Cell of origin influences pancreatic cancer subtype
Open accessPublished version of a preprint
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with a 5-year survival rate of approximately 9%. An improved understanding of PDAC initiation and progression is paramount for discovering strategies to better detect and combat this disease. Although transcriptomic analyses have uncovered distinct molecular subtypes of human PDAC, the factors that influence subtype development remain unclear. Here, we interrogate the impact of cell of origin and different Trp53 alleles on tumor evolution, using a panel of tractable genetically engineered mouse models. Oncogenic KRAS expression, coupled with Trp53 deletion or point mutation, drives PDAC from both acinar and ductal cells. Gene-expression analysis reveals further that ductal cell–derived and acinar cell–derived tumor signatures are enriched in basal-like and classical subtypes of human PDAC, respectively. These findings highlight cell of origin as one factor that influences PDAC molecular subtypes and provide insight into the fundamental impact that the very earliest events in carcinogenesis can have on cancer evolution. Significance: Although human PDAC has been classified into different molecular subtypes, the etiology of these distinct subtypes remains unclear. Using mouse genetics, we reveal that cell of origin is an important determinant of PDAC molecular subtype. Deciphering the biology underlying pancreatic cancer subtypes may reveal meaningful distinctions that could improve clinical intervention. This article is highlighted in the In This Issue feature, p. 521
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Deletion of Trp53 in the adult ductal lineage leads to rapid development of invasive carcinoma in mice.
“the deletion of Trp53 leads to the rapid development of invasive carcinoma125–127.”
From Pancreatic cancer: Advances and challenges (2023) · cites this paper as [127]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Siegel, R. L., Miller, K. D., & Jemal, A. (2020) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21590 · Cited by 20,444 · see citing works
GSVA: gene set variation analysis for microarray and RNA-Seq data
Hänzelmann, S., Castelo, R., & Guinney, J. (2013) · BMC Bioinformatics · doi:10.1186/1471-2105-14-7 · Cited by 15,440 · see citing works
Rahib, L., Smith, B. D., Aizenberg, R., Rosenzweig, A. B., Fleshman, J. M., & Matrisian, L. M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0155 · Cited by 7,094 · see citing works
Genomic analyses identify molecular subtypes of pancreatic cancer
Bailey, P., Chang, D. K., Nones, K., Johns, A. L., Patch, A.-M., Gingras, M.-C., Miller, D. K., Christ, A. N., Bruxner, T. J. C., Quinn, M. C., et al. (2016) · Nature · doi:10.1038/nature16965 · Cited by 3,621 · cited 6× · see citing works
“We used publicly available gene expression and clinical data for the ICGC Australian (13), ICGC Canadian (PACA-CA, downloaded from the ICGC data portal – https://dcc.”
BackgroundMethodResultInfluentialSingle-cell transcriptomics of 20 mouse organs creates a Tabula Muris
The Tabula Muris Consortium, coordination, O., coordination, L., processing, O. C. A., sequencing, L. P. A., analysis, C. D., annotation, C. T., Writing group, Supplemental text writing group, & Principal investigators (2018) · Nature · doi:10.1038/s41586-018-0590-4 · Cited by 3,326 · see citing works
Hingorani, S. R., Wang, L., Multani, A. S., Combs, C., Deramaudt, T. B., Hruban, R. H., Rustgi, A. K., Chang, S., & Tuveson, D. A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.023 · Cited by 2,609 · see citing works
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Hingorani, S. R., Petricoin, E. F., Maitra, A., Rajapakse, V., King, C., Jacobetz, M. A., Ross, S., Conrads, T. P., Veenstra, T. D., Hitt, B. A., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00309-x · Cited by 2,471 · see citing works
Moffitt, R. A., Marayati, R., Flate, E. L., Volmar, K. E., Loeza, S. G. H., Hoadley, K. A., Rashid, N. U., Williams, L. A., Eaton, S. C., Chung, A. H., et al. (2015) · Nature Genetics · doi:10.1038/ng.3398 · Cited by 2,194 · see citing works
Integrated genomic characterization of pancreatic ductal adenocarcinoma
Raphael, B. J., Hruban, R. H., Aguirre, A. J., Moffitt, R. A., Yeh, J. J., Stewart, C., Robertson, A. G., Cherniack, A. D., Gupta, M., Getz, G., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.07.007 · Cited by 2,019 · see citing works
Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy
Collisson, E. A., Sadanandam, A., Olson, P., Gibb, W. J., Truitt, M., Gu, S., Cooc, J., Weinkle, J., Kim, G. E., Jakkula, L., et al. (2011) · Nature Medicine · doi:10.1038/nm.2344 · Cited by 1,967 · see citing works
A comparison of single-cell trajectory inference methods
Saelens, W., Cannoodt, R., Todorov, H., & Saeys, Y. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0071-9 · Cited by 1,670 · see citing works
Visvader, J. (2011) · Nature · doi:10.1038/nature09781 · Cited by 1,509 · see citing works
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome
Olive, K. P., Tuveson, D. A., Ruhe, Z. C., Yin, B., Willis, N. A., Bronson, R. T., Crowley, D., & Jacks, T. (2004) · Cell · doi:10.1016/j.cell.2004.11.004 · Cited by 1,308 · see citing works
A Single-Cell Transcriptome Atlas of the Human Pancreas
Muraro, M. J., Dharmadhikari, G., Grün, D., Gröen, N., Dielen, T., Jansen, E., van Gurp, L., Engelse, M. A., Carlotti, F., de Koning, E. J. P., et al. (2016) · Cell Systems · doi:10.1016/j.cels.2016.09.002 · Cited by 1,288 · see citing works
Guerra, C., Schuhmacher, A. J., Cañamero, M., Grippo, P. J., Verdaguer, L., Pérez-Gallego, L., Dubus, P., Sandgren, E. P., & Barbacid, M. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.01.012 · Cited by 1,224 · see citing works
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome
Lang, G. A., Iwakuma, T., Suh, Y.-A., Liu, G., Rao, V. A., Parant, J. M., Valentin-Vega, Y. A., Terzian, T., Caldwell, L. C., Strong, L. C., et al. (2004) · Cell · doi:10.1016/j.cell.2004.11.006 · Cited by 1,069 · see citing works
Aguirre, A. J., Bardeesy, N., Sinha, M., Lopez, L., Tuveson, D. A., Horner, J., Redston, M. S., & DePinho, R. A. (2003) · Genes & Development · doi:10.1101/gad.1158703 · Cited by 1,033 · see citing works
Molecular subtypes of pancreatic cancer
Collisson, E. A., Bailey, P., Chang, D. K., & Biankin, A. V. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0109-y · Cited by 892 · see citing works
KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer
Waters, A. M., & Der, C. J. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031435 · Cited by 875 · see citing works
Progression model for pancreatic cancer.
