Cited by 415Gastrointestinal motility and disordersInflammatory Bowel DiseaseGut microbiota and health

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Increased rectal mucosal expression of interleukin 1beta in recently acquired post-infectious irritable bowel syndrome

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Gwee, K-A·2003·Gut

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Abstract

BACKGROUND AND AIMS: Chronic bowel disturbances resembling irritable bowel syndrome (IBS) develop in approximately 25% of patients after an episode of infectious diarrhoea. Although we have previously shown that psychosocial factors operating at the time of, or prior to, the acute illness appear to predict the development of post-infectious IBS (PI-IBS), our finding of an increased inflammatory cell number in the rectum persisting for at least three months after the acute infection suggested that there is also an organic component involved in the development of PI-IBS. To evaluate this further, we measured expressions of interleukin 1beta (IL-1beta) and its receptor antagonist (IL-1ra) in these patients to provide additional evidence that the pathogenesis of PI-IBS is underpinned by an inflammatory process. METHODS: Sequential rectal biopsy samples were prospectively obtained during and three months after acute gastroenteritis, from eight patients who developed post-infectious IBS (INF-IBS) and seven patients who returned to normal bowel habits after acute gastroenteritis (infection controls, INF-CON). Eighteen healthy volunteers who had not suffered from gastroenteritis in the preceding two years served as normal controls (NOR-CON). IL-1beta and IL-1ra gene expressions were assayed by reverse transcriptase-polymerase chain reaction, and their levels of expression were quantitated by optical densitometry after electrophoresis on agarose gel. RESULTS: INF-IBS patients exhibited significantly greater expression of IL-1beta mRNA in rectal biopsies than INF-CON patients both during and three months after acute gastroenteritis. Moreover, IL-1beta mRNA expression had increased in biopsies taken from INF-IBS patients at three months after the acute infection but no consistent change was observed in INF-CON patients. IL-1beta mRNA expression of INF-IBS patients at three months post gastroenteritis was significantly greater than NOR-CON whereas that of INF-CON patients was not significantly different from NOR-CON. Despite these differential changes in IL-1beta mRNA expression, no significant changes were observed in IL-1ra mRNA expression among the three groups. CONCLUSIONS: These findings indicate that those patients who develop IBS post infection exhibit greater IL-1beta mRNA expression, both during and after the infection, compared with individuals who do not develop PI-IBS. We conclude that such patients may be susceptible to inflammatory stimuli, and that inflammation may play a role in the pathogenesis of PI-IBS.

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Authors: Gwee, K.-A.
Venue: Gut
Publisher: BMJ
Published: 2003-04-01
Volume: 52
Issue: 4
Pages: 523-526
ISSN: 0017-5749 (ISSN-L)
DOI: 10.1136/gut.52.4.523
PMC: PMC1773606
OpenAlex: W2148823535
Cited by: 415
References: 26
Citations by year: 2026: 5 · 2025: 3 · 2024: 9 · 2023: 8 · 2022: 10 · 2021: 11 · 2020: 9 · 2019: 16 · 2018: 13 · 2017: 13 · 2016: 8 · 2015: 13 · 2014: 23 · 2013: 21 · 2012: 24
FWCI: 19.73
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Gut (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
National University of Singapore (submittedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: Wellcome Trust
Royal College of Physicians and Surgeons of Glasgow
National University of Singapore
Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: post-infectious irritable bowel syndrome, IL-1β, interleukin-1 receptor antagonist, rectal mucosa, intestinal inflammation, acute gastroenteritis, gene expression, rectal biopsy, psychosocial factors
MeSH terms: Acute Disease, Adult, Bacterial Infections, Colonic Diseases, Functional, Female, Gastroenteritis, Humans, Interleukin-1, Intestinal Mucosa, Male, Middle Aged, Prospective Studies, Rectum, RNA, Messenger, Sialoglycoproteins, Gene Expression, Genetic Predisposition to Disease, Reverse Transcriptase Polymerase Chain Reaction, Interleukin 1 Receptor Antagonist Protein

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Increased rectal mucosal expression of interleukin 1beta in recently acquired post-infectious irritable bowel syndrome

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