PROBLEMS OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS: REPORT BY THE PANEL ON THE EVALUATION OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS
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Early MS diagnostic criteria were based primarily on clinical evidence.
“Early MS diagnostic criteria were based primarily on clinical evidence. 1”
From Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria (2018) · cites this paper as [1]
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Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria
Polman, C. H., Reingold, S. C., Banwell, B., Clanet, M., Cohen, J. A., Filippi, M., Fujihara, K., Havrdova, E., Hutchinson, M., Kappos, L., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22366 · Cited by 9,802 · see citing works
Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria
Thompson, A. J., Banwell, B. L., Barkhof, F., Carroll, W. M., Coetzee, T., Comi, G., Correale, J., Fazekas, F., Filippi, M., Freedman, M. S., et al. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30470-2 · Cited by 8,167 · see citing works
Wallin, M. T., Culpepper, W. J., Nichols, E., Bhutta, Z. A., Gebrehiwot, T. T., Hay, S. I., Khalil, I. A., Krohn, K. J., Liang, X., Naghavi, M., et al. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30443-5 · Cited by 1,108 · see citing works
A consensus protocol for the standardization of cerebrospinal fluid collection and biobanking
Teunissen, C. E., Petzold, A., Bennett, J. L., Berven, F. S., Brundin, L., Comabella, M., Franciotta, D., Frederiksen, J. L., Fleming, J. O., Furlan, R., et al. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c47cc2 · Cited by 845 · see citing works
Epidemiologic evidence for multiple sclerosis as an infection
Kurtzke, J. F. (1993) · Clinical Microbiology Reviews · doi:10.1128/cmr.6.4.382 · Cited by 472 · see citing works
Self-citationAssociation between stressful life events and exacerbation in multiple sclerosis: a meta-analysis
Mohr, D. C., Hart, S. L., Julian, L., Cox, D., & Pelletier, D. (2004) · BMJ · doi:10.1136/bmj.38041.724421.55 · Cited by 401 · see citing works
The Sonya Slifka Longitudinal Multiple Sclerosis Study: methods and sample characteristics
Minden, S. L., Frankel, D., Hadden, L., Perloff, J., Srinath, K. P., & Hoaglin, D. C. (2006) · Multiple Sclerosis Journal · doi:10.1191/135248506ms1262oa · Cited by 272 · see citing works
Psychological interventions for multiple sclerosis.
Thomas, P. W., Thomas, S., Hillier, C., Galvin, K., & Baker, R. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004431.pub2 · Cited by 271 · see citing works
Cramer, S. P., Simonsen, H., Frederiksen, J. L., Rostrup, E., & Larsson, H. B. W. (2014) · NeuroImage: Clinical · doi:10.1016/j.nicl.2013.12.001 · Cited by 232 · see citing works
“Relapsewasdefined as new or worsening symptoms that lasted 24 h and occurred in the absence of fever or infection (Schumacher et al., 1965).”
BackgroundWallin, M. T., Page, W. F., & Kurtzke, J. F. (2004) · Annals of Neurology · doi:10.1002/ana.10788 · Cited by 224 · see citing works
Self-citationLongitudinal assessment of anxiety, depression, and fatigue in people with multiple sclerosis.
Brown, R. F., Valpiani, E. M., Tennant, C. C., Dunn, S. M., Sharrock, M., Hodgkinson, S., & Pollard, J. D. (2009) · Psychology and Psychotherapy: Theory, Research and Practice · doi:10.1348/147608308x345614 · Cited by 150 · see citing works
Information provision for people with multiple sclerosis
Köpke, S., Solari, A., Khan, F., Heesen, C., & Giordano, A. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008757.pub2 · Cited by 118 · see citing works
Janssens, A. C., Buljevac, D., van Doorn, P. A., van der Meché, F. G., Polman, C. H., Passchier, J., & Hintzen, R. Q. (2006) · Multiple Sclerosis Journal · doi:10.1177/1352458506070935 · Cited by 107 · see citing works
Cerebrospinal-fluid vasopressin in neurological and psychiatric-disorders
Sorensen, P. S., Gjerris, A., & Hammer, M. (1985) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.48.1.50 · Cited by 103 · see citing works
Zivadinov, R., Iona, L., Monti-Bragadin, L., Bosco, A., Jurjevic, A., Taus, C., Cazzato, G., & Zorzon, M. (2003) · Neuroepidemiology · doi:10.1159/000067107 · Cited by 102 · see citing works
Fatigue at time of CIS is an independent predictor of a subsequent diagnosis of multiple sclerosis
Runia, T. F., Jafari, N., Siepman, D. A. M., & Hintzen, R. Q. (2015) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-308374 · Cited by 70 · see citing works
- Authors
- Schumacher, G. A., Beebe, G., Kibler, R. F., Kurland, L. T., Kurtzke, J. F., McDowell, F., Nagler, B., Sibley, W. A., Tourtellotte, W. W., & Willmon, T. L.
- Affiliations
- University of Vermont (US)
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 1965-03
- Volume
- 122
- Issue
- 1
- Pages
- 552-568
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2064687595
- Cited by
- 1,438
- References
- 0
- Citations by year
- 2026: 16 · 2025: 17 · 2024: 17 · 2023: 19 · 2022: 18 · 2021: 32 · 2020: 26 · 2019: 31 · 2018: 30 · 2017: 24 · 2016: 28 · 2015: 25 · 2014: 28 · 2013: 37 · 2012: 38
- FWCI
- 6.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- multiple sclerosis, experimental treatment, clinical trial design, treatment evaluation, clinical trials
- MeSH terms
- Drug Therapy, Humans, Models, Theoretical, Multiple Sclerosis, Biomedical Research
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