Hruban, R. H., Goggins, M., Parsons, J., & Kern, S. E. (2000) · PubMed · Cited by 872 · see citing works
Bouaoun, L., Sonkin, D., Ardin, M., Hollstein, M., Byrnes, G., Zavadil, J., & Olivier, M. (2016) · Human Mutation · doi:10.1002/humu.23035 · Cited by 730 · see citing works
Kopp, J. L., von Figura, G., Mayes, E., Liu, F.-F., Dubois, C. L., Morris, J. P., Pan, F. C., Akiyama, H., Wright, C. V. E., Jensen, K., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.10.025 · Cited by 697 · see citing works
Bardeesy, N., Cheng, K.-H., Berger, J. H., Chu, G. C., Pahler, J., Olson, P., Hezel, A. F., Horner, J., Lauwers, G. Y., Hanahan, D., et al. (2006) · Genes & Development · doi:10.1101/gad.1478706 · Cited by 674 · see citing works
Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution
Chan-Seng-Yue, M., Kim, J. C., Wilson, G. W., Ng, K., Figueroa, E. F., O’Kane, G. M., Connor, A. A., Denroche, R. E., Grant, R. C., McLeod, J., et al. (2020) · Nature Genetics · doi:10.1038/s41588-019-0566-9 · Cited by 669 · see citing works
Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer
Morton, J. P., Timpson, P., Karim, S. A., Ridgway, R. A., Athineos, D., Doyle, B., Jamieson, N. B., Oien, K. A., Lowy, A. M., Brunton, V. G., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908428107 · Cited by 657 · see citing works
Bardeesy, N. M., Aguirre, A. J., Chu, G. C., Cheng, K., Lopez, L. V., Hezel, A. F., Feng, B., Brennan, C. W., Weissleder, R., Mahmood, U., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601273103 · Cited by 575 · see citing works
SOX9 is required for maintenance of the pancreatic progenitor cell pool
Seymour, P. A., Freude, K., Tran, M. N., Mayes, E., Jensen, J. N., Kist, R., Scherer, G., & Sander, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609217104 · Cited by 567 · see citing works
Stratification of pancreatic ductal adenocarcinomas based on tumor and microenvironment features
Puleo, F., Nicolle, R., Blum, Y., Cros, J., Marisa, L., Demetter, P., Quertinmont, E., Svrcek, M., Elarouci, N., Iovanna, J., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.08.033 · Cited by 563 · see citing works
Genetics and biology of pancreatic ductal adenocarcinoma
Ying, H., Dey, P., Yao, W., Kimmelman, A. C., Draetta, G. F., Maitra, A., & DePinho, R. A. (2016) · Genes & Development · doi:10.1101/gad.275776.115 · Cited by 527 · see citing works
Guerra, C., Collado, M., Navas, C., Schuhmacher, A. J., Hernández-Porras, I., Cañamero, M., Rodriguez-Justo, M., Serrano, M., & Barbacid, M. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.05.011 · Cited by 516 · see citing works
Structure–function–rescue: the diverse nature of common p53 cancer mutants
Joerger, A. C., & Fersht, A. R. (2007) · Oncogene · doi:10.1038/sj.onc.1210291 · Cited by 430 · see citing works
Habbe, N., Shi, G., Meguid, R. A., Fendrich, V., Esni, F., Chen, H., Feldmann, G., Stoffers, D. A., Konieczny, S. F., Leach, S. D., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810097105 · Cited by 410 · see citing works
Izeradjene, K., Combs, C., Best, M., Gopinathan, A., Wagner, A., Grady, W. M., Deng, C.-X., Hruban, R. H., Adsay, N. V., Tuveson, D. A., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.01.017 · Cited by 379 · see citing works
Morphological lesions associated with human primary invasive nonendocrine pancreas cancer.
Cubilla, A. L., & FITZGERALD, P. J. (1976) · PubMed · Cited by 352 · see citing works
Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic K-Ras
Friedlander, S., Chu, G. C., Snyder, E. L., Girnius, N., Dibelius, G., Crowley, D. G., Vasile, E., DePinho, R. A., & Jacks, T. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.09.027 · Cited by 338 · see citing works
Pancreatic cancer: why is it so hard to treat?
