The DOI matches its Crossref record; 56 of the 59 references it cites were found in a registry or an index.
Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset colorectal cancer among women
Open accessAbstract
Objective: Sugar-sweetened beverage (SSB) consumption had substantially increased across successive US birth cohorts until 2000, and adolescents and young adults under age 50 years have the highest consumption. However, the link between SSBs and early-onset colorectal cancer (EO-CRC) remains unexamined. Design: In the Nurses’ Health Study II (1991–2015), we prospectively investigated the association of SSB intake in adulthood and adolescence with EO-CRC risk among 95 464 women who had reported adulthood beverage intake using validated food frequency questionnaires (FFQs) every 4 years. A subset of 41 272 participants reported beverage intake at age 13–18 years using a validated high school-FFQ in 1998. Cox proportional hazards models were used to estimate relative risks (RRs) with 95% CIs. Results: We documented 109 EO-CRC cases. Compared with individuals who consumed <1 serving/week of SSBs in adulthood, women who consumed ≥2 servings/day had a more than doubled risk of EO-CRC (RR 2.18; 95% CI 1.10 to 4.35; p trend =0.02), with a 16% higher risk (RR 1.16; 95% CI 1.00 to 1.36) per serving/day increase. Each serving/day increment of SSB intake at age 13–18 years was associated with a 32% higher risk of EO-CRC (RR 1.32; 95% CI 1.00 to 1.75). Replacing each serving/day of adulthood SSB intake with that of artificially sweetened beverages, coffee, reduced fat milk or total milk was associated with a 17%–36% lower risk of EO-CRC. Conclusion: Higher SSB intake in adulthood and adolescence was associated with a higher risk of EO-CRC among women. Reduction of SSB consumption among adolescents and young adults may serve as a potential strategy to alleviate the growing burden of EO-CRC.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“excessive fructose consumption might lead to intestinal flora disturbance and intestinal barrier deterioration, which promote the development of metabolic endotoxaemia, inflammation, and lipid accumulation, finally leading to colorectal carcinogenesis.20 122 123”
From Dietary sugar consumption and health: umbrella review (2023) · cites this paper as [20]
Experimental — accuracy not yet measuredIn the citing paper
“Compared with women who consumed less than one serving a week of sugar sweetened beverages in adulthood, those who consumed two or more servings a day had a 118% higher risk of early onset colorectal cancer (risk ratio 2.18, 1.10 to 4.35).”
From Dietary sugar consumption and health: umbrella review (2023) · cites this paper as [20]
In the citing paper
“Notably, the non-significant association between sugar sweetened beverage consumption and the risk of colorectal cancer observed both in this study and in our umbrella review was inconsistent with another cohort conducted in women.20”
From Dietary sugar consumption and health: umbrella review (2023) · cites this paper as [20]
In the citing paper
“Each one serving a day increment of sugar sweetened beverage consumption was associated with a 16% (risk ratio 1.16, 1.00 to 1.36) increased risk of early onset colorectal cancer.20”
From Dietary sugar consumption and health: umbrella review (2023) · cites this paper as [20]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Colorectal cancer statistics, 2020
Siegel, R. L., Miller, K. D., Sauer, A. G., Fedewa, S. A., Butterly, L. F., Anderson, J. C., Cercek, A., Smith, R. A., & Jemal, A. (2020) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21601 · Cited by 5,080
Prevalence of and Trends in Diabetes Among Adults in the United States, 1988-2012
