Cited by 2,440Gastrointestinal motility and disordersPsychosomatic Disorders and Their TreatmentsGastroesophageal reflux and treatments

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Functional bowel disorders and functional abdominal pain

Open access

Thompson, W G, Longstreth, G F, Drossman, D A, Heaton, K W, Irvine, E J, Müller-Lissner, S A·1999·Gut

DOI 10.1136/gut.45.2008.ii43PMC PMC1766683

Open this paper in CoChat — free account Open PDF

Abstract

The Rome diagnostic criteria for the functional bowel disorders and functional abdominal pain are used widely in research and practice. A committee consensus approach, including criticism from multinational expert reviewers, was used to revise the diagnostic criteria and update diagnosis and treatment recommendations, based on research results. The terminology was clarified and the diagnostic criteria and management recommendations were revised. A functional bowel disorder (FBD) is diagnosed by characteristic symptoms for at least 12 weeks during the preceding 12 months in the absence of a structural or biochemical explanation. The irritable bowel syndrome, functional abdominal bloating, functional constipation, and functional diarrhea are distinguished by symptom-based diagnostic criteria. Unspecified FBD lacks criteria for the other FBDs. Diagnostic testing is individualized, depending on patient age, primary symptom characteristics, and other clinical and laboratory features. Functional abdominal pain (FAP) is defined as either the FAP syndrome, which requires at least six months of pain with poor relation to gut function and loss of daily activities, or unspecified FAP, which lacks criteria for the FAP syndrome. An organic cause for the pain must be excluded, but aspects of the patient’s pain behavior are of primary importance. Treatment of the FBDs relies upon confident diagnosis, explanation, and reassurance. Diet alteration, drug treatment, and psychotherapy may be beneficial, depending on the symptoms and psychological features.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1136/gut.45.2008.ii43

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

U. S. Householder survey of functional gastrointestinal disorders: Prevalence, sociodemography, and health impact
Drossman, D. A., Li, Z., Andruzzi, E., Temple, R. D., Talley, N. J., Grant Thompson, W., Whitehead, W. E., Janssens, J., Funch-Jensen, P., Corazziari, E., et al. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01303162 · Cited by 2,198
Self-citation
Towards positive diagnosis of the irritable bowel.
Manning, A. P., Thompson, W., Heaton, K. W., & Morris, A. F. (1978) · BMJ · doi:10.1136/bmj.2.6138.653 · Cited by 1,404
Self-citation
Defecation frequency and timing, and stool form in the general population: a prospective study.
Heaton, K. W., Radvan, J., Cripps, H., Mountford, R. A., Braddon, F. E., & Hughes, A. O. (1992) · Gut · doi:10.1136/gut.33.6.818 · Cited by 733
Self-citation
Irritable bowel syndrome: A technical review for practice guideline development
Drossman, D. A., Whitehead, W. E., & Camilleri, M. (1997) · Gastroenterology · doi:10.1053/gast.1997.v112.agast972120 · Cited by 571
Self-citation
Detection of pseudodiarrhoea by simple clinical assessment of intestinal transit rate.
O'Donnell, L. J. D., Virjee, J., & Heaton, K. (1990) · British medical journal · doi:10.1136/bmj.300.6722.439 · Cited by 537
Self-citation
A Comparison of Symptoms after the Consumption of Milk or Lactose-Hydrolyzed Milk by People with Self-Reported Severe Lactose Intolerance
Suarez, F. L., Savaiano, D. A., & Levitt, M. D. (1995) · New England Journal of Medicine · doi:10.1056/nejm199507063330101 · Cited by 508
THE IRRITABLE COLON SYNDROME
Chaudhary, N. A., & Truelove, S. C. (1962) · QJM · doi:10.1093/oxfordjournals.qjmed.a066971 · Cited by 498
Medical costs in community subjects with irritable bowel syndrome
Talley, N. J., Gabriel, S. E., Harmsen, W. S., Zinsmeister, A. R., & Evans, R. W. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90738-6 · Cited by 460 · cited 1×
“5 It accounts for high direct medical expenses 6 and indirect costs, including absenteeism from work.”
Background
A longitudinal survey of self-reported bowel habits in the United States
Everhart, J. E., Go, V. L. W., Johannes, R. S., FitzSimmons, S. C., Roth, H. P., & White, L. R. (1989) · Digestive Diseases and Sciences · doi:10.1007/bf01537261 · Cited by 384
A diagnostic score for the irritable bowel syndrome. Its value in the exclusion of organic disease.
Kruis, W., Thieme, C., Weinzierl, M., Schüßler, P., Holl, J., & Paulus, W. J. (1984) · PubMed · Cited by 318