Oberstein, P. E., & Olive, K. P. (2013) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x13478680 · Cited by 334 · see citing works
Kim, M. P., & Lozano, G. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.185 · Cited by 313 · see citing works
Pten constrains centroacinar cell expansion and malignant transformation in the pancreas
Stanger, B. Z., Stiles, B. L., Lauwers, G. Y., Bardeesy, N. M., Mendoza, M. J., Wang, Y., Greenwood, A. L., Cheng, K., McLaughlin, M. M., Brown, D., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.07.015 · Cited by 294 · see citing works
Tracing the cellular origin of cancer
Blanpain, C. (2013) · Nature Cell Biology · doi:10.1038/ncb2657 · Cited by 275 · see citing works
Experimental microdissection enables functional harmonisation of pancreatic cancer subtypes
Maurer, C., Holmstrom, S. R., He, J., Laise, P., Su, T., Ahmed, A., Hibshoosh, H., Chabot, J. A., Oberstein, P. E., Sepulveda, A. R., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-317706 · Cited by 216 · see citing works
Hayashi, A., Fan, J., Chen, R., Ho, Y.-J., Makohon-Moore, A. P., Lecomte, N., Zhong, Y., Hong, J., Huang, J., Sakamoto, H., et al. (2020) · Nature Cancer · doi:10.1038/s43018-019-0010-1 · Cited by 204 · see citing works
Self-citationRas Activity Levels Control the Development of Pancreatic Diseases
Ji, B., Tsou, L., Wang, H., Gaiser, S., Chang, D. Z., Daniluk, J., Bi, Y., Grote, T., Longnecker, D. S., & Logsdon, C. D. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.05.052 · Cited by 194 · see citing works
A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer
Mello, S. S., Valente, L. J., Raj, N., Seoane, J. A., Flowers, B. M., McClendon, J., Bieging-Rolett, K. T., Lee, J., Ivanochko, D., Kozak, M. M., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.09.007 · Cited by 179 · see citing works
Self-citationp53 mutations cooperate with oncogenic Kras to promote adenocarcinoma from pancreatic ductal cells
Bailey, J. M., Hendley, A. M., Lafaro, K. J., Pruski, M. A., Jones, N. C., Alsina, J., Younes, M., Maitra, A., McAllister, F., Iacobuzio-Donahue, C. A., et al. (2016) · Oncogene · doi:10.1038/onc.2015.441 · Cited by 154 · see citing works
Cell of origin affects tumour development and phenotype in pancreatic ductal adenocarcinoma
Lee, A. Y. L., Dubois, C. L., Sarai, K., Zarei, S., Schaeffer, D. F., Sander, M., & Kopp, J. L. (2019) · Gut · doi:10.1136/gutjnl-2017-314426 · Cited by 139 · see citing works
Ferreira, R. M. M., Sancho, R., Messal, H. A., Nye, E. L., Spencer‐Dene, B., Stone, R. K., Stamp, G., Rosewell, I. R., Quaglia, A., & Behrens, A. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.093 · Cited by 130 · see citing works
HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer
Brunton, H., Caligiuri, G., Cunningham, R., Upstill‐Goddard, R., Bailey, U., Garner, I., Nourse, C., Dreyer, S. B., Jones, M. D., Moran‐Jones, K., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107625 · Cited by 124 · see citing works
Single-Cell Analysis Uncovers Clonal Acinar Cell Heterogeneity in the Adult Pancreas
Wollny, D., Zhao, S., Everlien, I., Lun, X., Brunken, J., Brüne, D., Ziebell, F., Tabansky, I., Weichert, W., Marciniak-Czochra, A. K., et al. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.10.002 · Cited by 114 · see citing works
Dynamic development of the pancreas from birth to adulthood
Bonner‐Weir, S., Aguayo‐Mazzucato, C., & Weir, G. C. (2016) · Upsala Journal of Medical Sciences · doi:10.3109/03009734.2016.1154906 · Cited by 78 · see citing works
Not all p53 gain-of-function mutants are created equal
Mello, S. S., & Attardi, L. D. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.53 · Cited by 69 · see citing works
Self-citationLee, J., Snyder, E. R., Liu, Y., Gu, X., Wang, J., Flowers, B. M., Kim, Y. J., Park, S., Szot, G. L., Hruban, R. H., et al. (2017) · Nature Communications · doi:10.1038/ncomms14686 · Cited by 62 · see citing works
Self-citationThe p53R172H Mutant Does Not Enhance Hepatocellular Carcinoma Development and Progression
Ahronian, L. G., Driscoll, D. R., Klimstra, D. S., & Lewis, B. C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123816 · Cited by 9 · see citing works
Flagged first, then by citations
Research works printed but not linked: 5
- [16]Collisson EA, Sadanandam A, Olson P, Gibb WJ, Truitt M, Gu SD, Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy. Nat Med 2011; 17(4): 500– U140 doi 10.1038/nm.2344. 21460848 PMC3755490 · DOI · Paper page
- [17]Moffitt RA, Marayati R, Flate EL, Volmar KE, Loeza SGH, Hoadley KA, Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma. Nature Genet 2015; 47(10): 1168- + doi 10.1038/ng.3398. 26343385 PMC4912058 · DOI · Paper page
