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Cited by 711Long-Term Effects of COVID-19COVID-19 Clinical Research StudiesAcute Ischemic Stroke Management

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Characteristics of ischaemic stroke associated with COVID-19

Open access
Beyrouti, Rahma, Adams, Matthew E, Benjamin, Laura, Cohen, Hannah, Farmer, Simon F, Goh, Yee Yen, Humphries, Fiona, Jäger, Hans Rolf, Losseff, Nicholas A, Perry, Richard J, Shah, Sachit, Simister, Robert J, Turner, David, Chandratheva, Arvind, Werring, David J·2020·Journal of Neurology, Neurosurgery & Psychiatry
DOI 10.1136/jnnp-2020-323586PMC PMC7231545
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Abstract

Characteristics of ischaemic stroke associated with COVID-19Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is associated with coagulopathy causing venous and arterial thrombosis. 1 2 Recent data from the pandemic epicentre in Wuhan, China, reported neurological complications in 36% of 214 patients with COVID-19; acute cerebrovascular disease (mainly ischaemic stroke) was more common among 88 patients with severe COVID-19 than those with nonsevere disease (5.7% vs 0.8%).3 However, the mechanisms, phenotype and optimal management of ischaemic stroke associated with COVID-19 remain uncertain.We describe the demographic, clinical, radiological and laboratory characteristics of six consecutive patients assessed between 1 st and 16 th April 2020 at the National Hospital for Neurology and Neurosurgery, Queen Square, London, UK, with acute ischaemic stroke and COVID-19 (confirmed by reverse-transcriptase PCR (RT-PCR)) (table 1).All six patients had large vessel occlusion with markedly elevated D-dimer levels (≥1000μg/L).Three patients had multiterritory infarcts, two had concurrent venous thrombosis, and, in two, ischaemic strokes occurred despite therapeutic anticoagulation.

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Authors
Beyrouti, R., Adams, M. E., Benjamin, L., Cohen, H., Farmer, S. F., Goh, Y. Y., Humphries, F., Jäger, H. R., Losseff, N. A., Perry, R. J., Shah, S., Simister, R. J., Turner, D., Chandratheva, A., & Werring, D. J.
Affiliations
  • University College London Hospitals NHS Foundation Trust (GB)
  • University of Liverpool (GB)
  • University College London (GB)
Corresponding author
Werring, David J
ORCID
Venue
Journal of Neurology, Neurosurgery & Psychiatry
Publisher
BMJ
Published
2020-04-30
Volume
91
Issue
8
Pages
889-891
ISSN
  • 0022-3050 (ISSN-L)
  • 1468-330X
DOI
10.1136/jnnp-2020-323586
PMC
PMC7231545
OpenAlex
W3022807497
Cited by
711
References
5
Citations by year
2026: 3 · 2025: 14 · 2024: 32 · 2023: 40 · 2022: 117 · 2021: 253 · 2020: 250
FWCI
71.40
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Neurology Neurosurgery & Psychiatry (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
  • Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Keywords
COVID-19 pandemic, SARS-CoV-2, ischemic stroke, large vessel occlusion, D-dimer, coagulopathy, venous thrombosis, anticoagulation failure, neurological complications of COVID-19, stroke features
MeSH terms
Betacoronavirus, COVID-19, SARS-CoV-2, Aged, Aged, 80 and over, Brain Ischemia, Female, Humans, Male, Middle Aged, Pneumonia, Viral, Coronavirus Infections, Stroke, Pandemics

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