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Cited by 306

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis

Pröbstel, A.K., Dornmair, K., Bittner, R., Sperl, P., Jenne, D., Magalhaes, S., Villalobos, A., Breithaupt, C., Weissert, R., Jacob, U., Krumbholz, M., Kuempfel, T., Blaschek, A., Stark, W., Gärtner, J., Pohl, D., Rostasy, K., Weber, F., Forne, I., Khademi, M., Olsson, T., Brilot, F., Tantsis, E., Dale, R.C., Wekerle, H., Hohlfeld, R., Banwell, B., Bar-Or, A., Meinl, E., Derfuss, T.·2011·Neurology
DOI 10.1212/wnl.0b013e318228c0b1
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Abstract

OBJECTIVE: To study the longitudinal dynamics of anti-myelin oligodendrocyte glycoprotein (MOG) autoantibodies in childhood demyelinating diseases. METHODS: We addressed the kinetics of anti-MOG immunoglobulins in a prospective study comprising 77 pediatric patients. This was supplemented by a cross-sectional study analyzing 126 pediatric patients with acute demyelination and 62 adult patients with multiple sclerosis (MS). MOG-transfected cells were used for detection of antibodies by flow cytometry. RESULTS: Twenty-five children who were anti-MOG immunoglobulin (Ig) positive at disease onset were followed for up to 5 years. Anti-MOG antibodies rapidly and continuously declined in all 16 monophasic patients with acute disseminated encephalomyelitis and in one patient with clinically isolated syndrome. In contrast, in 6 of 8 patients (75%) eventually diagnosed with childhood MS, the antibodies to MOG persisted with fluctuations showing a second increase during an observation period of up to 5 years. Antibodies to MOG were mainly IgG 1 and their binding was largely blocked by pathogenic anti-MOG antibodies derived from a spontaneous animal model of autoimmune encephalitis. The cross-sectional part of our study elaborated that anti-MOG Ig was present in about 25% of children with acute demyelination, but in none of the pediatric or adult controls. Sera from 4/62 (6%) adult patients with MS had anti-MOG IgG at low levels. CONCLUSIONS: The persistence or disappearance of antibodies to MOG may have prognostic relevance for acute childhood demyelination.

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Metadata

Authors
Pröbstel, A. K., Dornmair, K., Bittner, R., Sperl, P., Jenne, D., Magalhaes, S., Villalobos, A., Breithaupt, C., Weissert, R., Jacob, U., Krumbholz, M., Kuempfel, T., Blaschek, A., Stark, W., Gärtner, J., Pohl, D., Rostasy, K., Weber, F., Forne, I., Khademi, M., Olsson, T., Brilot, F., Tantsis, E., Dale, R. C., Wekerle, H., Hohlfeld, R., Banwell, B., Bar-Or, A., Meinl, E., & Derfuss, T.
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2011-08-09
Volume
77
Issue
6
Pages
580-588
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.0b013e318228c0b1
OpenAlex
W2049923210
Cited by
306
References
30
FWCI
12.20
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis. https://app.cochat.ai/papers/10.1212/wnl.0b013e318228c0b1
The paper
Pröbstel, A. K., Dornmair, K., Bittner, R., Sperl, P., Jenne, D., Magalhaes, S., Villalobos, A., Breithaupt, C., Weissert, R., Jacob, U., Krumbholz, M., Kuempfel, T., Blaschek, A., Stark, W., Gärtner, J., Pohl, D., Rostasy, K., Weber, F., Forne, I., . . . Derfuss, T. (2011). Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis. Neurology. https://doi.org/10.1212/wnl.0b013e318228c0b1

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.