Cited by 336Cardiovascular Function and Risk FactorsCardiovascular Disease and AdiposityDiabetes, Cardiovascular Risks, and Lipoproteins

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Effects of isolated obesity on systolic and diastolic left ventricular function

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Pascual, M, Pascual, D A, Soria, F, Vicente, T, Hernández, A M, Tébar, F J, Valdés, M·2003·Heart

DOI 10.1136/heart.89.10.1152PMC PMC1767886

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Abstract

Background: Obesity is associated with increased cardiovascular morbidity and mortality. A direct effect of isolated obesity on cardiac function is not well established. Objective: To determine the direct effect of different grades of isolated obesity on echocardiographic indices of systolic and diastolic left ventricular function. Methods: 48 obese and 25 normal weight women were studied. They had no other pathological conditions. Obesity was classed as slight (n = 17; body mass index (BMI) 25–29.9 kg/m 2), moderate (n = 20; BMI 30–34.9 kg/m 2), or severe (n = 11; BMI ⩾ 35 kg/m 2). Echocardiographic indices of systolic and diastolic function were obtained, and dysfunction was assumed when at least two values differed by ⩾ 2 SD from the normal weight group. Results: Ejection fraction (p < 0.05), fractional shortening (p < 0.05), and mean velocity of circumferential shortening (p < 0.05) were increased in slight and moderate obesity. Left ventricular dimensions were increased (p < 0.001) but relative wall thickness was unchanged. No obese patients met criteria for systolic dysfunction. In obese subjects, the mitral valve pressure half time (p < 0.01) and the left atrial diameter (p < 0.001) were increased and the deceleration slope was decreased (p < 0.01); all other diastolic variables were unchanged. No differences were found between obesity subgroups. Subclinical diastolic dysfunction was more prevalent among obese subjects (p = 0.002), being present in two with slight obesity (12%), seven with moderate obesity (35%), and five with severe obesity (45%). BMI correlated significantly with indices of left ventricular function. Conclusions: Subclinical left ventricular diastolic dysfunction is present in all grades of isolated obesity, correlates with BMI, and is associated with increased systolic function in the early stages of obesity.

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Authors: Pascual, M., Pascual, D. A., Soria, F., Vicente, T., Hernández, A. M., Tébar, F. J., & Valdés, M.
Affiliations: Hospital Universitario Virgen de la Arrixaca (ES)
Corresponding author: Valdés, M
Venue: Heart
Publisher: BMJ
Published: 2003-09-15
Volume: 89
Issue: 10
Pages: 1152-1156
ISSN: 1355-6037 (ISSN-L)
1468-201X
DOI: 10.1136/heart.89.10.1152
PMC: PMC1767886
OpenAlex: W2150530329
Cited by: 336
References: 40
Citations by year: 2026: 5 · 2025: 10 · 2024: 9 · 2023: 8 · 2022: 11 · 2021: 16 · 2020: 16 · 2019: 17 · 2018: 10 · 2017: 13 · 2016: 31 · 2015: 13 · 2014: 18 · 2013: 20 · 2012: 16
FWCI: 6.83
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Heart (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: left ventricular function, systolic function, diastolic dysfunction, subclinical diastolic dysfunction, body mass index, ejection fraction, mitral inflow, left atrial diameter, women
MeSH terms: Adolescent, Adult, Diastole, Echocardiography, Female, Humans, Middle Aged, Obesity, Stroke Volume, Systole, Body Mass Index, Ventricular Dysfunction, Left

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Effects of isolated obesity on systolic and diastolic left ventricular function

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