The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Fatigue in primary biliary cirrhosis
Open accessAbstract
Background—Fatigue is a frequent and debilitating symptom in patients with primary biliary cirrhosis (PBC). Aims—To study fatigue in relation to sleep, depression, and liver disease severity. Methods—Patients with PBC completed validated self report questionnaires measuring fatigue, sleep quality, depression, and functional capacity. Verbally reported fatigue and observer rated measure of depression and ursodeoxycholic acid (UDCA) use were recorded. Liver biochemistry and tests to rule out metabolic causes of fatigue were performed. Results—Mean age of the 88 patients enrolled was 57 years; 86% were female and mean duration of disease was 6.6 years. Median bilirubin was 13 μmol/l (mean 18.6). Verbally reported fatigue (for more than six months) was present in 60 patients (68%). The self rated Fatigue Severity Score (FSS) correlated well with verbally reported fatigue (p=0.0001). The FSS did not correlate with age, duration of disease, serum bilirubin, Mayo Risk Score, or UDCA use, but correlation was seen with sleep quality. Fatigued patients had more sleep problems and higher depression scores than non-fatigued patients. Self rated depression was present in 28% (17/60) of fatigued compared with 4% (1/28) of non-fatigued patients. Conclusions—Long term fatigue affected 68% of the patients with PBC but it was not related to the severity of their liver disease. Poor sleep quality and depression were commonly associated with fatigue.
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“Although fatigue is not specific to PBC, it is frequently reported by patients (over 50%) and when severe, as it is in 20% of patients, is a significant cause of QoL impairment.12 171 205–208”
From The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines (2018) · cites this paper as [206]
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267
The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research
Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989) · Psychiatry Research · doi:10.1016/0165-1781(89)90047-4 · Cited by 35,234
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
Hirono, N., Mori, E., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H., & Ikeda, M. (1997) · PubMed · Cited by 21,012
Diagnostic and Statistical Manual of Mental Disorders
(2012) · Springer eBooks · doi:10.1007/springerreference_121117 · Cited by 20,772
Kok, J. S., Berg, I. J., & Scherder, E. J. A. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353441 · Cited by 20,589
Older Adults' Reasons for Using Technology while Aging in Place
Peek, S. T. M., Luijkx, K. G., Rijnaard, M. D., Nieboer, M. E., van der Voort, C. S., Aarts, S., van Hoof, J., Vrijhoef, H. J., & Wouters, E. (2015) · Gerontology · doi:10.1159/000430949 · Cited by 19,852
Sensitivity and False Alarm Rate of a Fall Sensor in Long-Term Fall Detection in the Elderly
Kangas, M., Korpelainen, R., Vikman, I., Nyberg, L., & Jämsä, T. J. (2014) · Gerontology · doi:10.1159/000362720 · Cited by 19,007
Research works printed but not linked: 7
- 10.1016/0270-9139(94)90861-3 · DOI · Paper page
- 10.1016/0270-9139(95)90171-X · DOI
- Nelles, 1996, Fatigue assessment in patients with hepatitis C [abstract]., Gastroenterology, 110, A1276
- Mahl, 1996, Fatigue in patients with chronic hepatitis C [abstract]., Gastroenterology, 110, A1254
- McCoy, 1992, Quantitative assessment of fatigue in routine care of patients with rheumatic diseases [abstract]., Arthritis Care Research, 5, S15
- 10.1001/archneur.1989.00520460115022 · DOI · Paper page
- Swain, 1994, Facilitation of ACTH and cortisol responses to corticotropin-releasing hormone (CRH) in patients with primary biliary cirrhosis (PBC) [abstract]., Hepatology, 20, 146A
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Hu, J., Lin, S., Hsieh, Y., & Chen, N. (2011) · BMC Gastroenterology · doi:10.1186/1471-230x-11-55 · Cited by 1
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Segal, B. M. (2011) · Springer eBooks · doi:10.1007/978-0-85729-947-5_9 · Cited by 1
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Wessmann, A., Volk, H. A., Shelton, G. D., Chandler, K., BAINES, S. J., & Cappello, R. (2006) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.2006.tb01827.x · Cited by 1
Ekerfors, U., Simrén, M., Marschall, H., Demir, D., & Josefsson, A. (2023) · BMC Gastroenterology · doi:10.1186/s12876-023-02885-2 · Cited by 1
Primary Biliary Cholangitis: Its Science and Practice
Wang, L., Bowlus, C. L., Wang, F., & Gershwin, M. E. (2017) · Springer eBooks · doi:10.1007/978-3-319-50168-0_8 · Cited by 1
Holistic Patient Care in Primary Biliary Cholangitis: Managing Both the Disease and the Symptoms
Roberts, E. (2022) · EMJ Hepatology · doi:10.33590/emjhepatol/10166227 · Cited by 1
Gossard, A. A., & Lindor, K. D. (2008) · Cambridge University Press eBooks · doi:10.1017/cbo9780511547416.011 · Cited by 1
Heathcote, E. J., & Milkiewicz, P. (2007) · Wiley eBooks · doi:10.1002/9780470691861.ch11a · Cited by 1
