Simple Sugar and Sugar-Sweetened Beverage Intake During Adolescence and Risk of Colorectal Cancer Precursors
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Abstract
Background & aims Recent increasing trends in early-onset colorectal cancer (CRC) strongly supports that early-life diet is involved in CRC development. However, data are lacking on the relationship with high sugar intake during early life.Methods We prospectively investigated the association of adolescent simple sugar (fructose, glucose, added sugar, total sugar) and sugar-sweetened beverage (SSB) intake with CRC precursor risk in 33,106 participants of the Nurses' Health Study II who provided adolescent dietary information in 1998 and subsequently underwent lower gastrointestinal endoscopy between 1999 and 2015. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression for clustered data.Results During follow-up, 2909 conventional adenomas (758 high-risk) and 2355 serrated lesions were identified (mean age at diagnoses, 52.2 ± 4.3 years). High sugar and SSB intake during adolescence was positively associated with risk of adenoma, but not serrated lesions. Per each increment of 5% of calories from total fructose intake, multivariable ORs were 1.17 (95% CI, 1.05-1.31) for total and 1.30 (95% CI, 1.06-1.60) for high-risk adenoma. By subsite, ORs were 1.12 (95% CI, 0.96-1.30) for proximal, 1.24 (95% CI, 1.05-1.47) for distal, and 1.43 (95% CI, 1.10-1.86) for rectal adenoma. Per 1 serving/day increment in SSB intake, ORs were 1.11 (95% CI, 1.02-1.20) for total and 1.30 (95% CI, 1.08-1.55) for rectal adenoma. Contrary to adolescent intake, sugar and SSB intake during adulthood was not associated with adenoma risk.Conclusions High intake of simple sugars and SSBs during adolescence was associated with increased risk of conventional adenoma, especially rectal adenoma.
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Another prospective cohort study showed that excessive consumption of sugars and sugar sweetened beverage during adolescence was significantly associated with the risk of colorectal adenoma (odds ratio 1.20, 1.04 to 1.39).
“another prospective cohort study showed that excessive consumption of sugars and sugar sweetened beverage during adolescence was significantly associated with the risk of colorectal adenoma (odds ratio 1.20, 1.04 to 1.39).146”
From Dietary sugar consumption and health: umbrella review (2023) · cites this paper as [146]
Each one serving a day increase in sugar sweetened beverage consumption was associated with 11% higher risk of total colorectal adenoma (odds ratio 1.11, 1.02 to 1.20) and 30% higher risk of rectal adenoma (odds ratio 1.30, 1.08 to 1.55).
“Each one serving a day increase in sugar sweetened beverage consumption was associated with 11% (odds ratio 1.11, 1.02 to 1.20) and 30% (1.30, 1.08 to 1.55) higher risks of total colorectal adenoma and rectal adenoma, respectively.146”
From Dietary sugar consumption and health: umbrella review (2023) · cites this paper as [146]
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“Similarly, findings from the Nurses’ Health Study II suggest that dietary patterns in adolescence, including meat and fish intake 87 , dairy intake 88 and sugar-sweetened beverage intake 89,90 , increase the risk of early-onset CRC and colorectal adenoma (Supplementary Table 1).”