- [18]Bailey P, Chang DK, Nones K, Johns AL, Patch AM, Gingras MC, Genomic analyses identify molecular subtypes of pancreatic cancer. Nature 2016; 531(7592): 47- + doi 10.1038/nature16965. 26909576 · DOI · Paper page
- [20]Aguirre AJ, Hruban RH, Raphael BJ, Canc Genome Atlas Res N. Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma. Cancer Cell 2017; 32(2): 185– 203 doi 10.1016/j.ccell.2017.07.007. 28810144 PMC5964983 · DOI · Paper page
- [40]Gidekel Friedlander SYG, Chu GC, Snyder EL, Girnius N, Dibelius G, Crowley D, Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic K-Ras. Cancer Cell 2009; 16(5): 379– 89 doi 10.1016/j.ccr.2009.09.027. 19878870 PMC3048064 · DOI
Cited by
Sorted by citations
Pancreatic cancer: Advances and challenges
Halbrook, C. J., Lyssiotis, C. A., Pasca di Magliano, M., & Maitra, A. (2023) · Cell · doi:10.1016/j.cell.2023.02.014 · Cited by 1,321 · see citing works
Han, L., Wu, Y., Fang, K., Sweeney, S., Roesner, U. K., Parrish, M., Patel, K., Walter, T., Piermattei, J., Trimboli, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-022-34464-6 · Cited by 369 · see citing works
Epigenetic regulation during cancer transitions across 11 tumour types
Terekhanova, N. V., Karpova, A. Y., Liang, W.-W., Strzalkowski, A. J., Chen, S., Li, Y., Southard-Smith, A. N., Iglesia, M. D., Wendl, M. C., Jayasinghe, R. G., et al. (2023) · Nature · doi:10.1038/s41586-023-06682-5 · Cited by 205 · see citing works
Impact of risk factors on early cancer evolution
Weeden, C. E., Hill, W., Lim, E. L., Gronroos, E. C., & Swanton, C. (2023) · Cell · doi:10.1016/j.cell.2023.03.013 · Cited by 143 · see citing works
Pancreatic cancer tumor microenvironment is a major therapeutic barrier and target
Hartupee, C. D., Nagalo, B. M., Chabu, C. Y., Tesfay, M. Z., Coleman‐Barnett, J., West, J. T., & Moaven, O. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1287459 · Cited by 109 · see citing works
Koltai, T., Reshkin, S. J., Carvalho, T. M. A., Molfetta, D. D., Greco, M. R., Alfarouk, K. O., & Cardone, R. A. (2022) · Cancers · doi:10.3390/cancers14102486 · Cited by 107 · see citing works
Targeting Tumor-Stromal Interactions in Pancreatic Cancer: Impact of Collagens and Mechanical Traits
Maneshi, P., Mason, J. E., Dongre, M., & Öhlund, D. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.787485 · Cited by 65 · see citing works
A Balancing Act: p53 Activity from Tumor Suppression to Pathology and Therapeutic Implications
Wang, M., & Attardi, L. D. (2021) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-042320-025840 · Cited by 60 · see citing works
Self-citationKRAS mutation: The booster of pancreatic ductal adenocarcinoma transformation and progression
Zhang, Z., Zhang, H., Liao, X., & Tsai, H. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1147676 · Cited by 62 · see citing works
Intrapancreatic fat, pancreatitis, and pancreatic cancer
Lilly, A. C., Astsaturov, I. A., & Golemis, E. A. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04855-z · Cited by 59 · see citing works
Uncertain Beginnings: Acinar and Ductal Cell Plasticity in the Development of Pancreatic Cancer
Grimont, A., Leach, S. D., & Chandwani, R. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.07.014 · Cited by 58 · see citing works
Tissue mechanics in tumor heterogeneity and aggression
Finger, A., Hendley, A. M., Figueroa, D. A., Velozo, H. G., & Weaver, V. M. (2025) · Trends in cancer · doi:10.1016/j.trecan.2025.04.004 · Cited by 59 · see citing works
Faraoni, E. Y., Singh, K., Chandra, V., Roux, O. L., Dai, Y., Şahin, İ., O’Brien, B. J., Strickland, L. N., Li, L., Vucic, E., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-22-2553 · Cited by 57 · see citing works
Roles of microbiota in pancreatic cancer development and treatment
Cruz, M. S., Tintelnot, J., & Gagliani, N. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2320280 · Cited by 58 · see citing works
KRAS: the Achilles’ heel of pancreas cancer biology
Drizyte‐Miller, K., Talabi, T., Somasundaram, A., Cox, A. D., & Der, C. J. (2025) · Journal of Clinical Investigation · doi:10.1172/jci191939 · Cited by 63 · see citing works
Acinar cell clonal expansion in pancreas homeostasis and carcinogenesis
Neuhöfer, P., Roake, C. M., Kim, S. J., Lu, R. J., West, R. B., Charville, G. W., & Artandi, S. E. (2021) · Nature · doi:10.1038/s41586-021-03916-2 · Cited by 57 · see citing works
Multifaceted role for p53 in pancreatic cancer suppression
Mello, S. S., Flowers, B. M., Mazur, P. K., Lee, J. J., Müller, F., Denny, S. K., Ferreira, S., Hanson, K., Kim, S. K., Greenleaf, W. J., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2211937120 · Cited by 55 · see citing works