Show all 36 references

Sorted by citations

Items 501–600 of 1,017

Acute tryptophan depletion affects brain-gut responses in irritable bowel syndrome patients and controls
Kilkens, T. O. C., Honig, A., van Nieuwenhoven, M. A., Riedel, W. J., & Brummer, R. J. (2004) · Gut · doi:10.1136/gut.2004.041657 · Cited by 103
Slow transit constipation: A functional disorder becomes an enteric neuropathy
Bassotti, G. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i29.4609 · Cited by 103
The presentation of irritable bowel syndrome in the context of somatization disorder
North, C. S., Downs, D., Clouse, R. E., Alrakawi, A., Dokucu, M. E., Cox, J., Spitznagel, E. L., & Alpers, D. H. (2004) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00350-7 · Cited by 102
Quality of life in children and adults with constipation
Wald, A. M., & Sigurðsson, L. (2011) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2010.12.004 · Cited by 102
Association between dietary fiber, water and magnesium intake and functional constipation among young Japanese women
Murakami, K., Sasaki, S., Okubo, H., Takahashi, Y., Hosoi, Y., ITABASHI, M., & and the Freshmen in Dietetic Courses Study II Group (2006) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602573 · Cited by 104
Effect of asimadoline, a κ opioid agonist, on pain induced by colonic distension in patients with irritable bowel syndrome
Delvaux, M. M., Beck, A., Jacob, J., Bouzamondo, H., Weber, F. T., & Frexinos, J. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.01922.x · Cited by 102
A prospective study into the aetiology of lymphocytic duodenosis
Aziz, I., Evans, K., Hopper, A. D., Smillie, D., & Sanders, D. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04477.x · Cited by 101
Relationship between symptoms and hypersensitivity to rectal distension in patients with irritable bowel syndrome
Kuiken, S., Lindeboom, R., Tytgat, G. N. J., & Boeckxstaens, G. E. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02524.x · Cited by 101
Intestinal gas distribution determines abdominal symptoms
Harder, H. (2003) · Gut · doi:10.1136/gut.52.12.1708 · Cited by 101
Systematic review: probiotics for functional constipation in children
Wojtyniak, K., & Szajewska, H. (2017) · European Journal of Pediatrics · doi:10.1007/s00431-017-2972-2 · Cited by 100
Symptom overlap and comorbidity of irritable bowel syndrome with other conditions
Frissora, C. L., & Koch, K. L. (2005) · Current Gastroenterology Reports · doi:10.1007/s11894-005-0018-9 · Cited by 100
Salmonella Gastroenteritis During Childhood Is a Risk Factor for Irritable Bowel Syndrome in Adulthood
Cremon, C., Stanghellini, V., Pallotti, F., Fogacci, E., Bellacosa, L., Morselli‐Labate, A. M., Paccapelo, A., Nardo, G. D., Cogliandro, R. F., GIORGIO, R. D., et al. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.03.013 · Cited by 106
Pan-enteric dysmotility, impaired quality of life and alexithymia in a large group of patients meetingROMEII criteria for irritable bowel syndrome
Portincasa, P. (2003) · World Journal of Gastroenterology · doi:10.3748/wjg.v9.i10.2293 · Cited by 100
Biofeedback and/or sphincter exercises for the treatment of faecal incontinence in adults
Norton, C. S., Cody, J. D., & Hosker, G. L. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002111.pub2 · Cited by 100
Psychiatric and psychological dysfunction in irritable bowel syndrome and the role of psychological treatments.
Palsson, O. S., & Drossman, D. A. (2005) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2005.02.004 · Cited by 99
Self-citation
Irritable bowel syndrome in Asia: Pathogenesis, natural history, epidemiology, and management
Gwee, K., Ghoshal, U., & Chen, M.-H. (2018) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.13987 · Cited by 103
Antibiotic therapy in small intestinal bacterial overgrowth: rifaximin versus metronidazole.
Lauritano, E., Gabrielli, M., Scarpellini, E., Ojetti, V., Roccarina, D., Villita, A., Fiore, E., Flore, R. A., Santoliquido, A., Tondi, P., et al. (2009) · PubMed · Cited by 99
Clinical and subclinical intestinal inflammation assessed by the mucosal patch technique: studies of mucosal neutrophil and eosinophil activation in inflammatory bowel diseases and irritable bowel syndrome
Kristjansson, G., Venge, P., Wanders, A., Lööf, L., & Hällgren, R. (2004) · Gut · doi:10.1136/gut.2003.036418 · Cited by 99