Metabolism and Colorectal Cancer
Sedlak, J. C., Yilmaz, Ö. H., & Roper, J. (2022) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-031521-041113 · Cited by 201 · see citing works
Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines
Cavestro, G. M., Mannucci, A., Balaguer, F., Hampel, H., Kupfer, S. S., Repici, A., Bianchi, A. S., Seppälä, T. T., Valentini, V., Boland, C. R., et al. (2022) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2022.12.006 · Cited by 151 · see citing works
Self-citationRisk factors for early-onset colorectal cancer: systematic review and meta-analysis
Hua, H., Jiang, Q., Sun, P., & Xu, X. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1132306 · Cited by 107 · see citing works
“…Southern California (KPSC) Nguyen 2021 (34) cohort (1991- 2015) 25-42 2911 The United States F adenoma sulfur microbial diet Nurses’ Health Study II Joh 2021 (35) cohort (1999- 2015) 25-42 4364 The United States F adenomas High sugar, sugar-sweetened beverage Nurses’ Health Study II Chen 2021…”
BackgroundInfluentialColorectal Cancer in Younger Adults
Dharwadkar, P., Zaki, T. A., & Murphy, C. C. (2022) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2022.02.005 · Cited by 106 · see citing works
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Self-citationDiet as a Risk Factor for Early-Onset Colorectal Adenoma and Carcinoma: A Systematic Review
Carroll, K. L., Frugé, A. D., Heslin, M. J., Lipke, E. A., & Greene, M. W. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.896330 · Cited by 63 · see citing works
Liang, Y., Zhang, N., Wang, M., Liu, Y., Ma, L., Wang, Q., Yang, Q., Liu, X., Zhou, F., & Wei, Y. (2023) · Nutrients · doi:10.3390/nu16010132 · Cited by 61 · see citing works
“For example, high intake of simple sugars and sugar-sweetened beverages during adolescence was found to be associated with an increased risk of rectal adenoma [14].”
BackgroundMignogna, C., Costanzo, S., Castelnuovo, A. F. D., Ruggiero, E., Shivappa, N., Hébert, J. R., Esposito, S., Curtis, A. D., Persichillo, M., Cerletti, C., et al. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.08.020 · Cited by 56 · see citing works
Zhang, Q., Chumanevich, A. A., Nguyen, I., Chumanevich, A. A., Sartawi, N., Hogan, J., Khazan, M., Harris, Q., Massey, B., Chatzistamou, I., et al. (2023) · Toxicology Reports · doi:10.1016/j.toxrep.2023.08.006 · Cited by 45 · see citing works
Food Intake and Colorectal Cancer
Kumar, A., Chinnathambi, S., Kumar, M., & Pandian, G. N. (2023) · Nutrition and Cancer · doi:10.1080/01635581.2023.2242103 · Cited by 43 · see citing works
“43) adenoma for each increment of 5% of calories from total fructose intake following high sugar and SSB consumption during adolescence (68).”
BackgroundDietary and metabolic effects on intestinal stem cells in health and disease
Shay, J. E. S., & Yilmaz, Ö. H. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00980-7 · Cited by 42 · see citing works
“HFCS consumption increased in the latter part of the twentieth century in parallel with rising rates of obesity and incidence of early-onset CRC 108,109 .”
Shon, W.-J., Jung, M. H., Kim, Y.-H., Kang, G. H., Choi, E. Y., & Shin, D. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109254 · Cited by 42 · see citing works
Huang, C., Liang, Z., Ma, J., Hu, D., Yao, F., & Qin, P. (2023) · Nutrition · doi:10.1016/j.nut.2023.112032 · Cited by 35 · see citing works
Long-Term Effectiveness Associated With Fecal Immunochemical Testing for Early-Age Screening
Chiu, H., Chen, S. L., Su, C., Yen, A. M.-F., Hsu, W., Hsu, C.-Y., Lin, T.-Y., Lee, Y., Wu, M., & Chen, T. H.-H. (2025) · JAMA Oncology · doi:10.1001/jamaoncol.2025.1433 · Cited by 36 · see citing works
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Serum 25-Hydroxyvitamin D Levels and Risk of Colorectal Cancer: An Age-Stratified Analysis
Kim, Y., Chang, Y., Cho, Y., Chang, J., Kim, K., Park, D. I., Park, S., Joh, H., Kim, M. K., Kim, C., et al. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.06.029 · Cited by 26 · see citing works
Self-citationGenetics, diet, microbiota, and metabolome: partners in crime for colon carcinogenesis
Vecchia, M. L., Sala, G., Sculco, M., Aspesi, A., & Dianzani, I. (2024) · Clinical and Experimental Medicine · doi:10.1007/s10238-024-01505-x · Cited by 26 · see citing works
“Particularly in adolescence, high intake of SSBs and other added sugars may alter the insulin-like growth factor axis, leading to insulin resistance, obesity, type 2 diabetes, and increased inflammation, all of which can contribute to the development of CRC [111, 112].”
