The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Experimental microdissection enables functional harmonisation of pancreatic cancer subtypes
Open accessAbstract
Objective: Pancreatic ductal adenocarcinoma (PDA) has among the highest stromal fractions of any cancer and this has complicated attempts at expression-based molecular classification. The goal of this work is to profile purified samples of human PDA epithelium and stroma and examine their respective contributions to gene expression in bulk PDA samples. Design: We used laser capture microdissection (LCM) and RNA sequencing to profile the expression of 60 matched pairs of human PDA malignant epithelium and stroma samples. We then used these data to train a computational model that allowed us to infer tissue composition and generate virtual compartment-specific expression profiles from bulk gene expression cohorts. Results: Our analysis found significant variation in the tissue composition of pancreatic tumours from different public cohorts. Computational removal of stromal gene expression resulted in the reclassification of some tumours, reconciling functional differences between different cohorts. Furthermore, we established a novel classification signature from a total of 110 purified human PDA stroma samples, finding two groups that differ in the extracellular matrix-associated and immune-associated processes. Lastly, a systematic evaluation of cross-compartment subtypes spanning four patient cohorts indicated partial dependence between epithelial and stromal molecular subtypes. Conclusion: Our findings add clarity to the nature and number of molecular subtypes in PDA, expand our understanding of global transcriptional programmes in the stroma and harmonise the results of molecular subtyping efforts across independent cohorts.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Mauer et al., found isolated epithelial tissues supported the Moffitt “classical” or “basal-like” subtypes, while they found no evidence of the Bailey “ADEX” subtype or Collisson “exocrine-like” subtypes in epithelial enriched tumor samples132.”
From Pancreatic cancer: Advances and challenges (2023) · cites this paper as [132]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Siegel, R. L., Miller, K. D., & Jemal, A. (2017) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21387 · Cited by 14,712
Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969
Genomic analyses identify molecular subtypes of pancreatic cancer
Bailey, P., Chang, D. K., Nones, K., Johns, A. L., Patch, A.-M., Gingras, M.-C., Miller, D. K., Christ, A. N., Bruxner, T. J. C., Quinn, M. C., et al. (2016) · Nature · doi:10.1038/nature16965 · Cited by 3,621
Olive, K. P., Jacobetz, M. A., Davidson, C. J., Gopinathan, A., McIntyre, D., Honess, D., Madhu, B., Goldgraben, M. A., Caldwell, M. E., Allard, D., et al. (2009) · Science · doi:10.1126/science.1171362 · Cited by 3,170
Self-citationWhole genomes redefine the mutational landscape of pancreatic cancer
Initiative, A. P. C. G., Waddell, N., Pajic, M., Patch, A.-M., Chang, D. K., Kassahn, K. S., Bailey, P., Johns, A. L., Miller, D., Nones, K., et al. (2015) · Nature · doi:10.1038/nature14169 · Cited by 2,642
Provenzano, P. P., Cuevas, C., Chang, A. E., Goel, V. K., Von Hoff, D. D., & Hingorani, S. R. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.01.007 · Cited by 2,195
Moffitt, R. A., Marayati, R., Flate, E. L., Volmar, K. E., Loeza, S. G. H., Hoadley, K. A., Rashid, N. U., Williams, L. A., Eaton, S. C., Chung, A. H., et al. (2015) · Nature Genetics · doi:10.1038/ng.3398 · Cited by 2,194
Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
Rhim, A. D., Oberstein, P. E., Thomas, D. H., Mirek, E. T., Palermo, C. F., Sastra, S. A., Dekleva, E. N., Saunders, T., Becerra, C. P., Tattersall, I. W., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.021 · Cited by 2,085
Self-citationPancreatic cancer genomes reveal aberrations in axon guidance pathway genes
Initiative, A. P. C. G., Biankin, A. V., Waddell, N., Kassahn, K. S., Gingras, M.-C., Muthuswamy, L. B., Johns, A. L., Miller, D. K., Wilson, P. J., Patch, A.-M., et al. (2012) · Nature · doi:10.1038/nature11547 · Cited by 2,058
Integrated genomic characterization of pancreatic ductal adenocarcinoma
Raphael, B. J., Hruban, R. H., Aguirre, A. J., Moffitt, R. A., Yeh, J. J., Stewart, C., Robertson, A. G., Cherniack, A. D., Gupta, M., Getz, G., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.07.007 · Cited by 2,019
Self-citation
Cited by
Sorted by citations
Pancreatic cancer: Advances and challenges
Halbrook, C. J., Lyssiotis, C. A., Pasca di Magliano, M., & Maitra, A. (2023) · Cell · doi:10.1016/j.cell.2023.02.014 · Cited by 1,321
Diversity and biology of cancer-associated fibroblasts
Biffi, G., & Tuveson, D. A. (2021) · Physiological Reviews · doi:10.1152/physrev.00048.2019 · Cited by 1,265
Cross-tissue organization of the fibroblast lineage
Buechler, M. B., Pradhan, R., Krishnamurty, A. T., Cox, C. B., Calviello, A. K., Wang, A. W., Yang, Y. A., Tam, L., Caothien, R. H., Roose‐Girma, M., et al. (2021) · Nature · doi:10.1038/s41586-021-03549-5 · Cited by 1,100
Dominguez, C. X., Müller, S., Keerthivasan, S., Koeppen, H., Hung, J., Gierke, S., Breart, B., Foreman, O., Bainbridge, T. W., Castiglioni, A., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0644 · Cited by 857
Proteogenomic characterization of pancreatic ductal adenocarcinoma
Cao, L., Huang, C., Cui Zhou, D., Hu, Y., Lih, T. M., Savage, S. R., Krug, K., Clark, D. J., Schnaubelt, M., Chen, L., et al. (2021) · Cell · doi:10.1016/j.cell.2021.08.023 · Cited by 578
Accurate and efficient detection of gene fusions from RNA sequencing data
Uhrig, S., Ellermann, J., Walther, T., Burkhardt, P., Fröhlich, M., Hutter, B., Toprak, U. H., Neumann, O., Stenzinger, A., Scholl, C., et al. (2021) · Genome Research · doi:10.1101/gr.257246.119 · Cited by 526
LRRC15(+) myofibroblasts dictate the stromal setpoint to suppress tumour immunity
Krishnamurty, A. T., Shyer, J. A., Thai, M., Gandham, V., Buechler, M. B., Yang, Y. A., Pradhan, R. N., Wang, A. W., Sanchez, P. L., Qu, Y., et al. (2022) · Nature · doi:10.1038/s41586-022-05272-1 · Cited by 436
Spatially confined sub-tumor microenvironments in pancreatic cancer
Grünwald, B. T., Devisme, A., Andrieux, G., Vyas, F., Aliar, K., McCloskey, C. W., Macklin, A., Jang, G. H., Denroche, R., Romero, J. M., et al. (2021) · Cell · doi:10.1016/j.cell.2021.09.022 · Cited by 433
Wang, S., Zheng, Y., Yang, F., Zhu, L., Zhu, X.-Q., Wang, Z.-F., Wu, X.-L., Zhou, C.-H., Yan, J.-Y., Hu, B.-Y., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00659-4 · Cited by 369
Microenvironmental Determinants of Pancreatic Cancer
Heßmann, E., Buchholz, S., Demir, İ. E., Singh, S. K., Gress, T. M., Ellenrieder, V., & Neeße, A. (2020) · Physiological Reviews · doi:10.1152/physrev.00042.2019 · Cited by 336
Zhou, D. C., Jayasinghe, R. G., Chen, S., Herndon, J. M., Iglesia, M. D., Navale, P., Wendl, M. C., Caravan, W., Sato, K., Storrs, E. P., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01157-1 · Cited by 290
