CoChat
Sign Up
Cited by 27Cardiac pacing and defibrillation studiesCardiovascular Syncope and Autonomic DisordersCardiac electrophysiology and arrhythmias

Syncope in paced patients with sick sinus syndrome from the DANPACE trial: incidence, predictors and prognostic implication

Ng Kam Chuen, Marie Jennyfer, Kirkfeldt, Rikke Esberg, Andersen, Henning Rud, Nielsen, Jens Cosedis·2014·Heart
DOI 10.1136/heartjnl-2013-304976
Open this paper in CoChat — free account

Abstract

OBJECTIVES: Syncope is a cause of significant morbidity in sick sinus syndrome (SSS) which may not be resolved with permanent pacemaker therapy. We aimed to determine the incidence, predictors and prognostic implication of syncope in paced patients with SSS. METHODS: We studied 1415 patients (mean age 72.9 years, SD 11.1) with SSS who were randomised in the DANPACE study to either rate-responsive single chamber pacing (n=707) or rate-responsive dual chamber pacing (n=708). Main outcome measures were patient-reported syncope after pacemaker implantation and mortality. RESULTS: Mean follow-up was 5.4 years (SD 2.6). A total of 247 (17.5%) patients experienced syncope after pacemaker implantation (135 (19%) from the rate-responsive single chamber pacing group, and 112 (15.8%) from the rate-responsive dual chamber pacing group. Predictors of syncope post pacemaker implantation included: age 0-39 years (HR 2.9, 95% CI 1.4 to 6.3, p=0.01; reference range 60-79 years), age ≥80 years (HR 1.4, 95% CI 1.0 to 1.8, p=0.03), syncope prior to pacemaker implant (HR 1.8, 95% CI 1.4 to 2.3, p<0.001), previous myocardial infarction (HR 1.5, 95% CI 1.1 to 2.1, p=0.03), heart failure (HR 1.4, 95% CI 1.0 to 1.9, p=0.046), and high Charlson comorbidity index (HR 1.6, 95% CI 1.1 to 2.2, p=0.01). Patients who experienced syncope post pacemaker implant had higher mortality compared with patients who did not (adjusted HR 1.6, 95% CI 1.3 to 2.1, p<0.001). CONCLUSIONS: Syncope in paced patients with SSS is common, and is associated with higher mortality. The predictors identified in this study suggest a multifactorial aetiology of syncope.

Integrity signals

Registry

Crossref · 10.1136/heartjnl-2013-304976

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In the absence of correlation between symptoms and ECG, despite adequate pacing, syncope recurs in approximately 15-28% of patients with sinus node disease at 5 years.

    “In the absence of the above situations, despite adequate pacing, syncope recurs in approximately 15-28% of patients at 5 years 339-341 (see Supplementary Data Table 9 ).”

    From 2018 ESC Guidelines for the diagnosis and management of syncope (2018) · cites this paper as [340]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Ng Kam Chuen, M. J., Kirkfeldt, R. E., Andersen, H. R., & Nielsen, J. C.
Affiliations
  • Department of Cardiology, Nottingham University Hospitals NHS Trust, Nottingham, UK
  • Aarhus University Hospital (DK)
ORCID
Venue
Heart
Publisher
BMJ
Published
2014-04-07
Volume
100
Issue
11
Pages
842-847
ISSN
  • 1355-6037 (ISSN-L)
  • 1468-201X
DOI
10.1136/heartjnl-2013-304976
OpenAlex
W2118437531
Cited by
27
References
26
Citations by year
2025: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 4 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 1
FWCI
2.97
Type
journal article
Language
en
Open access
closed
Locations
  • Heart (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
  • Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords
sick sinus syndrome, permanent pacemaker, rate-responsive pacing, single-chamber pacing, DDD pacing, mortality, heart failure, myocardial infarction, comorbidities, age, patient-reported outcomes, pacemaker implantation complications, prognosis, atrial fibrillation, atrial tachyarrhythmia
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Cardiac Pacing, Artificial, Child, Child, Preschool, Female, Follow-Up Studies, United Kingdom, Humans, Infant, Infant, Newborn, Male, Middle Aged, Morbidity, Prognosis, Retrospective Studies, Risk Factors, Sick Sinus Syndrome, Syncope, Time Factors, Treatment Outcome, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review