Menke, A., Casagrande, S., Geiss, L., & Cowie, C. C. (2015) · JAMA · doi:10.1001/jama.2015.10029 · Cited by 2,362
International Tables of Glycemic Index and Glycemic Load Values: 2008
Atkinson, F. S., Foster-Powell, K., & Brand-Miller, J. C. (2008) · Diabetes Care · doi:10.2337/dc08-1239 · Cited by 1,965
Alternative Dietary Indices Both Strongly Predict Risk of Chronic Disease
Chiuve, S. E., Fung, T. T., Rimm, E. B., Hu, F. B., McCullough, M. L., Wang, M., Stampfer, M. J., & Willett, W. C. (2012) · The Journal of Nutrition · doi:10.3945/jn.111.157222 · Cited by 1,951
Self-citationLudwig (2002) · doi:10.1001/jama.287.18.2414 · Cited by 1,775
Malik, V. S., Pan, A., Willett, W. C., & Hu, F. B. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.058362 · Cited by 1,668
Self-citationSugar-Sweetened Beverages, Obesity, Type 2 Diabetes Mellitus, and Cardiovascular Disease Risk
Malik, V. S., Popkin, B. M., Bray, G. A., Després, J.-P., & Hu, F. B. (2010) · Circulation · doi:10.1161/circulationaha.109.876185 · Cited by 1,641
Salvini, S., Hunter, D. J., SAMPSON, L., Stampfer, M. J., Colditz, G. A., ROSNER, B. A., & Willett, W. C. (1989) · International Journal of Epidemiology · doi:10.1093/ije/18.4.858 · Cited by 1,038
Self-citationColorectal Cancer Incidence Patterns in the United States, 1974–2013
Siegel, R. L., Fedewa, S. A., Anderson, W. F., Miller, K. D., Ma, J., Rosenberg, P. S., & Jemal, A. (2017) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djw322 · Cited by 1,002
Global patterns and trends in colorectal cancer incidence in young adults
Siegel, R. L., Torre, L. A., Soerjomataram, I., Hayes, R. B., Bray, F., Weber, T. K., & Jemal, A. (2019) · Gut · doi:10.1136/gutjnl-2019-319511 · Cited by 979
Cited by
Sorted by citations
Items 101–200 of 228
Myllymäki, H., Kelly, L., Elliot, A. M., Carter, R. N., Johansson, J. A., Chang, K.-M., Cholewa-Waclaw, J., Morton, N. M., & Feng, Y. (2024) · Oncogenesis · doi:10.1038/s41389-024-00507-4 · Cited by 8
“The excess glucose resource mediated PNC hyper-proliferation might provide a mechanism linking dietary high sugar intake to cancer incidence that has been observed in humans [39, 40].”
BackgroundDevall, M., Eaton, S., Hu, G.-Z., Sun, X.-Q., Jakum, E., Venkatesh, S., Powell, S. M., Yoshida, C., Weisenberger, D., Cooper, G. S., et al. (2025) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2025.01.005 · Cited by 8
Pham, Y. T., Wang, R., Behari, J., Chen, G., van Dam, R. M., Yuan, J., & Luu, H. N. (2025) · International Journal of Cancer · doi:10.1002/ijc.70057 · Cited by 8
Li, S., Xiang, Y., Yang, X., Chen, J., Xian, W., & Wang, Y. (2024) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2024.07.001 · Cited by 9
Azad, A. K., & Huque, R. (2023) · BMC Public Health · doi:10.1186/s12889-023-16290-7 · Cited by 8
“The consequences of SSB consumption on health are well documented in the literature [3–8].”
BackgroundMurphy, N., Campbell, P. T., & Gunter, M. J. (2021) · Gut · doi:10.1136/gutjnl-2021-324614 · Cited by 8
Dalamaga, Μ., Rozani, S., & Petropoulou, D. (2026) · Current Obesity Reports · doi:10.1007/s13679-026-00700-z · Cited by 9
“Meta-analytic data indicate that processed meat intake confers an OR of ~ 1.5, while SSB consumption is associated with ORs of ~ 1.5–2.0, with stronger associations observed for distal and rectal tumors [18 , 55 , 56 ].”
InfluentialThe Influence of Ultra-Processed Food on Colorectal Cancer: A Systematic Review
Cáceres‐Matos, R., Castro-Méndez, A., Domínguez, M., Pabón-Carrasco, D., & Pabón‐Carrasco, M. (2024) · Gastrointestinal Disorders · doi:10.3390/gidisord6010012 · Cited by 7
“On the contrary, Chang, Cotterchio, and Tinmouth (2021) did not obtain statistically significant results for the association between processed meat consumption and CRC.”