A Controlled Study of Colonic Immune Activity and β7+ Blood T Lymphocytes in Patients With Irritable Bowel Syndrome
Öhman, L., Isaksson, S., Lundgren, A., Simrén, M., & Sjövall, H. (2005) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(05)00410-6 · Cited by 98
Prospective evaluation of faecal neutrophil‐derived proteins in identifying intestinal inflammation: combination of parameters does not improve diagnostic accuracy of calprotectin
Schröder, O., Naumann, M., Shastri, Y., Povse, N., & Stein, J. M. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03457.x · Cited by 98
Sex‐based differences in gastrointestinal pain
Mayer, E. A., Berman, S. M., Chang, L., & Naliboff, B. D. (2004) · European Journal of Pain · doi:10.1016/j.ejpain.2004.01.006 · Cited by 98
Effect of a laxative with and without tegaserod in adolescents with constipation predominant irritable bowel syndrome
Khoshoo, V., ARMSTEAD, C., & Landry, L. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.02705.x · Cited by 98
Dyspeptic symptoms and gastric emptying in the irritable bowel syndrome
Stanghellini, V., Tosetti, C., Barbara, G., GIORGIO, R. D., Cogliandro, L., Cogliandro, R. F., & Corinaldesi, R. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.07062.x · Cited by 98
Activated Mast Cells Infiltrate in Close Proximity to Enteric Nerves in Diarrhea-predominant Irritable Bowel Syndrome
Park, C., Joo, Y., Choi, S. K., Rew, J. S., Kim, S. J., & Lee, M. C. (2003) · Journal of Korean Medical Science · doi:10.3346/jkms.2003.18.2.204 · Cited by 98
Studying the Overlap Between IBS and GERD: A Systematic Review of the Literature
Nastaskin, I., Mehdikhani, E., Conklin, J., Park, S., & Pimentel, M. (2006) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9306-y · Cited by 98
Biofeedback for treatment of chronic idiopathic constipation in adults
Woodward, S., Norton, C. S., & Chiarelli, P. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008486.pub2 · Cited by 97
The Association of Irritable Bowel Syndrome and Somatization Disorder
Miller, A. R., North, C. S., Clouse, R. E., Wetzel, R. D., Spitznagel, E. L., & Alpers, D. (2001) · Annals of Clinical Psychiatry · doi:10.1023/a:1009060731057 · Cited by 97
International Society for the Study of Women’s Sexual Health (ISSWSH) Review of Epidemiology and Pathophysiology, and a Consensus Nomenclature and Process of Care for the Management of Persistent Genital Arousal Disorder/Genito-Pelvic Dysesthesia (PGAD/GPD)
Goldstein, I., Komisaruk, B. R., Pukall, C. F., Kim, N. N., Goldstein, A. T., Goldstein, S. W., Hartzell-Cushanick, R., Kellogg-Spadt, S., Kim, C. W., Jackowich, R. A., et al. (2021) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2021.01.172 · Cited by 96
Modulation of the gut microbiota composition by rifaximin in non-constipated irritable bowel syndrome patients: a molecular approach
Soldi, S., Vasileiadis, S., Uggeri, F., Campanale, M. C., Morelli, L., Calanni, F., Grimaldi, M., Gasbarrini, A., & Fogli, M. V. (2015) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s89999 · Cited by 98
Effects of chili on postprandial gastrointestinal symptoms in diarrhoea predominant irritable bowel syndrome: evidence for capsaicin‐sensitive visceral nociception hypersensitivity
Gonlachanvit, S., Mahayosnond, A., & Kullavanijaya, P. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01167.x · Cited by 96
Effects of physical activity on intestinal gas transit and evacuation in healthy subjects
Dainese, R., Serra, J., Azpiroz, F., & Malagelada, J. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2003.12.018 · Cited by 96
Sugar malabsorption in functional abdominal bloating: A pilot study on the long-term effect of dietary treatment
Fernández‐Bañares, F., Rosinach, M., Esteve, M., Forné, M., Espinós, J. C., & Viver, J. M. (2006) · Clinical Nutrition · doi:10.1016/j.clnu.2005.11.010 · Cited by 96
Contemporary understanding and management of reflux and constipation in the general population and pregnancy: a consensus meeting
Tytgat, G. N. J., Heading, R. C., Müller-Lissner, S. A., Kamm, M. A., Schölmerich, J., Berstad, A., Fried, M., Chaussade, S., Jewell, D., & Briggs, A. H. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01679.x · Cited by 96
Self-citation
Effects of multispecies probiotic supplementation on intestinal microbiota in irritable bowel syndrome
KAJANDER, K., KROGIUS‐KURIKKA, L., RINTTILÄ, T., KARJALAINEN, H., PALVA, A., & KORPELA, R. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03391.x · Cited by 95
