citations
Cites
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., Takeda, K., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80119-3 · Cited by 3,680
Coombes, J. L., Siddiqui, K. R. R., Arancibia-Cárcamo, C. V., Hall, J. A., Sun, C., Belkaid, Y., & Powrie, F. M. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070590 · Cited by 2,708
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
the NIDDK IBD Genetics Consortium, Barrett, J. C., the Belgian-French IBD Consortium, the Wellcome Trust Case Control Consortium, Hansoul, S., Nicolae, D. L., Cho, J. H., Duerr, R. H., Rioux, J. D., Brant, S. R., et al. (2008) · Nature Genetics · doi:10.1038/ng.175 · Cited by 2,593
Franke, A., McGovern, D. P. B., Barrett, J. C., Wang, K., Radford-Smith, G. L., Ahmad, T., Lees, C. W., Balschun, T., Lee, J., Roberts, R., et al. (2010) · Nature Genetics · doi:10.1038/ng.717 · Cited by 2,520
Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection
Girardin, S. E., Boneca, I. G., Viala, J., Chamaillard, M., Labigne-Roussel, A., Thomas, G. D., Philpott, D. J., & Sansonetti, P. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c200651200 · Cited by 2,397
Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach
Manichanh, C., Rigottier-Gois, L., Bonnaud, E., Gloux, K., Pelletier, E., Frangeul, L., Nalin, R., Jarrin, C., Chardon, P., Marteau, P., et al. (2006) · Gut · doi:10.1136/gut.2005.073817 · Cited by 2,277
Kruis, W., Frič, P., Pokrotnieks, J., Lukáš, M., Fixa, B., Kaščák, M., Kamm, M. A., Weismueller, J., Beglinger, C., Stolte, M., et al. (2004) · Gut · doi:10.1136/gut.2003.037747 · Cited by 1,285
Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis
Bouskra, D., Brézillon, C., Bérard, M., Werts, C., Varona, R., Boneca, I. G., & Eberl, G. (2008) · Nature · doi:10.1038/nature07450 · Cited by 1,107
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–300 of 375
Implication of Paraprobiotics in Age-Associated Gut Dysbiosis and Neurodegenerative Diseases
Rahman, Z., & Dandekar, M. P. (2022) · NeuroMolecular Medicine · doi:10.1007/s12017-022-08722-1 · Cited by 25
Baik, J. E., Jang, Y.-O., Kang, S., Cho, K., Yun, C., & Han, S. H. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.01.007 · Cited by 24
Digehsara, S. G., Name, N., Esfandiari, B., Karim, E., Taheri, S., Ebrahimi, M. T., & Arasteh, J. (2020) · Inflammation · doi:10.1007/s10753-020-01339-1 · Cited by 24
An Integrated Engineering Approach to Creating Health‐Modulating Postbiotics
Chikindas, M. L., Roopchand, D. E., Tiwari, S. K., Sichel, L. S., Karwe, M. V., Nitin, N., Fagundes, V. L., Popov, I. V., Tagg, J. R., Lu, X., et al. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70326 · Cited by 26
Examining host–microbial interactions through the lens of NOD: From plants to mammals
Robertson, S. J., Rubino, S. J., Geddes, K., & Philpott, D. J. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.01.001 · Cited by 24
Mobergslien, A., Vasovič, V., Mathiesen, G., Fredriksen, L., Westby, P., Eijsink, V. G. H., Peng, Q., & Sioud, M. (2015) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2015.1056952 · Cited by 23
Hrdý, J., Couturier-Maillard, A., Boutillier, D., Lapadatescu, C., Blanc, P., Procházka, J., Pot, B., Ryffel, B., Grangette, C., & Chamaillard, M. (2022) · Scientific Reports · doi:10.1038/s41598-022-21643-0 · Cited by 22
Meshkibaf, S., Fritz, J., Gottschalk, M. G., & Kim, S. O. (2015) · BMC Microbiology · doi:10.1186/s12866-015-0578-2 · Cited by 22
Schäffler, H., Schneider, N., Hsieh, C., Reiner, J., Nadalin, S., Witte, M. B., Königsrainer, A., Blumenstock, G., & Lamprecht, G. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2013.02.014 · Cited by 22
Masaki, S., Masuta, Y., Honjo, H., Kudo, M., & Watanabe, T. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1433620 · Cited by 24
Molecular mechanisms of probiotic action: it's all in the strains!