BackgroundCurrent Evidence in Water and Hydration Science
Lukito, W. (2021) · Annals of Nutrition and Metabolism · doi:10.1159/000521769 · Cited by 7
Ni, P., Lansdorp‐Vogelaar, I., Zauber, A. G., & Cao, Y. (2023) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-22-1126 · Cited by 8
Self-citationTang, N., Li, J., & Zhang, Z. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.03.069 · Cited by 6
Approach Toward Early Detection and Prevention of Early-Onset Colorectal Cancer
Fritz, C. D. L., George, M., Carethers, J. M., & Cao, Y. (2025) · Annual Review of Medicine · doi:10.1146/annurev-med-043024-025918 · Cited by 6
Self-citationKuan, T., Wu, C. L., Chen, C., Giovannucci, E. L., & Liu, J. J. (2026) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.70401 · Cited by 6
Self-citationIs early-onset colorectal cancer an evolving pandemic? Real-world data from a tertiary cancer center
Angelakas, A., Christodoulou, T., Kamposioras, K. V., Barriuso, J., Braun, M., Hasan, J., Marti, K., Misra, V., Mullamitha, S., Saunders, M. P., et al. (2024) · The Oncologist · doi:10.1093/oncolo/oyae239 · Cited by 7
“66 Hur et al 66 Prospective cohort study 95 464 females Demonstrated that higher SSBs intake in adolescence and adulthood is associated with a higher risk of EOCRC among women.”
Zhang, S., Hur, J., Song, R., Wang, P., Cao, Y., Wu, K., & Giovannucci, E. L. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02255-5 · Cited by 6
Self-citationZhu, Z., Peng, L., Gu, H., Tang, Y., Xiao, Y., He, H., Yang, M., Xiang, L., & Wang, Y. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1142067 · Cited by 6
“org lung cancer risk is currently lacking, they are believed to be closely associated with risk factors for lung cancer, such as insulin resistance, inflammation, obesity, and type 2 diabetes (31).”
BackgroundSuárez, J., Alsina, M., Unanua, N. C., Marín, G., Llanos, C., Oronoz, B., Mata, E., Aznárez, R., Jiménez, G., Martínez, M., et al. (2024) · ESMO Gastrointestinal Oncology · doi:10.1016/j.esmogo.2023.100033 · Cited by 6
“29,30 These discrepancies can be partially explained by other confounding factors associated with BMI, such as those related to the Western diet, 31 sugar-sweetened beverages 32 or sedentary lifestyle.”
Fan, Z., Shi, T., Yang, Y., He, W., & Chai, D. (2024) · BMC Public Health · doi:10.1186/s12889-024-20158-9 · Cited by 5
“In addition, increased SSB consumption has been associated with an increased risk of rectal cancer [18, 19].”
BackgroundLuévano, J. M., Liu, J. C., & Stappenbeck, T. S. (2025) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000864 · Cited by 6
“Sugar-sweetened drinks associated with increased EoCRC risk (33), particularly in women (34), although fructose associated with increased proximal but not distal CRC mortality (35).”
Li, Z., Song, Y., Huang, X., Dong, S., Lin, X., Chen, J., Zhou, Y., Wang, X., Liu, Q., Yang, L., et al. (2025) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2025.06.016 · Cited by 6
Janak, A., Jain, A. K., García-Milian, R., Aladelokun, O. B., Ma, X., Paty, P. B., Khan, S. A., & Johnson, C. H. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.08.052 · Cited by 5
A Systematic Review of Nonsugar Sweeteners and Cancer Epidemiology Studies
Boon, D., Marchitti, S. A., Colonna, K. J., Chowdhury-Paulino, I. M., Li, W., Berky, A. J., Restrepo, C., Jack, M. M., & Goodman, J. E. (2025) · Advances in Nutrition · doi:10.1016/j.advnut.2025.100527 · Cited by 5
“Two studies reported decreased risk with NSS intake [79,114].”