Allura Red AC is a xenobiotic. Is it also a carcinogen?
Hofseth, L. J., Hébert, J. R., Murphy, E. A., Trauner, E., Vikas, A., Harris, Q., & Chumanevich, A. A. (2024) · Carcinogenesis · doi:10.1093/carcin/bgae057 · Cited by 24 · see citing works
Identification of specific susceptibility loci for the early-onset colorectal cancer
Wang, H., Cai, Y., Jin, M., Huang, C. Q., Ning, C., Niu, S., Fan, L., Li, B., Zhang, M., Lu, Z., et al. (2023) · Genome Medicine · doi:10.1186/s13073-023-01163-w · Cited by 22 · see citing works
Fructose metabolism and its roles in metabolic diseases, inflammatory diseases, and cancer
Li, Z., Fan, X., Gao, F., Pan, S., Ma, X., Cheng, H., Nakatsukasa, H., Zhang, W., & Zhang, D. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00287-2 · Cited by 20 · see citing works
Gong, D., Adomako-Bonsu, A. G., Wang, M., & Li, J. (2023) · PeerJ · doi:10.7717/peerj.15777 · Cited by 18 · see citing works
“Previous studies have shown that genetic mutations and immune disorders, the main features of CRC, were closely related to lifestyle, the environment, genetics and gut microbiota (Punt, Koopman & Vermeulen, 2017; Zhou & Sonnenberg, 2018; Janney, Powrie & Mann, 2020; Wieczorska, Stolarek & Stec, 2020; Calibasi-Kocal et…”
BackgroundDietary Sugar Intake Associated with a Higher Risk of Dementia in Community-Dwelling Older Adults
Agarwal, P., Ford, C. N., Leurgans, S. E., Beck, T. L., Desai, P., Dhana, K., Evans, D. A., Halloway, S., Holland, T. M., Krueger, K. R., et al. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230013 · Cited by 18 · see citing works
“Percent calories from sugar was also computed (calories from sugar ((total sugar (grams/day) multiplied by 4 kilocalorie (Kcal) / total calories)*100) [19].”
Liu, F., Lv, Y., Peng, Y., Qiao, Y., Wang, P., Si, C., Wang, X., Gong, J., Zhou, H., Zhang, M., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04522-8 · Cited by 18 · see citing works
Liu, C., Zheng, S., Gao, H., Yuan, X., Zhang, Z., Xie, J., Yu, C., & Xu, L. (2022) · European Journal of Nutrition · doi:10.1007/s00394-022-02993-x · Cited by 17 · see citing works
“Recent prospective cohort studies suggest that higher SSB intake has increased trends in conventional colorectal adenoma and early-onset CRC [11, 12].”
Deng, J., Zhou, Y., Dai, W., Chen, H., Zhou, C., Zhu, C., Ma, X., Pan, S., Cui, Y., Xu, J., et al. (2023) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.16243 · Cited by 17 · see citing works
“Several studies have explored the risk effect of arti fi - cially sweetened soft drinks and sugar-sweetened beverages on CRC. 16,30,31 Based on previous studies, we included additional food items with a high sugar content, incorporating the dietary habits of modern young people.”
BackgroundBeneficial microbiome and diet interplay in early-onset colorectal cancer
Zhou, Z., Kleis, L., Depetris-Chauvin, A., Jaskulski, S., Damerell, V., Michels, K. B., Gigic, B., Nöthlings, U., & Panagiotou, G. (2024) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00177-0 · Cited by 19 · see citing works
Fructose 1-phosphate, an evolutionary signaling molecule of abundancy
Brouwers, M. C. G. J. (2022) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2022.07.007 · Cited by 14 · see citing works
Kato, T., Kagawa, M., Suda, W., Tsuboi, Y., Inoue-Suzuki, S., Kikuchi, J., Hattori, M., Ohta, T., & Ohno, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911728 · Cited by 14 · see citing works
“In fact, fructose consumption is linked to the rising incidence of obesity and cancer, which are two of the leading causes of morbidity and mortality globally [31,32].”