Definition and Classification of Irritable Bowel Syndrome: Current Consensus and Controversies
Longstreth, G. F. (2005) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2005.02.011 · Cited by 95
Self-citation
Prevalence of Gastro-Esophageal Reflux-Type Symptoms in Individuals With Irritable Bowel Syndrome in the Community: A Meta-Analysis
Lovell, R. M., & Ford, A. C. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.336 · Cited by 95
Relative importance of abnormalities of CCK and 5‐HT (serotonin) in Giardia ‐induced post‐infectious irritable bowel syndrome and functional dyspepsia
Dizdar, V., Spiller, R. E., SINGH, G., Hanevik, K., Gilja, O. H., El‐Salhy, M., & Hausken, T. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04251.x · Cited by 95
Rectal intussusception in symptomatic patients is different from that in asymptomatic volunteers
Dvorkin, L. S., Gladman, M. A., Epstein, J., Scott, S. M., Williams, N. S., & Lunniss, P. J. (2005) · British journal of surgery · doi:10.1002/bjs.4912 · Cited by 95
A randomised controlled study of the effect of cholinesterase inhibition on colon function in patients with diabetes mellitus and constipation
Bharucha, A. E., Low, P. A., Camilleri, M., Veil, E. B., Burton, D. D., Kudva, Y. C., Shah, P., Gehrking, T. L., & Zinsmeister, A. R. (2012) · Gut · doi:10.1136/gutjnl-2012-302483 · Cited by 96
Frequency of Functional Bowel Disorders among Healthy Volunteers in Mexico City
Schmulson, M. J., Ortíz, O., Santiago-Lomeli, M., Gutiérrez‐Reyes, G., Gutiérrez‐Ruíz, M. C., Robles‐Díaz, G., & Morgan, D. R. (2006) · Digestive Diseases · doi:10.1159/000092887 · Cited by 95
Incontinence in the Frail Elderly
Fonda, D., Ce, D., Harari, D., Ouslander, J., Palmer, M. H., & Roe, B. H. (2005) · Edge Hill University Research Information Repository (Edge Hill University) · Cited by 94
Current patterns of irritable bowel syndrome in Taiwan: the Rome II questionnaire on a Chinese population
Lu, C., Chen, C.-M., Lang, H., Luo, J., Wang, S., Chang, F. ‐., & Lee, S. ‐. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01711.x · Cited by 94
A randomised controlled trial of self-help interventions in patients with a primary care diagnosis of irritable bowel syndrome
Robinson, A., Lee, V., Kennedy, A. P., Middleton, L., Rogers, A. E., Thompson, D. G., & Reeves, D. (2005) · Gut · doi:10.1136/gut.2004.062901 · Cited by 94
New-Onset Constipation at Acute Stage After First Stroke
Su, Y., Zhang, X., Zeng, J., Pei, Z., Cheung, R. T. F., Zhou, Q., Li, L., Yu, J., Tan, J., & Zhang, Z. (2009) · Stroke · doi:10.1161/strokeaha.108.534776 · Cited by 94
Clinical trial: the glucagon‐like peptide‐1 analogue ROSE‐010 for management of acute pain in patients with irritable bowel syndrome: a randomized, placebo‐controlled, double‐blind study
Hellström, P. M., Hein, J., Bytzer, P. M., BJÖRNSSÖN, E., KRISTENSEN, J., & Schambye, H. T. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03870.x · Cited by 93
Inflammation as a basis for functional GI disorders
Spiller, R. E. (2004) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2004.04.002 · Cited by 93
Comorbidity of Irritable Bowel Syndrome, Panic Disorder, and Agoraphobia in a Japanese Representative Sample
Kumano, H., Kaiya, H., Yoshiuchi, K., Yamanaka, G., Sasaki, T., & Kuboki, T. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.04048.x · Cited by 93
Prevalence and health/social impacts of functional dyspepsia in Taiwan: A study based on the Rome Criteria Questionnaire Survey assisted by endoscopic exclusion among a physical check-up population
Lu, C., Lang, H., Chang, F.-Y., Chen, C., Luo, J., Wang, S.-S., & Lee, S. (2005) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520510012190 · Cited by 93
Utility of the Rome I and Rome II criteria for irritable bowel syndrome in U.S. women
Chey, W. D., Olden, K. W., Carter, E., Boyle, J. M., Drossman, D. A., & Chang, L. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.07026.x · Cited by 93
Self-citation
Effects of long‐term treatment with oxytocin in chronic constipation; a double blind, placebo‐controlled pilot trial
Ohlsson, B., Truedsson, M., Bengtsson, M., Torstenson, R., Sjölund, K., Björnsson, E. S., & Simrèn, M. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00679.x · Cited by 92