Accelerating discovery of cancer causes for prevention in the era of rising early-onset cancers
Shi, M., Patti, G. J., Gunter, M. J., Govindan, R., Lansdorp‐Vogelaar, I., Wang, T., Townsend, J. P., Colditz, G. A., Belkaid, Y., & Cao, Y. (2026) · Cell · doi:10.1016/j.cell.2026.03.019 · Cited by 7
Self-citationAdvances in Understanding Early-Onset Colorectal Cancer
Hayes, R. B. (2021) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-21-0844 · Cited by 5
Invisible foes: how air pollution and lifestyle conspire in the rise of colorectal cancer
Zhao, D., & Zhu, M. (2025) · QJM · doi:10.1093/qjmed/hcaf074 · Cited by 5
Sweet Beverages and Cancer: A Scoping Review of Quantitative Studies
Yeary, K. H.-C. K., Quisenberry, A. J., Hall, M. G., Yu, H., Henry, W. A. E., Rodriguez, E. M., & Zoellner, J. M. (2022) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-21-0507 · Cited by 5
Chen, H., Buziau, A. M., Rentería, M. E., Simons, P. I. H. G., & Brouwers, M. C. G. J. (2024) · European Journal of Endocrinology · doi:10.1093/ejendo/lvae006 · Cited by 5
Hughner, R. S., & Dumitrescu, C. (2024) · Journal of Business Research · doi:10.1016/j.jbusres.2024.114812 · Cited by 5
Environmental and lifestyle drivers of early-onset cancer
Hamada, T., Inamura, K., Ben‐Aharon, I., Ugai, T., & Ogino, S. (2026) · Nature Health · doi:10.1038/s44360-026-00122-0 · Cited by 4
“Other putative risk factors include dietary and nutritional factors such as sugary beverages 71 , red meat 65 , vitamin D insufficiency 72 and hyperinsuli-naemia-associated dietary and lifestyle patterns 73 .”
Self-citationPatients younger than 40 years with colorectal cancer have a similar prognosis to older patients
Abe, T., Matsuda, T., Sawada, R., Hasegawa, H., Yamashita, K., Kato, T., Harada, H., Urakawa, N., Goto, H., Kanaji, S., et al. (2023) · International Journal of Colorectal Disease · doi:10.1007/s00384-023-04488-5 · Cited by 4
“Western-style diets and sugar-sweetened beverages are associated with a trend toward a younger onset of CRC [14, 15], and it is possible that the onset of CRC will be even younger in the future.”
Racial/Ethnic Disparities in Early-Onset Colorectal Cancer Outcomes
Tsai, M., Shahsavari, D., Chen, J., Moazzami, B., & Sridhar, S. (2025) · Journal of Racial and Ethnic Health Disparities · doi:10.1007/s40615-025-02450-5 · Cited by 4
Li, X., Zhou, X. K., Chen, Y., & Liu, W. (2025) · BMC Cancer · doi:10.1186/s12885-025-14802-9 · Cited by 4
“…CRC is closely associated with unhealthy dietary patterns such as diet high-energy foods, sugary beverages and metabolic factors, such as high BMI, which usually exist in higher SDI regions for that rapid urban-isation and industrialisation have accelerated changes in people’s lifestyles [53, 54].”
The association of excessive soft drinks consumption with early-onset colorectal cancer
Rehman, O. U., Fatima, E., & Arabpour, J. (2023) · European Journal of Cancer · doi:10.1016/j.ejca.2023.113242 · Cited by 4
Role of dietary nutrients and metabolism in colorectal cancer.
Ye, J., Bao, X., Wei, J., Zhang, Y., Liu, Y., & Xin, L. (2024) · PubMed Central · doi:10.6133/apjcn.202406_33(2).0002 · Cited by 5
Zhou, Y.-L., Deng, J., Liu, Z.-H., Ma, X., Zhu, C., Xie, Y., Zhou, C., & Fang, J. (2025) · BMJ Open Gastroenterology · doi:10.1136/bmjgast-2024-001597 · Cited by 4
Erdem, S., Gros, H. L., Gass, J., Huber, A.-K., Worni, M., Henschel, M., Viehl, C. T., Müller, A., Zingg, U., Stimpfle, D., et al. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000002964 · Cited by 4
“The mention of sugar-sweetened beverages (SSBs), including juices or sodas, was introduced as a hypothesis to contextualize and interpret our findings, based on previous literature [ 32 , 33 ] .”
Ma, S., Zhang, Y., Xie, S., Li, X., Chen, R., Wang, S., & Wei, W. (2025) · International Journal of Cancer · doi:10.1002/ijc.35402 · Cited by 3
Colorectal cancer molecular profiling: Opportunities for early detection
Sala, A., van den Driest, L., Rattray, N. J. W., Johnson, C. H., Cameron, J. M., Khan, S. A., Palmer, D. S., & Baker, M. J. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70474 · Cited by 3
“23,26 Other factors that have been linked with early-onset include environmental exposures, and dysbiosis of the gut microbiota caused by antibiotic exposure, alcohol consumption and various components of the diet.”