BackgroundZhang, R., Boakye, D., Yang, N., Zhou, X., Zhou, Y., Jiang, F., Yu, L., Wang, L., Sun, J., Yuan, S., et al. (2023) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-22-1316 · Cited by 14 · see citing works
Self-citationNovel insights in intestinal and hepatic fructose metabolism: from mice to men
Koene, E., Schrauwen‐Hinderling, V. B., Schrauwen, P., & Brouwers, M. C. G. J. (2022) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000853 · Cited by 13 · see citing works
Luo, C.-Y., Luo, J.-H., Zhang, Y.-H., Lu, B., Li, N., Zhou, Y., Chen, S., Wu, S.-L., Zhang, Q.-S., Dai, M., et al. (2024) · Journal of the National Cancer Center · doi:10.1016/j.jncc.2024.04.006 · Cited by 18 · see citing works
“42 Findings from Joh et al. 41 also indicate that high intake of simple sugars and sugar-sweetened beverages during adolescence was significantly associated with increased risk of colorectal adenoma (CRC precancerous lesions), highlighting adolescence as a potentially crucial period when individuals…”
Zhang, Y., Shen, W., Chen, Z., He, J., Feng, L., Wang, L., & Chen, S. (2024) · Journal of Gastroenterology · doi:10.1007/s00535-024-02138-3 · Cited by 13 · see citing works
“A prospective study also revealed that the high intake of SSBs during adolescence was associated with an increased risk of conventional adenoma, especially rectal adenoma [13].”
BackgroundThe role of gut microbiota and drug interactions in the development of colorectal cancer
Wu, J., Xia, C., Liu, C., Zhang, Q., & Xia, C. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1265136 · Cited by 12 · see citing works
“Young women with high consumption of sugary drinks were substantially associated with increased publication rates of colorectal adenomas (particularly rectal adenomas) (Joh et al., 2021).”
BackgroundFructose shields human colorectal cancer cells from hypoxia-induced necroptosis
Huang, X.-H., & Huang, C. (2024) · npj Science of Food · doi:10.1038/s41538-024-00318-2 · Cited by 12 · see citing works
“High consumption of simple sugars and sugar-sweetened beverages, especially those containing added fructose, during adolescence, has been signi fi cantly associated with an increased risk of conventional adenoma in adulthood, with rectal adenoma being notably prevalent 4 .”
High Sugar-Sweetened Beverage Intake and Oral Cavity Cancer in Smoking and Nonsmoking Women
Gomez-Castillo, L., Cushing‐Haugen, K. L., Useche, M., Norouzi, A., Rizvi, Z. H., Ferrandino, R. M., Futran, N. D., Marchiano, E. J., Rodriguez, T., Harris, H. R., et al. (2025) · JAMA Otolaryngology–Head & Neck Surgery · doi:10.1001/jamaoto.2024.5252 · Cited by 12 · see citing works
Emerging trends in the global burden of colorectal cancer
Lee, D., Parikh, A., Sirohi, B., Cao, Y., & Chan, A. T. (2026) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-026-01149-8 · Cited by 11 · see citing works
“Since the publication of the WCRF/AICR Third Expert Report, growing evidence points to sugar-sweetened beverages as a potential risk factor for CRC, including early-onset CRC 91,92 .”