Is there a benefit from intensified medical and psychological interventions in patients with functional dyspepsia not responding to conventional therapy?
Haag, S., Senf, W., Tagay, S., Langkafel, M., Braun-Lang, U., Pietsch, A. P., Heuft, G., Talley, N. J., & Holtmann, G. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03277.x · Cited by 92
Alterations in colonic motility and relationship to pain in colonic diverticulosis
Bassotti, G., Battaglia, E., de Roberto, G., Morelli, A., Tonini, M., & Villanacci, V. (2005) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00614-7 · Cited by 92
Normal aspects of colorectal motility and abnormalities in slow transit constipation
Bassotti, G. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i18.2691 · Cited by 92
The involvement of the interstitial Cajal cells and the enteric nervous system in bowel endometriosis
Remorgida, V., Ragni, N., Ferrero, S., Anserini, P., Torelli, P., & Fulcheri, E. (2004) · Human Reproduction · doi:10.1093/humrep/deh568 · Cited by 92
Effect of antispasmodic agents, alone or in combination, in the treatment of Irritable Bowel Syndrome: Systematic review and meta-analysis
Martinez-Vazquez, M. A., Vázquez‐Elizondo, G., González, J. A., Gutiérrez-Udave, R., Maldonado-Garza, H. J., & Bosques‐Padilla, F. (2012) · Revista de Gastroenterología de México · doi:10.1016/j.rgmx.2012.04.002 · Cited by 92
Constipation: an emerging risk factor for Parkinson's disease?
Stirpe, P., Hoffman, M., Badiali, D., & Colosimo, C. (2016) · European Journal of Neurology · doi:10.1111/ene.13082 · Cited by 94
Subject's Global Assessment of Relief: An appropriate method to assess the impact of treatment on irritable bowel syndrome-related symptoms in clinical trials
Müller-Lissner, S. (2003) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(03)00027-1 · Cited by 91
Self-citation
Compositional dynamics of the human intestinal microbiota with aging: Implications for health
Lakshminarayanan, B., Stanton, C., O’Toole, P. W., & Ross, R. P. (2014) · The journal of nutrition health & aging · doi:10.1007/s12603-014-0549-6 · Cited by 93
Mosapride
Curran, M. P., & Robinson, D. M. (2008) · Drugs · doi:10.2165/00003495-200868070-00007 · Cited by 91
Serotonin transporter gene polymorphism and irritable bowel syndrome
Park, J. M., Choi, M., Park, J., Oh, J. H., Cho, Y. K., Lee, I. S., Kim, S. W., Choi, K.-Y., & Chung, I. ‐. (2006) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00829.x · Cited by 91
Efficacy and safety of bisacodyl in the acute treatment of constipation: a double‐blind, randomized, placebo‐controlled study
Kienzle-Horn, S., VIX, J. ‐., Schuijt, C., Peil, H., Jordan, C., & Kamm, M. A. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.02903.x · Cited by 91
Influence of sex and experimental protocol on the effect of maternal deprivation on rectal sensitivity to distension in the adult rat
Rosztoczy, A. I., Fioramonti, J., Jármay, K., Barreau, F., Wittmann, T., & Bueno, L. P. (2003) · Neurogastroenterology & Motility · doi:10.1046/j.1350-1925.2003.00451.x · Cited by 91
Outlet type constipation in Parkinson's disease: results of botulinum toxin treatment
Cadeddu, F., Bentivoglio, A. R., Brandara, F., Marniga, G., Brisinda, G., & Maria, G. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02669.x · Cited by 91
Visceral hypersensitivity in endometriosis: a new target for treatment?
Issa, B., Onon, T. S., Agrawal, A., Shekhar, C., Morris, J., Hamdy, S., & Whorwell, P. J. (2012) · Gut · doi:10.1136/gutjnl-2011-300306 · Cited by 90
A systematic review of the association between fibromyalgia and functional gastrointestinal disorders
Erdrich, S., Hawrelak, J. A., Myers, S. P., & Harnett, J. (2020) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756284820977402 · Cited by 95
Evaluating Breath Methane as a Diagnostic Test for Constipation-Predominant IBS
Hwang, L. J., Low, K., Khoshini, R., MELMED, G. Y., Sahakian, A. B., Makhani, M. D., Pokkunuri, V. B., & Pimentel, M. (2009) · Digestive Diseases and Sciences · doi:10.1007/s10620-009-0778-4 · Cited by 90
A randomized, controlled exploratory study of clonidine in diarrhea-predominant irritable bowel syndrome
Camilleri, M., Kim, D.-Y., McKinzie, S., Kim, H. J., Thomforde, G. M., Burton, D. D., Low, P. A., & Zinsmeister, A. R. (2003) · Clinical Gastroenterology and Hepatology · doi:10.1053/cgh.2003.50019 · Cited by 90