Pan, J. H., Aykin‐Burns, N., Krager, K. J., Shin, H. R., Lee, C. H., Lee, J. H., Kong, B. C., Myoung, J., Choi, K., & Kim, J. K. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01584-0 · Cited by 3
Moosavi, D., Lim, U., Hullar, M. A. J., Rettenmeier, C., Kwee, S. A., Monroe, K. R., Ernst, T., Randolph, T., Wilkens, L. R., Marchand, L. L., et al. (2026) · European Journal of Clinical Nutrition · doi:10.1038/s41430-026-01743-0 · Cited by 3
“Future longitudinal studies are warranted to establish causality and evaluate the effectiveness of tailored dietary interventions.”
Sala, I., Botteri, E., Berstad, P. M., Fontvieille, E., Zouiouich, S., Sánchez, S.-J., Guevara, M., Dorronsoro, A., Olsen, A., Kyrø, C., et al. (2026) · European Journal of Cancer · doi:10.1016/j.ejca.2026.116869 · Cited by 3
Joseph, P. L., & Fleary, S. A. (2024) · Health Education & Behavior · doi:10.1177/10901981241292313 · Cited by 4
“Engagement in preventive health behaviors (PHBs), such as healthy eating, sleep, and physical activity, during adolescence is associated with reduced risk for chronic conditions including cancer and diabetes (Farvid et al., 2016; Hur et al., 2021; Whooten et al., 2019).”
[Research Progress in High-Sugar Diet and Inflammatory Diseases].
Zhang, W., Ma, X., Cheng, H., & Zhang, D. (2022) · PubMed Central · doi:10.12182/20220560103 · Cited by 3
Own price elasticities of the demand for sugar-sweetened beverages in Bangladesh
Huque, R., Azad, A. K., & Ahmed, N. (2024) · BMC Public Health · doi:10.1186/s12889-024-18544-4 · Cited by 3
Ma, S.-R., Zhang, Y., Fan, Z., He, F., & Wei, W. (2023) · journal of nutritional oncology · doi:10.1097/jn9.0000000000000025 · Cited by 2
Chen, P., Shan, G., Zhang, Y., & Xia, T. (2025) · World Journal of Urology · doi:10.1007/s00345-025-05643-z · Cited by 2
Gut microbiota and diet in colorectal cancer: Converging determinants of carcinogenesis
Thakur, B. K., Choudhury, S. R., Turpin, W., & Martín, A. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2664684 · Cited by 4
“132 Moreover, the rapid rise in the consumption of SSBs, particularly beverages containing added sugars, high-fructose corn syrup, or sucrose, parallels increasing CRC incidence and mortality in young adults.”
Role of Diet in the Pathogenesis of Colorectal Polyps and Cancer
Patel, A. A., Houston, K., Saadeh, M., Vilela, A., Yoo, B. S., D’Souza, S. M., & Johnson, D. A. (2022) · Recent Progress in Nutrition · doi:10.21926/rpn.2203018 · Cited by 2
Garrett, C., Steffens, D., Ackland, S. P., Solomon, M. J., & Koh, C. (2024) · Asia-Pacific Journal of Clinical Oncology · doi:10.1111/ajco.14081 · Cited by 2
Hao, M., Li, Y., Ma, W., Wang, L., Zheng, J., & Wu, Y. (2024) · Journal of Cancer · doi:10.7150/jca.95456 · Cited by 2
“…research has consistently indicated that the consumption of sugar-sweetened beverages is linked to a greater risk of liver cancer [28], as well as pancreatic cancer [29], along with increased mortality from colorectal cancer and an increased risk of early-onset colorectal cancer in women [30].”
BackgroundYang, J., Ning, M., Tian, Y., Chen, Z., Liu, Y., Yu, Q., Li, X., Huang, C., Li, Y., & Wu, X. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.10.060 · Cited by 2
Toxic AGEs (TAGE) Cause Lifestyle-Related Diseases
Takeuchi, M. (2024) · Antioxidants · doi:10.3390/antiox13111372 · Cited by 2
Dietary factors and the risk of gastric and colorectal cancers: A Mendelian randomization study
Zhang, Y., Xia, H., Yang, S., Yu, W., Liu, M., & Li, D. (2025) · Medicine · doi:10.1097/md.0000000000041610 · Cited by 2
“[13,14] For example, the The authors have no funding and conflicts of interest to disclose.”