Self-citationYang, S., Tang, W., Azizian, A., Gaedcke, J., Ströbel, P., Wang, L., Cawley, H., Ohara, Y., Valenzuela, P., Zhang, L., et al. (2022) · Carcinogenesis · doi:10.1093/carcin/bgac092 · Cited by 51 · see citing works
Backx, E., Coolens, K., den Bossche, J.-L. V., Houbracken, I., Espinet, E., & Rooman, I. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.11.010 · Cited by 45 · see citing works
Pancreatic cancer: molecular pathogenesis and emerging therapeutic strategies
Rozengurt, E., & Eibl, G. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02499-y · Cited by 45 · see citing works
Breathing new insights into the role of mutant p53 in lung cancer
Chen, T., Ashwood, L. M., Kondrashova, O., Strasser, A., Kelly, G. L., & Sutherland, K. D. (2024) · Oncogene · doi:10.1038/s41388-024-03219-6 · Cited by 44 · see citing works
Cell Lineage Infidelity in PDAC Progression and Therapy Resistance
Malinova, A., Veghini, L., Real, F. X., & Corbo, V. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.795251 · Cited by 35 · see citing works
Pitter, K. L., Grbovic-Huezo, O., Joost, S., Singhal, A., Blum, M., Wu, K., Holm, M., Ferrena, A., Bhutkar, A. J., Hudson, A., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-1742 · Cited by 31 · see citing works
Martens, S., Coolens, K., Bulck, M. V., Arsenijevic, T., Casamitjana, J., Ruiz, A. F., Kaoutari, A. E., de Villarreal, J. M., Madhloum, H., Esni, F., et al. (2021) · Gut · doi:10.1136/gutjnl-2020-322874 · Cited by 32 · see citing works
Artificial Intelligence in Pancreatic Image Analysis: A Review
Liu, W., Zhang, B., Liu, T., Jiang, J., & Liu, Y. (2024) · Sensors · doi:10.3390/s24144749 · Cited by 35 · see citing works
Rozengurt, E., & Eibl, G. (2021) · Cancers · doi:10.3390/cancers13205126 · Cited by 30 · see citing works
Pedro, B. A., & Wood, L. D. (2025) · Journal of Clinical Investigation · doi:10.1172/jci191937 · Cited by 28 · see citing works
Self-citationPrecision Oncology: Current Landscape, Emerging Trends, Challenges, and Future Perspectives
Qiao, D., Wang, R. C., & Wang, Z. (2025) · Cells · doi:10.3390/cells14221804 · Cited by 38 · see citing works
Pancreatic Organoids for Regenerative Medicine and Cancer Research
Casamitjana, J., Espinet, E., & Rovira, M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.886153 · Cited by 28 · see citing works
ROR2 Regulates Cellular Plasticity in Pancreatic Neoplasia and Adenocarcinoma
Benitz, S., Steep, A., Nasser, M. M., Preall, J. B., Mahajan, U. M., McQuithey, H., Loveless, I. M., Davis, E. T., Wen, H.-J., Long, D. W., et al. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-0137 · Cited by 27 · see citing works
Evaluation of KRAS inhibitor-directed therapies for pancreatic cancer treatment
Long, S.-A., Amparo, A. M., Goodhart, G., Ahmad, S. A., & Waters, A. M. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1402128 · Cited by 26 · see citing works
Current status of molecular diagnostic approaches using liquid biopsy
Takahashi, K., Takeda, Y., Ono, Y., Isomoto, H., & Mizukami, Y. (2023) · Journal of Gastroenterology · doi:10.1007/s00535-023-02024-4 · Cited by 26 · see citing works
PDAC as an immune evasive disease: can 3D model systems aid to tackle this clinical problem?
Narayanan, S., Vicent, S., & Ponz-Sarvisé, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.787249 · Cited by 24 · see citing works
p53: from understanding its structure to advances in therapeutic targeting
Wang, W., Liu, X., Liu, H., Abolhassani, H., Yan, H., Zhang, H., & Wang, X. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02549-5 · Cited by 25 · see citing works
Xu, Y., Nipper, M. H., Dominguez, A. A., Ye, Z., Akanuma, N., Lopez, K. M., Deng, J., Arenas, D., Sánchez, A., Sharkey, F. E., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45097-2 · Cited by 22 · see citing works
The Integrated Stress Response in Pancreatic Development, Tissue Homeostasis, and Cancer
Malnassy, G., Ziolkowski, L. M., Macleod, K. F., & Oakes, S. A. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.05.009 · Cited by 21 · see citing works
Kamran, M. Z., Bhattacharya, U., Omar, M., Marchionni, L., & Ince, T. A. (2022) · npj Breast Cancer · doi:10.1038/s41523-022-00474-2 · Cited by 20 · see citing works
Zhang, X., Du, Y., Behrens, A., & Lan, L. (2025) · Developmental Cell · doi:10.1016/j.devcel.2025.07.002 · Cited by 19 · see citing works
Understanding the heterogeneity of pancreatic ductal adenocarcinoma
Iovanna, J., Fraunhoffer, N. A., Urrutia, R. A., & Dusetti, N. (2025) · Translational Oncology · doi:10.1016/j.tranon.2025.102479 · Cited by 18 · see citing works
The biology of pancreatic cancer morphology