Rashid, N. U., Peng, X. L., Jin, C., Moffitt, R. A., Volmar, K. E., Belt, B. A., Panni, R. Z., Nywening, T. M., Herrera, S. G., Moore, K. J., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-1467 · Cited by 239
The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer
Michaelis, K. A., Norgard, M. A., Zhu, X., Levasseur, P. R., Sivagnanam, S., Liudahl, S. M., Burfeind, K. G., Olson, B. G., Pelz, K. R., Ramos, D. M. A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12657-w · Cited by 231
Self-citationTumour-selective activity of RAS-GTP inhibition in pancreatic cancer
Wasko, U. N., Jiang, J., Dalton, T. C., Curiel-Garcia, A., Edwards, A. C., Wang, Y., Lee, B., Orlen, M., Tian, S., Stalnecker, C. A., et al. (2024) · Nature · doi:10.1038/s41586-024-07379-z · Cited by 209
Self-citationZhu, Z., Achreja, A., Meurs, N., Animasahun, O., Owen, S., Mittal, A., Parikh, P., Lo, T.-W., Franco-Barraza, J., Shi, J., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0226-5 · Cited by 204
Kemp, S. B., Carpenter, E. S., Steele, N. G., Donahue, K. L., Nwosu, Z. C., Pacheco, A., Velez-Delgado, A., Menjivar, R. E., Lima, F., The, S., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-3929 · Cited by 197
Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer
Dreyer, S. B., Upstill‐Goddard, R., Paulus-Hock, V., Paris, C., Lampraki, E.-M., Dray, E. V., Serrels, B., Caligiuri, G., Rebus, S., Plenker, D., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.09.043 · Cited by 165
Sharbeen, G., McCarroll, J. A., Akerman, A., Kopecky, C., Youkhana, J., Kokkinos, J., Holst, J., Boyer, C. A., Erkan, M., Goldstein, D., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-2496 · Cited by 135
Miyabayashi, K., Baker, L. A., Deschênes, A., Traub, B., Caligiuri, G., Plenker, D., Alagesan, B., Belleau, P., Li, S., Kendall, J., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-0133 · Cited by 124
Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
Klomp, J. A., Klomp, J. E., Stalnecker, C. A., Bryant, K. L., Edwards, A. C., Drizyte‐Miller, K., Hibshman, P. S., Diehl, J. N., Lee, Y. S., Morales, A. J., et al. (2024) · Science · doi:10.1126/science.adk0775 · Cited by 139
Espinet, E., Gu, Z., Imbusch, C. D., Giese, N. A., Büscher, M., Safavi, M., Weisenburger, S., Klein, C., Vogel, V., Falcone, M., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1202 · Cited by 124
Cell of origin influences pancreatic cancer subtype
Flowers, B. M., Xu, H., Mulligan, A. S., Hanson, K. J., Seoane, J. A., Vogel, H., Curtis, C., Wood, L. D., & Attardi, L. D. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-0633 · Cited by 118
Tu, M., Klein, L., Espinet, E., Georgomanolis, T., Wegwitz, F., Li, X., Urbach, L., Danieli‐Mackay, A., Küffer, S., Bojarczuk, K., et al. (2021) · Nature Cancer · doi:10.1038/s43018-021-00258-w · Cited by 115
Poh, A. R., & Ernst, M. (2021) · Cancers · doi:10.3390/cancers13122860 · Cited by 106
Tian, J., Zhu, Y., Rao, M., Cai, Y., Lu, Z., Zou, D., Peng, X., Ying, P., Zhang, M., Niu, S., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-320179 · Cited by 97
Matrix stiffness drives stromal autophagy and promotes formation of a protumorigenic niche
Hupfer, A., Brichkina, A. I., Koeniger, A., Keber, C. U., Denkert, C., Pfefferle, P. I., Helmprobst, F., Pagenstecher, A., Visekruna, A., & Lauth, M. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2105367118 · Cited by 101
Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation
Somerville, T. D. D., Biffi, G., Daßler‐Plenker, J., Hur, S. K., He, X., Vance, K. E., Miyabayashi, K., Xu, Y., Maia-Silva, D., Klingbeil, O., et al. (2020) · eLife · doi:10.7554/elife.53381 · Cited by 87
Tuft Cells Inhibit Pancreatic Tumorigenesis in Mice by Producing Prostaglandin D2
DelGiorno, K. E., Chung, C., Vavinskaya, V., Maurer, H. C., Novak, S. W., Lytle, N. K., Ma, Z., Giraddi, R. R., Wang, D., Fang, L., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.07.037 · Cited by 82
Self-citationCheung, P. F., Yang, J., Fang, R., Borgers, A., Krengel, K., Stoffel, A., Althoff, K., Yip, C. W., Siu, E. H.-L., Ng, L. W. C., et al. (2022) · Nature Communications · doi:10.1038/s41467-021-27088-9 · Cited by 84
Coordinated single-cell tumor microenvironment dynamics reinforce pancreatic cancer subtype
Oh, K., Yoo, Y. J., Torre-Healy, L. A., Rao, M., Fassler, D., Wang, P., Caponegro, M. D., Gao, M., Kim, J., Sasson, A. R., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40895-6 · Cited by 85
Dijk, F., Veenstra, V. L., Soer, E. C., Dings, M. P. G., Zhao, L., Halfwerk, J. B. G., Hooijer, G. K. J., Damhofer, H., Marzano, M., Steins, A., et al. (2020) · Scientific Reports · doi:10.1038/s41598-019-56826-9 · Cited by 77
Martens, S., Lefesvre, P., Nicolle, R., Biankin, A. V., Puleo, F., Laethem, J. V., & Rooman, I. (2019) · Annals of Oncology · doi:10.1093/annonc/mdz181 · Cited by 78
Clinical Impact of Molecular Subtyping of Pancreatic Cancer
Zhou, X., Hu, K., Bailey, P. J., Springfeld, C., Roth, S., Kurilov, R., Brors, B., Gress, T. M., Buchholz, M., An, J., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.743908 · Cited by 84
Metastasis in Pancreatic Ductal Adenocarcinoma: Current Standing and Methodologies
Pereira, M. A., & Chio, I. I. C. (2019) · Genes · doi:10.3390/genes11010006 · Cited by 75
The m6A-Related mRNA Signature Predicts the Prognosis of Pancreatic Cancer Patients
Meng, Z., Yuan, Q., Zhao, J., Wang, B., Li, S., Offringa, R., Jin, X., & Wu, H. (2020) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2020.04.011 · Cited by 72
Boelaars, K., Rodríguez, E., Huinen, Z. R., Liu, C., Wang, D., Springer, B. O., Olesek, K., Kruijssen, L. J. W., van Ee, T., Lindijer, D., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-06087-8 · Cited by 75
Alternative polyadenylation drives oncogenic gene expression in pancreatic ductal adenocarcinomaPreprint
Venkat, S., Tisdale, A. A., Schwarz, J. R., Alahmari, A. A., Maurer, H. C., Olive, K. P., Eng, K. H., & Feigin, M. E. (2020) · Genome Research · doi:10.1101/gr.257550.119 · Cited by 72
Self-citationMechanisms of PDAC subtype heterogeneity and therapy response
Espinet, E., Klein, L., Puré, E., & Singh, S. K. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.08.005 · Cited by 70
Microdissected pancreatic cancer proteomes reveal tumor heterogeneity and therapeutic targets
Large, T. Y. S. L., Mantini, G., Meijer, L. L., Pham, T. V., Funel, N., van Grieken, N. C. T., Kok, B., Knol, J. C., van Laarhoven, H. W. M., Piersma, S. R., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.138290 · Cited by 62
Somerville, T. D. D., Xu, Y., Wu, X., Maia-Silva, D., Hur, S. K., de Almeida, L. M. N., Preall, J. B., Koo, P. K., & Vakoc, C. R. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1921484117 · Cited by 60
The vascular landscape of human cancer
Kahn, B., Lucas, A., Alur, R. G., Wengyn, M. D., Schwartz, G. W., Li, J., Sun, K., Maurer, H. C., Olive, K. P., Faryabi, R. B., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci136655 · Cited by 59
