Resistance of germfree rats to indomethacin-induced intestinal lesions
Abstract
Indomethacin given orally to conventional rats produced in three days a syndrome, often fatal, of intestinal lesions characterized by multiple ulcers and peritonitis. Male germfree rats were found to be resistant to this effect of indomethacin, while female germfree rats developed very mild lesions. Germfree rats became sensitive again to such lesions when monocontaminated with E. coli. In such animals, however, the lesions were less severe than in conventional animals, presumably because more than one microorganism is necessary for the full syndrome to develop. These results suggest that microorganisms are necessary for the development of indomethacin-induced intestinal lesions. Secondary bile acids, absent in germfree animals, may also be necessary. The prostaglandin deficiency caused by indomethacin appears to weaken the resistance of the intestinal mucosa to microorganisms and/or their toxins. The latter may then penetrate the mucosa, damage the cells and produce ulcers and perforations. Since several prostaglandins also protect against indomethacin-induced lesions, the hypothesis is advanced that certain prostaglandins may protect the mucosa ("cytoprotection") by preventing the spread of microorganisms and/or their toxin through the intestinal wall.
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Germ-free mice are less susceptible to intestinal lesions induced by NSAIDs and NSAID-induced enteropathy is transferable via microbiota.
“Moreover, germ-free mice are less susceptible to intestinal lesions induced by NSAIDs and it has been documented that NSAID-induced enteropathy is transferable via microbiota[98,101,102].”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [102]
Cites
Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs
VANE, J. R. (1971) · Nature New Biology · doi:10.1038/newbio231232a0 · Cited by 8,605 · see citing works
Small intestinal ulcers and intestinal flora in rats given indomethacin.
Kent, T. H., Cardelli, R. M., & Stamler, F. W. (1969) · PubMed · Cited by 295 · see citing works
An Intestinal Disease Produced Experimentally by a Prostaglandin Deficiency
Robert, A. (1975) · Gastroenterology · doi:10.1016/s0016-5085(19)32433-3 · Cited by 211 · see citing works
Self-citationIndomethacin-induced intestinal lesions in the rat
Brodie, D. A., Cook, P. G., Bauer, B. J., & Dagle, G. E. (1970) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(70)90036-0 · Cited by 197 · see citing works
DETERMINATION OF GERMFREE STATUS*
Wagner, M. (1959) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1959.tb53097.x · Cited by 140 · see citing works
Relationship of the Enterohepatic Cycle to Ulcerogenesis in the Rat Small Bowel with Flufenamic Acid
Wax, J. E., Clinger, W. A., Varner, P., Bass, P., & Winder, C. V. (1970) · Gastroenterology · doi:10.1016/s0016-5085(70)80149-4 · Cited by 105 · see citing works
Fecal neutral steroids and bile acids from germfree rats
Kellogg, T. F., & Wostmann, B. S. (1969) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43040-8 · Cited by 97 · see citing works
Effects of prostaglandins on the stomach and the intestine
Robert, A. (1974) · Prostaglandins · doi:10.1016/s0090-6980(74)80062-6 · Cited by 82 · see citing works
Self-citationBile Acid Metabolism in Gnotobiotic Animals
Kellogg, T. F. (1973) · Springer eBooks · doi:10.1007/978-1-4684-0898-0_11 · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Experimental models of inflammatory bowel disease
Elson, C. O., Sartor, R. B., Tennyson, G. S., & Riddell, R. H. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90599-5 · Cited by 1,212 · see citing works
Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans
Bjarnason, I., Hayllar, J. S., Macpherson, A., & Russell, A. N. T. S. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90667-2 · Cited by 1,020 · see citing works
Nonsteroidal anti-inflammatory drugs and gastroenteropathy: The second hundred years
Jl, W. (1997) · Gastroenterology · doi:10.1053/gast.1997.v112.pm9041264 · Cited by 568 · see citing works
Radiation enteropathy—pathogenesis, treatment and prevention
Hauer‐Jensen, M., Denham, J. W., & Andreyev, J. N. (2014) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2014.46 · Cited by 491 · see citing works
Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation
Hausmann, M., Kießling, S., Mestermann, S., Webb, G. R., Spöttl, T., Andus, T., Schölmerich, J., Herfarth, H. H., Ray, K., Falk, W., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.33662 · Cited by 488 · see citing works
Proton Pump Inhibitors Exacerbate NSAID-Induced Small Intestinal Injury by Inducing Dysbiosis
Wallace, J. L., Syer, S., Denou, E., de Palma, G., Vong, L., McKnight, W., Jury, J., Bolla, M., Bercik, P., Collins, S. M., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.075 · Cited by 460 · see citing works
Neonatal complications after the administration of indomethacin for preterm labor
Norton, M. E., Merrill, J., Cooper, B., Kuller, J. A., & Clyman, R. I. (1993) · New England Journal of Medicine · doi:10.1056/nejm199311253292202 · Cited by 438 · see citing works
Whittle, B. J. R. (1981) · Gastroenterology · doi:10.1016/0016-5085(81)90196-7 · Cited by 438 · see citing works
Hawkey, C. J., & Rampton, D. S. (1985) · Gastroenterology · doi:10.1016/0016-5085(85)90225-2 · Cited by 369 · see citing works
Lang, J., Price, A. B., Levi, A. J., Burke, M., Gumpel, J. M., & Bjarnason, I. (1988) · Journal of Clinical Pathology · doi:10.1136/jcp.41.5.516 · Cited by 360 · see citing works
The influence of non-steroidal anti-inflammatory drugs on the gut microbiome
Rogers, M. A. M., & Aronoff, D. M. (2016) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2015.10.003 · Cited by 346 · see citing works
Nonsteroidal antiinflammatory drug-induced intestinal inflammation in humans
Bjarnason, I., Zanelli, G. D., Smith, T., Prouse, P., Williams, P., Smethurst, P., DELACEY, G. J., Gumpel, M., & Levi, A. J. (1987) · Gastroenterology · doi:10.1016/0016-5085(87)90909-7 · Cited by 351 · see citing works
Mechanisms of acute and chronic intestinal inflammation induced by indomethacin
Yamada, T., Deitch, E. A., Specian, R. D., Perry, M. A., Sartor, R. B., & Grisham, M. B. (1993) · Inflammation · doi:10.1007/bf00920471 · Cited by 316 · see citing works
Bjarnason, I., So, A., Levi, A. J., Peters, T. B., Williams, P., Zanelli, G. D., Gumpel, J. M., & Ansell, B. M. (1984) · The Lancet · doi:10.1016/s0140-6736(84)92739-9 · Cited by 303 · see citing works
Present status and strategy of NSAIDs-induced small bowel injury
Higuchi, K., Umegaki, E., Watanabe, T., Yoda, Y., Morita, E., Murano, M., Tokioka, S., & Arakawa, T. (2009) · Journal of Gastroenterology · doi:10.1007/s00535-009-0102-2 · Cited by 292 · see citing works
Bjarnason, I., Williams, P., Smethurst, P., Peters, T. J., & Levi, A. J. (1986) · Gut · doi:10.1136/gut.27.11.1292 · Cited by 267 · see citing works
Matsui, H., Shimokawa, O., Kaneko, T., Nagano, Y. N., Rai, K., & Hyodo, I. (2011) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.10-79 · Cited by 269 · see citing works
Systematic review: human gut dysbiosis induced by non-antibiotic prescription medications