Shanahan, F. (2011) · Gut · doi:10.1136/gut.2011.241026 · Cited by 21
Kwan, J. M. C., & Qiao, Y. (2023) · ChemBioChem · doi:10.1002/cbic.202200693 · Cited by 21
In vitro evaluation of Pediococcus acidilactici NCDC 252 for its probiotic attributes
Attri, P., Jodha, D., Gandhi, D., Chanalia, P., & Dhanda, S. (2015) · International Journal of Dairy Technology · doi:10.1111/1471-0307.12194 · Cited by 22
Gut microbiota in ischemic stroke: Where we stand and challenges ahead
Long, J.-X., Wang, J., Li, Y., & Chen, D. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1008514 · Cited by 22
Prebiotics, Probiotics and Postbiotics: The Changing Paradigm of Functional Foods
Kango, N., & Nath, S. (2024) · Journal of Dietary Supplements · doi:10.1080/19390211.2024.2363199 · Cited by 27
Meijerink, M., Mercenier, A., & Wells, J. M. (2013) · Beneficial Microbes · doi:10.3920/bm2012.0035 · Cited by 20
Martens, K., Boeck, I. D., Jokicevic, K., Kiekens, F., Farré, R., Vanderveken, O. M., Seys, S., Lebeer, S., Hellings, P. W., & Steelant, B. (2021) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2021.13.4.560 · Cited by 17
Hiramatsu, Y., Satho, T., Irie, K., Shiimura, S., Okuno, T., Sharmin, T., Uyeda, S., Fukumitsu, Y., Nakashima, Y., Miake, F., et al. (2012) · Microbes and Infection · doi:10.1016/j.micinf.2012.11.003 · Cited by 17
Odun-Ayo, F., & Reddy, L. (2022) · Gastroenterology Insights · doi:10.3390/gastroent13010006 · Cited by 18
Bumgardner, S., Zhang, L., LaVoy, A. S., Andre, B., Frank, C., Kajikawa, A., Klaenhammer, T. R., & Dean, G. A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0196950 · Cited by 17
Antioxidant and Anti-Inflammatory Activities of Probiotic Strains
Căliman-Sturdza, O. A., Vaz, J. A., Lupăescu, A.-V., Lobiuc, A., Bran, C., & Gheorghita, R. E. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27021079 · Cited by 18
Wong, W., Chan, B., Cho, P.-T., Leung, T.-W., & Tai, W. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106167 · Cited by 16
The Influence of Probiotic Lactobacilli on COVID-19 and the Microbiota
Taufer, C. R., da Silva, J., & Rampelotto, P. H. (2024) · Nutrients · doi:10.3390/nu16091350 · Cited by 15
Zhao, L., Suolang, Y., Zhou, D., Tang, Y., & Zhang, Y. (2017) · Microbiology and Immunology · doi:10.1111/1348-0421.12562 · Cited by 15
Lactobacillus plantarumNRIC1832 Enhances IL-10 Production from CD4+T Cellsin Vitro
NOGUCHI, S., Hattori, M., SUGIYAMA, H., HANAOKA, A., Okada, S., & Yoshida, T. (2012) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.120404 · Cited by 16
Pontes, D. S., de Azevedo, M. S. P., Innocentin, S., Blugeon, S., Lefèvre, F., Azevedo, V., Miyoshi, A., Courtin, P., Chapot, M.-P., Langella, P., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084509 · Cited by 15
Ladda, B., Theparee, T., Chimchang, J., Tanasupawat, S., & Taweechotipatr, M. (2015) · Anaerobe · doi:10.1016/j.anaerobe.2015.03.002 · Cited by 15
Bifidobacteria and subsets of dendritic cells: friendly players in immune regulation!: Figure 1
Grangette, C. (2011) · Gut · doi:10.1136/gutjnl-2011-301476 · Cited by 15
Lin, Z., Luo, W. T., Zhang, K., & Dai, S. (2023) · Gut and Liver · doi:10.5009/gnl230179 · Cited by 14
Liuu, S., Nepelska, M., Pfister, H. B., Magalhaes, J. G., Chevalier, G., Strozzi, F., Billerey, C., Maresca, M., Nicoletti, C., Pasquale, E. D., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2306863120 · Cited by 15
Wheeler, R., & Boneca, I. G. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2395099 · Cited by 16
