Lyophilised oral faecal microbiota transplantation for ulcerative colitis (Lotus): a randomised, double-blind, placebo-controlled trial
Abstract
Background Faecal microbiota transplantation (FMT) delivered via colonoscopic infusion or enemas have been shown to induce remission in a proportion of patients with active ulcerative colitis. Whether orally administered FMT is effective in ulcerative colitis is unknown. We aimed to assess the efficacy of oral lyophilised FMT for the treatment of active ulcerative colitis. Methods A double-blind, randomised, placebo-controlled trial was conducted at two centres in Australia. Eligible patients were aged 18-75 years with active ulcerative colitis (defined as clinical and endoscopic active ulcerative colitis, with a total Mayo score of 4-10, and a Mayo endoscopic subscore ≥1). After 2 weeks of amoxicillin, metronidazole, and doxycycline, patients were randomly assigned in a 1:1 ratio to receive either oral lyophilised FMT or placebo capsules for 8 weeks, using a prespecified computer-generated randomisation list with a permuted block size of 8. The primary outcome was corticosteroid-free clinical remission with endoscopic remission or response (total Mayo score ≤2, all subscores ≤1, and ≥1 point reduction in endoscopic subscore) at week 8. At week 8, FMT responders were randomly assigned (in a 1:1 ratio, permuted block size of 8) to either continue or withdraw FMT for a further 48 weeks. Analyses were done by modified intention-to-treat, including all patients who received at least one study dose. This trial is registered with Australian New Zealand Trial Registry, number ACTRN…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Capsulized FMT is sustainable in the long-term, especially in its lyophilized form.
“Capsulized FMT is sustainable in the long-term, especially in its lyophilized form, 98”
From Key determinants of success in fecal microbiota transplantation: From microbiome to clinic (2023) · cites this paper as [98]
There is emerging evidence that FMT may act as a chronic therapy.
“As described in this review, there is emerging evidence that FMT may act as a chronic therapy. 98”
From Key determinants of success in fecal microbiota transplantation: From microbiome to clinic (2023) · cites this paper as [98]
Cites
Metagenomic biomarker discovery and explanation
Segata, N., Izard, J., Waldron, L., Gevers, D., Miropolsky, L., Garrett, W. S., & Huttenhower, C. (2011) · Genome Biology · doi:10.1186/gb-2011-12-6-r60 · Cited by 16,192 · see citing works
Coated Oral 5-Aminosalicylic Acid Therapy for Mildly to Moderately Active Ulcerative Colitis
Schroeder, K. W., Tremaine, W. J., & Ilstrup, D. M. (1987) · New England Journal of Medicine · doi:10.1056/nejm198712243172603 · Cited by 3,037 · see citing works
Turner, D., Ricciuto, A., Lewis, A., D’Amico, F., Dhaliwal, J., Griffiths, A. M., Bettenworth, D., Sandborn, W. J., Sands, B. E., Reinisch, W., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.12.031 · Cited by 2,911 · see citing works
Bayesian community-wide culture-independent microbial source tracking
Knights, D., Kuczynski, J., Charlson, E. S., Zaneveld, J., Mozer, M. C., Collman, R. G., Bushman, F. D., Knight, R. D., & Kelley, S. T. (2011) · Nature Methods · doi:10.1038/nmeth.1650 · Cited by 1,839 · see citing works
Moayyedi, P., Surette, M. G., Kim, P. T., Libertucci, J., Wolfe, M., Onischi, C., Armstrong, D., Marshall, J. K., Kassam, Z., Reinisch, W., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.04.001 · Cited by 1,499 · see citing works
Paramsothy, S., Kamm, M. A., Kaakoush, N. O., Walsh, A. J., van den Bogaerde, J., Samuel, D., Leong, R. W. L., Connor, S., Ng, W., Paramsothy, R., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30182-4 · Cited by 1,276 · see citing works
Effect of Fecal Microbiota Transplantation on 8-Week Remission in Patients With Ulcerative Colitis
Costello, S. P., Hughes, P. A., Waters, O. R., Bryant, R. V., Vincent, A. D., Blatchford, P. A., Katsikeros, R., Makanyanga, J. C., Campaniello, M. A., Mavrangelos, C., et al. (2019) · JAMA · doi:10.1001/jama.2018.20046 · Cited by 855 · see citing works
Travis, S. P. L., Schnell, D. J., Krzeski, P., Abreu, M. T., Altman, D. G., Colombel, J., Feagan, B. G., Hanauer, S. B., Lémann, M., Lichtenstein, G. R., et al. (2011) · Gut · doi:10.1136/gutjnl-2011-300486 · Cited by 631 · see citing works