Self-citationHyeon, D. Y., Nam, D., Han, Y., Kim, D. K., Kim, G., Kim, D., Bae, J., Back, S., Mun, D., Madar, I. H., et al. (2022) · Nature Cancer · doi:10.1038/s43018-022-00479-7 · Cited by 57
Pre-clinical Models of Metastasis in Pancreatic Cancer
Miquel, M., Zhang, S., & Pilarsky, C. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.748631 · Cited by 53
Clinical functional proteomics of intercellular signalling in pancreatic cancer
Huang, P., Gao, W., Fu, C., Wang, M., Li, Y., Chu, B., He, A., Li, Y., Deng, X., Zhang, Y., et al. (2024) · Nature · doi:10.1038/s41586-024-08225-y · Cited by 52
Hosen, S. M. Z., Uddin, M. N., Xu, Z., Buckley, B. J., Perera, C. J., Pang, T., Mekapogu, A. R., Moni, M. A., Notta, F., Gallinger, S., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1060957 · Cited by 50
The Role of the Microbiome in Pancreatic Cancer
Miyabayashi, K., Ijichi, H., & Fujishiro, M. (2022) · Cancers · doi:10.3390/cancers14184479 · Cited by 48
Laser Capture Proteomics: spatial tissue molecular profiling from the bench to personalized medicine
Liotta, L. A., Pappalardo, P. A., Carpino, A., Haymond, A. N., Howard, M., Espina, V. A., Wulfkuhle, J., & Petricoin, E. F. (2021) · Expert Review of Proteomics · doi:10.1080/14789450.2021.1984886 · Cited by 45
Nicolle, R., Bachet, J., Harlé, A., Iovanna, J., Hammel, P. R., Rebours, V., Turpin, A., Abdelghani, M. B., Wei, A. C.-C., Mitry, E., et al. (2023) · Journal of Clinical Oncology · doi:10.1200/jco.22.02668 · Cited by 40
Molecular and Metabolic Subtypes Correspondence for Pancreatic Ductal Adenocarcinoma Classification
Espiau-Romera, P., Courtois, S., Parejo-Alonso, B., & Sancho, P. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9124128 · Cited by 43
Genomic Heterogeneity of Pancreatic Ductal Adenocarcinoma and Its Clinical Impact
Gutiérrez, M. L., Muñoz‐Bellvís, L., & Órfão, A. (2021) · Cancers · doi:10.3390/cancers13174451 · Cited by 41
Murphy, K. J., Chambers, C. R., Herrmann, D., Timpson, P., & Pereira, B. (2021) · Cancers · doi:10.3390/cancers13143481 · Cited by 37
Secretome of Stromal Cancer-Associated Fibroblasts (CAFs): Relevance in Cancer
Mishra, D., & Banerjee, D. (2023) · Cells · doi:10.3390/cells12040628 · Cited by 38
Combinatorial Gli activity directs immune infiltration and tumor growth in pancreatic cancer
Scales, M. K., Velez-Delgado, A., Steele, N. G., Schrader, H. E., Stabnick, A. M., Yan, W., Mercado-Soto, N. M., Nwosu, Z., Johnson, C. N., Zhang, Y.-Q., et al. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1010315 · Cited by 28
Self-citationSwietlik, J. J., Bärthel, S., Falcomatà, C., Fink, D., Sinha, A., Cheng, J., Ebner, S., Landgraf, P., Dieterich, D. C., Daub, H., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38171-8 · Cited by 38
Dissecting FGF Signalling to Target Cellular Crosstalk in Pancreatic Cancer
Carter, E. P., Coetzee, A. S., Bort, E. T., Wang, Q., Kocher, H. M., & Grose, R. P. (2021) · Cells · doi:10.3390/cells10040847 · Cited by 34
A mucus production programme promotes classical pancreatic ductal adenocarcinoma
Tonelli, C., Yordanov, G. N., Hao, Y., Deschênes, A., Hinds, J., Belleau, P., Klingbeil, O., Brosnan, E., Doshi, A., Park, Y., et al. (2024) · Gut · doi:10.1136/gutjnl-2023-329839 · Cited by 34
Samain, R., Brunel, A., Douché, T., Fanjul, M., Cassant‐Sourdy, S., Rochotte, J., Cros, J. F., Neuzillet, C., Raffenne, J., Duluc, C., et al. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.01.008 · Cited by 32