Le Bastard, Q., Al‐Ghalith, G. A., Grégoire, M., Chapelet, G., Javaudin, F., Dailly, E., Batard, E., Knights, D., & Montassier, E. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14451 · Cited by 263 · see citing works
Duchmann, R., May, E., Heike, M., Knolle, P. A., Neurath, M. F., & BÜSCHENFELDE, K.-H. M. Z. (1999) · Gut · doi:10.1136/gut.44.6.812 · Cited by 258 · see citing works
Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified
Bruno, G., Zaccari, P., Rocco, G., Scalese, G., Panetta, C., Porowska, B., Pontone, S., & Severi, C. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i22.2706 · Cited by 258 · see citing works
Rifaximin, a Poorly Absorbed Antibiotic: Pharmacology and Clinical Potential
Scarpignato, C., & Pelosini, I. (2005) · Chemotherapy · doi:10.1159/000081990 · Cited by 242 · see citing works
Gastric mucosal barrier: hydrophobic lining to the lumen of the stomach
Hills, B. A., Butler, B. D., & Lichtenberger, L. M. (1983) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1983.244.5.g561 · Cited by 235 · see citing works
Acyl glucuronide reactivity in perspective: biological consequences
Bailey, M. J., & DICKINSON, R. G. (2003) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(03)00020-6 · Cited by 232 · see citing works
Watanabe, T., Higuchi, K., Kobata, A., Nishio, H., Tanigawa, T., Shiba, M., Tominaga, K., Fujiwara, Y., Oshitani, N., Asahara, T., et al. (2007) · Gut · doi:10.1136/gut.2007.125963 · Cited by 227 · see citing works
Schultz, M., Tonkonogy, S. L., Sellon, R. K., Veltkamp, C., Godfrey, V., Kwon, J., Grenther, W. B., Balish, E., Horak, I. D., & Sartor, R. B. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.276.6.g1461 · Cited by 200 · see citing works
Somasundaram, S. G., Hayllar, H., Rafi, S., Wrigglesworth, J. M., Macpherson, A. J., & Bjarnason, I. (1995) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529509093280 · Cited by 183 · see citing works
Nonsteroidal Anti-Inflammatory Drugs and Lower Gastrointestinal Complications
Lanas, Á., & Sopeña, F. (2009) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2009.03.007 · Cited by 178 · see citing works
Mucosal injury and inflammation in a model of chronic granulomatous colitis in rats
Yamada, T., Sartor, R. B., Marshall, S. J., Specian, R. D., & Grisham, M. B. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)91011-6 · Cited by 175 · see citing works
Ogawa, H., Fukushima, K., Naito, H., Funayama, Y., Unno, M., Takahashi, K.-I., Kitayama, T., Matsuno, S., Ohtani, H., Takasawa, S., et al. (2003) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200305000-00003 · Cited by 172 · see citing works
Mechanisms, prevention and clinical implications of nonsteroidal anti-inflammatory drug-enteropathy
Wallace, J. L. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i12.1861 · Cited by 171 · see citing works
Wallace, J. L. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01509.x · Cited by 173 · see citing works
The influence of normal microbial flora on the development of chronic mucosal inflammation
Sartor, R. B. (1997) · Research in Immunology · doi:10.1016/s0923-2494(98)80151-x · Cited by 164 · see citing works
Intestinal permeability in the pathogenesis of NSAID-induced enteropathy
Bjarnason, I., & Takeuchi, K. (2009) · Journal of Gastroenterology · doi:10.1007/s00535-008-2266-6 · Cited by 161 · see citing works
NSAID–Gut Microbiota Interactions
Maseda, D., & Ricciotti, E. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01153 · Cited by 166 · see citing works
Tanaka, A., Hase, S., Miyazawa, T., & Takeuchi, K. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.300.3.754 · Cited by 159 · see citing works