Kao, D., Roach, B., Silva, M., Beck, P., Rioux, K., Kaplan, G. G., Chang, H.-J., Coward, S., Goodman, K. J., Xu, H., et al. (2017) · JAMA · doi:10.1001/jama.2017.17077 · Cited by 615 · see citing works
Paramsothy, S., Nielsen, S. J., Kamm, M. A., Deshpande, N., Faith, J. J., Clemente, J. C., Paramsothy, R., Walsh, A. J., van den Bogaerde, J., Samuel, D., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.12.001 · Cited by 516 · see citing works
Development and validation of the Nancy histological index for UC
Bressenot, A., Salleron, J., Boulagnon‐Rombi, C., Bastien, C., Cahn, V., Cadiot, G., Diébold, M.-D., Danese, S., Reinisch, W., Schreiber, S., et al. (2015) · Gut · doi:10.1136/gutjnl-2015-310187 · Cited by 484 · see citing works
Biodiversity and species competition regulate the resilience of microbial biofilm community
Feng, K., Zhang, Z., Cai, W., Liu, W., Xu, M., Yin, H., Wang, A., He, Z., & Deng, Y. (2017) · Molecular Ecology · doi:10.1111/mec.14356 · Cited by 474 · see citing works
Paramsothy, S., Paramsothy, R., Rubin, D. T., Kamm, M. A., Kaakoush, N. O., Mitchell, H. M., & Castaño-Rodríguez, N. (2017) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjx063 · Cited by 436 · see citing works
Vermeire, S., Joossens, M., Verbeke, K., Wang, J., Machiels, K., Sabino, J., Ferrante, M., Van Assche, G., Rutgeerts, P., & Raes, J. (2016) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjv203 · Cited by 311 · see citing works
Elvers, K. T., Wilson, V. J., Hammond, A., Duncan, L., Huntley, A. L., Hay, A. D., & van der Werf, E. T. (2020) · BMJ Open · doi:10.1136/bmjopen-2019-035677 · Cited by 228 · see citing works
Yang, C., Mogno, I., Contijoch, E. J., Borgerding, J. N., Aggarwala, V., Li, Z., Siu, S., Grasset, E. K., Helmus, D. S., Dubinsky, M. C., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.01.016 · Cited by 221 · see citing works
Sood, A., Mahajan, R., Singh, A., Midha, V., Mehta, V., Narang, V., Singh, T., & Pannu, A. S. (2019) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjz060 · Cited by 150 · see citing works
Donor Recruitment for Fecal Microbiota Transplantation
Paramsothy, S., Borody, T. J., Lin, E., Finlayson, S., Walsh, A. J., Samuel, D., van den Bogaerde, J., Leong, R. W. L., Connor, S. J., Ng, W., et al. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000405 · Cited by 149 · see citing works
Reorganisation of Faecal Microbiota Transplant Services During the COVID-19 Pandemic
Ianiro, G., Mullish, B. H., Kelly, C. R., Kassam, Z., Kuijper, E. J., Ng, S. C., Iqbal, T. H., Allegretti, J. R., Bibbò, S., Sokol, H., et al. (2020) · Gut · doi:10.1136/gutjnl-2020-321829 · Cited by 147 · see citing works
Ishikawa, D., Sasaki, T., Osada, T., Kuwahara‐Arai, K., Haga, K., Shibuya, T., Hiramatsu, K., & Watanabe, S. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000975 · Cited by 135 · see citing works
Crothers, J. W., Chu, N. D., Nguyen, L. T. T., Phillips, M., Collins, C. C., Fortner, K. A., del Río, R., Lavoie, B. A., CALLAS, P. W., Velez, M., et al. (2021) · BMC Gastroenterology · doi:10.1186/s12876-021-01856-9 · Cited by 127 · see citing works
Haifer, C., Kelly, C. R., Paramsothy, S., Andresen, D. N., Papanicolas, L. E., McKew, G. L., Borody, T. J., Kamm, M. A., Costello, S. P., Andrews, J. M., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-320260 · Cited by 106 · see citing works
Ihekweazu, F. D., Fofanova, T. Y., Queliza, K., Nagy‐Szakal, D., Stewart, C. J., Engevik, M. A., Hultén, K. G., Tatevian, N., Graham, D. Y., Versalovic, J. A., et al. (2019) · Gut Microbes · doi:10.1080/19490976.2018.1560753 · Cited by 98 · see citing works
Ihekweazu, F. D., Engevik, M. A., Ruan, W. H., Shi, Z., Fultz, R., Engevik, K. A., Chang‐Graham, A. L., Freeborn, J., Park, E. S., Venable, S. F., et al. (2021) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.01.009 · Cited by 95 · see citing works
Ohkusa, T., Nomura, T., Terai, T., Miwa, H., Kobayashi, O., Hojo, M., Takei, Y., Ogihara, T., Hirai, S., Okayasu, I., et al. (2005) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520510023648 · Cited by 93 · see citing works
Reygner, J., Charrueau, C., Delannoy, J., Mayeur, C., Robert, V., Cuinat, C., Meylheuc, T., Mauras, A., Augustin, J., Nicolis, I., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1759489 · Cited by 51 · see citing works
The role of faecal microbiota transplantation in the treatment of inflammatory bowel disease