de Oliveira, G., Freire, P. P., Cury, S. S., de Moraes, D., Oliveira, J. S., Dal‐Pai‐Silva, M., Reis, P. P., & Carvalho, R. F. (2020) · Cancers · doi:10.3390/cancers12030716 · Cited by 34
Cellular metabolism in pancreatic cancer as a tool for prognosis and treatment (Review)
Zuzčák, M., & Trnka, J. (2022) · International Journal of Oncology · doi:10.3892/ijo.2022.5383 · Cited by 33
Gene Targeting in Disease Networks
Weighill, D. A., Guebila, M. B., Glass, K., Platig, J., Yeh, J. J., & Quackenbush, J. F. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.649942 · Cited by 30
Suurmeijer, J. A., Soer, E. C., Dings, M. P. G., Kim, Y., Strijker, M., Bonsing, B. A., Brosens, L. A. A., Busch, O. R., Groen, J. V., Halfwerk, J. B. G., et al. (2022) · British journal of surgery · doi:10.1093/bjs/znac272 · Cited by 30
Morphological Heterogeneity in Pancreatic Cancer Reflects Structural and Functional Divergence
Sántha, P., Lenggenhager, D. M., Finstadsveen, A. V., Dorg, L. T., Tøndel, K., Amrutkar, M., Gladhaug, I. P., & Verbeke, C. S. (2021) · Cancers · doi:10.3390/cancers13040895 · Cited by 33
Ramu, I., Buchholz, S. M., Patzak, M. S., Goetze, R. G., Singh, S. K., Richards, F. M., Jodrell, D. I., Sipos, B., Ströbel, P., Ellenrieder, V., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.09.024 · Cited by 29
GPCRs in pancreatic adenocarcinoma: Contributors to tumour biology and novel therapeutic targets
Sriram, K., Salmerón, C., Wiley, S. Z., & Insel, P. A. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15028 · Cited by 29
Miyabayashi, K., Nakagawa, H., & Koike, K. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.682872 · Cited by 28
Pancreatic Organoids for Regenerative Medicine and Cancer Research
Casamitjana, J., Espinet, E., & Rovira, M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.886153 · Cited by 29
ROR2 Regulates Cellular Plasticity in Pancreatic Neoplasia and Adenocarcinoma
Benitz, S., Steep, A., Nasser, M. M., Preall, J. B., Mahajan, U. M., McQuithey, H., Loveless, I. M., Davis, E. T., Wen, H.-J., Long, D. W., et al. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-0137 · Cited by 29
Birnbaum, D. J., Begg, S. K. S., Finetti, P., Vanderburg, C. R., Kulkarni, A. S., Neyaz, A., Hank, T. P., Tai, E. C., Deshpande, V., Bertucci, F., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-1039 · Cited by 27
A Tumor Microenvironment Model of Pancreatic Cancer to Elucidate Responses toward Immunotherapy
Kast, V., Nadernezhad, A., Pette, D., Gabrielyan, A., Fusenig, M., Honselmann, K. C., Stange, D. E., Werner, C., & Loessner, D. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202201907 · Cited by 27
Torre-Healy, L. A., Kawalerski, R. R., Oh, K., Chrastecka, L., Peng, X. L., Aguirre, A. J., Rashid, N. U., Yeh, J. J., & Moffitt, R. A. (2023) · Communications Biology · doi:10.1038/s42003-023-04461-6 · Cited by 28
Pervasiveness of HLA allele-specific expression loss across tumor types
Filip, I., Wang, A., Kravets, O., Orenbuch, R., Zhao, J., Perea-Chamblee, T. E., Manji, G. A., de Maturana, E. L., Malats, N., Olive, K. P., et al. (2023) · Genome Medicine · doi:10.1186/s13073-023-01154-x · Cited by 24
Self-citationJiang, Z., Zheng, X., Li, M., & Liu, M. (2023) · Frontiers of Medicine · doi:10.1007/s11684-023-1050-6 · Cited by 24
The Gut Microbiome and Pancreatic Cancer Development and Treatment
Attebury, H., & Daley, D. (2023) · The Cancer Journal · doi:10.1097/ppo.0000000000000647 · Cited by 24
Drivers of Gene Expression Dysregulation in Pancreatic Cancer
