Vitamin D: A negative acute phase reactant
Abstract
Objective: We evaluated the effect of the systemic inflammatory response (SIR), as provoked by elective orthopaedic surgery, on serum vitamin D [25-(OH)D]. Methods: Serum 25-(OH)D, serum vitamin D binding protein (VDBP) and urinary VDBP were measured in 30 patients before and 48-hours after knee or hip arthroplasty. C-reactive protein (CRP) was measured to assess the SIR. Results: The mean (SD) CRP increased following surgery [5.0 (5.5) vs 116.0 (81.2) mg/L; P<0.0001] as did urine VDBP/Creatinine ratio [8 (9) vs 20 (25) pg/mmol; p=0.0004]. Serum 25-(OH)D [56.2 (30.3) vs 46.0 (27.6) nmol/L; p = 0.0006] and serum VDBP [334 (43) vs 298 (37) mg/L]; P<0.0001] decreased. Conclusions: Serum 25-(OH)D is a negative acute phase reactant, which has implications for acute and chronic inflammatory diseases. Serum 25-(OH)D is an unreliable biomarker of vitamin D status after acute inflammatory insult. Hypovitaminosis D may be the consequence rather than cause of chronic inflammatory diseases.
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Inflammation, gastrointestinal issues, antiepileptic drugs and genetics are among factors affecting vitamin D metabolism or absorption.
“Inflammation [120,121], gastrointestinal issues [123,124], antiepileptic drugs [125] and genetics are among these factors.”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [120]
Children in Molloy et al. were suffering from some form of acute inflammation, which potentially had an effect on 25(OH)D levels.
“Children were suffering from some form of acute inflammation, which potentially had an effect on 25(OH)D levels [120,121].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [120]
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Inflammation and vitamin D: The infection connection
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- Authors
- Waldron, J. L., Ashby, H. L., Cornes, M. P., Bechervaise, J., Razavi, C., Thomas, O. L., Chugh, S., Deshpande, S., Ford, C., & Gama, R.
- Affiliations
- New Cross Hospital (GB)
- University of Wolverhampton (GB)
- Corresponding author
- Waldron, Jenna Louise
- Venue
- Journal of Clinical Pathology
- Publisher
- BMJ
- Published
- 2013-03-01
- Volume
- 66
- Issue
- 7
- Pages
- 620-622
- ISSN
- 0021-9746 (ISSN-L)
- 1472-4146
- OpenAlex
- W2021501597
- Cited by
- 280
- References
- 13
- Citations by year
- 2026: 14 · 2025: 10 · 2024: 14 · 2023: 25 · 2022: 30 · 2021: 43 · 2020: 21 · 2019: 16 · 2018: 23 · 2017: 15 · 2016: 22 · 2015: 25 · 2014: 18 · 2013: 3
- FWCI
- 16.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Pathology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- vitamin D, 25-hydroxyvitamin D, acute phase proteins, systemic inflammatory response, vitamin D binding protein, C-reactive protein, arthroplasty, knee arthroplasty, total hip arthroplasty, vitamin D deficiency, vitamin D status biomarkers
- MeSH terms
- Acute-Phase Proteins, C-Reactive Protein, Humans, Postoperative Complications, Vitamin D, Vitamin D Deficiency, Biomarkers, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
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