Methane positive small intestinal bacterial overgrowth in inflammatory bowel disease and irritable bowel syndrome: A systematic review and meta-analysis
Gandhi, A., Shah, A., Jones, M. P., Koloski, N. A., Talley, N. J., Morrison, M., & Holtmann, G. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1933313 · Cited by 92
Giardia lamblia infection in patients with irritable bowel syndrome and dyspepsia: A prospective study
Grazioli, B. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i12.1941 · Cited by 89
Increased visceral sensitivity in Giardia‐induced postinfectious irritable bowel syndrome and functional dyspepsia. Effect of the 5HT3‐antagonist ondansetron
Dizdar, V., Gilja, O. H., & Hausken, T. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.00988.x · Cited by 89
Alosetron Improves Quality of Life in Women With Diarrhea-Predominant Irritable Bowel Syndrome
Watson, M. E., Lacey, L., Kong, S., Northcutt, A. R., McSorley, D., Hahn, B., & Mangel, A. W. (2001) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03525.x · Cited by 88
Prebiotics: tools to manipulate the gut microbiome and metabolome
Enam, F., & Mansell, T. J. (2019) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-019-02203-4 · Cited by 90
Overlap of disorders of gut–brain interaction: a systematic review and meta-analysis
Fairlie, T., Shah, A., Talley, N. J., Chey, W. D., Koloski, N. A., Lee, Y. Y., Gwee, K., Jones, M. P., & Holtmann, G. (2023) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(23)00102-4 · Cited by 88
Compliance, tone and sensitivity of the rectum in different subtypes of irritable bowel syndrome
Steens, J., Schaar, P. J. V. D., Penning, C., Brussee, J. E., & Masclee, A. (2002) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2002.00332.x · Cited by 88
Diagnostic testing for dyssynergic defecation in chronic constipation: meta‐analysis
Videlock, E. J., Lembo, A. J., & Cremonini, F. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12096 · Cited by 88
Autoimmunity Links Vinculin to the Pathophysiology of Chronic Functional Bowel Changes Following Campylobacter jejuni Infection in a Rat Model
Pimentel, M., Morales, W., Pokkunuri, V. B., Brikos, C., Kim, S. M., Kim, S., Τriantafyllou, Κ., Weitsman, S. R., Marsh, Z. A., Marsh, E., et al. (2014) · Digestive Diseases and Sciences · doi:10.1007/s10620-014-3435-5 · Cited by 88
The usual medical care for irritable bowel syndrome
Whitehead, W. E., Levy, R. L., Korff, M. V., Feld, A., Palsson, O. S., Turner, M. J., & Drossman, D. A. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02256.x · Cited by 88
Self-citation
Diet, physical inactivity and the prevalence of constipation throughout and after pregnancy
Derbyshire, E. J., Davies, J., Costarelli, V., & Dettmar, P. W. (2006) · Maternal and Child Nutrition · doi:10.1111/j.1740-8709.2006.00061.x · Cited by 88
Psychosocial aspects of assessment and treatment of irritable bowel syndrome in adults and recurrent abdominal pain in children.
Blanchard, E. B., & Scharff, L. (2002) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.70.3.725 · Cited by 88
High Prevalence of Idiopathic Bile Acid Diarrhea Among Patients With Diarrhea-Predominant Irritable Bowel Syndrome Based on Rome III Criteria
Aziz, I., Mumtaz, S., Bholah, H., Chowdhury, F. U., Sanders, D. S., & Ford, A. C. (2015) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2015.03.002 · Cited by 87
Is a negative colonoscopy associated with reassurance or improved health-related quality of life in irritable bowel syndrome?
Spiegel, B. M. R., Gralnek, I. M., Bolus, R., Chang, L., Dulai, G. S., Naliboff, B., & Mayer, E. A. (2005) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2005.08.016 · Cited by 87
Opioid-induced bowel dysfunction in cancer-related pain: Causes, consequences, and a novel approach for its management
Holzer, P. D., Ahmedzai, S. H., Niederle, N., Leyendecker, P., Hopp, M., Bosse, S. B., Spohr, I., & Reimer, K. (2018) · Journal of Opioid Management · doi:10.5055/jom.2009.0015 · Cited by 87
The Irritable Bowel Syndrome has Origins in the Childhood Socioeconomic Environment
Howell, S. C., Talley, N. J., Quine, S., & Poulton, R. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.40188.x · Cited by 87
Depression and Somatization Are Associated With Increased Postprandial Symptoms in Patients With Irritable Bowel Syndrome
Oudenhove, L. V., Törnblom, H., Störsrud, S., Tack, J. F., & Simrén, M. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.11.010 · Cited by 87