Whitfield-Cargile, C., Cohen, N. D., Chapkin, R. S., Weeks, B. R., Davidson, L. A., Goldsby, J. S., Hunt, C. L., Steinmeyer, S. H., Menon, R., Suchodolski, J. S., et al. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1156827 · Cited by 146 · see citing works
Multiple NSAID-Induced Hits Injure the Small Intestine: Underlying Mechanisms and Novel Strategies
Boelsterli, U. A., Redinbo, M. R., & Saitta, K. S. (2012) · Toxicological Sciences · doi:10.1093/toxsci/kfs310 · Cited by 143 · see citing works
Role of M Cells in Intestinal Barrier Function
Kucharzik, T. F., Lügering, N., Rautenberg, K., Lügering, A., Schmidt, M. A., Stoll, R., & Domschke, W. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05240.x · Cited by 141 · see citing works
Ohkusa, T., Kato, K., Terao, S., Chiba, T., Mabe, K., Murakami, K., Mizokami, Y., Sugiyama, T., Yanaka, A., Takeuchi, Y., et al. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.84 · Cited by 138 · see citing works
Watanabe, T., Fujiwara, Y., & Chan, F. K. L. (2019) · Journal of Gastroenterology · doi:10.1007/s00535-019-01657-8 · Cited by 135 · see citing works
Tanaka, A., Hase, S., Miyazawa, T., Ohno, R., & Takeuchi, K. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.041715 · Cited by 133 · see citing works
IL-10 produced by macrophages regulates epithelial integrity in the small intestine
Morhardt, T. L., Hayashi, A., Ochi, T., Quirós, M., Kitamoto, S., Nagao‐Kitamoto, H., Kuffa, P., Atarashi, K., Honda, K., Kao, J. Y., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-38125-x · Cited by 129 · see citing works
Non-steroidal anti-inflammatory drug-induced enteropathy
Shin, S. J., Noh, C., Lim, S. G., Lee, K. M., & Lee, K. J. (2017) · Intestinal Research · doi:10.5217/ir.2017.15.4.446 · Cited by 127 · see citing works
Role of intestinal microflora in chronic inflammation and ulceration of the rat colon.
Videla, S., Vilaseca, J., Guarner, F., Salas, A., Tresserra, F., Crespo, E., Antolı́n, M., & Malagelada, J. (1994) · Gut · doi:10.1136/gut.35.8.1090 · Cited by 126 · see citing works
Detection and prevention of NSAID-induced enteropathy.
Davies, N. M., Saleh, J. Y., & Skjodt, N. M. (2000) · PubMed · Cited by 126 · see citing works
Konaka, A., Kato, S., Tanaka, A., Kunikata, T., Korolkiewicz, R. P., & Takeuchi, K. (1999) · Pharmacological Research · doi:10.1006/phrs.1999.0550 · Cited by 123 · see citing works
Whittle, B. J. R., László, F. A., Evans, S. M., & Moncada, S. (1995) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1995.tb15066.x · Cited by 119 · see citing works
Seitz, S., & Boelsterli, U. A. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70026-5 · Cited by 118 · see citing works
The gut microbiome and the mechanism of surgical infection
Alverdy, J. C., Hyoju, S. K., Weigerinck, M., & Gilbert, J. A. (2017) · British journal of surgery · doi:10.1002/bjs.10405 · Cited by 119 · see citing works
Satoh, H., Guth, P. H., & Grossman, M. I. (1983) · Gastroenterology · doi:10.1016/0016-5085(83)90071-9 · Cited by 114 · see citing works
Intestinal microbiota and ulcerative colitis
Ohkusa, T., & Koido, S. (2015) · Journal of Infection and Chemotherapy · doi:10.1016/j.jiac.2015.07.010 · Cited by 113 · see citing works
Mechanisms underlying intestinal injury induced by anti-inflammatory COX inhibitors
Whittle, B. J. R. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.07.042 · Cited by 113 · see citing works
Uejima, M., Kinouchi, T., Kataoka, K., Hiraoka, I., & Ohnishi, Y. (1996) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1996.tb01108.x · Cited by 110 · see citing works