Venkat, S., Alahmari, A. A., & Feigin, M. E. (2021) · Trends in cancer · doi:10.1016/j.trecan.2021.01.008 · Cited by 23
MicroRNA-sensitive oncolytic measles virus for chemovirotherapy of pancreatic cancer
Singh, H. M., Leber, M. F., Bossow, S., Engeland, C. E., Dessila, J., Grossardt, C., Zaoui, K., Bell, J. C., Jäger, D., Kalle, C. V., et al. (2021) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2021.04.015 · Cited by 23
Targeting the Stroma in the Management of Pancreatic Cancer
Edwards, P., Kang, B. W., & Chau, I. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.691185 · Cited by 22
Laise, P., Turunen, M. M., Garcia, A. C., Tomassoni, L., Maurer, H. C., Elyada, E., Schmierer, B., Worley, J., Kesner, J. S., Tan, X., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.27.357269 · Cited by 21
Self-citationFAK promotes stromal PD-L2 expression associated with poor survival in pancreatic cancer
Davidson, C., Taggart, D., Sims, A. H., Lonergan, D. W., Canel, M., & Serrels, A. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01966-5 · Cited by 20
Tamagawa, H., Fujii, M., Togasaki, K., Seino, T., Kawasaki, S., Takano, A., Toshimitsu, K., Takahashi, S., Ohta, Y., Matano, M., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01498-5 · Cited by 22
Cannon, A. C., Thompson, C. M., Maurer, H. C., Atri, P., Bhatia, R., West, S. C., Ghersi, D., Olive, K. P., Sushil Kumar, K., & Batra, S. K. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-1359 · Cited by 19
Self-citationSchreyer, D., Neoptolemos, J. P., Barry, S. T., & Bailey, P. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.795735 · Cited by 19
Serum levels of iCAF ‐derived osteoglycin predict favorable outcome in pancreatic cancer
Dings, M. P. G., Manoukian, P., Waasdorp, C., Quik, J. S. E., Strijker, M., Lodestijn, S. C., van Neerven, S. M., Moreno, L. F., de Oliveira, R. L., Bonsing, B. A., et al. (2022) · International Journal of Cancer · doi:10.1002/ijc.34276 · Cited by 19
Laser Capture Microdissection: A Gear for Pancreatic Cancer Research
Rao, B. H., Souček, P., & Hlaváč, V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314566 · Cited by 19
Transcriptomic subtyping of gastrointestinal malignancies
de Back, T. R., van Hooff, S. R., Sommeijer, D. W., & Vermeulen, L. (2024) · Trends in cancer · doi:10.1016/j.trecan.2024.06.007 · Cited by 19
Krebs, N., Klein, L., Wegwitz, F., Espinet, E., Maurer, H. C., Tu, M., Penz, F., Küffer, S., Xu, X., Bohnenberger, H., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.154475 · Cited by 16
A tangled tale of molecular subtypes in pancreatic cancer
Singh, S. K., Hasselluhn, M. C., & Neeße, A. (2019) · Gut · doi:10.1136/gutjnl-2018-318086 · Cited by 16
Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion
Bort, E. T., Joseph, M. D., Wang, Q., Carter, E. P., Roth, N. J., Gibson, J., Samadi, A., Kocher, H. M., Simoncelli, S., McCormick, P. J., et al. (2023) · eLife · doi:10.7554/elife.86971 · Cited by 15
Alfarano, G., Audano, M., Chiaro, P. D., Balestrieri, C., Milan, M., Polletti, S., Spaggiari, P., Zerbi, A., Diaferia, G. R., Mitro, N., et al. (2022) · Gut · doi:10.1136/gutjnl-2021-325811 · Cited by 17
Lowe, M. E., Andersen, D. K., Caprioli, R. M., Choudhary, J., Cruz-Monserrate, Z., Dasyam, A. K., Forsmark, C. E., Gorelick, F. S., Gray, J. W., Haupt, M., et al. (2019) · Pancreas · doi:10.1097/mpa.0000000000001412 · Cited by 15
Self-citationGlapiński, F., Zając, W., Fudalej, M. M., Deptała, A., Czerw, A. I., Sygit, K., Kozłowski, R., & Badowska-Kozakiewicz, A. M. (2025) · Cancers · doi:10.3390/cancers17101599 · Cited by 15