Irritable bowel syndrome: Psychosocial assessment and treatment.
Blanchard, E. B. (2001) · American Psychological Association eBooks · doi:10.1037/10393-000 · Cited by 87
Small Intestinal Bacterial Overgrowth in Functional Dyspepsia: A Systematic Review and Meta-Analysis
Gurusamy, S. R., Shah, A., Talley, N. J., Koloski, N. A., Jones, M. P., Walker, M. M., Morrison, M., & Holtmann, G. (2021) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000001197 · Cited by 86
Prevalence of irritable bowel syndrome (IBS) and variability of diagnostic criteria
Bommelaer, G., Poynard, T., Pen, C. L., Gaudin, A.-F., Maurel, F., Priol, G., Amouretti, M., Frexinos, J., Ruszniewski, P. B., & Hasnaoui, A. E. (2004) · Gastroentérologie Clinique et Biologique · doi:10.1016/s0399-8320(04)95011-7 · Cited by 86
Epidemiological Aspects of Irritable Bowel Syndrome in Europe and North America
Müller-Lissner, S. A., Bollani, S., Brummer, R. J., Coremans, G., Dapoigny, M. C., Marshall, J. K., Muris, J. W. M., Oberndorff, A., Pace, F., Rodrigo, L., et al. (2001) · Digestion · doi:10.1159/000048862 · Cited by 87
Self-citation
Irritable bowel syndrome
Talley, N. J. (2006) · Internal Medicine Journal · doi:10.1111/j.1445-5994.2006.01217.x · Cited by 87
Effect of a multispecies probiotic supplement on quantity of irritable bowel syndrome-related intestinal microbial phylotypes
Lyra, A., Krogius-Kurikka, L., Nikkilä, J., Malinen, E., Kajander, K., Kurikka, K., Korpela, R., & Palva, A. (2010) · BMC Gastroenterology · doi:10.1186/1471-230x-10-110 · Cited by 86
Abdominal Bloating: Pathophysiology and Treatment
Seo, A. Y., Kim, N., & Oh, D. H. (2013) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2013.19.4.433 · Cited by 82
Structured patient education is superior to written information in the management of patients with irritable bowel syndrome: a randomized controlled study
Ringström, G., Störsrud, S., Posserud, I., Lundqvist, S., Westman, B., & Simrén, M. (2010) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e3283333b61 · Cited by 85
Epidemiology of Irritable Bowel Syndrome in Children and Adolescents in Asia
Devanarayana, N. M., Rajindrajith, S., Pathmeswaran, A., Abegunasekara, C., Gunawardena, N. K., & Benninga, M. A. (2015) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000714 · Cited by 85
Relationship between severity of symptoms and quality of life in 858 patients with irritable bowel syndrome
Coffin, B., Dapoigny, M. C., Cloarec, D., Comet, D., & Dyard, F. (2004) · Gastroentérologie Clinique et Biologique · doi:10.1016/s0399-8320(04)94834-8 · Cited by 85
Rectal Intussusception: Characterization of Symptomatology
Dvorkin, L. S., Knowles, C. H., Scott, S. M., Williams, N. S., & Lunniss, P. J. (2005) · Diseases of the Colon & Rectum · doi:10.1007/s10350-004-0834-2 · Cited by 85
Outcome in severe irritable bowel syndrome with and without accompanying depressive, panic and neurasthenic disorders
Creed, F. H., Ratcliffe, J., Fernandes, L., Palmer, S., Rigby, C., Tomenson, B., Guthrie, E., Read, N., & Thompson, D. G. (2005) · The British Journal of Psychiatry · doi:10.1192/bjp.186.6.507 · Cited by 85
Effects of probiotic fermented milk on symptoms and intestinal flora in patients with irritable bowel syndrome: a randomized, placebo-controlled trial
Søndergaard, B., Olsson, J., Ohlson, K., Svensson, U., Bytzer, P., & Ekesbo, R. (2011) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2011.565066 · Cited by 84
Validation of Irritable Bowel Syndrome Global Improvement Scale: An Integrated Symptom End Point for Assessing Treatment Efficacy
Gordon, S., Ameen, V. Z., Bagby, B., Shahan, B., Jhingran, P. M., & Carter, E. (2003) · Digestive Diseases and Sciences · doi:10.1023/a:1024159226274 · Cited by 84
The Efficacy of an Herbal Medicine, Carmint, on the Relief of Abdominal Pain and Bloating in Patients with Irritable Bowel Syndrome: A Pilot Study
Vejdani, R., Shalmani, H. M., Mir-Fattahi, M., Sajed-Nia, F., Abdollahi, M., Zali, M. R., Alizadeh, A. H. M., Bahari, A., & Amin, G. (2006) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9079-3 · Cited by 84
Prevalence and impact of self‐reported irritable bowel symptoms in the general population
den Houte, K. V., Carbone, F., Pannemans, J., Corsetti, M., Fischler, B., Piessevaux, H. H., & Tack, J. F. (2018) · United European Gastroenterology Journal · doi:10.1177/2050640618821804 · Cited by 84