McDonald, O. G. (2021) · Pathology · doi:10.1016/j.pathol.2021.09.012 · Cited by 18 · see citing works
Targeting p53 gain-of-function activity in cancer therapy: a cautionary tale
Attardi, L. D., & Boutelle, A. M. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01253-7 · Cited by 18 · see citing works
Self-citationΓκουντάκος, Α., Martelli, F. M., Silvestris, N., Bevere, M., Bellis, M. D., Alaimo, L., Sapuppo, E., Masetto, F., Mombello, A., Simbolo, M., et al. (2023) · Cancers · doi:10.3390/cancers15051454 · Cited by 16 · see citing works
Jiang, Y., Ye, Y., Huang, Y., Wu, Y., Wang, G., Gui, Z., Zhang, M., & Zhang, M. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-05285-x · Cited by 15 · see citing works
Hong, J., Choi, E., Kim, D., Seo, M.-K., Kang, H., Park, B., & Kim, S. (2024) · npj Precision Oncology · doi:10.1038/s41698-024-00501-4 · Cited by 15 · see citing works
Impact of CRISPR/Cas9-Mediated CD73 Knockout in Pancreatic Cancer
Zhang, J., Zhang, S., Dörflein, I., Ren, X., Pfeffer, S., Britzen‐Laurent, N., Grützmann, R., Duan, X., & Pilarsky, C. P. (2023) · Cancers · doi:10.3390/cancers15194842 · Cited by 14 · see citing works
Wang, J., Seo, J. W., Kare, A. J., Schneider, M. K., Pandrala, M., Tumbale, S. K., Raie, M. N., Engudar, G., Zhang, N., Guo, Y., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54761-6 · Cited by 14 · see citing works
Self-citationRoth, S., Apte, M. V., Balachandran, V. P., Biffi, G., Conroy, T., Cukierman, E., Dotan, E., Esposito, I., Grünwald, B. T., Klauß, M., et al. (2026) · Nature Reviews Disease Primers · doi:10.1038/s41572-026-00699-6 · Cited by 16 · see citing works
Iyer, M. K., Fletcher, A. A., Okoye, J. O., Shi, C., Chen, F., Kanu, E. N., Eckhoff, A. M., Bao, M., di Magliano, M. P., Frankel, T. L., et al. (2025) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-24-1529 · Cited by 12 · see citing works
Bhattacharya, U., Kamran, M. Z., Manai, M., Cristofanilli, M., & Ince, T. A. (2023) · Cancers · doi:10.3390/cancers15020332 · Cited by 12 · see citing works
Ohara, Y., Liu, H., Moreno, P., Suzuki, S., & Hussain, S. P. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108946 · Cited by 11 · see citing works
Notch signaling pathway in pancreatic tumorigenesis
Chung, W.-C., & Xu, K. (2023) · Advances in cancer research · doi:10.1016/bs.acr.2023.02.001 · Cited by 11 · see citing works
Lu, Z., Shi, M., Zheng, X., Liang, Y., Wang, J., Zou, Z., Luo, R., Feng, M., Yang, X., Zhou, Y., et al. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124946 · Cited by 11 · see citing works
He, B., Stoffel, L. A., He, C. J., Cho, K., Li, A. M., Jiang, H., Flowers, B. M., Nguyen, K. T., Wang, K., Zhao, A. Y., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06460-9 · Cited by 10 · see citing works
Self-citationMolecular Analysis of Prognosis and Immune Pathways of Pancreatic Cancer Based on TNF Family Members
Zhu, Z., Tang, C., Xu, T., & Zhao, Z. (2021) · Journal of Oncology · doi:10.1155/2021/2676996 · Cited by 10 · see citing works
Cellular Origins and Lineage Plasticity in CancerPreprint
Pitarresi, J. R., & Stanger, B. Z. (2023) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041389 · Cited by 10 · see citing works
Rios-Morris, E., Ngaffi, V. T., Costagliola, S., & Romitti, M. (2025) · European Thyroid Journal · doi:10.1530/etj-24-0392 · Cited by 9 · see citing works
A Prognostic Survival Model of Pancreatic Adenocarcinoma Based on Metabolism-Related Gene Expression
Xie, L., Huang, H.-Y., Fang, T., Liang, J., Hao, Y., Zhang, X., Xie, Y.-X., Wang, C., Tan, Y., & Zeng, L. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.804190 · Cited by 9 · see citing works
Salvador-Barberó, B., Alatsatianos, M., Morton, J. P., Sansom, O. J., & Hogan, C. (2025) · Gastroenterology · doi:10.1053/j.gastro.2025.02.042 · Cited by 8 · see citing works
Cell of Origin of Pancreatic cancer
Zheng, C., Wang, J., Wang, J., Zhang, Q., & Liang, T. (2024) · Pancreas · doi:10.1097/mpa.0000000000002301 · Cited by 8 · see citing works
Patil, S., Dou, Y., & Kopp, J. L. (2021) · Visceral Medicine · doi:10.1159/000520946 · Cited by 8 · see citing works
HMGA2 and protein leucine methylation drive pancreatic cancer lineage plasticity
Dobersch, S., Yamamoto, N., Schutter, A., Cavender, S. M., Robertson, T. M., Kartha, N., Samraj, A. N., Doron, B., Poole, L. A., Wladyka, C. L., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60129-1 · Cited by 8 · see citing works
Li, Y., Pan, L., Mugaanyi, J., Li, H., Li, G., Huang, J., & Dai, L. (2024) · Scientific Reports · doi:10.1038/s41598-024-79619-1 · Cited by 6 · see citing works
Histamine H1 Receptor: A potential therapeutic target for pancreatic ductal adenocarcinoma
