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Cited by 65Helicobacter pylori-related gastroenterology studiesSleep and Work-Related FatigueGastrointestinal Bleeding Diagnosis and Treatment

Shift work increases the frequency of duodenal ulcer in H pylori infected workers

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Pietroiusti, A, Forlini, A, Magrini, A, Galante, A, Coppeta, L, Gemma, G, Romeo, E, Bergamaschi, A·2006·Occupational and Environmental Medicine
DOI 10.1136/oem.2006.027367PMC PMC2077998
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Abstract

Aim:To evaluate whether shift work is associated with an increased rate of peptic ulcer in H pylori infected workers. Methods:During a two year period, consecutive dyspeptic workers underwent non-invasive evaluation of H pylori status by means of urea 13 C breath test or stool testing. Those testing positive were included in the study and divided into two main categories: day-time workers and shift workers. An upper gastrointestinal endoscopy was performed in all workers, and biopsy specimens were taken from the stomach to confirm the presence of H pylori infection (culture and histology). Results:A total of 247 day-time workers and 101 shift workers were included. The prevalence of duodenal ulcer was significantly higher in shift workers than in day-time workers (29 of 101 v 23 of 247; OR = 3.92, 95% CI 2.13 to 7.21), and persisted after multivariate analysis, taking into account possible confounding factors (OR = 3.96, 95% CI 2.10 to 7.47). Conclusion:Shift work increases the ulcerogenic potential of H pylori infection and should be considered a risk factor for duodenal ulcer in infected shift workers. Treatment of infection in this high risk group may improve the health of workers and may reduce the economic impact of peptic ulcer.

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  • Gastrointestinal dysfunction may explain the significantly higher rate of ulcers in night workers compared to day workers.

    “Dysfunction of the gastrointestinal tract may also explain the significantly higher rate of ulcers in night workers compared to day workers [44], and may have impactful consequences for shift workers’ long-term health.”

    From Shift Work: Disrupted Circadian Rhythms and Sleep—Implications for Health and Well-being (2017) · cites this paper as [44]

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Authors
Pietroiusti, A., Forlini, A., Magrini, A., Galante, A., Coppeta, L., Gemma, G., Romeo, E., & Bergamaschi, A.
Affiliations
University of Rome Tor Vergata (IT)
Corresponding author
Pietroiusti, A
ORCID
Venue
Occupational and Environmental Medicine
Publisher
BMJ
Published
2006-10-18
Volume
63
Issue
11
Pages
773-775
ISSN
  • 0007-1072 (ISSN-L)
  • 1351-0711
  • 1470-7926
DOI
10.1136/oem.2006.027367
PMC
PMC2077998
OpenAlex
W2035598810
Cited by
65
References
16
Citations by year
2026: 2 · 2025: 3 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 6 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 4 · 2013: 3 · 2012: 6
FWCI
2.04
Type
journal article
Language
en
Open access
Locations
  • Occupational and Environmental Medicine (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
Keywords
shift work, duodenal ulcer, Helicobacter pylori infection, peptic ulcer, occupational risk factors, workers, dyspepsia
MeSH terms
Adult, Biopsy, Breath Tests, Duodenal Ulcer, Female, Gastroscopy, Humans, Male, Middle Aged, Peptic Ulcer, Risk Factors, Work Schedule Tolerance, Prevalence, Odds Ratio, Helicobacter pylori, Helicobacter Infections

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