Self-citationEarly‐onset colorectal cancer: why it should be high on our list of differentials
Garrett, C., Steffens, D., Solomon, M. J., & Koh, C. (2022) · ANZ Journal of Surgery · doi:10.1111/ans.17698 · Cited by 12 · see citing works
“Data from the Nurses’ Health Study II has been further analysed by two studies which found that consumption of sugar-sweetened beverages both in adulthood and adolescence conferred a greater risk of EOCRC and colorectal adenomas.(17,18) More specifically, this risk was highest when consumption occurred during adolesce…”
MethodWang, H., Wang, J., Zhao, X., Ye, R., Sun, L., Wang, J., Li, L., Liang, H., Wang, S., & Lu, Y. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c00436 · Cited by 11 · see citing works
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Freitas, R. D. S., & da Silva, J. (2025) · Nutrition · doi:10.1016/j.nut.2025.112800 · Cited by 11 · see citing works
The Diet as a Modulator of Tumor Microenvironment in Colorectal Cancer Patients
Collado, M., Castillo, M., de Mier, G. M., de la Pinta, C., & Peña, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087317 · Cited by 11 · see citing works
“Likewise, diets rich in whole grains, fiber, fruits, and vegetables are associated with a lower risk of cancer [16].”
BackgroundZhang, Y., Xu, P., Song, Y., Ma, N., & Lu, J. (2023) · BMC Public Health · doi:10.1186/s12889-023-15987-z · Cited by 15 · see citing works
Diet and Cancer MetabolismPreprint
Locasale, J. W., Goncalves, M. D., Tano, M. D., & Burgos-Barragan, G. (2024) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041549 · Cited by 11 · see citing works
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Ribeiro, A. C. P., Barão, C. E., Filho, E. R. T., Esmerino, E. A., Silva, R., da Cruz, A. G., & Pimentel, T. C. (2024) · Food Research International · doi:10.1016/j.foodres.2024.115455 · Cited by 10 · see citing works
Dietary Risk Factors and Odds of Colorectal Adenoma in Malaysia: A Case Control Study
Sharif, R., Mohammad, N. M. A., Xin, Y. J., Hamid, N. H. A., Shahar, S., & Ali, R. A. R. (2021) · Nutrition and Cancer · doi:10.1080/01635581.2021.2022167 · Cited by 10 · see citing works
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“Among others, it was demonstrated that a high intake of simple carbohydrates was associated with increased risk for the occurrence of CP (6), whereas green vegetables were negatively associated with CP (7).”
Knowledge mapping of early-onset colorectal cancer from 2000 to 2022: A bibliometric analysis
Zhang, M., Zhu, S., Chen, L., Wu, Y., Ye, Y., Wang, G., Gui, Z., Zhang, C., & Zhang, M. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e18499 · Cited by 7 · see citing works
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Self-citationFan, Z., Shi, T., Yang, Y., He, W., & Chai, D. (2024) · BMC Public Health · doi:10.1186/s12889-024-20158-9 · Cited by 5 · see citing works
“In addition, increased SSB consumption has been associated with an increased risk of rectal cancer [18, 19].”
BackgroundHu, W., Wang, X., Fang, Z. H., Zhang, J., Tirumalasetty, M. B., & Miao, Q. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115947 · Cited by 5 · see citing works
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“Emerging evidence suggests that heightened sugar intake, particularly fructose, poses an elevated risk for the development of colorectal cancers, pancreatic cancers, and cancers related to adiposity [32-34].”
BackgroundSweet Beverages and Cancer: A Scoping Review of Quantitative Studies
Yeary, K. H.-C. K., Quisenberry, A. J., Hall, M. G., Yu, H., Henry, W. A. E., Rodriguez, E. M., & Zoellner, J. M. (2022) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-21-0507 · Cited by 5 · see citing works
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The role of dietary prehabilitation on anastomotic healing
Alverdy, J. C. (2023) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000956 · Cited by 5 · see citing works
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Role of dietary nutrients and metabolism in colorectal cancer.
Ye, J., Bao, X., Wei, J., Zhang, Y., Liu, Y., & Xin, L. (2024) · PubMed Central · doi:10.6133/apjcn.202406_33(2).0002 · Cited by 4 · see citing works
Dietary nutrients involved in one-carbon metabolism and colorectal cancer risk
Deng, L., Huangfu, Y., & Ma, Y. (2024) · LabMed discovery. · doi:10.1016/j.lmd.2024.100022 · Cited by 4 · see citing works
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“Each additional weekly report of higher sugar intake was associated with a 20% increased risk of EOCC ( P 0.001), highlighting the influence of dietary habits [ 31 ] .”