Self-citationHealth Status Assessment and Economic Analyses in Cirrhosis and Portal Hypertension
Talwalkar, J. A., & Kim, W. R. (2005) · Humana Press eBooks · doi:10.1007/978-1-59259-885-4_28
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Chaparro, M., Moreno-Monteagudo, J. A., Garca-Buey, L. C., & Moreno‐Otero, R. (2008) · Medicine - Programa de Formación Médica Continuada Acreditado · doi:10.1016/s0211-3449(08)73154-0
McFarlane, I. G. (2004) · Principles of medical biology · doi:10.1016/s1569-2582(04)15015-0
Chapter 12 Primary Biliary Cirrhosis
Abdalian, R., & Heathcote, J. (2008) · Technical report · doi:10.1016/s1571-5078(07)00012-8
Long-term survival with HIV-infection : the reverse side of the medal
de Jong, E. M. G. J. (2010) · Utrecht University Repository (Utrecht University)
Caso clinico: una mujer de 65 años, con prurito y astenia
Fajardo, A. (2003) · Salus Journal of Health Sciences
Cirrosis Biliar Primaria en una mujer de 65 años con prurito y astenia. A propósito de un caso
Fajardo, A., Colombet, M., & Mejías, M. T. P. A. (2003)
The pathogenesis of chronic fatigue in primary biliary cirrhosis
Raszeja‐Wyszomirska, J., Wunsch, E., Koziarska, D., & Milkiewicz, P. (2012) · Gastroenterology Review · doi:10.5114/pg.2012.30501
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McClean, A. (2016) · University of Birmingham Institutional Research Archive (University of Birmingham)
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Talwalkar, J. A., Kim, W. R., & Dickson, E. R. (2005) · Elsevier eBooks · doi:10.1016/b978-0-7216-0118-2.50017-3
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Swain, M. G. (2004) · Springer eBooks · doi:10.1007/978-1-4419-9034-1_21
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Carey, E. J., & Levy, C. (2018) · Clinics in Liver Disease · doi:10.1016/s1089-3261(18)30044-8
Abdalian, R., Heathcote, J., & Ramos‐Casals, M. (2017) · Technical report · doi:10.1016/b978-0-444-63707-9.00005-2
Bassendine, M. F. (2011) · Wiley eBooks · doi:10.1002/9781444341294.ch15
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Phaw, N. A., & Jones, D. E. (2019) · Digestive Diseases and Sciences · doi:10.1007/s10620-019-05552-3
Faculty Opinions recommendation of Ursodeoxycholic acid for primary biliary cirrhosis.
Rosenthal, P. J. (2013) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.717969424.793469137
Newton, J. L., & Jones, D. E. J. (2010) · Occupational Medicine · doi:10.1093/occmed/kqq169
Abe, K., Fujita, M., Hayashi, M., Takahashi, A., & Ohira, H. (2020) · doi:10.21203/rs.3.rs-26504/v1
Skat-Rørdam, P. A., Eliasson, J., Kjær, M. S., Jeppesen, P. B., & Ytting, H. (2023) · Minerva Gastroenterology · doi:10.23736/s2724-5985.23.03206-0
Primary Biliary Cirrhosis Scenario of Libyan Patients in Tripoli University Hospital
Omar, S., Diekna, W. A. A., Allafi, M. M., & Torjman, F. (2023) · Libyan Journal of Medical Research · doi:10.54361/ljmr.17-04
Roberts, E. (2024) · EMJ Hepatology · doi:10.33590/emjhepatol/pgqp6795
Khakoo, N. S., & Levy, C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23947-2.00039-4
Böttcher, M. H., Bossen, L., Mellemkjær, A., Holland‐Fischer, P., Hansen, J. B., Møller, H. J., & Grønbæk, H. (2025) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2025.2602520
Chung, A. H.-L., Tan, J. J.-R., Yap, R. X. J., Loo, J. H., Tay, W. X., Singh, C. L., Ong, S. J., Low, A. Y. J., Lin, Y., Lytvyak, E., et al. (2026) · Hepatology Communications · doi:10.1097/hc9.0000000000000940
Nathani, Z., Hemarga, C., Ahmed, N., & Oyeka, M. (2026) · Personalized Medicine in Psychiatry · doi:10.1016/j.pmip.2026.100199
Saruhan, M. A., Oyman, F., Dertsiz, B., Saruhan, K., & Adalı, G. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15207967
Falls and fall related injury in older people with chronic liver disease
Frith, J. (2011) · OpenGrey (Institut de l'Information Scientifique et Technique)
Metadata
- Authors
- Cauch-Dudek, K., Abbey, S., Stewart, D. E., & Heathcote, E. J.
- Affiliations
- aDepartment of Medicine, bDepartment of Psychiatry, Toronto Hospital, University of Toronto, Canada
- University of Toronto (CA)
- ORCID
- Abbey, S
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1998-11-01
- Volume
- 43
- Issue
- 5
- Pages
- 705-710
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1727314
- OpenAlex
- W2031912248
- Cited by
- 237
- References
- 42
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 7 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 6 · 2018: 11 · 2017: 7 · 2016: 5 · 2015: 9 · 2014: 3 · 2013: 5 · 2012: 9
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Keywords
- primary biliary cirrhosis, fatigue, sleep quality, depression, liver disease severity, Fatigue Severity Scale, ursodeoxycholic acid, functional capacity, Mayo risk score, bilirubin
- MeSH terms
- Adult, Aged, Aged, 80 and over, Cognition Disorders, Depressive Disorder, Fatigue, Female, Humans, Liver Cirrhosis, Biliary, Male, Middle Aged, Surveys and Questionnaires, Self Disclosure, Sleep Wake Disorders
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