Toxic effects of nonsteroidal antiinflammatory drugs on the small bowel, colon, and rectum
Thiéfin, G., & Beaugerie, L. (2004) · Joint Bone Spine · doi:10.1016/j.jbspin.2004.10.004 · Cited by 107 · see citing works
Hammers, A. L., Sanchez-Ramos, L., & Kaunitz, A. M. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2014.10.1091 · Cited by 101 · see citing works
Bidirectional interactions between indomethacin and the murine intestinal microbiota
Liang, X., Bittinger, K. L., Li, X., Abernethy, D. R., Bushman, F. D., & FitzGerald, G. A. (2015) · eLife · doi:10.7554/elife.08973 · Cited by 101 · see citing works
Rainsford, K. D. (1982) · Rheumatology International · doi:10.1007/bf00541263 · Cited by 100 · see citing works
Kunikata, T., Tanaka, A., Miyazawa, T., Kato, S., & Takeuchi, K. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1014725024519 · Cited by 98 · see citing works
Vanhaesebrouck, P., Thiery, M., Leroy, J. G., Govaert, P. P., Praeter, C. D., Coppens, M. J., Cuvelier, C. A., & Dhont, M. A. (1988) · The Journal of Pediatrics · doi:10.1016/s0022-3476(88)80392-5 · Cited by 94 · see citing works
Microbiota Plays a Key Role in Non-Steroidal Anti-Inflammatory Drug-Induced Small Intestinal Damage
Otani, K., Tanigawa, T., Watanabe, T., Shimada, S., Nadatani, Y., Nagami, Y., Tanaka, F., Kamata, N., Yamagami, H., Shiba, M., et al. (2017) · Digestion · doi:10.1159/000452356 · Cited by 94 · see citing works
Ohkusa, T., Nomura, T., Terai, T., Miwa, H., Kobayashi, O., Hojo, M., Takei, Y., Ogihara, T., Hirai, S., Okayasu, I., et al. (2005) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520510023648 · Cited by 93 · see citing works
Marlicz, W., Łoniewski, I., Grimes, D. S., & Quigley, E. M. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2014.07.015 · Cited by 91 · see citing works
Roles of COX inhibition in pathogenesis of NSAID-induced small intestinal damage
Takeuchi, K., Tanaka, A., Kato, S., Amagase, K., & Satoh, H. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2009.12.026 · Cited by 91 · see citing works
Taha, A. S., Nakshabendi, I. M., Lee, F. D., Sturrock, R. D., & Russell, R. I. (1992) · Journal of Clinical Pathology · doi:10.1136/jcp.45.2.135 · Cited by 91 · see citing works
Zádori, Z., Király, K. P., Al‐Khrasani, M., & Gyires, K. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108327 · Cited by 90 · see citing works
Mechanisms of Gastrointestinal Toxicity of Nonsteroidal Anti-Inflammatory Drugs
Rainsford, K. D. (1989) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528909091169 · Cited by 88 · see citing works
Jia, L., Chopp, M., Wang, L., Lu, X., Szalad, A., & Zhang, Z. G. (2018) · The FASEB Journal · doi:10.1096/fj.201800597r · Cited by 86 · see citing works
Do non-steroidal anti-inflammatory drugs increase colonic permeability?
Jenkins, A. P., Trew, D. R., Crump, B. J., Nukajam, W. S., Foley, J. A., Menzies, I. S., & Creamer, B. (1991) · Gut · doi:10.1136/gut.32.1.66 · Cited by 85 · see citing works
Wallace, J. L. (1994) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y94-215 · Cited by 85 · see citing works
Utzeri, E., & Usai, P. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i22.3954 · Cited by 86 · see citing works
Montalto, M., Gallo, A., Curigliano, V., D’Onofrio, F., Santoro, L., Covino, M., Dalvai, S., Gasbarrini, A., & Gasbarrini, G. B. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04324.x · Cited by 83 · see citing works
Kwo, P. Y., & Tremaine, W. J. (1995) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)64666-1 · Cited by 83 · see citing works
Microbial Flora in NSAID-Induced Intestinal Damage: A Role for Antibiotics?