Allouche, R., Hafeez, Z., Papier, F., Dary, A., Genay, M., & Miclo, L. (2022) · Foods · doi:10.3390/foods11081157 · Cited by 14
Li, A., Sun, Y.-Q., Du, P., Meng, X., Guo, L., Li, S., & Zhang, C. (2017) · PubMed · Cited by 14
Fuke, N., Takagi, T., Higashimura, Y., Tsuji, T., Umeda, R., Mizushima, K., Tanaka, M., Suganuma, H., Aizawa, K., Yajima, N., et al. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izx003 · Cited by 15
Belguesmia, Y., Alard, J., Mendil, R., Ravallec, R., Grangette, C., Drider, D., & Cudennec, B. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.04.028 · Cited by 14
Ou, Q., Wang, L., Wang, K., & Shao, P. (2021) · Annals of Palliative Medicine · doi:10.21037/apm-21-1056 · Cited by 13
Kim, D.-H., Choi, H., Oh, H., Lee, J., Hwang, Y., & Kang, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010042 · Cited by 14
Kang, Y. Y., Song, H. J., Park, S. Y., Oh, D. N., Kim, G. Y., Been, N. Y., Kim, D. Y., Lee, E. J., Nam, B., & Lee, J. M. (2025) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2411.11045 · Cited by 13
Ito, M., Kim, Y.-G., Tsuji, H., Takahashi, T., Kiwaki, M., Nomoto, K., Danbara, H., & Okada, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0083876 · Cited by 13
Tipping the balance in autoimmunity: are regulatory t cells the cause, the cure, or both?
Hardtke‐Wolenski, M., & Landwehr-Kenzel, S. (2024) · Molecular and Cellular Pediatrics · doi:10.1186/s40348-024-00176-8 · Cited by 17
Prossomariti, A., Sokol, H., & Ricciardiello, L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01039 · Cited by 12
Sohail, G., Xu, X., Christman, M. C., & Tompkins, T. A. (2018) · World Journal of Clinical Cases · doi:10.12998/wjcc.v6.i15.961 · Cited by 15
Microbes little helpers and suppliers for therapeutic asthma approaches
Reuter, S., Raspe, J., & Taube, C. (2024) · Respiratory Research · doi:10.1186/s12931-023-02660-7 · Cited by 11
Lee, M.-K., Chen, I.-H., Hsu, I.-L., Tsai, W.-H., Lee, T.-Y., Jhong, J.-H., Liu, B.-C., Huang, T.-Y., Lin, F.-K., Chang, W., et al. (2024) · BMC Oral Health · doi:10.1186/s12903-024-04251-4 · Cited by 13
Zeolite and Neurodegenerative Diseases
Panaiotov, S., Tancheva, L. P., Kalfin, R. E., & Petkova-Kirova, P. S. (2024) · Molecules · doi:10.3390/molecules29112614 · Cited by 15
García-González, N., Núñez‐Sánchez, M. Á., Recio, M. V., Battista, N., Gahan, C. G. M., & Corsetti, A. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.557143 · Cited by 11
Iloba, I., McGarry, S. V., Yu, L., Cruickshank, D., & Jensen, G. S. (2023) · Microorganisms · doi:10.3390/microorganisms11102564 · Cited by 11
Analgesic and Acute Anti-inflammatory Activities of Aqueous Root Extract of Salacia lehmbachii
Takem, L. P., Lawal, B. A. S., & Udia, P. M. (2014) · Journal of Pharmaceutical Research International · doi:10.9734/bjpr/2014/9250 · Cited by 11
When the Host Encounters the Cell Wall and Vice Versa
Kho, K., Cheng, T., Buddelmeijer, N., & Boneca, I. G. (2024) · Annual Review of Microbiology · doi:10.1146/annurev-micro-041522-094053 · Cited by 10
The efficacy of Akkermansia muciniphila YGMCC2602-derived postbiotics in skin repair
He, Z., Song, W., Zhang, S., Zhao, M., Wang, F., He, S., Jie, X., Gao, Q., & Chen, J. (2025) · Journal of Functional Foods · doi:10.1016/j.jff.2025.106950 · Cited by 10
Probiotic Molecules That Inhibit Inflammatory Diseases
Zamora-Pineda, J. B., Kalinina, O., Osborne, B. A., & Knight, K. L. (2022) · Applied Sciences · doi:10.3390/app12031147 · Cited by 10
NOD2 in monocytes negatively regulates macrophage development through TNFalpha