InfluentialKim, H., & Lee, S.-K. (2025) · 대한지역사회영양학회지 · doi:10.5720/kjcn.2024.00339 · Cited by 4 · see citing works
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Self-citationAssociation between different metabolic obesity phenotypes and colorectal adenoma
Lin, L., Ying, Y., Shu, L., Lv, X., & Zhu, Q. (2026) · PLoS ONE · doi:10.1371/journal.pone.0343556 · Cited by 3 · see citing works
Dietary sugar intervention: A promising approach for cancer therapy
Zhou, X., Song, Y., Wang, Z., Fu, L., Xu, L., Feng, X., Zhang, Z., & Yuan, K. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189402 · Cited by 4 · see citing works
Detección y vigilancia pospolipectomía de pólipos colónicos
Laudanno, O. M. O., Pucci, B., & Brayer, S. (2022) · Acta gastroenteorológica latinoamericana/Acta gastroenterológica latinoamericana · doi:10.52787/agl.v52i1.157 · Cited by 3 · see citing works
Fructose metabolism and its role in pig production: A mini-review
Xie, J., Shi, S., Liu, Y., Wang, S., Rajput, S. A., & Song, T. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.922051 · Cited by 3 · see citing works
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“Dietary improvements such as increased whole grain and vegetable intake may improve fi ber consumption and gut microbial composition (42, 43), while reducing intake of sugar-sweetened beverages and ultra-processed foods may help stabilize glycemic levels (37, 44).”
Role of Diet in the Pathogenesis of Colorectal Polyps and Cancer
Patel, A. A., Houston, K., Saadeh, M., Vilela, A., Yoo, B. S., D’Souza, S. M., & Johnson, D. A. (2022) · Recent Progress in Nutrition · doi:10.21926/rpn.2203018 · Cited by 2 · see citing works
Oxidative DNA damage: Induction by fructose, in vitro, and its enhancement by hydrogen peroxide
Midorikawa, K., Kobayashi, K., Kato, S., Kawanishi, S., Kobayashi, H., Oikawa, S., & Murata, M. (2023) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2023.503719 · Cited by 2 · see citing works
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“An examination of 33,106 teenagers revealed a correlation between a high intake of basic sugars and sweet drinks in youth and a heightened chance of developing typical adenoma, notably rectal adenoma [22].”
BackgroundDiet, inflammation, and cancer
Chumanevich, A. A., Hébert, J. R., Spicer, M., & Hofseth, L. J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822130-3.00016-8 · Cited by 1 · see citing works
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“Some studies have found that sugar and sugar-containing soft drink consumption in adulthood is not associated with the risk of adenomas 27 and carbohydrate intake is not associated with the risk of colorectal polyps 28 .”
Zhao, L., Cheng, C.-S., Ma, G., Feng, G., & Wang, X. (2025) · Nutrición Hospitalaria · doi:10.20960/nh.05785 · Cited by 1 · see citing works
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“…Health II found that higher adolescent intake of simple sugars and SSBs was associated with increased risk of colorectal adenomas, especially rectal lesions (OR = 1.43, 95% CI: 1.10–1.86 for fructose; OR = 1.30, 95% CI: 1.08–1.55 for SSBs), while adult sugar intake showed no association [126].”
InfluentialAnti-Diabetic Drugs Inhibit Bulimia Induced Obesity
Li, Z., Jia, J., Hao, H., Qiao, S., Zhang, Q., Zhang, X., Yu, Q., Sun, X., Wang, K., Gu, R., et al. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2805097 · Cited by 1 · see citing works
“As reported, nearly 90% of individuals with Type 2 diabetes (T2D) are overweight or obese [2].”