Lanas, Á., & Scarpignato, C. (2006) · Digestion · doi:10.1159/000089789 · Cited by 83 · see citing works
Bjarnason, I. (1994) · Gut · doi:10.1136/gut.35.1_suppl.s18 · Cited by 83 · see citing works
Bertrand, V., Guimbaud, R., Tulliez, M., Mauprivez, C., Sogni, P., Couturier, D., Giroud, J. P., Chaussade, S., & Chauvelot‐Moachon, L. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701968 · Cited by 82 · see citing works
NSAID enteropathy and bacteria: a complicated relationship
Syer, S. D., Blackler, R. W., Martin, R., de Palma, G., Rossi, L., Verdu, E., Bercik, P., Surette, M. G., Aucouturier, A., Langella, P., et al. (2015) · Journal of Gastroenterology · doi:10.1007/s00535-014-1032-1 · Cited by 80 · see citing works
Role of Food in Gastrointestinal Ulceration Produced by Indomethacin in the Rat
Satoh, H., Guth, P. H., & Grossman, M. I. (1982) · Gastroenterology · doi:10.1016/0016-5085(82)90177-9 · Cited by 78 · see citing works
Hagiwara, M., Kataoka, K., Arimochi, H., Kuwahara, T., & Ohnishi, Y. (2004) · The Journal of Medical Investigation · doi:10.2152/jmi.51.43 · Cited by 77 · see citing works
Early histological features of small intestinal injury induced by indomethacin
Anthony, A., Dhillon, A. P., Nygård, G., Hudson, M., Piasecki, C., STRONG, P., Trevethick, M. A., Clayton, N. M., Jordan, C., Pounder, R. E., et al. (1993) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.1993.tb00066.x · Cited by 77 · see citing works
Non‐steroidal anti‐inflammatory drugs, aspirin and newly diagnosed colitis: a case–control study
Gleeson, M. H., & Davis, A. J. M. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01519.x · Cited by 75 · see citing works
Sex differences in NSAID‐induced perturbation of human intestinal barrier function and microbiota
Edogawa, S., Peters, S. A., Jenkins, G. D., Gurunathan, S. V., Sundt, W. J., Johnson, S., Lennon, R. J., Dyer, R. B., Camilleri, M., Kashyap, P., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201800560r · Cited by 73 · see citing works
Host Responses to Intestinal Microbial Antigens in Gluten-Sensitive Mice
Natividad, J. M., Huang, X., Slack, E., Jury, J., Sanz, Y., David, C., Denou, E., Yang, P., Murray, J., McCoy, K. D., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006472 · Cited by 73 · see citing works
Effects of metronidazole and misoprostol on indomethacin-induced changes in intestinal permeability
Davies, G. R., Wilkie, M. E., & Rampton, D. S. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01316493 · Cited by 73 · see citing works
Banerjee, A. K., & Peters, T. J. (1990) · Gut · doi:10.1136/gut.31.12.1358 · Cited by 73 · see citing works
RetractedYvon, S., Olier, M., Leveque, M., Jard, G., Tormo, H., Haimoud-Lekhal, D. A., Peter, M., & Eutamène, H. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1304-z · Cited by 70 · see citing works
Gut Microbiota in NSAID Enteropathy: New Insights From Inside
Wang, X., Tang, Q., Hou, H., Zhang, W., Li, M., Chen, D., Gu, Y., Wang, B., Hou, J., Liu, Y., et al. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.679396 · Cited by 69 · see citing works
The Gut Microbiome, Metformin, and Aging
Induri, S. N. R., Kansara, P., Thomas, S. C., Xu, F., Saxena, D. B., & Li, X. (2021) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-051920-093829 · Cited by 66 · see citing works
Protective effect of rebamipide on indomethacin‐induced intestinal damage in rats
Mizoguchi, H., Ogawa, Y., Kanatsu, K., Tanaka, A., Kato, S., & Takeuchi, K. (2001) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2001.02592.x · Cited by 68 · see citing works