Sweet beverages and the risk of colorectal cancer: the Norwegian Women and Cancer Study
Hauan, M., Rylander, C., & Skeie, G. (2025) · BMC Cancer · doi:10.1186/s12885-025-13835-4 · Cited by 3
“The authors of these studies [22, 23] suggested that unabsorbed fructose may promote colorectal carcinogenesis by increasing gut permeability and promoting tumor growth in the colon.”
InfluentialLi, C., Chen, T., Chen, H., Zhang, B., Sun, B., Zhou, P., Li, Q., & Chen, W. (2025) · Cancer Control · doi:10.1177/10732748251327715 · Cited by 2
Jeena, B. P., Kodali, P. B., Longchar, W., & Hense, S. (2023) · Nutrition & Food Science · doi:10.1108/nfs-03-2023-0050 · Cited by 3
Early-onset colorectal cancer: Never too young
Frizelle, F. A., Waddell, O., & Keenan, J. I. (2022) · New Zealand Medical Journal · doi:10.26635/6965.e1563 · Cited by 1
Sugar-Sweetened Beverage Consumption and Implications for Aviation Preflight Indoctrination Students
Sather, T. E. (2023) · Aerospace Medicine and Human Performance · doi:10.3357/amhp.6277.2024 · Cited by 1
Li, S., Wang, J., Zhang, J., Zou, Y., Deng, Y., & Xu, J. (2024) · Endocrine Journal · doi:10.1507/endocrj.ej24-0042 · Cited by 1
Li, F., Lu, M. S., Xu, B., Xiang, Z., Zhang, Y., Cao, B., Li, X., Wu, Y., Zheng, R., Qin, C., et al. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1553194 · Cited by 1
Huang, H., Zhang, L., Zhang, D., Yang, M., Lin, Y., Wang, Z., Wei, P., Lin, J., Huang, J., Wei, P., et al. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1649279 · Cited by 1
“Furthermore, studies have shown that high sugar intake can increase the risk of various cancers, including breast cancer, colorectal cancer, and pancreatic cancer (41–43).”
Zhang, M., Peng, Y., Zhang, J., Du, B., Wang, M., Chen, S., Ding, H., Wei, M., Zhu, C., Geng, W., et al. (2025) · Nutrition Research · doi:10.1016/j.nutres.2025.10.003 · Cited by 1
The effects of dietary fructose on blood pressure are modified by the food matrix
van Oeteren, M. A. J., de Groot, D. M., Buziau, A. M., Scheijen, J. L. J. M., van de Waarenburg, M. P. H., Kroon, A. A., Eussen, S. J. P. M., Dagnelie, P. C., van Greevenbroek, M. M. J., Houben, A. J. H. M., et al. (2025) · Clinical Nutrition · doi:10.1016/j.clnu.2025.10.017 · Cited by 1
Lee, H., Lee, J. E., & Kang, M. (2025) · Scientific Reports · doi:10.1038/s41598-025-24698-x · Cited by 2
Khaled, K., Jardaly, H., & Oh, B. (2026) · Onco · doi:10.3390/onco6010005 · Cited by 1
“In the same cohort, SSB intake in adolescence and adulthood was also linked to increased risk of early-onset colorectal cancer [127].”