BackgroundSelf-citationInterrelationship in Organized Biological Systems
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Benefits of Colorectal Cancer Screening with Fecal Immunochemical Test for Individuals Aged 40 to 49Preprint
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Sugar intake during adolescence and risk of colorectal polyps
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Sugary Truth of Early-Onset Colorectal Neoplasia—Not So Sweet After All
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Self-citationHoher Zuckerkonsum im Jugendalter erhöht Risiko für Darmkrebs
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Distinct Approaches to Inhibit Obesity Related to Eating DisordersPreprint
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Self-citationHoher Zuckerkonsum im Jugendalter erhöht Risiko für Darmkrebs
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Self-citation
- Authors
- Joh, H.-K., Lee, D. H., Hur, J., Nimptsch, K., Chang, Y., Joung, H., Zhang, X., Rezende, L. F. M., Lee, J. E., Ng, K., Yuan, C., Tabung, F. K., Meyerhardt, J. A., Chan, A. T., Pischon, T., Song, M., Fuchs, C. S., Willett, W. C., Cao, Y., Ogino, S., Giovannucci, E., & Wu, K.
- Affiliations
- Harvard University (US)
- Kangbuk Samsung Hospital (KR)
- Seoul National University (KR)
- Brigham and Women's Hospital (US)
- Universidade Federal de São Paulo (BR)
- Broad Institute (US)
- Max Delbrück Center (DE)
- Yale Cancer Center (US)
- Washington University in St. Louis (US)
- Corresponding author
- Joh, Hee-Kyung
- ORCID
- Joh, Hee-Kyung
- Lee, Dong Hoon
- Hur, Jinhee
- Nimptsch, Katharina
- Chang, Yoosoo
- Joung, Hyojee
- Zhang, Xuehong
- Rezende, Leandro F.M.
- Lee, Jung Eun
- Ng, Kimmie
- Yuan, Chen
- Tabung, Fred K.
- Meyerhardt, Jeffrey A.
- Chan, Andrew T.
- Pischon, Tobias
- Song, Mingyang
- Fuchs, Charles S.
- Willett, Walter C.
- Cao, Yin
- Ogino, Shuji
- Giovannucci, Edward
- Wu, Kana
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2021-07
- Volume
- 161
- Issue
- 1
- Pages
- 128-142.e20
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC8238879
- OpenAlex
- W3139120779
- Cited by
- 122
- References
- 80
- Citations by year
- 2026: 13 · 2025: 20 · 2024: 20 · 2023: 36 · 2022: 27 · 2021: 6
- FWCI
- 12.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Gastroenterology (acceptedVersion)
- medRxiv (acceptedVersion, cc-by-nc)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (acceptedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Funders
- Amylin Pharmaceuticals
- Taiho Pharmaceutical
- National Cancer Institute Division of Cancer Epidemiology and Genetics (K07 CA188126, K24 DK098311, K99 CA215314, R01 CA151993, R01 CA205406, R03 CA197879, R21 CA222940, R21 CA230873, R35 CA197735, R35 CA253185)
- National Institutes of Health (R01 CA67262, U01 CA176726, U01 HL145386)
- Eli Lilly and Company
- Pfizer
- National Cancer Institute
- American Institute for Cancer Research
- Boehringer Ingelheim
- Unum Therapeutics
- U.S. Department of Defense (CA160344)
- Boston Biomedical
- American Cancer Society (MRSG-17-220-01, RSG-20-124-01-CCE, RSG130476)
- Daiichi-Sankyo
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- sugar-sweetened beverages, fructose, glucose, added sugars, adolescent diet, colorectal cancer precursors, colorectal adenoma, serrated lesions, rectal adenoma, early-onset colorectal cancer, dietary risk factors
- MeSH terms
- Sugar-Sweetened Beverages, Adolescent, Adolescent Behavior, Age Factors, Colonic Polyps, Feeding Behavior, Female, Humans, Middle Aged, Monosaccharides, Precancerous Conditions, Prospective Studies, Risk Factors, Time Factors, United States, Colorectal Neoplasms, Adenomatous Polyps, Risk Assessment
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