Cited by 158Inflammatory Bowel DiseaseOcular Diseases and Behçet’s SyndromeDiverticular Disease and Complications

Systematic review with meta-analysis: inflammatory bowel disease in the elderly

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Gisbert, J. P., Chaparro, M.·2014·Alimentary Pharmacology & Therapeutics

Abstract

BACKGROUND: Elderly patients represent an increasing proportion of the inflammatory bowel disease (IBD) population. AIM: To critically review available data regarding the care of elderly IBD patients. METHODS: Bibliographic searches (MEDLINE) up to June 2013. RESULTS: Approximately 10-15% of cases of IBD are diagnosed in patients aged >60 years, and 10-30% of the IBD population are aged >60 years. In the elderly, IBD is easily confused with other more common diseases, mainly diverticular disease and ischaemic colitis. The clinical features of IBD in older patients are generally similar to those in younger patients. Crohn's disease (CD) in elderly patients is characterised by its predominantly colonic localisation and uncomplicated course. Proctitis and left-sided ulcerative colitis are more common in patients aged >60 years. Infections are associated with age and account for significant mortality in IBD patients. The treatment of IBD in the elderly is generally similar. However, the therapeutic approach in the elderly should be 'start low-go slow'. The benefit of thiopurines in older CD patients remains debatable. Although the indications for anti-tumour necrosis factors in the elderly are generally similar to those for younger patients, lower response and higher adverse events have been reported in the elderly. Surgery in elderly patients does not generally differ. Ileal pouch-anal anastomosis can be successful, provided the patient retains good anal sphincter function. CONCLUSIONS: Management of the older IBD patient differs from that of younger patients; therefore, conventional practice algorithms may have to be modified to account for advanced age.

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Crossref · 10.1111/apt.12616

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184 of 184 references verified0 citation errors · 0 not checkable

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  • The prevalence of IBD has been shown to be higher in females and with increasing age, and most common in Caucasians as compared with other ethnicities.

    “Moreover, the prevalence of IBD has been shown to be higher in females and with increasing age, and most common in Caucasians as compared with other ethnicities [50, 51].”

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Authors
Gisbert, J. P., & Chaparro, M.
Affiliations
Hospital Universitario de La Princesa (ES)
Corresponding author
Gisbert, J. P.
Venue
Alimentary Pharmacology & Therapeutics
Publisher
Wiley
Published
2014-01-09
Volume
39
Issue
5
Pages
459-477
ISSN
  • 0269-2813 (ISSN-L)
  • 1365-2036
OpenAlex
W2169988437
Cited by
158
References
184
Citations by year
2026: 3 · 2025: 10 · 2024: 13 · 2023: 16 · 2022: 3 · 2021: 12 · 2020: 16 · 2019: 15 · 2018: 22 · 2017: 14 · 2016: 20 · 2015: 10 · 2014: 4
FWCI
2.11
Type
journal article
Language
en
Open access
Locations
  • Alimentary Pharmacology & Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
  • Health Sciences › Medicine › Surgery › Diverticular Disease and Complications
Keywords
inflammatory bowel disease, elderly patients, Crohn's disease, ulcerative colitis, diverticular disease, ischemic colitis, differential diagnosis, thiopurines, anti-TNF therapy, ileal pouch-anal anastomosis, anal sphincter function
MeSH terms
Aged, Humans, Middle Aged, Inflammatory Bowel Diseases

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