Blackler, R. W., Motta, J., Manko, A., Workentine, M., Bercik, P., Surette, M. G., & Wallace, J. L. (2015) · British Journal of Pharmacology · doi:10.1111/bph.12961 · Cited by 66 · see citing works
Davies, N. M., & Wallace, J. L. (1997) · Journal of Gastroenterology · doi:10.1007/bf01213310 · Cited by 65 · see citing works
Comparative effects of Indomethacin, Prostaglandin E1, and Ibuprofen on bowel ischemia
Grosfeld, J. L., Kamman, K., Gross, K. R., Cikrit, D. F., Ross, D., Wolfe, M., Katz, S., & Weber, T. R. (1983) · Journal of Pediatric Surgery · doi:10.1016/s0022-3468(83)80015-3 · Cited by 65 · see citing works
Markedly reduced intestinal toxicity of a diclofenac derivative
Reuter, B. K., Cirino, G., & Wallace, J. L. (1994) · Life Sciences · doi:10.1016/0024-3205(94)90083-3 · Cited by 65 · see citing works
Teratogen update: Fetal effects of indomethacin administration during pregnancy
Norton, M. E. (1997) · Teratology · doi:10.1002/(sici)1096-9926(199710)56:4 · Cited by 64 · see citing works
Sydora, B. C., Tavernini, M. M., Wessler, A., Jewell, L. D., & Fedorak, R. N. (2003) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200303000-00002 · Cited by 61 · see citing works
Kato, S., Tanaka, A., Kunikata, T., Umeda, M., & Takeuchi, K. (2000) · Digestion · doi:10.1159/000007734 · Cited by 61 · see citing works
Non-steroidal anti-inflammatory agents and the gastrointestinal tract
Somerville, K. W., & Hawkey, C. J. (1986) · Postgraduate Medical Journal · doi:10.1136/pgmj.62.723.23 · Cited by 61 · see citing works
Terán-Ventura, E., Aguilera, M., Vergara, P., & Martínez, V. (2014) · Journal of Crohn's and Colitis · doi:10.1016/j.crohns.2014.02.001 · Cited by 59 · see citing works
NSAID-induced intestinal damage: are luminal bacteria the therapeutic target?
Scarpignato, C. (2008) · Gut · doi:10.1136/gut.2007.134502 · Cited by 59 · see citing works
Gut Microbiota Mediates Protection Against Enteropathy Induced by Indomethacin
Xiao, X., Nakatsu, G., Jin, Y., Wong, S. H., Yu, J. Q., & Lau, J. Y. W. (2017) · Scientific Reports · doi:10.1038/srep40317 · Cited by 59 · see citing works
Bhatt, A. P., Gunasekara, D. B., Speer, J. E., Reed, M. I., Peña, A. N., Midkiff, B. R., Magness, S. T., Bultman, S. J., Allbritton, N. L., & Redinbo, M. R. (2017) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.7b00139 · Cited by 59 · see citing works
- Authors
- Robert, A., & Asano, T.
- Affiliations
- University of Notre Dame (US)
- Venue
- Prostaglandins
- Publisher
- Elsevier BV
- Published
- 1977-08
- Volume
- 14
- Issue
- 2
- Pages
- 333-341
- ISSN
- 0090-6980 (ISSN-L)
- OpenAlex
- W2059605635
- Cited by
- 312
- References
- 9
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 4 · 2023: 6 · 2022: 2 · 2021: 9 · 2020: 7 · 2019: 11 · 2018: 2 · 2017: 12 · 2016: 7 · 2015: 11 · 2014: 12 · 2013: 5 · 2012: 11
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Prostaglandins (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Keywords
- germ-free rats, indomethacin, intestinal lesions, intestinal ulceration, peritonitis, Escherichia coli, secondary bile acids, prostaglandin deficiency, drug-induced intestinal injury, sex differences
- MeSH terms
- Animals, Escherichia coli, Female, Germ-Free Life, Indomethacin, Intestinal Diseases, Intestines, Male, Peritonitis, Prostaglandins E, Rats, Inbred Strains, Sex Factors, Ulcer, Rats
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