Cardiff Crohn's disease jubilee: the incidence over 50 years.
Open accessAbstract
The incidence of Crohn's disease in Cardiff between 1931 and 1985 has been examined using hospital diagnostic indices supplemented in recent years by records from clinicians, and the departments of pathology and radiology. Four hundred and seven new patients were confirmed after all notes had been reviewed. There has been a large increase from 0.18 cases/10(5) of the population per year in the 1930s to current values of 8.3/10(5)/year. The incidence continues to rise and shows an increasing proportion of patients with colorectal disease. Peak age specific incidences occur in the third and eighth decades of life.
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In Cardiff, Wales, Crohn's disease incidence was low and flat in the 1930s and 1940s, spiked to 9.1 per 100,000 in 1983, and then stabilized at 6.0 per 100,000 in 1993 and 7.0 per 100,000 in 2003.
“Initially, the incidence was low and flat (0.27 and 0.09 per 100,000 in 1933 and 1943, respectively), but showed a spike towards the 1980s (0.98 per 100,000 in 1953, 2.4 per 100,000 in 1963, 5.2 per 100,000 in 1973 and 9.1 per 100,000 in 1983). Thereafter, the incidence stabilized (6.0 per 100,000 in 1993 and 7.0 per 100,000 in 2003)29–31.”
From The four epidemiological stages in the global evolution of inflammatory bowel disease (2021) · cites this paper as [31]
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- Authors
- Rose, J. D., Roberts, G. M., Williams, G., Mayberry, J. F., & Rhodes, J.
- Affiliations
- University Hospital of Wales (GB)
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1988-03
- Volume
- 29
- Issue
- 3
- Pages
- 346-351
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1433600
- OpenAlex
- W2168534336
- Cited by
- 136
- References
- 18
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 1 · 2020: 5 · 2018: 1 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 5
- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Keywords
- Crohn's disease, incidence, temporal trends, Cardiff, age-specific incidence
- MeSH terms
- Age Factors, Colon, Crohn Disease, Female, Humans, Ileum, Male, Rectum, Sex Factors, Time Factors, Wales
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