Response to faecal microbiota transplantation in ulcerative colitis is not sustained long term following induction therapy
Abstract
We read with interest the paper by Ng et al, 1 which discussed the need to optimise faecal microbiota transplantation (FMT) processes in order to increase its therapeutic potential, especially in inflammatory bowel disease (IBD). While there is randomised controlled trial evidence that FMT can be effective in the induction of remission in patients with ulcerative colitis (UC),2–5 the durability of therapeutic response following FMT cessation is unknown. Furthermore, there is limited long-term safety data following FMT, especially in patients with IBD. In the FOCUS study, FMT delivered via an initial colonoscopy infusion, followed by enema therapy for 8 weeks was effective in mild to moderate UC remission induction.2 Here, we report the long-term outcomes from the FOCUS study. Enrolled study participants who received FMT (2013–2015) were contacted to assess time to disease relapse for patients in clinical remission following FMT induction (defined as worsening symptoms requiring escalation of medical therapy or surgery), disease progression and the development of adverse events or new medical conditions. Long-term data were obtained from 87% (68/78) of participants who received FMT, with a median follow-up of …
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Responses to FMT are typically not sustained long term for chronic noncommunicable disorders.
“As expected, responses to FMT are typically not sustained long term for chronic noncommunicable disorders.”
From Key determinants of success in fecal microbiota transplantation: From microbiome to clinic (2023) · cites this paper as [121]
Cites
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Effect of Fecal Microbiota Transplantation on 8-Week Remission in Patients With Ulcerative Colitis
Costello, S. P., Hughes, P. A., Waters, O. R., Bryant, R. V., Vincent, A. D., Blatchford, P. A., Katsikeros, R., Makanyanga, J. C., Campaniello, M. A., Mavrangelos, C., et al. (2019) · JAMA · doi:10.1001/jama.2018.20046 · Cited by 855 · see citing works
Paramsothy, S., Paramsothy, R., Rubin, D. T., Kamm, M. A., Kaakoush, N. O., Mitchell, H. M., & Castaño-Rodríguez, N. (2017) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjx063 · Cited by 436 · see citing works
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Ng, S. C., Kamm, M. A., Yeoh, Y. K., Chan, P. K. S., Zuo, T., Tang, W., Sood, A., Andoh, A., Ohmiya, N., Zhou, Y., et al. (2019) · Gut · doi:10.1136/gutjnl-2019-319407 · Cited by 120 · see citing works
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Haifer, C., Paramsothy, S., Kaakoush, N. O., Saikal, A., Ghaly, S., Yang, T., Luu, L. D. W., Borody, T. J., & Leong, R. W. (2022) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(21)00400-3 · Cited by 285 · see citing works
Kedia, S., Virmani, S., K Vuyyuru, S., Kumar, P., Kante, B., Sahu, P., Kaushal, K., Farooqui, M., Singh, M., Verma, M., et al. (2022) · Gut · doi:10.1136/gutjnl-2022-327811 · Cited by 201 · see citing works
Lopetuso, L. R., Deleu, S., Godny, L., Petito, V., Puca, P., Facciotti, F., Sokol, H., Ianiro, G., Masucci, L., Abreu, M., et al. (2023) · Gut · doi:10.1136/gutjnl-2023-329948 · Cited by 129 · see citing works
Self-citation
- Authors
- Haifer, C., Saikal, A., Paramsothy, R., Kaakoush, N. O., Leong, R. W., Borody, T. J., Kamm, M. A., & Paramsothy, S.
- Affiliations
- The University of Sydney (AU)
- UNSW Sydney (AU)
- Blacktown & Mount Druitt Hospital (AU)
- Centre For Digestive Diseases (AU)
- St Vincent's Hospital Melbourne (AU)
- Corresponding author
- Paramsothy, Sudarshan
- ORCID
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2020-12-10
- Volume
- 70
- Issue
- 11
- Pages
- 2210-2211
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W3110831975
- Cited by
- 25
- References
- 6
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 7 · 2023: 5 · 2022: 4 · 2021: 4
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gut (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Microscopic Colitis
- Keywords
- fecal microbiota transplantation, ulcerative colitis, inflammatory bowel disease, remission induction, long-term outcomes, recurrence, enema therapy, FOCUS study, long-term safety
- MeSH terms
- Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Colitis, Ulcerative, Feces, Humans, Induction Chemotherapy
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