Salmerón, C., Bort, E. T., Sriram, K., Paydar, M. J., Smitham, J. E., Pham, K., Grose, R. P., McCormick, P. J., Nardo, A. D., Weitz, J., et al. (2025) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2025.103573 · Cited by 6 · see citing works
mTORC2 promotes pancreatic cancer progression and parp inhibitor resistance
Bu, C., Zhao, L., Wang, L., Yu, Z., & Zhou, J. (2023) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.32604/or.2023.029309 · Cited by 6 · see citing works
Franco, A., Duryea, J., & McDonald, O. G. (2023) · Cancer and Metastasis Reviews · doi:10.1007/s10555-023-10116-z · Cited by 5 · see citing works
Xu, Y., Nipper, M. H., Dominguez, A. A., He, C., Sharkey, F. E., Khan, S., Xu, H., Zhou, D., Zheng, L., Luan, Y., et al. (2026) · Journal of Clinical Investigation · doi:10.1172/jci194395 · Cited by 5 · see citing works
Self-citationChauhan, R., Kondaveeti, S. B., Babu, N., Pathak, V. M., Kaur, D., Tuli, H. S., Ranjan, A., Joshi, N. C., Dufossé, L., & Chauhan, A. P. S. (2026) · Phytomedicine Plus · doi:10.1016/j.phyplu.2026.100974 · Cited by 6 · see citing works
Saeki, K., Wood, I. S., Wang, W., Patil, S., Sun, Y., Schaeffer, D. F., Su, G. H., & Kopp, J. L. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.101387 · Cited by 5 · see citing works
Pancreatic cancer: why the cell of origin matters
Mayerle, J. V. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00595-w · Cited by 5 · see citing works
A triple hormone receptor ER, AR, and VDR signature is a robust prognosis predictor in breast cancer
Omar, M., Harrell, J. C., Tamimi, R. M., Marchionni, L., Erdoğan, C., Nakshatri, H., & Ince, T. A. (2024) · Breast Cancer Research · doi:10.1186/s13058-024-01876-9 · Cited by 4 · see citing works
Zhang, J., Xu, H., Wu, Y., Cho, W. C. S., Li, Y., Ren, P., Xian, Y., & Lin, Z. (2024) · Acta Materia Medica · doi:10.15212/amm-2024-0016 · Cited by 4 · see citing works
Self-citationHandschin, C., Shalhoub, H., Mazet, A., Guyon, C., Dusserre, N., Boutet-Robinet, E. A., Oliveira, H., & Guillermet‐Guibert, J. (2025) · Biofabrication · doi:10.1088/1758-5090/adb51c · Cited by 4 · see citing works
Du, Y., Wang, X., Liu, X., Li, Y., Miao, Q., Jiang, M., Sheng, W., & Zhen, Y. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115057 · Cited by 4 · see citing works
Singh, K., Faraoni, E. Y., Dai, Y., Chandra, V., Vucic, E., Mills, T., Pruski, M. A., Clark, T., Buren, G. V., Thosani, N. C., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.29.470415 · Cited by 4 · see citing works
Tonelli, C., Deschênes, A., Yao, M. A., Park, Y., & Tuveson, D. A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.31.472823 · Cited by 4 · see citing works
CD73 Is a Critical Immune Checkpoint in a Molecular Subtype of Pancreatic Cancer
DelGiorno, K. E. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-0268 · Cited by 4 · see citing works
Derakhshani, A., Fonte, R., Porcelli, L., Orang, F. N., Shadbad, M. A., Feriz, A. M., Safarpour, H., Dufour, A., Baradaran, B., Calabrese, A., et al. (2026) · Clinical Immunology · doi:10.1016/j.clim.2026.110665 · Cited by 3 · see citing works
Organoids in the research of pancreatic neoplasms: cultivation, applications, and limitations
Du, C., Liu, Y., Lu, X., Zhang, M., Jiang, S., Cao, Z., Yang, G., Qiu, J., Zhang, T., & Zhao, Y. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217968 · Cited by 3 · see citing works
Asadzadeh, Z., Hemmat, N., Hassanian, H., Alizadeh, N., Mokhtarzadeh, A., Jafarlou, M., & Baradaran, B. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.155012 · Cited by 3 · see citing works
Wallig, M. A., Vahle, J. L., & Sullivan, J. M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-821046-8.00008-6 · Cited by 3 · see citing works
Li, J. W., Deng, Z., Yan, Z., Huang, S., Jin, J., Xie, C., & Gan, J. (2025) · Scientific Reports · doi:10.1038/s41598-025-13196-9 · Cited by 2 · see citing works
Handler, J. S., Li, Z., Dveirin, R. K., Lin, J., Fang, W., Wu, S., Forsmo, J. E., Goodarzi, H., Fertig, E. J., & Kalhor, R. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116701 · Cited by 3 · see citing works
LY6D identifies persistent stem-like cells driving pancreatic tumourigenesis
Shi, J., Wang, X., Tang, Y., Meng, S., Zhang, Z., Lu, P., Xu, J., Yu, F., Wang, X., Wang, Z., et al. (2026) · Gut · doi:10.1136/gutjnl-2025-336460 · Cited by 2 · see citing works
Association between cancer genes and germ layer specificity
Lee, H., Lee, S., Cho, W. J., Shin, M., & Park, L. (2022) · Medical Oncology · doi:10.1007/s12032-022-01823-8 · Cited by 2 · see citing works
Road Map to Defeat Pancreatic Cancer
Ferguson, L. P., & Tuveson, D. A. (2025) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-060624-044323 · Cited by 2 · see citing works