Mohamed, I., Abuelazm, M. T., Zoubi, B. M. A., Aref, A., Jaber, F., Dahiya, D. S., Abosheaishaa, H. M., Mahmoud, M., Duong, N. K., Ibdah, J. A., et al. (2026) · Baylor University Medical Center Proceedings · doi:10.1080/08998280.2026.2659523 · Cited by 1
Gutiérrez, J. J. P., Gallardo, M. C., & Pizarro‐Moreno, Á. (2023) · Revista Andaluza de Patología Digestiva · doi:10.37352/2023462.2 · Cited by 1
Gaps in care of early onset colorectal cancer
Burke, D., & Reid, H. (2025) · BMJ · doi:10.1136/bmj.r1121 · Cited by 1
Cold stress induces colitis-like phenotypes in mice by altering gut microbiota and metabolitesPreprint
Sun, L., Chen, Y., Song, J., Yuan, Q., Wang, X., Zhao, Y., Liang, C., Zhang, H., Lian, B., & Zhang, J. (2022) · Research Square · doi:10.21203/rs.3.rs-1400518/v1 · Cited by 1
Ein hoher Konsum von zuckergesüßten Getränken erhöht das Darmkrebsrisiko
Metzger, L. (2022) · Zeitschrift für Gastroenterologie · doi:10.1055/a-1710-0884
Dietary components associated with being overweight, having obesity, and cancer
Anisman, H., & Kusnecov, A. W. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91904-3.00018-5
Cold stress induces colitis-like phenotypes in mice by altering gut microbiota and metabolitesPreprint
Sun, L., Wang, X., Chen, Y., Song, J., Liang, C., & Zhang, J. (2022) · Research Square · doi:10.21203/rs.3.rs-1400518/v2
Heyens, L. J. M., Bauer, J., & Koek, G. H. (2022) · Tijdschrift voor Geneeskunde · doi:10.47671/tvg.78.22.106
Li, L., Xia, J., Huang, Z., Liu, W., Cui, Z., Zhang, Y., Zhang, S., Zou, Y., Liu, W., & Qi, Z. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121469
Semagn, B. E., Abubakari, A., & Kebede, S. D. (2023) · Research Square · doi:10.21203/rs.3.rs-2706037/v1
Adherence to safe food-handling practices and dietary patterns in cancer survivors
Huanca, P., Guzmán, C., & Durán‐Agüero, S. (2023) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2023.04.030
Devall, M., Eaton, S., Hu, G.-Z., Sun, X.-Q., Jakum, E., Venkatesh, S., Powell, S. M., Yoshida, C., Weisenberger, D., Cooper, G. S., et al. (2023) · medRxiv · doi:10.1101/2023.05.31.23290777
Combatting the Fructose Epidemic
Buziau, A. M. (2023) · Research Publications (Maastricht University) · doi:10.26481/dis.20231113ab
Miyamoto, K., Yasuda, T., Akaho, T., Ibusuki, R., Shimoshikiryo, I., Nishimoto, D., Miyahara, H., Tokushige, K., Tanoue, S., Koriyama, C., et al. (2023) · PubMed Central · doi:10.6133/apjcn.202312_32(4).0007
He, L., Wu, Y., Chen, Y., Zhao, C., Li, W., Lu, Y., & Guo, F. (2024) · Research Square · doi:10.21203/rs.3.rs-3777520/v1
Aranis, S. D., Putra, S., Setiarini, A., & Prasetyo, T. J. (2024) · Indonesian Journal of Public Health Nutrition · doi:10.7454/ijphn.v4i2.8075
Vanguardia, M. K., Lew, C., Nguyen, T. C., Teoh, W., & Narasimhan, V. (2025) · ANZ Journal of Surgery · doi:10.1111/ans.19416
“12 One of the pivotal advances in recent years has been the recognition that the gut microbiome plays a central role in the development of CRC. Bacteria such a fusobacterium species, bacteroides frag-iles, pks + E. Coli , salmonella enterica are strongly associated with CRC carcinogenesis through a…”
Wang, K., Han, L., Cheng, S., Zhao, X., Zhao, J., Yang, S., Yu, W., & Li, A. (2025) · Food Science and Human Wellness · doi:10.26599/fshw.2025.9250510
The effectiveness of sugar tax in controlling sugar consumption
Haniyah, R., Johantri, B., & Sustiyo, J. (2025) · Educoretax · doi:10.54957/educoretax.v5i5.1519
Gweon, T., Ha, J., Kim, H., Du, M., Song, M., & Chan, A. T. (2025) · Gastro Hep Advances · doi:10.1016/j.gastha.2026.101097
Self-citationChiao, E. J., Luong, T., Mahadevan, A., & Dayyani, F. (2025) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-25-0040
Diet and Colorectal Cancer: Updates for the Practicing Clinician
Yosief, S., & Kieber‐Emmons, A. (2025) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-025-00474-8
“Interestingly, one study found women consuming two or more SSBs servings per day had more than double the risk of developing risk of early-onset CRC compared to those consuming less than one serving per week [49].”
Associations of the Healthy Beverage Index and the risk of colorectal cancer: a case-control study
El‐Sehrawy, A. A. M. A., Kadem, M., Ahmad, I., & Hjazi, A. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1595246
“For instance, a longitudinal study by Hur et al. (16) found that sugar-sweetened beverage intake during adulthood and adolescence was linked to an elevated risk of early-onset CRC in women, potentially due to the disruption of glucose metabolism and promotion of pro-inflammatory pathways.”
