The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Balloon pulmonary angioplasty in patients with inoperable chronic thromboembolic pulmonary hypertension
Abstract
Objective: To examine the effect of balloon pulmonary angioplasty (BPA) on chronic thromboembolic pulmonary hypertension (CTEPH) in patients with inoperable disease or persistent pulmonary hypertension after pulmonary endarterectomy. Design: Observational cohort study. Setting: Referred patients with inoperable or persistent CTEPH. Patients: Twenty consecutive CTEPH patients (10 females), aged 60±10 years. Interventions: BPA. Main outcome measures: Right heart catheterisation, functional capacity (cardiopulmonary exercise testing (CPET) and NYHA class) and blood sampled biomarkers N-terminal pro-brain natriuretic peptide (NT-proBNP) and troponin T examined at the time of diagnosis and repeated in all patients 3 months after the last BPA. Results: Seventy-three catheterisations were performed with 18.6±6.1 BPAs per patient on segmental and subsegmental arteries. Two deaths occurred following the first BPA, with an overall 10% periprocedural death rate. Reperfusion oedema complicated seven procedures. Comparisons before and after BPA showed significant haemodynamic improvements, including decreased mean pulmonary artery pressure (mPAP) (45±11 mm Hg vs 33±10 mm Hg; p<0.001) and increased cardiac output (4.9±1.6 L/min vs 5.4±1.9 L/min; p=0.011). Reduced right ventricular strain was indicated by significantly lower plasma levels of NT-proBNP and troponin T. Significant improvement in functional capacity was evident as assessed by NYHA class (3.0±0.5 vs 2.0±0.5; p<0.001) and CPET (13.6±5.6 mL/kg/min vs 17.0±6.5 mL/kg/min; p<0.001). Seventeen patients (85%) were alive after 51±30 months of follow-up. Conclusions: BPA may offer an alternative form of treatment in selected CTEPH patients. While prognostic markers such as haemodynamics, functional capacity and biomarkers improve, significant periprocedural complications must be recognised. Randomised trials are warranted.
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ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension
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Cited by
2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension
Galiè, N., Humbert, M., Vachiery, J.-L., Gibbs, S., Lang, I., Torbicki, A., Simonneau, G., Peacock, A., Vonk Noordegraaf, A., Beghetti, M., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv317 · Cited by 6,931
Self-citationAntithrombotic Therapy for VTE Disease
Kearon, C., Akl, E. A., Ornelas, J., Blaivas, A., Jimenez, D., Bounameaux, H., Huisman, M., King, C. S., Morris, T. A., Sood, N., et al. (2016) · Chest · doi:10.1016/j.chest.2015.11.026 · Cited by 4,830
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2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism
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2015 ESC/ERS Guidelines for the Diagnosis and Treatment of Pulmonary Hypertension
Galiè, N., Humbert, M., Vachiery, J.-L., Gibbs, S., Lang, I., Torbicki, A., Simonneau, G., Peacock, A., Noordegraaf, A. V., Beghetti, M., et al. (2016) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2016.01.002 · Cited by 357
Metadata
- Authors
- Andreassen, A. K., Ragnarsson, A., Gude, E., Geiran, O., & Andersen, R.
- Venue
- Heart
- Publisher
- BMJ
- Published
- 2013-07-11
- Volume
- 99
- Issue
- 19
- Pages
- 1415-1420
- ISSN
- 1355-6037 (ISSN-L)
- 1468-201X
- OpenAlex
- W2100144849
- Cited by
- 262
- References
- 23
- FWCI
- 18.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- Andreassen, A. K., Ragnarsson, A., Gude, E., Geiran, O., & Andersen, R. (2013). Balloon pulmonary angioplasty in patients with inoperable chronic thromboembolic pulmonary hypertension. Heart. https://doi.org/10.1136/heartjnl-2012-303549
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