The corpus callosum in the diagnosis of multiple sclerosis and other CNS demyelinating and inflammatory diseases
Abstract
Lesions in the corpus callosum (CC) are important radiological clues to the diagnosis of multiple sclerosis (MS), but may also occur in other neuroinflammatory and non-neuroinflammatory conditions. In this article, we discuss the radiological features of lesions within the CC in MS and other central nervous system inflammatory and acquired demyelinating diseases. An understanding of the appearance and location of lesions in the CC is important not only for accurate diagnosis and treatment of these various conditions, but as it also provides insights into pathogenesis.
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In addition to obtaining brain images with an axial orientation, a sagittal T2 FLAIR sequence is recommended for detecting juxtacortical and corpus callosum lesions, which can be helpful in differentiating MS from other disorders.
“In addition to obtaining brain images with an axial orientation, a sagittal T2 fluid-attenuated inversion recovery (FLAIR) sequence is recommended for detecting juxtacortical and corpus callosum lesions, which can be helpful in differentiating MS from other disorders.12,13”
From Diagnosis of multiple sclerosis: progress and challenges (2017) · cites this paper as [13]
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- Authors
- Garg, N., Reddel, S. W., Miller, D. H., Chataway, J., Riminton, D. S., Barnett, Y., Masters, L., Barnett, M. H., & Hardy, T. A.
- Affiliations
- The University of Sydney (AU)
- National Hospital for Neurology and Neurosurgery (GB)
- St Vincent's Hospital Sydney (AU)
- Corresponding author
- Hardy, Todd A
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 2015-04-09
- Volume
- 86
- Issue
- 12
- Pages
- jnnp-2014-309649
- ISSN
- 0022-3050 (ISSN-L)
- 1468-330X
- OpenAlex
- W2111682801
- Cited by
- 76
- References
- 92
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 7 · 2023: 6 · 2022: 5 · 2021: 8 · 2020: 9 · 2019: 10 · 2018: 9 · 2017: 10 · 2016: 5
- FWCI
- 6.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Institute for Health and Care Research (NF-SI-0508-10058)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- corpus callosum, multiple sclerosis, demyelinating disease, neuroinflammation, morphine, mu-opioid receptor, G protein beta subunit, proteasomal degradation, ubiquitin-proteasome system, lipid rafts, opioid use disorder, proteomics
- MeSH terms
- Corpus Callosum, Demyelinating Diseases, Encephalitis, Humans, Magnetic Resonance Imaging, Multiple Sclerosis
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