InfluentialEarly-onset Colorectal Cancer: Epidemiology, Risk Factors, and Prognosis
Lee, S. B. (2025) · Journal of Digestive Cancer Research · doi:10.52927/jdcr.2025.13.2.112
Chang, Y., Liu, Y., Hao, Y., Guo, J., Bai, K., Huang, F., & Hu, Y. (2025) · Research Square · doi:10.21203/rs.3.rs-7724776/v1
Ren, Y.-M., Fan, Z.-E., Liu, X., Li, Q.-L., & Zhou, P.-H. (2026) · Cancer Control · doi:10.1177/10732748261460115
“These findings support the hypothesis 58 that risk accumulation begins early in life, with long-latency mechanisms—ranging from mucosal inflammation 59 and metabolic stress 60,61 to gut microbiome disruption 62-64 —culminating in middle-age disease.”
Cui, Y., Liu, H., Wang, Z., Zhang, H., Tian, J., Wang, Z., Song, W., Guo, H., Liu, L., Tian, R., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23803258
Li, Q., Yu, M., Lv, H., Zhang, L., Deng, Y., & Yu, H. (2023) · Figshare · doi:10.6084/m9.figshare.23812649
Cui, Y., Liu, H., Wang, Z., Zhang, H., Tian, J., Wang, Z., Song, W., Guo, H., Liu, L., Tian, R., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23803240
Cui, Y., Liu, H., Wang, Z., Zhang, H., Tian, J., Wang, Z., Song, W., Guo, H., Liu, L., Tian, R., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23803249
Cui, Y., Liu, H., Wang, Z., Zhang, H., Tian, J., Wang, Z., Song, W., Guo, H., Liu, L., Tian, R., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23803252
Liu, F., Lv, Y., Peng, Y., Qiao, Y., Wang, P., Si, C., Wang, X., Gong, J., Zhou, H., Zhang, M., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24209048
Oliero, M., Hajjar, R., Cuisiniere, T., Fragoso, G., Calvé, A., Dagbert, F., Loungnarath, R., Sebajang, H., Schwenter, F., Wassef, R., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26557955
Waddell, O., Pearson, J., McCombie, A., Marshall, H., Purcell, R., Keenan, J. I., Glyn, T., & Frizelle, F. (2024) · Figshare · doi:10.6084/m9.figshare.25596480
Cui, Y., Liu, H., Wang, Z., Zhang, H., Tian, J., Wang, Z., Song, W., Guo, H., Liu, L., Tian, R., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23803243
Metadata
- Authors
- Hur, J., Otegbeye, E., Joh, H.-K., Nimptsch, K., Ng, K., Ogino, S., Meyerhardt, J. A., Chan, A. T., Willett, W. C., Wu, K., Giovannucci, E., & Cao, Y.
- Affiliations
- Harvard University (US)
- Washington University in St. Louis (US)
- Broad Institute (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Cao, Yin
- ORCID
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2021-05-06
- Volume
- 70
- Issue
- 12
- Pages
- 2330-2336
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC8571123
- OpenAlex
- W3159187004
- Cited by
- 229
- References
- 59
- Citations by year
- 2026: 34 · 2025: 50 · 2024: 36 · 2023: 57 · 2022: 44 · 2021: 8
- FWCI
- 31.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Funders
- National Institutes of Health (K07 CA218377, R01 CA151993, R01 CA205406, R03 CA197879, R21 CA222940, R21 CA230873, R35 CA197735, R35 CA253185, R37 CA246175, T32 CA009621, U01 CA176726)
- U.S. Department of Defense (CA160344)
- Massachusetts General Hospital (Stuart and Suzanne Steele MGH Research Scholar)
- American Institute for Cancer Research (Investigator Initiated Grant)
- Project P Fund (N/A)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- sugar-sweetened beverages, early-onset colorectal cancer, women, artificially sweetened beverages, coffee, milk consumption, dietary risk factors, Nurses' Health Study II
- MeSH terms
- Sugar-Sweetened Beverages, Adolescent, Adult, Female, Humans, Prospective Studies, Surveys and Questionnaires, United States, Colorectal Neoplasms
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