Chauvin, C., Álvarez-Simón, D., Radulovic, K., Boulard, O., Laine, W., Delacre, M., Waldschmitt, N., Segura, É., Kluza, J., Chamaillard, M., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1181823 · Cited by 10
Wu, Z. F., Pan, D., Guo, Y., Zeng, X., & Sun, Y. (2015) · PROTEOMICS · doi:10.1002/pmic.201400580 · Cited by 10
Protein-Based HIV-1 Microbicides
Dey, B., Lagenaur, L. A., & Lusso, P. (2014) · Current HIV Research · doi:10.2174/1570162x11666140101120709 · Cited by 10
Probiotics in the Rescue of Gut Inflammation
Ghosh, A. R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814625-5.00006-6 · Cited by 10
The peripheral immune response of mice infected with a neuropathogenic schistosome
Majer, M., Macháček, T., Súkeníková, L., Hrdý, J., & Horák, P. (2020) · Parasite Immunology · doi:10.1111/pim.12710 · Cited by 10
Maillard, F., Meynier, M., Mondot, S., Pepke, F., Galbert, C., Torres-Maravilla, E., Kropp, C., Sokol, H., Carvalho, F. A., Jacouton, E., et al. (2023) · Microorganisms · doi:10.3390/microorganisms11040906 · Cited by 11
Understanding Immunomodulatory Effects of Probiotics
Pot, B., Foligné, B., Daniel, C., & Grangette, C. (2013) · Nestlé Nutrition Institute Workshop series · doi:10.1159/000351388 · Cited by 12
Induction of ALDH Activity in Intestinal Dendritic Cells byLactobacillus plantarumNRIC0380
Yoshida, T., Enomoto, M., Nakayama, S., ADACHI, Y., Fujiwara, W., SUGIYAMA, H., Shimojoh, M., Okada, S., & Hattori, M. (2013) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.130144 · Cited by 10
Bacterial membrane vesicles restore gut anaerobiosis
Pitt, N., Morrissette, M., Gates, M. F., Bargabos, R., Krumpoch, M. T., Hawkins, B. A., & Lewis, K. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00676-z · Cited by 9
Mehta, J. P., Sahoo, P., Ayakar, S. R., & Singhal, R. S. (2025) · The Microbe · doi:10.1016/j.microb.2025.100304 · Cited by 9
The role of probiotics in promoting systemic immune tolerance in systemic lupus erythematosus
Mohamed, A. H., Shafie, A., Al-Samawi, R. I., Jamali, M. C., Ashour, A. A., Felemban, M. F., Alqarni, A., Ahmad, I., Mansuri, N., Ahmad, F., et al. (2025) · Gut Pathogens · doi:10.1186/s13099-025-00702-7 · Cited by 11
Mai, E., Percopo, C. M., Limkar, A. R., Sek, A. C., Ma, M., & Rosenberg, H. F. (2020) · Viruses · doi:10.3390/v13010002 · Cited by 9
Diet, microbiome, and colorectal cancer
Konstantinov, S. R. (2017) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2017.09.007 · Cited by 9
Súkeníková, L., Černý, V., Věcek, J., Petrásková, P., Novotná, O., Vobruba, Š., Michalčíková, T., Procházka, J., Kolářová, L., Prokešová, L., et al. (2022) · Cells · doi:10.3390/cells11101624 · Cited by 8
Li, A., Yang, S., Han, X., Liu, C., Zheng, J., Ma, Y., Cheng, S., Zhao, J., Zhou, W., & Du, P. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.103437 · Cited by 10
Siddiqui, A., Haider, R., Aaqil, S. I., Vohra, L. I., Qamar, K., Jawed, A., Fatima, N., Adnan, A., Parikh, V., Ochani, S., et al. (2024) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000002007 · Cited by 9
LeBlanc, J. G., del Carmen, S., Zurita-Turk, M., Lima, F., Pontes, D. S., Miyoshi, A., Azevedo, V., & de LeBlanc, A. D. M. (2012) · Anti-Infective Agents · doi:10.2174/22113626130107 · Cited by 8
Tumorigenesis in Inflammatory Bowel Disease: Microbiota-Environment Interconnections
Mignini, I., Ainora, M. E., Francesco, S. D., Galasso, L., Gasbarrini, A., & Zocco, M. A. (2023) · Cancers · doi:10.3390/cancers15123200 · Cited by 9
Tulini, F. L., Hymery, N., Choiset, Y., Chobert, J., Haertlé, T., Martinis, E. C. P. D., & Blay, G. L. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.04.004 · Cited by 8
