Cited by 67Gastrointestinal motility and disordersGut microbiota and healthProbiotics and Fermented Foods

Bacteria: A New Player in Gastrointestinal Motility Disorders—Infections, Bacterial Overgrowth, and Probiotics

Quigley, Eamonn M.M.·2007·Gastroenterology Clinics of North America

Abstract

Irritable bowel syndrome (IBS) may result from a dysfunctional interaction between the indigenous flora and the intestinal mucosa, which in turn leads to immune activation in the colonic mucosa. Some propose that bacterial overgrowth is a common causative factor in the pathogenesis of symptoms in IBS; others point to evidence suggesting that the cause stems from more subtle qualitative changes in the colonic flora. Bacterial overgrowth will probably prove not to be a major factor in what will eventually be defined as IBS. Nevertheless, short-term therapy with either antibiotics or probiotics seems to reduce symptoms among IBS patients. However, in the long term, safety issues will favor the probiotic approach; results of long-term studies with these agents are eagerly awaited.

Integrity signals

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Crossref · 10.1016/j.gtc.2007.07.012

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Authors
Quigley, E. M. M.
Affiliations
University College Cork (IE)
Corresponding author
Quigley, Eamonn M.M.
Venue
Gastroenterology Clinics of North America
Publisher
Elsevier BV
Published
2007-09
Volume
36
Issue
3
Pages
735-748
ISSN
0889-8553 (ISSN-L)
OpenAlex
W2056321725
Cited by
67
References
104
Citations by year
2025: 1 · 2023: 1 · 2022: 4 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 8 · 2016: 5 · 2015: 1 · 2014: 5 · 2013: 2 · 2012: 4
FWCI
1.02
Type
journal article
Language
en
Open access
closed
Locations
  • Gastroenterology Clinics of North America (publishedVersion)
  • PubMed (publishedVersion)
  • Lenus, The Irish Health Repository (Dr Steevens Hospital Library) (submittedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
irritable bowel syndrome, bacterial overgrowth, probiotics, gut microbiota, gastrointestinal motility disorders, intestinal infection, colonic mucosa, immune activation, antibiotic therapy, probiotic safety
MeSH terms
Bacteria, Bacterial Infections, Gastrointestinal Diseases, Humans, Probiotics, Gastrointestinal Tract

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