Haifer, C., Leong, R. W. L., & Paramsothy, S. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2020.08.009 · Cited by 32 · see citing works
Haifer, C., Paramsothy, S., Borody, T. J., Clancy, A. K., Leong, R. W. L., & Kaakoush, N. O. (2021) · mSystems · doi:10.1128/msystems.00905-20 · Cited by 30 · see citing works
Haifer, C., Saikal, A., Paramsothy, R., Kaakoush, N. O., Leong, R. W., Borody, T. J., Kamm, M. A., & Paramsothy, S. (2021) · Gut · doi:10.1136/gutjnl-2020-323581 · Cited by 25 · see citing works
Lin, E., Jaworski, A., Furnari, V., Wong, C., Bull, M. K., Chapman, B., & Borody, T. J. (2015) · Gastroenterology · doi:10.1016/s0016-5085(15)33288-1 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
ESPEN guideline on Clinical Nutrition in inflammatory bowel disease
Bischoff, S. C., Bager, P., Escher, J. C., Forbes, A., Hébuterne, X., Hvas, C. L., Joly, F., Kłęk, S., Krznarić, Ž., Ockenga, J., et al. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2022.12.004 · Cited by 399 · see citing works
Fecal microbiota transplantation: current challenges and future landscapes
Yadegar, A., Bar‐Yoseph, H., Monaghan, T. M., Pakpour, S., Severino, A., Kuijper, E. J., Smits, W. K., Terveer, E. M., Neupane, S., Nabavi-Rad, A., et al. (2024) · Clinical Microbiology Reviews · doi:10.1128/cmr.00060-22 · Cited by 379 · see citing works
Key determinants of success in fecal microbiota transplantation: From microbiome to clinic
Porcari, S., Benech, N., Valles-Colomer, M., Segata, N., Gasbarrini, A., Cammarota, G., Sokol, H., & Ianiro, G. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.03.020 · Cited by 331 · see citing works
Peery, A. F., Kelly, C. R., Kao, D. H., Vaughn, B. P., Lebwohl, B., Singh, S. S., Imdad, A., & Altayar, O. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.01.008 · Cited by 282 · see citing works
Microbiome-based interventions to modulate gut ecology and the immune system
Hitch, T. C. A., Hall, L. J., Walsh, S. K., Leventhal, G. E., Slack, E. M. C., de Wouters, T., Walter, J., & Clavel, T. (2022) · Mucosal Immunology · doi:10.1038/s41385-022-00564-1 · Cited by 251 · see citing works
Kedia, S., Virmani, S., K Vuyyuru, S., Kumar, P., Kante, B., Sahu, P., Kaushal, K., Farooqui, M., Singh, M., Verma, M., et al. (2022) · Gut · doi:10.1136/gutjnl-2022-327811 · Cited by 201 · see citing works
Ma, L., Shen, Q., Lyu, W., Lv, L., Wang, W., Yu, M., Yang, H., Tao, S., & Xiao, Y. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.01368-22 · Cited by 188 · see citing works
Xu, J., Xu, J., Shi, T., Zhang, Y., Chen, F., Yang, C., Guo, X., Liu, G., Shao, D., Leong, K. W., et al. (2022) · Advanced Materials · doi:10.1002/adma.202207890 · Cited by 180 · see citing works
Fecal Microbiota Transplantation as New Therapeutic Avenue for Human Diseases
Biazzo, M., & Deidda, G. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11144119 · Cited by 166 · see citing works
Huang, C., Yi, P., Zhu, M., Zhou, W., Zhang, B., Yi, X., Long, H., Zhang, G., Wu, H., Tsokos, G. C., et al. (2022) · Journal of Autoimmunity · doi:10.1016/j.jaut.2022.102844 · Cited by 137 · see citing works
Lopetuso, L. R., Deleu, S., Godny, L., Petito, V., Puca, P., Facciotti, F., Sokol, H., Ianiro, G., Masucci, L., Abreu, M., et al. (2023) · Gut · doi:10.1136/gutjnl-2023-329948 · Cited by 129 · see citing works
Wang, Y., Zhang, S., Borody, T. J., & Zhang, F. (2022) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002339 · Cited by 113 · see citing works
Fecal microbiota transplantation: Emerging applications in autoimmune diseases
Yang, R., Chen, Z., & Cai, J. (2023) · Journal of Autoimmunity · doi:10.1016/j.jaut.2023.103038 · Cited by 97 · see citing works
Chehade, N. E. H., Ghoneim, S., Shah, S. N., Chahine, A., Mourad, F. H., Francis, F. F., Binion, D. G., Farraye, F. A., & Hashash, J. G. (2022) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izac135 · Cited by 97 · see citing works
Fecal transplantation for treatment of inflammatory bowel disease
Imdad, A., Pandit, N. G., Zaman, M., Minkoff, N. Z., Tanner‐Smith, E. E., Gomez-Duarte, O. G., Acra, S. A., & Nicholson, M. R. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012774.pub3 · Cited by 96 · see citing works
Feng, J. Q., Chen, Y., Liu, Y., Lin, L., Lin, X., Gong, W., Xia, R., He, J., Sheng, J., Cai, H., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-41182-6 · Cited by 93 · see citing works
Advances in Fecal Microbiota Transplantation for Gut Dysbiosis‐Related Diseases