Dong, M., Tang, R., Wang, W., Xu, J., Liu, J., Liang, C., Hua, J., Meng, Q., Yu, X., Zhang, B., et al. (2023) · Translational Oncology · doi:10.1016/j.tranon.2023.101692 · Cited by 13
Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function
Carter, E. P., Yoneten, K. K., Gavara, N., Tyler, E. J., Gauthier, V., Murray, E. R., ten Dijke, P., Cameron, A. J. M., Pearce, O. M. T., & Grose, R. P. (2023) · The Journal of Pathology · doi:10.1002/path.6214 · Cited by 15
Naso, J. R., Topham, J. T., Karasinska, J. M., Lee, M. K. C., Kalloger, S. E., Wong, H., Nelson, J., Moore, R. A., Mungall, A. J. J., Jones, S. J. M., et al. (2020) · Cancer Medicine · doi:10.1002/cam4.3695 · Cited by 13
Melzer, M. K., Breunig, M., Arnold, F., Wezel, F., Azoitei, A., Roger, É., Krüger, J., Merkle, J., Schütte, L. D., Resheq, Y. J., et al. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202102345 · Cited by 15
Hajkarim, M. C., May, M. S., Amin, A. D., Jamison, J. K. R., Tagore, S., D’Souza, E. K., Caprio, L., Walsh, Z. H., Fan, J. L., Zhang, M., et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02345-5 · Cited by 13
Self-citationPathology and Molecular Characteristics of Pancreatic Cancer
Kearney, J. F., Adsay, V. N., & Yeh, J. J. (2021) · Surgical Oncology Clinics of North America · doi:10.1016/j.soc.2021.06.003 · Cited by 15
Heterogeneity in Pancreatic Cancer Fibroblasts—TGFβ as a Master Regulator?
Watt, D. M., & Morton, J. P. (2021) · Cancers · doi:10.3390/cancers13194984 · Cited by 12
Ohara, Y., Liu, H., Moreno, P., Suzuki, S., & Hussain, S. P. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108946 · Cited by 11
Monkman, J. H., Thompson, E. W., & Nagaraj, S. H. (2019) · Cancers · doi:10.3390/cancers11111745 · Cited by 12
Eicosanoids in the Pancreatic Tumor Microenvironment—A Multicellular, Multifaceted Progression
Gubbala, V. B., Jytosana, N., Trinh, V. Q., Maurer, H. C., Naeem, R. F., Lytle, N. K., Ma, Z., Zhao, S., Lin, W., Han, H., et al. (2022) · Gastro Hep Advances · doi:10.1016/j.gastha.2022.02.007 · Cited by 11
Self-citation
Metadata
- Authors
- Maurer, C., Holmstrom, S. R., He, J., Laise, P., Su, T., Ahmed, A., Hibshoosh, H., Chabot, J. A., Oberstein, P. E., Sepulveda, A. R., Genkinger, J. M., Zhang, J., Iuga, A. C., Bansal, M., Califano, A., & Olive, K. P.
- Affiliations
- Columbia University Irving Medical Center (US)
- NYU Langone Health (US)
- University of California San Diego (US)
- Psychogenics (United States) (US)
- Corresponding author
- Califano, Andrea
- ORCID
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2019-01-18
- Volume
- 68
- Issue
- 6
- Pages
- 1034-1043
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC6509007
- OpenAlex
- W2910033560
- Cited by
- 216
- References
- 27
- Citations by year
- 2026: 15 · 2025: 27 · 2024: 30 · 2023: 22 · 2022: 36 · 2021: 43 · 2020: 27 · 2019: 16
- FWCI
- 12.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Gut (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Keywords
- pancreatic ductal adenocarcinoma, tumor stroma, molecular subtypes, stromal gene expression, extracellular matrix, antitumor immunity
- MeSH terms
- Adenocarcinoma, Computer Simulation, Extracellular Matrix, Humans, Pancreatic Neoplasms, Sensitivity and Specificity, Gene Expression Regulation, Neoplastic, Case-Control Studies, Gene Expression Profiling, Carcinoma, Pancreatic Ductal, Microdissection
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review