Fei, P., Li, L., Cai, X., Zhang, X., Bai, H., Jiang, Y., Feng, Z., & Guo, L. J. (2016) · Jundishapur Journal of Microbiology · doi:10.5812/jjm.32356 · Cited by 8
Guo, L. J., Bai, H., Dong, Y., Huang, D. X., Zhang, X., Gong, S., Zhao, X., & Fei, P. (2016) · Iranian Journal of Pediatrics · doi:10.5812/ijp.6397 · Cited by 8
Bhushan, B., Singh, B. P., Kumari, M., Mishra, V., Saini, K., & Singh, D. (2019) · Environmental chemistry for a sustainable world · doi:10.1007/978-3-030-04675-0_7 · Cited by 9
Coll-Marqués, J. M., Bäuerl, C., Zúñiga, M., & Pérez‐Martínez, G. (2020) · FEMS Microbiology Letters · doi:10.1093/femsle/fnaa102 · Cited by 8
D-alanylation of Teichoic Acids in Bacilli impedes the immune sensing of peptidoglycan in DrosophilaPreprint
Attieh, Z., Awad, M. K., Réjasse, A., Courtin, P., Boneca, I. G., Chapot, M.-P., Sanchis, V., & Chamy, L. E. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/631523 · Cited by 8
Abbaszadeh, S. H., Hosseini, S. R. A., Mahmoodpoor, A., Yousefi, M., Lotfi‐Dizaji, L., & Ebrahimi‐Mameghani, M. (2024) · Indian Journal of Microbiology · doi:10.1007/s12088-024-01421-4 · Cited by 7
Zhong, H., Yu, Y., Abdullah, Zhang, H., Du, J., Sun, J., Chen, L., Feng, F., & Guan, R. (2025) · Food & Function · doi:10.1039/d4fo06100d · Cited by 7
Synthesis and validation of click-modified NOD1/2 agonists
Bharadwaj, R., Anonick, M. V., Jaiswal, S., Mashayekh, S., Brown, A., Wodzanowski, K. A., Okuda, K., Silverman, N. S., & Grimes, C. L. (2023) · Innate Immunity · doi:10.1177/17534259231207198 · Cited by 7
The Current and Future Role of Drugs and Probiotics in the Management of Inflammatory Bowel Disease
de Souza, M. D. S. S., Barbalho, S. M., Goulart, R. D. Á., & de Carvalho, A. D. C. A. (2015) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2015.38008 · Cited by 7
Phenotypic Differences in Primary Murine Microglia Treated with NOD1, NOD2, and NOD1/2 Agonists
Wasmuth, S., Jalilvand, T. V., Laffer, B., Busch, M., Bauer, D., Langmann, T., Thanos, S., Kasper, M., & Heiligenhaus, A. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-019-01466-x · Cited by 8
Classification and Reclassification of Inflammatory Bowel Diseases
Chang, S., & Shen, B. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811388-2.00002-6 · Cited by 7
Gupta, M., Pattanaik, A. K., Singh, A., Sharma, S., & Jadhav, S. E. (2020) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.10744 · Cited by 7
Lactic Acid Bacteria and Host Immunity
Wang, L., Zhao, H., Tian, P., & Wang, G. (2019) · Springer eBooks · doi:10.1007/978-981-13-7832-4_9 · Cited by 7
Rana, A., & Smriti (2026) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.70275 · Cited by 7
Lee, S., Lee, Y. S., Lee, H., Yu, J., Kim, K. O., Kim, T.-Y., Lee, S.-H., Qiao, Y., KIM, S., & Kweon, M. (2026) · Gut Microbes · doi:10.1080/19490976.2025.2611603 · Cited by 8
Allela, O. Q. B., Shareef, A., Sameer, H. N., Yaseen, A., Athab, Z. H., & Adil, M. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1761985 · Cited by 6
Probiotic supplements and stress-related occupational health outcomes: A scoping review
Jun, J., Kasumova, A., Tussing, T. E., Mackos, A. R., Justice, S. S., & McDaniel, J. C. (2023) · Journal of Occupational Health · doi:10.1002/1348-9585.12404 · Cited by 6
Obesity-Associated Gut Microbiota
Shen, Q. X., & Maitin, V. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407825-3.00011-3 · Cited by 6
The dual roles of peptidoglycans: NOD1 and NOD2 inversely regulate bone metabolism
