The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Clinical and neuroradiological differences of paediatric acute disseminating encephalomyelitis with and without antibodies to the myelin oligodendrocyte glycoprotein
Abstract
BACKGROUND: Myelin oligodendrocyte glycoprotein (MOG) antibodies have been recently described in children with acute disseminating encephalomyelitis (ADEM), but the clinical and neuroradiological characterisation of this subgroup is lacking. OBJECTIVE: To compare the clinical and neuroradiological features of paediatric ADEM with and without MOG antibodies. METHODS: Clinical course, cerebrospinal fluid (CSF)-, MRI studies, outcome and MOG status of 33 paediatric ADEM prospectively studied were reviewed. RESULTS: MOG antibodies (median 1:2560; range 1:160-1:20 480) were detected in 19 children with ADEM. The majority of children showed a decline of serum MOG-IgG titres over time. Children with MOG antibodies did not differ in their age at presentation, sex ratio, the presence of oligoclonal bands, clinical symptoms or initial severity, apart from a higher CSF cell count (p=0.038), compared with children without MOG antibodies. In addition, further relapsing demyelinating episodes associated with MOG antibodies were observed only in children with MOG antibodies. All 19 children with MOG antibodies had a uniform MRI pattern, characterised by large, hazy and bilateral lesions and the absence of atypical MRI features (eg, mainly small lesions, well-defined lesions), which was significantly different compared to that of children without MOG antibodies (p=0.003; and p=0.032, respectively). In addition, children with MOG antibodies had involvement of more anatomical areas (p=0.035) including the myelon characterised by a longitudinally extensive transverse myelitis (p=0.003), more often a complete resolution of lesions (p=0.036) and a better outcome (p=0.038). CONCLUSIONS: Patients with ADEM with MOG antibodies in our cohort had a uniform MRI characterised by large, bilateral and widespread lesions with an increased frequency of longitudinal extensive transverse myelitis and a favourable clinical outcome in contrast to children lacking MOG antibodies.
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Self-citationDistinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders
Sato, D. K., Callegaro, D., Lana-Peixoto, M. A., Waters, P. J., Jorge, F. M. D. H., Takahashi, T., Nakashima, I., Apostolos-Pereira, S. L., Talim, N., Simm, R. F., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000101 · Cited by 850
Acute disseminated encephalomyelitis: A long-term follow-up study of 84 pediatric patients
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Mader, S., Gredler, V., Schanda, K., Rostasy, K., Dujmovic, I., Pfaller, K., Lutterotti, A., Jarius, S., Di Pauli, F., Kuenz, B., et al. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-184 · Cited by 449
Self-citationMyelin-oligodendrocyte glycoprotein antibodies in adults with a neuromyelitis optica phenotype
Kitley, J., Woodhall, M., Waters, P., Leite, M. I., Devenney, E., Craig, J., Palace, J., & Vincent, A. (2012) · Neurology · doi:10.1212/wnl.0b013e31826aac4e · Cited by 445
Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein
O'Connor, K. C., McLaughlin, K. A., De Jager, P. L., Chitnis, T., Bettelli, E., Xu, C., Robinson, W. H., Cherry, S. V., Bar-Or, A., Banwell, B., et al. (2007) · Nature Medicine · doi:10.1038/nm1488 · Cited by 416
Self-citationThe spectrum of MOG autoantibody-associated demyelinating diseases
Reindl, M., Di Pauli, F., Rostásy, K., & Berger, T. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.118 · Cited by 375
Self-citationBrilot, F., Dale, R. C., Selter, R. C., Grummel, V., Reddy Kalluri, S., Aslam, M., Busch, V., Zhou, D., Cepok, S., & Hemmer, B. (2009) · Annals of Neurology · doi:10.1002/ana.21916 · Cited by 322
Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis
Pröbstel, A. K., Dornmair, K., Bittner, R., Sperl, P., Jenne, D., Magalhaes, S., Villalobos, A., Breithaupt, C., Weissert, R., Jacob, U., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e318228c0b1 · Cited by 306
Self-citationMRI prognostic factors for relapse after acute CNS inflammatory demyelination in childhood
Mikaeloff, Y. (2004) · Brain · doi:10.1093/brain/awh218 · Cited by 259
Cited by
Banwell, B., Bennett, J. L., Marignier, R., Kim, H. J., Brilot, F., Flanagan, E. P., Ramanathan, S., Waters, P., Tenembaum, S., Graves, J. S., et al. (2023) · The Lancet Neurology · doi:10.1016/s1474-4422(22)00431-8 · Cited by 1,246
Self-citationClinical spectrum and prognostic value of CNS MOG autoimmunity in adults: The MOGADOR study
Cobo-Calvo, A., Ruiz, A., Maillart, E., Audoin, B., Zephir, H., Bourre, B., Ciron, J., Collongues, N., Brassat, D., Cotton, F., et al. (2018) · Neurology · doi:10.1212/wnl.0000000000005560 · Cited by 538
Acute disseminated encephalomyelitis: Updates on an inflammatory CNS syndrome
Pohl, D., Alper, G., Van Haren, K., Kornberg, A. J., Lucchinetti, C. F., Tenembaum, S., & Belman, A. L. (2016) · Neurology · doi:10.1212/wnl.0000000000002825 · Cited by 462
Clinical approach to the diagnosis of autoimmune encephalitis in the pediatric patient
Cellucci, T., Van Mater, H., Graus, F., Muscal, E., Gallentine, W., Klein-Gitelman, M. S., Benseler, S. M., Frankovich, J., Gorman, M. P., Van Haren, K., et al. (2020) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000663 · Cited by 373
Prognostic relevance of MOG antibodies in children with an acquired demyelinating syndrome
Hennes, E.-M., Baumann, M., Schanda, K., Anlar, B., Bajer-Kornek, B., Blaschek, A., Brantner-Inthaler, S., Diepold, K., Eisenkölbl, A., Gotwald, T., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000004312 · Cited by 341
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Metadata
- Authors
- Baumann, M., Sahin, K., Lechner, C., Hennes, E. M., Schanda, K., Mader, S., Karenfort, M., Selch, C., Hausler, M., Eisenkolbl, A., Salandin, M., Gruber-Sedlmayr, U., Blaschek, A., Kraus, V., Leiz, S., Finsterwalder, J., Gotwald, T., Kuchukhidze, G., Berger, T., Reindl, M., & Rostasy, K.
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 2014-08-13
- Volume
- 86
- Issue
- 3
- Pages
- 265-272
- ISSN
- 0022-3050 (ISSN-L)
- OpenAlex
- W2021865068
- Cited by
- 314
- References
- 24
- FWCI
- 20.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- Baumann, M., Sahin, K., Lechner, C., Hennes, E. M., Schanda, K., Mader, S., Karenfort, M., Selch, C., Hausler, M., Eisenkolbl, A., Salandin, M., Gruber-Sedlmayr, U., Blaschek, A., Kraus, V., Leiz, S., Finsterwalder, J., Gotwald, T., Kuchukhidze, G., Berger, T., . . . Rostasy, K. (2015). Clinical and neuroradiological differences of paediatric acute disseminating encephalomyelitis with and without antibodies to the myelin oligodendrocyte glycoprotein. Journal of Neurology, Neurosurgery & Psychiatry. https://doi.org/10.1136/jnnp-2014-308346
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