The true impact of fatigue in primary biliary cirrhosis: A population study
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Background & aims Patient surveys suggest that fatigue is a common problem in primary biliary cirrhosis (PBC). The actual extent of the problems caused by fatigue in PBC has yet to be determined as previous studies addressing this question have tended to use selected patient subgroups and subjective or non-quantitative fatigue assessment tools. Here, we have attempted to more accurately assess the extent of fatigue in PBC, and the specificity of the symptom for this disease, by the application of an objective measure of fatigue impact (the fatigue impact score [FIS]) to a geographically based patient cohort, age- and sex-matched normal controls, and chronic liver disease controls. Methods Postal completion of the FIS and linked symptom assessment tools. Results Median FIS was significantly higher in patients (n = 136) than community controls (40 [0-138] vs. 28 [0-156]; P < 0.0001) and chronic liver disease controls (n = 38) (20.5 [0-145]; P < 0.05). Fatigue scores in the 11 patients who had undergone liver transplantation (median 3.5 years previously) were the same as those in non-transplanted patients with advanced disease. Conclusions Fatigue is a significant and specific problem in PBC. It is not, however, universal and affects fewer patients than has previously been thought to be the case based on data from selected patient cohorts. This definition of the "normal range" for fatigue in PBC will assist in future studies of etiology and therapy.
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Fatigue is not specific to PBC, is frequently reported by patients (over 50%) and when severe (20%) is a significant cause of QoL impairment.
“Although fatigue is not specific to PBC, it is frequently reported by patients (over 50%) and when severe, as it is in 20% of patients, is a significant cause of QoL impairment.12 171 205–208”
From The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines (2018) · cites this paper as [208]
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- Authors
- Goldblatt, J., Taylor, P. J. S., Lipman, T., Prince, M. I., Baragiotta, A., Bassendine, M. F., James, O. F. W., & Jones, D. E. J.
- Affiliations
- Newcastle University (GB)
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2002-05
- Volume
- 122
- Issue
- 5
- Pages
- 1235-1241
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2054440991
- Cited by
- 202
- References
- 4
- Citations by year
- 2026: 5 · 2025: 3 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 8 · 2019: 6 · 2018: 13 · 2017: 6 · 2016: 6 · 2015: 9 · 2014: 5 · 2013: 3 · 2012: 10
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Keywords
- primary biliary cirrhosis, fatigue, objective fatigue assessment, chronic liver disease, liver transplantation, symptom burden
- MeSH terms
- Adult, Aged, Aged, 80 and over, Chronic Disease, Fatigue, Female, Humans, Liver Cirrhosis, Biliary, Liver Diseases, Male, Middle Aged, Liver Transplantation
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