Park, O.-J., Kim, J., Lim, Y., Park, C. Y., Yun, C., & Han, S. H. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01522-0 · Cited by 5
Sécher, T., Couturier-Maillard, A., Huot, L., Bouscayrol, H., Grandjean, T., Boulard, O., Hot, D., Ryffel, B., & Chamaillard, M. (2022) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjac106 · Cited by 5
Scope of bacterial surface effector molecules beyond probiotics
Bhawal, S., Kumari, A., Rana, S., Kapila, S., & Kapila, R. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.103180 · Cited by 7
Genetically Engineered Lactobacilli for Technological and Functional Food Applications
Yebra, M. J., Monedero, V., Pérez‐Martínez, G., & Rodríguez‐Díaz, J. (2012) · InTech eBooks · doi:10.5772/32909 · Cited by 5
Sengupta, R., Anderson, R. C., Altermann, E., McNabb, W. C., Ganesh, S., Armstrong, K. M., Moughan, P. J., & Roy, N. C. (2015) · MicrobiologyOpen · doi:10.1002/mbo3.260 · Cited by 5
Phosphorylation of peptidoglycan from Lactobacillus acidophilus and its immunoregulatory function
Wu, Z. F., Pan, D., Zeng, X., Sun, Y., & Cao, J. (2016) · International Journal of Food Science & Technology · doi:10.1111/ijfs.13028 · Cited by 5
Zeiher, C., Kuhrt, H., Rifflet, A., Winter, K., Boon, L., Stassart, R. M., Nutma, E., Middeldorp, J., Strating, I. M., Boneca, I. G., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.10.024 · Cited by 5
Giacchi, V., Sciacca, P., & Betta, P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-802189-7.00019-8 · Cited by 5
Okada, Y., Sugihara, N., Nishii, S., Itoh, S., Mizoguchi, A., Tanemoto, R., Horiuchi, K., Tomioka, A., Nishimura, H., Higashiyama, M., et al. (2022) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.16058 · Cited by 4
PROBIOTIC-HUMAN IMMUNE SYSTEM INTERACTIONS
Akpınar, D. D., & Türköz, B. K. (2019) · Food and Health · doi:10.3153/fh19027 · Cited by 4
Anti-inflammatory lactobacilli: strain specificity
Matuchansky, C. (2011) · Gut · doi:10.1136/gutjnl-2011-300881 · Cited by 4
Wang, X., Wang, Y., & Sun, L. (2024) · Biophysics Reports · doi:10.52601/bpr.2024.240050 · Cited by 3
Metadata
- Authors
- Fernandez, E. M., Valenti, V., Rockel, C., Hermann, C., Pot, B., Boneca, I. G., & Grangette, C.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- University of Konstanz (DE)
- Inserm (FR)
- Corresponding author
- Grangette, C.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2011-04-06
- Volume
- 60
- Issue
- 8
- Pages
- 1050-1059
- ISSN
- 0017-5749 (ISSN-L)
- OpenAlex
- W2160579940
- Cited by
- 376
- References
- 54
- Citations by year
- 2026: 8 · 2025: 17 · 2024: 25 · 2023: 25 · 2022: 28 · 2021: 27 · 2020: 29 · 2019: 25 · 2018: 20 · 2017: 20 · 2016: 19 · 2015: 28 · 2014: 27 · 2013: 28 · 2012: 33
- FWCI
- 49.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gut (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- Lactobacillus salivarius, peptidoglycan, muropeptides, NOD2, inflammatory bowel disease, experimental colitis, TNBS-induced colitis, IL-10, regulatory dendritic cells, regulatory T cells, MyD88, indoleamine 2,3-dioxygenase, probiotics, anti-inflammatory activity
- MeSH terms
- Animals, Chromatography, High Pressure Liquid, Colitis, Dendritic Cells, Disease Models, Animal, Immunity, Cellular, Immunologic Factors, Lactobacillus, Mice, Inbred BALB C, Mice, Inbred C57BL, Peptidoglycan, Interleukin-10, Probiotics, T-Lymphocytes, Regulatory, Mice, Nod2 Signaling Adaptor Protein, Myeloid Differentiation Factor 88
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review