Hou, S., Yu, J., Li, Y., Zhao, D., & Zhang, Z. (2025) · Advanced Science · doi:10.1002/advs.202413197 · Cited by 93 · see citing works
Microbiota therapeutics for inflammatory bowel disease: the way forward
Bethlehem, L., Estevinho, M. M., Grinspan, A. M., Magro, F., Faith, J. J., & Colombel, J. (2024) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(23)00441-7 · Cited by 80 · see citing works
Novel approaches in IBD therapy: targeting the gut microbiota-bile acid axis
Pan, Y., Zhang, H., Li, M., He, T., Guo, S., Zhu, L., Tan, J., & Wang, B. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2356284 · Cited by 78 · see citing works
Rees, N. P., Shaheen, W., Quince, C., Tselepis, C., Horniblow, R. D., Sharma, N., Beggs, A. D., Iqbal, T. H., & Quraishi, M. N. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104088 · Cited by 73 · see citing works
A review of the therapeutic management of ulcerative colitis
Aslam, N., Lo, S. W., Sikafi, R., Barnes, T., Segal, J. P., Smith, P. J., & Limdi, J. K. (2022) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848221138160 · Cited by 71 · see citing works
Oral fecal transplantation enriches Lachnospiraceae and butyrate to mitigate acute liver injury
Yang, C., Chang, H., Sung, P.-C., Ge, M.-C., Tang, H.-Y., Cheng, M., Cheng, H., Chou, H.-H., Lin, C.-Y., Lin, W., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113591 · Cited by 71 · see citing works
Gut microbiota bridges the iron homeostasis and host health
Xiao, L., Tang, R., Wang, J., Wan, D., Yin, Y., & Xie, L. (2023) · Science China Life Sciences · doi:10.1007/s11427-022-2302-5 · Cited by 70 · see citing works
Gut microbiota as a new target for anticancer therapy: from mechanism to means of regulation
Sun, J., Song, S., Liu, J., Chen, F., Li, X., & Wu, G. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00678-x · Cited by 72 · see citing works
Fecal Microbiota Transplantation
Cheng, Y., & Fischer, M. (2023) · Clinics in Colon and Rectal Surgery · doi:10.1055/s-0043-1760865 · Cited by 67 · see citing works
Ma, Z., Wang, Z., Cao, J., Dong, Y., & Chen, Y. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2560019 · Cited by 64 · see citing works
Future Modulation of Gut Microbiota: From Eubiotics to FMT, Engineered Bacteria, and Phage Therapy
Airola, C., Severino, A., Porcari, S., Fusco, W. G., Mullish, B. H., Gasbarrini, A., Cammarota, G., Ponziani, F. R., & Ianiro, G. (2023) · Antibiotics · doi:10.3390/antibiotics12050868 · Cited by 63 · see citing works
Huang, C., Hao, W., Wang, X., Zhou, R., & Lin, Q. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1211271 · Cited by 61 · see citing works
Unraveling the Impact of Gut and Oral Microbiome on Gut Health in Inflammatory Bowel Diseases
Elzayat, H., Mesto, G., & Al-Marzooq, F. I. (2023) · Nutrients · doi:10.3390/nu15153377 · Cited by 64 · see citing works
Li, J., Feng, S., Wang, Z., He, J., Zhang, Z., Zou, H., Wu, Z., Liu, X., Hong Kui, W. E. I., & Tao, S. (2023) · npj Biofilms and Microbiomes · doi:10.1038/s41522-023-00403-6 · Cited by 59 · see citing works
Xie, H., Yu, S. B., Tang, M., Xun, Y., Shen, Q., & Wu, G. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1608025 · Cited by 68 · see citing works
Microbial determinants of effective donors in faecal microbiota transplantation for UC
Haifer, C., Luu, L. D. W., Paramsothy, S., Borody, T. J., Leong, R. W. L., & Kaakoush, N. O. (2022) · Gut · doi:10.1136/gutjnl-2022-327742 · Cited by 57 · see citing works
Zhu, Y.-Y., Huang, X.-L., Deng, Z.-C., Bai, T., Gao, B.-W., Xu, C.-X., Fu, J.-L., Zhao, Y., Zhang, Y.-J., Zhang, M.-X., et al. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02802-z · Cited by 61 · see citing works
Fecal microbiota transplantation in clinical practice: Present controversies and future prospects
Tian, H., Wang, X., Fang, Z., Li, L., Wu, C., Bi, D., Li, N., Chen, Q., & Qin, H. (2024) · hLife · doi:10.1016/j.hlife.2024.01.006 · Cited by 56 · see citing works
Gut microbiota in regulatory T cell generation and function: mechanisms and health implications
Sharma, A., Sharma, G., & Im, S. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2516702 · Cited by 65 · see citing works
Precision microbiota therapy for IBD: premise and promise
Nagayama, M., Gogokhia, L., & Longman, R. S. (2025) · Gut microbes · doi:10.1080/19490976.2025.2489067 · Cited by 56 · see citing works
Current Trends and Challenges of Fecal Microbiota Transplantation—An Easy Method That Works for All?