Unraveling the therapeutic landscape of miRNAs in pancreatic cancer
El‐Moaty, Z. A., Wasef, M. W., Elsayed, Y. A., Shafiq, A. S., Elnagar, M. A., Mohamed, H. R., Elesawyf, A. E., Mageed, S. S. A., Mohammed, O. A., Abdel‐Reheim, M. A., et al. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04301-w · Cited by 2 · see citing works
Tremblay, J. R., Ortiz, J., Quijano, J. C., Zook, H. N., Erdem, N., LeBon, J. M., Li, W., Jou, K., Tsark, W. M. K., Mann, J. R., et al. (2024) · Stem Cells · doi:10.1093/stmcls/sxae005 · Cited by 2 · see citing works
Udayasuryan, B., Nguyen, T. T. D., Umaña, A., Ahmad, R. N., Roberts, L. M., Sobol, P., Jones, S. D., Munson, J. M., Slade, D. J., & Verbridge, S. S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.19.469245 · Cited by 2 · see citing works
Drug-Induced p53 Activation Limits Pancreatic Cancer InitiationPreprint
Twardowski, J. J., Heist, T. I., Soares, Z. G., Berry, E. S., Ruffolo, L. I., Pröschel, C., & Mello, S. S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.29.595146 · Cited by 2 · see citing works
Ex-Vivo 3D Cellular Models of Pancreatic Ductal Adenocarcinoma
Aćimović, I., Gabrielová, V., Martínková, S., Eid, M., Vlažný, J., Moravčík, P., Hlavsa, J., Moráň, L., Cakmakci, R. C., Staňo, P., et al. (2024) · Pancreas · doi:10.1097/mpa.0000000000002393 · Cited by 1 · see citing works
Lfng-expressing centroacinar cell is a unique cell-of-origin for p53 deficient pancreatic cancer
Chung, W.-C., Zhang, S., Atfi, A., & Xu, K. (2024) · Oncogene · doi:10.1038/s41388-024-03226-7 · Cited by 1 · see citing works
Cui, M., Bai, J., Chang, X., Xiao, R., Mo, S., Soares, K. C., Yang, S., You, L., Liao, Q., He, J. P., et al. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70416 · Cited by 1 · see citing works
Li, X., Fang, W., Jiang, T., Zhang, L., Sun, Q., Jiang, H., Guo, F., Ren, H., Zheng, W., Shen, X., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116487 · Cited by 1 · see citing works
Early cellular plasticity promotes progression and dissemination in pancreatic adenocarcinoma
Innamorati, G., Malpeli, G., Giacomello, L., Salvia, R., & Wilkie, T. M. (2026) · Cancer and Metastasis Reviews · doi:10.1007/s10555-026-10326-1 · Cited by 1 · see citing works
A shifting adversary: control of pancreatic cancer transcriptomic subtypes
David, C. J. (2022) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2022.71 · Cited by 1 · see citing works
Gopalan, V., & Hannenhalli, S. S. (2023) · Cancers · doi:10.3390/cancers15072159 · Cited by 1 · see citing works
Sun, J., Lu, P., Guan, S., & Liu, S. (2023) · PubMed Central · doi:10.12122/j.issn.1673-4254.2023.09.14 · Cited by 1 · see citing works
From Tissue Turnover to the Cell of Origin of Pancreatic Cancer
Kong, B., Thoma, E., & Michalski, C. W. (2023) · doi:10.1002/9781119876007.ch120 · Cited by 1 · see citing works
Faraoni, E. Y., Singh, K., Chandra, V., Roux, O. L., Dai, Y., Şahin, İ., O’Brien, B. J., Strickland, L. N., Li, L., Vucic, E., et al. (2023) · doi:10.1158/0008-5472.c.6487377
- Authors
- Flowers, B. M., Xu, H., Mulligan, A. S., Hanson, K. J., Seoane, J. A., Vogel, H., Curtis, C., Wood, L. D., & Attardi, L. D.
- Affiliations
- Stanford Medicine (US)
- 2Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California.
- Johns Hopkins University (US)
- Corresponding author
- Attardi, Laura D.
- ORCID
- Venue
- Cancer Discovery
- Published
- 2021-03-01
- Volume
- 11
- Issue
- 3
- Pages
- 660-677
- ISSN
- 2159-8274 (ISSN-L)
- 2159-8290
- PMC
- PMC8134763
- OpenAlex
- W3135319098
- Cited by
- 118
- References
- 52
- Citations by year
- 2026: 14 · 2025: 26 · 2024: 26 · 2023: 25 · 2022: 13 · 2021: 14
- FWCI
- 7.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cancer Discovery (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NCI R35 (CA197591)
- Blavatnik Family Fellowship
- NIH Director's Pioneer Award (DP1-CA238296)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- pancreatic ductal adenocarcinoma, cell of origin, tumor molecular subtypes, Trp53, KRAS, acinar cells, ductal cells, genetically engineered mouse models, basal-like subtype, classical subtype, tumor evolution, carcinogenesis
- MeSH terms
- Alleles, Animals, Cell Transformation, Neoplastic, Disease Models, Animal, Disease Susceptibility, Humans, Immunohistochemistry, Mutation, Oncogenes, Pancreatic Neoplasms, Prognosis, Biomarkers, Tumor, Gene Expression Regulation, Neoplastic, Proto-Oncogene Proteins p21(ras), Computational Biology, Gene Expression Profiling, Carcinoma, Pancreatic Ductal, Mice, Kaplan-Meier Estimate, Transcriptome, Acinar Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
