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Effects of isolated obesity on systolic and diastolic left ventricular function
Open accessAbstract
Background: Obesity is associated with increased cardiovascular morbidity and mortality. A direct effect of isolated obesity on cardiac function is not well established. Objective: To determine the direct effect of different grades of isolated obesity on echocardiographic indices of systolic and diastolic left ventricular function. Methods: 48 obese and 25 normal weight women were studied. They had no other pathological conditions. Obesity was classed as slight (n = 17; body mass index (BMI) 25–29.9 kg/m 2), moderate (n = 20; BMI 30–34.9 kg/m 2), or severe (n = 11; BMI ⩾ 35 kg/m 2). Echocardiographic indices of systolic and diastolic function were obtained, and dysfunction was assumed when at least two values differed by ⩾ 2 SD from the normal weight group. Results: Ejection fraction (p < 0.05), fractional shortening (p < 0.05), and mean velocity of circumferential shortening (p < 0.05) were increased in slight and moderate obesity. Left ventricular dimensions were increased (p < 0.001) but relative wall thickness was unchanged. No obese patients met criteria for systolic dysfunction. In obese subjects, the mitral valve pressure half time (p < 0.01) and the left atrial diameter (p < 0.001) were increased and the deceleration slope was decreased (p < 0.01); all other diastolic variables were unchanged. No differences were found between obesity subgroups. Subclinical diastolic dysfunction was more prevalent among obese subjects (p = 0.002), being present in two with slight obesity (12%), seven with moderate obesity (35%), and five with severe obesity (45%). BMI correlated significantly with indices of left ventricular function. Conclusions: Subclinical left ventricular diastolic dysfunction is present in all grades of isolated obesity, correlates with BMI, and is associated with increased systolic function in the early stages of obesity.
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“Many studies have shown increased LA dimensions in obese subjects compared with normal-weight control subjects (16, 17, 22, 140, 274, 371, 375).”
From Cardiac remodeling in obesity (2008) · cites this paper as [274]
In the citing paper
“Similarly, E-wave deceleration times have been reported to be increased (274) or unchanged (279) in obese subjects.”
From Cardiac remodeling in obesity (2008) · cites this paper as [274]
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“Some studies have found reduced early diastolic (E-wave) velocities (155) while others have found them to be unchanged (242, 266, 274, 279, 314).”
From Cardiac remodeling in obesity (2008) · cites this paper as [274]
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“More recently, however, several studies have found that LV ejection fraction is normal or even supranormal in the majority of obese subjects, even those with severe obesity (22, 28, 155, 191, 242, 274, 279, 375, 377).”
From Cardiac remodeling in obesity (2008) · cites this paper as [274]
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“Lastly, late diastolic (A-wave) velocities have been reported to be increased (28, 155, 242) or unchanged (266, 274, 279, 314).”
From Cardiac remodeling in obesity (2008) · cites this paper as [274]
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Metadata
- Authors
- Pascual, M., Pascual, D. A., Soria, F., Vicente, T., Hernández, A. M., Tébar, F. J., & Valdés, M.
- Affiliations
- Hospital Universitario Virgen de la Arrixaca (ES)
- Corresponding author
- Valdés, M
- Venue
- Heart
- Publisher
- BMJ
- Published
- 2003-09-15
- Volume
- 89
- Issue
- 10
- Pages
- 1152-1156
- ISSN
- 1355-6037 (ISSN-L)
- 1468-201X
- PMC
- PMC1767886
- OpenAlex
- W2150530329
- Cited by
- 336
- References
- 40
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 9 · 2023: 8 · 2022: 11 · 2021: 16 · 2020: 16 · 2019: 17 · 2018: 10 · 2017: 13 · 2016: 31 · 2015: 13 · 2014: 18 · 2013: 20 · 2012: 16
- FWCI
- 6.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Heart (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- left ventricular function, systolic function, diastolic dysfunction, subclinical diastolic dysfunction, body mass index, ejection fraction, mitral inflow, left atrial diameter, women
- MeSH terms
- Adolescent, Adult, Diastole, Echocardiography, Female, Humans, Middle Aged, Obesity, Stroke Volume, Systole, Body Mass Index, Ventricular Dysfunction, Left
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