Almeida, C., Oliveira, R., Baylina, P., Fernandes, R., Teixeira, F. G., & Barata, P. (2022) · Biomedicines · doi:10.3390/biomedicines10112742 · Cited by 52 · see citing works
Fecal microbiota transplantation in non-communicable diseases: Recent advances and protocols
Hamamah, S., Gheorghita, R. E., Lobiuc, A., Sîrbu, I. O., & Covașă, M. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.1060581 · Cited by 53 · see citing works
Turjeman, S. C., Rozera, T., Elinav, E., Ianiro, G., & Koren, O. (2025) · Cell · doi:10.1016/j.cell.2025.01.038 · Cited by 53 · see citing works
The gut microbiota-bile acid axis in cholestatic liver disease
Sun, D.-Y., Xie, C., Zhao, Y., Liao, J.-M., Li, S.-S., Zhang, Y.-N., Wang, D.-D., Hua, K., Gu, Y.-C., Du, J.-B., et al. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00830-x · Cited by 53 · see citing works
Zeng, L., Deng, Y., Yang, K., Chen, J., He, Q., & Chen, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.944387 · Cited by 49 · see citing works
Toresson, L., Spillmann, T., Pilla, R., Ludvigsson, U., Hellgren, J., Ölmedal, G., & Suchodolski, J. S. (2023) · Veterinary Sciences · doi:10.3390/vetsci10040271 · Cited by 47 · see citing works
The Role of Fecal Microbiota Transplantation in IBD
Fanizzi, F., D’Amico, F., Bombassaro, I., Zilli, A., Furfaro, F., Parigi, T. L., Cicerone, C., Fiorino, G., Peyrin‐Biroulet, L., Danese, S., et al. (2024) · Microorganisms · doi:10.3390/microorganisms12091755 · Cited by 48 · see citing works
Zhou, S., Cui, Y., Zhang, Y., Zhao, T., & Cong, J. (2023) · International Journal of Colorectal Disease · doi:10.1007/s00384-023-04354-4 · Cited by 46 · see citing works
An, Y., Zhai, Z., Wang, X., Ding, Y., He, L., Li, L., Mo, Q., Mu, C., Xie, R., Liu, T., et al. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.08.008 · Cited by 46 · see citing works
Laube, R., Selinger, C. P., Seow, C. H., Christensen, B., Flanagan, E. K., Kennedy, D. S., Mountifield, R. E., Seeho, S. K. M., Shand, A., Williams, A., et al. (2023) · Gut · doi:10.1136/gutjnl-2022-329304 · Cited by 45 · see citing works
Fan, L., Chen, J., Zhang, Q., Ren, J., Chen, Y., Yang, J., Wang, L., Guo, Z., Bu, P., Zhu, B., et al. (2025) · Microbiome · doi:10.1186/s40168-025-02118-6 · Cited by 45 · see citing works
Lahtinen, P., Jalanka, J., Mattila, E. J., Tillonen, J., Bergman, P., Satokari, R. M., & Arkkila, P. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i17.2666 · Cited by 45 · see citing works
Diet and Microbiome-Directed Therapy 2.0 for IBD
Ananthakrishnan, A. N., Whelan, K., Allegretti, J. R., & Sokol, H. (2024) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2024.05.049 · Cited by 43 · see citing works
Spondyloarthritis with inflammatory bowel disease: the latest on biologic and targeted therapies
Cozzi, G., Scagnellato, L., Lorenzin, M., Savarino, E. V., Zingone, F., Ometto, F., Favero, M., Doria, A., Vavricka, S. R., & Ramonda, R. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-023-00984-8 · Cited by 43 · see citing works
Caenepeel, C., Deleu, S., Vázquez-Castellanos, J. F., Arnauts, K., Braekeleire, S., Machiels, K., Baert, F., Mana, F., Pouillon, L., Hindryckx, P., et al. (2024) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2024.05.017 · Cited by 43 · see citing works
The Evolving Landscape of Fecal Microbial Transplantation
Shao, T., Hsu, R., Hacein-Bey, C., Zhang, W., Gao, L., Kurth, M. J., Zhao, H., Shuai, Z., & Leung, P. S. C. (2023) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-023-08958-0 · Cited by 42 · see citing works
Zhang, T., Li, X., Li, J., Sun, F., & Duan, L. (2024) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.16795 · Cited by 43 · see citing works
Porcari, S., Fusco, W. G., Spivak, I., Fiorani, M., Gasbarrini, A., Elinav, E., Cammarota, G., & Ianiro, G. (2024) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(23)00357-6 · Cited by 42 · see citing works
Shabani, M., Ghoshehy, A., Mottaghi, A. M., Chegini, Z., Kerami, A., Shariati, A., & Moghadam, M. T. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1516010 · Cited by 44 · see citing works
Microbiota-mediated mechanisms of mucosal immunity across the lifespan
Iliev, I. D., Blander, J. M., Collins, N., Guo, C., Longman, R., Sonnenberg, G. F., Zeng, M. Y., & Artis, D. (2025) · Nature Immunology · doi:10.1038/s41590-025-02281-w · Cited by 43 · see citing works
Zhu, M., Song, Y., Xu, Y., & Xu, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241311004 · Cited by 36 · see citing works
Microbiota-directed biotherapeutics: considerations for quality and functional assessment
Fekete, E. E. F., Figeys, D., & Zhang, X. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2186671 · Cited by 35 · see citing works
Olteanu, G., Pană, M.-A., Busnatu, Ș., Lupuliasa, D., Neacșu, S. M., Mititelu, M., Musuc, A. M., Ioniță-Mîndrican, C.-B., & Boroghină, S. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105561 · Cited by 34 · see citing works
Fecal Microbiota Transplantation Improves Cognitive Function of a Mouse Model of Alzheimer's Disease
Jiang, X., Zheng, Y., Sun, H., Dang, Y., Yin, M., Xiao, M., & Wu, T. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70259 · Cited by 35 · see citing works
Liu, Y., Li, X., Chen, Y., Yao, Q., Zhou, J., Wang, X., Meng, Q., Ji, J., Yu, Z., & Chen, X. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1556827 · Cited by 37 · see citing works
Levast, B., Fontaine, M., Nancey, S., Déchelotte, P., Dore, J. M., & Lehert, P. (2023) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000568 · Cited by 33 · see citing works
Allegretti, J. R., Khanna, S., Mullish, B. H., & Feuerstadt, P. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.05.004 · Cited by 34 · see citing works
Elmassry, M. M., Sugihara, K., Chankhamjon, P., Kim, Y., Camacho, F. R., Wang, S., Sugimoto, Y., Chatterjee, S., Chen, L. A., Kamada, N., et al. (2025) · Cell Host & Microbe · doi:10.1016/j.chom.2025.01.002 · Cited by 33 · see citing works
Wei, Z.-J., Dong, H.-B., Ren, Y.-T., & Jiang, B. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-3236 · Cited by 32 · see citing works
Kao, D. H., Wong, K., Jijon, H. B., Moayyedi, P., Franz, R., McDougall, C., Hotte, N., Panaccione, R., Semlacher, E. A., Kroeker, K. I., et al. (2024) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000003196 · Cited by 32 · see citing works
Potential role of gut microbiota and its metabolites in radiation-induced intestinal damage
Xin, J., Wang, J., Ding, Q., Chen, W., Xu, X., Wei, X., Lv, Y.-H., Wei, Y., Feng, Y., & Zu, X. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.114341 · Cited by 31 · see citing works
Bénard, M. V., Arretxe, I., Wortelboer, K., Harmsen, H. J. M., Davids, M., de Bruijn, C. M. A., Benninga, M. A., Hugenholtz, F., Herrema, H., & Ponsioen, C. Y. (2023) · Microorganisms · doi:10.3390/microorganisms11092238 · Cited by 32 · see citing works
Michaels, M., & Madsen, K. L. (2023) · Mucosal Immunology · doi:10.1016/j.mucimm.2022.11.001 · Cited by 30 · see citing works
Faecal (or intestinal) microbiota transplant: a tool for repairing the gut microbiome
Ghani, R., Chrysostomou, D., Roberts, L. A., Pandiaraja, M., Marchesi, J. R., & Mullish, B. H. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2423026 · Cited by 31 · see citing works
Translational strategies for oral delivery of faecal microbiota transplantation
Kamath, S., Bryant, R. V., Costello, S. P., Day, A. S., Forbes, B., Haifer, C., Hold, G. L., Kelly, C. R., Li, A., Pakuwal, E., et al. (2025) · Gut · doi:10.1136/gutjnl-2025-335077 · Cited by 34 · see citing works
Targeting the gut microbiota in inflammatory bowel diseases: where are we?
Benech, N., & Sokol, H. (2023) · Current Opinion in Microbiology · doi:10.1016/j.mib.2023.102319 · Cited by 31 · see citing works
Gut microbiome-based strategies for host health and disease
Wang, C., Bai, J., Chen, X., Song, J., Zhang, Y., Wang, H., & Suo, H. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2176464 · Cited by 29 · see citing works
Stallmach, A., Quickert, S., Puta, C., & Reuken, P. A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1352744 · Cited by 29 · see citing works
Porcari, S., Severino, A., Rondinella, D., Bibbò, S., Quaranta, G., Masucci, L., Maida, M. F., Scaldaferri, F., Sanguinetti, M., Gasbarrini, A., et al. (2023) · Journal of Autoimmunity · doi:10.1016/j.jaut.2023.103033 · Cited by 27 · see citing works
Bénard, M. V., de Goffau, M. C., Blonk, J., Hugenholtz, F., van Buuren, J., Paramsothy, S., Kaakoush, N. O., D’Haens, G., Borody, T. J., Kamm, M. A., et al. (2024) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2024.10.001 · Cited by 28 · see citing works
Huang, S., Ye, Q., Wang, A., & Chen, Y. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155873 · Cited by 26 · see citing works
Gut Microbiota Modulation in IBD: From the Old Paradigm to Revolutionary Tools
Murgiano, M., Bartocci, B., Puca, P., Vincenzo, F. D., GAUDIO, A. D., Papa, A., Cammarota, G., Gasbarrini, A., Scaldaferri, F., & Lopetuso, L. R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073059 · Cited by 30 · see citing works
The role of faecal microbiota transplantation in chronic noncommunicable disorders
Mullish, B. H., Tohumcu, E., Porcari, S., Fiorani, M., Tommaso, N. D., Gasbarrini, A., Cammarota, G., Ponziani, F. R., & Ianiro, G. (2023) · Journal of Autoimmunity · doi:10.1016/j.jaut.2023.103034 · Cited by 25 · see citing works
Chen, Q., Fan, Y., Zhang, B., Yan, C., Chen, Z., Wang, L., Hu, Y., Huang, Q., Su, J., Ren, J., et al. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1086885 · Cited by 25 · see citing works
Parthasarathy, R., Santiago, F., McCluskey, P., Kaakoush, N. O., Tedla, N. T., & Wakefield, D. (2022) · Trends in Microbiology · doi:10.1016/j.tim.2022.08.008 · Cited by 25 · see citing works
Liu, Z., Liu, H., Cheng, J., Wang, H., Yang, Y., Ye, J., & Liu, Y. (2023) · Chinese Chemical Letters · doi:10.1016/j.cclet.2023.109074 · Cited by 25 · see citing works
The practice of fecal microbiota transplantation in inflammatory bowel disease
Arora, U., Kedia, S., & Ahuja, V. (2023) · Intestinal Research · doi:10.5217/ir.2023.00085 · Cited by 30 · see citing works
Luu, L. D. W., Pandey, A., Paramsothy, S., Ngo, C., Castaño‐Rodríguez, N., Liu, C., Kamm, M. A., Borody, T. J., Man, S. M., & Kaakoush, N. O. (2024) · Nature Communications · doi:10.1038/s41467-024-46983-5 · Cited by 25 · see citing works
Gut microbiota in inflammation and colorectal cancer: A potential Toolbox for Clinicians.
Grellier, N., Severino, A., Archilei, S., Kim, J., Gasbarrini, A., Cammarota, G., Porcari, S., & Benech, N. (2024) · Best practice & research. Clinical gastroenterology · doi:10.1016/j.bpg.2024.101942 · Cited by 28 · see citing works
Lopetuso, L. R., Deleu, S., Puca, P., Abreu, M. T., Armuzzi, A., Barbara, G., Caprioli, F., Ng, S. C., Costello, S. P., Damiani, A., et al. (2025) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaf013 · Cited by 23 · see citing works
Gefen, R., Dourado, J., Emile, S. H., Wignakumar, A., Rogers, P. D., Aeschbacher, P., Garoufalia, Z., Horesh, N., & Wexner, S. D. (2025) · Techniques in Coloproctology · doi:10.1007/s10151-025-03113-7 · Cited by 27 · see citing works
Autoimmune diseases and gut microbiota: a bibliometric and visual analysis from 2004 to 2022
Zhang, Y., Peng, Y., & Xu, X. (2023) · Clinical and Experimental Medicine · doi:10.1007/s10238-023-01028-x · Cited by 24 · see citing works
Liu, H., Li, J., Yuan, J., Huang, J., & Youqi, X. (2023) · BMC Microbiology · doi:10.1186/s12866-023-03107-1 · Cited by 23 · see citing works
Zou, B., Liu, S., Dong, C., Shen, H., Lv, Y., He, J., Li, X., Ruan, M.-L., Huang, Z., & Shu, S. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-024-05832-1 · Cited by 22 · see citing works
Feng, Z., Burgermeister, E., Philips, A., Zuo, T., & Wen, W. (2025) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbaf010 · Cited by 22 · see citing works
Han, T., Zhang, Y., Zheng, G., & Guo, Y. M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1704651 · Cited by 24 · see citing works
Microbiota dysbiosis and myasthenia gravis: Do all roads lead to Rome?
Kapoor, B., Gulati, M., Gupta, R., & Singla, R. K. (2023) · Autoimmunity Reviews · doi:10.1016/j.autrev.2023.103313 · Cited by 23 · see citing works
Fecal Microbiota Transplantation: Indications, Methods, and Challenges
Lee, J. Y., Kim, Y., Kim, J., & Kim, J. K. (2024) · The Journal of Microbiology · doi:10.1007/s12275-024-00184-3 · Cited by 23 · see citing works
Causal role of the gut microbiome in certain human diseases: a narrative review
Prosty, C. J., Katergi, K., Papenburg, J., Lawandi, A., Lee, T. C., Shi, H., Burnham, P., Swem, L. R., Routy, B., Yansouni, C. P., et al. (2024) · eGastroenterology · doi:10.1136/egastro-2024-100086 · Cited by 22 · see citing works
Huang, S., Li, F., Quan, C., & Jin, D. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2423024 · Cited by 20 · see citing works
Gogokhia, L., Tran, N., Grier, A., Nagayama, M., Xiang, G., Funez-dePagnier, G., Lavergne, A., Ericsson, C., Maamar, S. B., Zhang, M., et al. (2025) · Med · doi:10.1016/j.medj.2025.100707 · Cited by 21 · see citing works
Lu, G., Zhang, S., Wang, R., Wu, X., Chen, Y., Wen, Q., Cui, B., Zhang, F., & Li, P. (2025) · BMC Medicine · doi:10.1186/s12916-025-04353-y · Cited by 21 · see citing works
Majzoub, M. E., Paramsothy, S., Haifer, C., Parthasarathy, R., Borody, T. J., Leong, R. W. L., Kamm, M. A., & Kaakoush, N. O. (2024) · Nature Communications · doi:10.1038/s41467-024-53454-4 · Cited by 23 · see citing works
Machine Learning and Canine Chronic Enteropathies: A New Approach to Investigate FMT Effects
Innocente, G., Patuzzi, I., Furlanello, T., Camillo, B. D., Bargelloni, L., Giron, M. C., Facchin, S., Savarino, E. V., Azzolin, M., & Simionati, B. (2022) · Veterinary Sciences · doi:10.3390/vetsci9090502 · Cited by 19 · see citing works
- Authors
- Haifer, C., Paramsothy, S., Kaakoush, N. O., Saikal, A., Ghaly, S., Yang, T., Luu, L. D. W., Borody, T. J., & Leong, R. W.
- Affiliations
- The University of Sydney (AU)
- UNSW Sydney (AU)
- Centre For Digestive Diseases (AU)
- Corresponding author
- Leong, Rupert W
- ORCID
- Venue
- The Lancet Gastroenterology & Hepatology
- Publisher
- Elsevier BV
- Published
- 2022-02
- Volume
- 7
- Issue
- 2
- Pages
- 141-151
- ISSN
- 2468-1156 (ISSN-L)
- 2468-1253
- OpenAlex
- W3215433280
- Cited by
- 285
- References
- 30
- Citations by year
- 2026: 45 · 2025: 79 · 2024: 60 · 2023: 68 · 2022: 32 · 2021: 1
- FWCI
- 22.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- The Lancet. Gastroenterology & hepatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Gastroenterological Society of Australia
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Microscopic Colitis
- Keywords
- fecal microbiota transplantation, ulcerative colitis, corticosteroid-free remission, endoscopic remission, treatment withdrawal, COVID-19 pandemic, inflammatory bowel disease, antibiotic pretreatment, clinical remission, endoscopic response, safety and tolerability
- MeSH terms
- Fecal Microbiota Transplantation, Administration, Oral, Adult, Anti-Bacterial Agents, Colitis, Ulcerative, Double-Blind Method, Female, Freeze Drying, Humans, Male, Middle Aged, Remission Induction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review