Association of inflammatory bowel disease with suicidal ideation, suicide attempts, and suicide: A systematic review and meta-analysis
Abstract
Objective Inflammatory bowel disease (IBD) is associated with psychiatric comorbidities. However, the association between IBD and suicidal ideation or suicide attempts has not been well established. This study aimed to perform a systematic review and meta-analysis to elucidate the relationship between IBD and suicidal ideation, suicide attempts, and suicide.Methods We systematically searched five electronic databases - PubMed, Embase, CENTRAL, Web of Science, and PsycINFO - from their inception to January 28, 2022. Quality assessment, data synthesis, subgroup analyses, sensitivity analyses, and publication bias assessment were performed on the included studies.Results We identified 28 studies with 1,047,755 patients with IBD. The pooled prevalence of suicidal ideation in patients with IBD was 17.3% (95% CI, 9.5%-25.2%). Patients with IBD were associated with an increased risk of suicide attempts (relative risk [RR], 1.39; 95% CI, 1.08-1.79) and suicide deaths (RR, 1.25; 95% CI, 1.09-1.43) than the controls without IBD. Patients with Crohn's disease subtypes, female IBD, pediatric-onset IBD, young adult IBD, and short-duration IBD had a particularly high risk for suicide.Conclusion Patients with IBD had a high prevalence of suicidal ideation and a significantly higher likelihood of suicide attempts and suicide. Caring for patients with IBD, including their mental health needs, may require concerted efforts among gastroenterologists and other healthcare providers.
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Crohn's disease subtypes, female patients, childhood-onset IBD, young-adult IBD, and short-duration IBD characteristics are factors that carry a high risk of suicide.
“Crohn’s disease subtypes, female patients, childhood-onset IBD, young-adult IBD, and short-duration IBD characteristics are factors that carry a high risk of suicide [106].”
From Association between Childhood Onset Inflammatory Bowel Disease and Psychiatric Comorbidities in Adulthood (2023) · cites this paper as [106]
Patients with inflammatory bowel disease have an increased risk of suicide attempts (relative risk=1.39; 95% CI, 1.08-1.79) and deaths from suicide (relative risk=1.25; 95% CI, 1.09-1.43) compared to controls.
“patients with inflammatory bowel disease were associated with an increased risk of suicide attempts (relative risk= 1.39; 95% CI, 1.08–1.79) and deaths from suicide (relative risk= 1.25; 95% CI, 1.09–1.43) compared to controls.”
From Association between Childhood Onset Inflammatory Bowel Disease and Psychiatric Comorbidities in Adulthood (2023) · cites this paper as [106]
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Sălcudean, A., Nan, A. G., Bodo, C. R., Cosma, M. C., Strete, E. G., & Lica, M. M. (2023) · Diagnostics · doi:10.3390/diagnostics13111868 · Cited by 24 · see citing works
- Authors
- Xiong, Q., Tang, F., Li, Y., Xie, F., Yuan, L., Yao, C., Wu, R., Wang, J., Wang, Q., & Feng, P.
- Affiliations
- Chengdu University of Traditional Chinese Medicine (CN)
- North Sichuan Medical University (CN)
- Corresponding author
- Feng, Peimin
- ORCID
- Venue
- Journal of Psychosomatic Research
- Publisher
- Elsevier BV
- Published
- 2022-09
- Volume
- 160
- Pages
- 110983
- ISSN
- 0022-3999 (ISSN-L)
- OpenAlex
- W4283758769
- Cited by
- 33
- References
- 65
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 7 · 2023: 10 · 2022: 1
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Psychosomatic Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Key Research and Development Program of China (2018YFC1705403)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- inflammatory bowel disease, suicidal ideation, suicide attempts, suicide, psychiatric comorbidity, Crohn's disease, female sex, disease duration, mental health
- MeSH terms
- Child, Crohn Disease, Female, Humans, Suicide, Attempted, Prevalence, Databases, Factual, Young Adult, Suicidal Ideation
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