Authors: Thompson, W. G., Longstreth, G. F., Drossman, D. A., Heaton, K. W., Irvine, E. J., & Müller-Lissner, S. A.
Affiliations: Kaiser Permanente (US)
Corresponding author: Thompson, W G
ORCID: Thompson, W G
Longstreth, G F
Drossman, D A
Venue: Gut
Publisher: BMJ
Published: 1999-09-01
Volume: 45
Issue: suppl 2
Pages: II43-II47
ISSN: 0017-5749 (ISSN-L)
1468-3288
DOI: 10.1136/gut.45.2008.ii43
PMC: PMC1766683
OpenAlex: W2166386674
Semantic Scholar: 9e1a4a0b207039b5d64277278fb3532bc6348472
Cited by: 2,440
References: 36
Citations by year: 2026: 11 · 2025: 20 · 2024: 18 · 2023: 38 · 2022: 28 · 2021: 47 · 2020: 36 · 2019: 30 · 2018: 47 · 2017: 43 · 2016: 64 · 2015: 77 · 2014: 81 · 2013: 92 · 2012: 123
FWCI: 64.06
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Gut (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
HighWire Press Open Archive (submittedVersion)
UNC Libraries
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
Keywords: functional bowel disorders, functional abdominal pain, irritable bowel syndrome, functional constipation, functional diarrhea, diagnostic criteria revision, treatment guidelines, pain behavior, dietary change, psychotherapy, pharmacotherapy
MeSH terms: Colonic Diseases, Functional, Constipation, Diarrhea, Gastrointestinal Diseases, Humans, Abdominal Pain

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Functional bowel disorders and functional abdominal pain

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks