Gut barrier disruption and chronic disease

Metabolic Endotoxemia Initiates Obesity and Insulin Resistance

Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638 · see citing works

Intestinal mucosal barrier function in health and disease

Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952 · see citing works

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

Franceschi, C., Garagnani, P., Parini, P., Giuliani, C., & Santoro, A. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0059-4 · Cited by 3,586 · see citing works

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders

Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283 · see citing works

A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility

Desai, M. S., Seekatz, A. M., Koropatkin, N. M., Kamada, N., Hickey, C. A., Wolter, M., Pudlo, N. A., Kitamoto, S., Terrapon, N., Muller, A., et al. (2016) · Cell · doi:10.1016/j.cell.2016.10.043 · Cited by 2,805 · see citing works

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: A proof-of-concept exploratory study

Depommier, C., Everard, A., Druart, C., Plovier, H., Van Hul, M., Vieira-Silva, S., Falony, G., Raes, J., Maiter, D., Delzenne, N. M., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0495-2 · Cited by 2,357 · see citing works

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

Plovier, H., Everard, A., Druart, C., Depommier, C., Van Hul, M., Geurts, L., Chilloux, J., Ottman, N., Duparc, T., Lichtenstein, L., et al. (2017) · Nature Medicine · doi:10.1038/nm.4236 · Cited by 2,204 · see citing works

Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers

Peng, L., Li, Z.-R., Green, R. S., Holzmanr, I. R., & Lin, J. (2009) · The Journal of Nutrition · doi:10.3945/jn.109.104638 · Cited by 2,130 · see citing works

Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome

Chassaing, B., Koren, O., Goodrich, J. K., Poole, A. C., Srinivasan, S., Ley, R. E., & Gewirtz, A. T. (2015) · Nature · doi:10.1038/nature14232 · Cited by 2,055 · see citing works

The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide

Viaud, S., Saccheri, F., Mignot, G., Yamazaki, T., Daillère, R., Hannani, D., Enot, D. P., Pfirschke, C., Engblom, C., Pittet, M. J., et al. (2013) · Science · doi:10.1126/science.1240537 · Cited by 2,050 · see citing works

Muc2-Deficient Mice Spontaneously Develop Colitis, Indicating That MUC2 Is Critical for Colonic Protection

Van der Sluis, M., De Koning, B. A. E., De Bruijn, A. C. J. M., Velcich, A., Meijerink, J. P. P., Van Goudoever, J. B., Büller, H. A., Dekker, J., Van Seuningen, I., Renes, I. B., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.04.020 · Cited by 1,684 · see citing works

Mucus barrier, mucins and gut microbiota: the expected slimy partners?

Paone, P., & Cani, P. D. (2020) · Gut · doi:10.1136/gutjnl-2020-322260 · Cited by 1,602 · see citing works

Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction

Thevaranjan, N., Puchta, A., Schulz, C., Naidoo, A., Szamosi, J. C., Verschoor, C. P., Loukov, D., Schenck, L. P., Jury, J., Foley, K. P., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.03.002 · Cited by 1,322 · see citing works

Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota

Chang, C., Lin, C.-S., Lu, C., Martel, J., Ko, Y., Ojcius, D. M., Tseng, S., Wu, T.-R., Chen, Y. M., Young, J. D., et al. (2015) · Nature Communications · doi:10.1038/ncomms8489 · Cited by 1,251 · see citing works

Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis

Bevins, C. L., & Salzman, N. H. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2546 · Cited by 1,238 · see citing works

Glycan foraging in vivo by an intestine-adapted bacterial symbiont

Sonnenburg, J. L., Xu, J., Leip, D. D., Chen, C.-H., Westover, B. P., Weatherford, J., Buhler, J. D., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1109051 · Cited by 1,184 · see citing works

Short-term antibiotic treatment has differing long-term impacts on the human throat and gut microbiome

Jakobsson, H. E., Jernberg, C., Andersson, A. F., Sjölund-Karlsson, M., Jansson, J. K., & Engstrand, L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009836 · Cited by 1,160 · see citing works

Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders

Kelly, J. R., Kennedy, P. J., Cryan, J. F., Dinan, T. G., Clarke, G., & Hyland, N. P. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00392 · Cited by 1,110 · see citing works

Circadian physiology of metabolism

Panda, S. (2016) · Science · doi:10.1126/science.aah4967 · Cited by 1,092 · see citing works

Leaky gut: mechanisms, measurement and clinical implications in humans

Camilleri, M. (2019) · Gut · doi:10.1136/gutjnl-2019-318427 · Cited by 1,081 · see citing works

Inflammaging and ‘Garb-aging’

Franceschi, C., Garagnani, P., Vitale, G., Capri, M., & Salvioli, S. (2017) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.09.005 · Cited by 997 · see citing works

Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer.

Fasano, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00003.2008 · Cited by 979 · see citing works

Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection

Thaiss, C. A., Levy, M., Grosheva, I., Zheng, D., Soffer, E., Blacher, E., Braverman, S., Tengeler, A. C., Barak, O., Elazar, M., et al. (2018) · Science · doi:10.1126/science.aar3318 · Cited by 942 · see citing works

Colorectal Cancer in Mice Genetically Deficient in the Mucin Muc2

Velcich, A., Yang, W., Heyer, J., Fragale, A., Nicholas, C., Viani, S., Kucherlapati, R., Lipkin, M., Yang, K., & Augenlicht, L. (2002) · Science · doi:10.1126/science.1069094 · Cited by 936 · see citing works

The intestinal epithelium: central coordinator of mucosal immunity

Allaire, J. M., Crowley, S. M., Law, H. T., Chang, S.-Y., Ko, H.-J., & Vallance, B. A. (2018) · Trends in Immunology · doi:10.1016/j.it.2018.04.002 · Cited by 933 · see citing works

Starving our Microbial Self: The Deleterious Consequences of a Diet Deficient in Microbiota-Accessible Carbohydrates

Sonnenburg, E. D., & Sonnenburg, J. L. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.07.003 · Cited by 871 · see citing works

Translocation of a gut pathobiont drives autoimmunity in mice and humans

Vieira, S. M., Hiltensperger, M., Kumar, V., Zegarra-Ruiz, D. F., Dehner, C. A., Khan, N., Costa, F. R. C., Tiniakou, E., Greiling, T. M., Ruff, W. E., et al. (2018) · Science · doi:10.1126/science.aar7201 · Cited by 843 · see citing works

Commensal bacteria protect against food allergen sensitization

Stefka, A. T., Feehley, T., Tripathi, P., Qiu, J., McCoy, K. D., Mazmanian, S. K., Tjota, M. Y., Seo, G., Cao, S. Z., Theriault, B. R., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412008111 · Cited by 795 · see citing works

Negative Effects of a High-Fat Diet on Intestinal Permeability: A Review

Rohr, M., Narasimhulu, C. A., Rudeski-Rohr, T., & Parthasarathy, S. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz061 · Cited by 766 · see citing works

Gut commensal Parabacteroides goldsteinii plays a predominant role in the anti-obesity effects of polysaccharides isolated from Hirsutella sinensis

Wu, T.-R., Lin, C.-S., Chang, C., Lin, T., Martel, J., Ko, Y., Ojcius, D. M., Lu, C., Young, J. D., & Lai, H. (2018) · Gut · doi:10.1136/gutjnl-2017-315458 · Cited by 757 · see citing works

Shifting the balance: antibiotic effects on host–microbiota mutualism

Willing, B. P., Russell, S. L., & Finlay, B. B. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2536 · Cited by 747 · see citing works

Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

Singh, R., Chandrashekharappa, S., Bodduluri, S. R., Baby, B. V., Hegde, B., Kotla, N. G., Hiwale, A. A., Saiyed, T., Patel, P., Vijay-Kumar, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-018-07859-7 · Cited by 713 · see citing works

Alcohol, liver disease and the gut microbiota

Bajaj, J. S. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0099-1 · Cited by 706 · see citing works

The composition of the gut microbiota shapes the colon mucus barrier

Jakobsson, H. E., Rodríguez‐Piñeiro, A. M., Schütte, A., Ermund, A., Boysen, P., Bemark, M., Sommer, F., Bäckhed, F., Hansson, G. C., & Johansson, M. E. (2015) · The EMBO Reports · doi:10.15252/embr.201439263 · Cited by 700 · see citing works

Gut microbiome pattern reflects healthy ageing and predicts survival in humans

Wilmanski, T. M., Diener, C., Rappaport, N., Patwardhan, S., Wiedrick, J. T., Lapidus, J., Earls, J. C., Zimmer, A., Glusman, G., Robinson, M., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00348-0 · Cited by 693 · see citing works

Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes

Mariño, E., Richards, J. L., McLeod, K. H., Stanley, D., Yap, Y. A., Knight, J., McKenzie, C., Kranich, J., Oliveira, A. C., Rossello, F. J., et al. (2017) · Nature Immunology · doi:10.1038/ni.3713 · Cited by 686 · see citing works

Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier

Kong, J., Zhang, Z., Musch, M. W., Ning, G., Sun, J., Hart, J., Bissonnette, M., & Li, Y. C. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00398.2007 · Cited by 669 · see citing works

Position of the American Dietetic Association: Health Implications of Dietary Fiber

(2008) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2008.08.007 · Cited by 654 · see citing works

Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila

Rera, M., Clark, R. I., & Walker, D. W. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215849110 · Cited by 619 · see citing works

Homeostasis of the gut barrier and potential biomarkers

Wells, J. M., Brummer, R. J., Derrien, M., MacDonald, T. T., Troost, F. J., Cani, P. D., Théodorou, V., Dekker, J. P., Méheust, A., de Vos, W. M., et al. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00048.2015 · Cited by 616 · see citing works

Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism

Vanuytsel, T., van Wanrooy, S., Vanheel, H., Vanormelingen, C., Verschueren, S., Houben, E., Salim Rasoel, S., Tόth, J., Holvoet, L., Farré, R., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-305690 · Cited by 615 · see citing works

The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression.

Maes, M. H. J., Kubera, M., & Leunis, J. (2008) · PubMed · Cited by 607 · see citing works

Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice

Ma, L., Ni, Y., Wang, Z., Tu, W., Ni, L., Zhuge, F., Zheng, A., Hu, L., Zhao, Y., Zheng, L., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1832857 · Cited by 596 · see citing works

How does hormesis impact biology, toxicology, and medicine?

Calabrese, E. J., & Mattson, M. P. (2017) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-017-0013-z · Cited by 593 · see citing works

Energy intake is associated with endotoxemia in apparently healthy men

Amar, J., Burcelin, R., Ruidavets, J. B., Cani, P. D., Fauvel, J., Alessi, M., Chamontin, B., & Ferrières, J. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1219 · Cited by 588 · see citing works

Meta-Analysis of Antibiotics and the Risk of Community-Associated Clostridium difficile Infection

Brown, K. A., Khanafer, N. L., Daneman, N., & Fisman, D. N. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02176-12 · Cited by 588 · see citing works

A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome

Rao, A. V., Bested, A. C., Beaulne, T. M., Katzman, M. A., Iorio, C., Berardi, J. M., & Logan, A. C. (2009) · Gut Pathogens · doi:10.1186/1757-4749-1-6 · Cited by 577 · see citing works

Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease

Wei, M., Brandhorst, S., Shelehchi, M., Mirzaei, H., Cheng, C. W., Budniak, J., Groshen, S., Mack, W. J., Guen, E., Di Biase, S., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aai8700 · Cited by 553 · see citing works

Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment

Liu, Z., Dai, X., Zhang, H., Shi, R., Hui, Y., Jin, X., Zhang, W., Wang, L., Wang, Q., Wang, D., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14676-4 · Cited by 549 · see citing works

A high-fat diet is associated with endotoxemia that originates from the gut

Pendyala, S., Walker, J. M., & Holt, P. R. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.01.034 · Cited by 546 · see citing works

Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis

van der Post, S., Jabbar, K. S., Birchenough, G. M. H., Arike, L., Akhtar, N., Sjövall, H., Johansson, M., & Hansson, G. C. (2019) · Gut · doi:10.1136/gutjnl-2018-317571 · Cited by 540 · see citing works

Western diet induces dysbiosis with increased <i>E coli</i> in CEABAC10 mice <i>,</i> alters host barrier function favouring AIEC colonisation

Martinez-Medina, M., Denizot, J., Dreux, N., Robin, F., Billard, E., Bonnet, R., Darfeuille-Michaud, A., & Barnich, N. (2014) · Gut · doi:10.1136/gutjnl-2012-304119 · Cited by 539 · see citing works

Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess

Bode, C., Kugler, V., & Bode, J. C. (1987) · Journal of Hepatology · doi:10.1016/s0168-8278(87)80003-x · Cited by 529 · see citing works

Structural basis for physiological regulation of paracellular pathways in intestinal epithelia

Madara, J., & Pappenheimer, J. R. (1987) · The Journal of Membrane Biology · doi:10.1007/bf02209147 · Cited by 522 · see citing works

Association of endotoxemia with carotid atherosclerosis and cardiovascular disease

Wiedermann, C. J., Kiechl, S., Dunzendorfer, S., Schratzberger, P., Egger, G., Oberhollenzer, F., & Willeit, J. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00448-9 · Cited by 505 · see citing works

Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis

Tajik, N., Frech, M., Schulz, O., Schälter, F., Lucas, S., Azizov, V., Dürholz, K., Steffen, F., Omata, Y., Rings, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15831-7 · Cited by 504 · see citing works

Hallmarks of Health

López-Otín, C., & Kroemer, G. (2021) · Cell · doi:10.1016/j.cell.2020.11.034 · Cited by 499 · see citing works

The ancestral and industrialized gut microbiota and implications for human health

Sonnenburg, E. D., & Sonnenburg, J. L. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0191-8 · Cited by 489 · see citing works

Host–microbiota interactions in immune-mediated diseases

Ruff, W. E., Greiling, T. M., & Kriegel, M. A. (2020) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0367-2 · Cited by 489 · see citing works

Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C

Cario, E., Gerken, G., & Podolsky, D. K. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.04.015 · Cited by 475 · see citing works

A Meta-Analysis of Probiotic Efficacy for Gastrointestinal Diseases

Ritchie, M. L., & Romanuk, T. N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034938 · Cited by 474 · see citing works

Translocation and dissemination of commensal bacteria in post-stroke infection

Stanley, D., Mason, L. J., Mackin, K. E., Srikhanta, Y. N., Lyras, D., Prakash, M. D., Nurgali, K., Venegas, A., Hill, M. D., Moore, R. J., et al. (2016) · Nature Medicine · doi:10.1038/nm.4194 · Cited by 464 · see citing works

Mechanisms of circulatory and intestinal barrier dysfunction during whole body hyperthermia

Hall, D. M., Buettner, G. R., Oberley, L. W., Xu, L., MATTHES, R. D., & GISOLFI, C. V. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.2.h509 · Cited by 463 · see citing works

Increased IgA and IgM responses against gut commensals in chronic depression: Further evidence for increased bacterial translocation or leaky gut

Maes, M., Kubera, M., Leunis, J.-C., & Berk, M. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.02.023 · Cited by 446 · see citing works

Increased intestinal permeability precedes clinical onset of type 1 diabetes

Bosi, E., Molteni, L., Radaelli, M. G., Folini, L., Fermo, I., Bazzigaluppi, E., Piemonti, L., Pastore, M. R., & Paroni, R. C. (2006) · Diabetologia · doi:10.1007/s00125-006-0465-3 · Cited by 444 · see citing works

Systematic review: exercise‐induced gastrointestinal syndrome—implications for health and intestinal disease

Costa, R. J. S., Snipe, R. M. J., Kitic, C. M., & Gibson, P. R. (2017) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14157 · Cited by 429 · see citing works

Fructan, Rather Than Gluten, Induces Symptoms in Patients With Self-Reported Non-Celiac Gluten Sensitivity

Skodje, G. I., Sarna, V. K., Minelle, I. H., Rolfsen, K. L., Muir, J. G., Gibson, P. R., Veierød, M. B., Henriksen, C., & Lundin, K. E. A. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.10.040 · Cited by 425 · see citing works

Increased intestinal permeability is associated with the development of multiple organ dysfunction syndrome in critically ill ICU patients

DOIG, C. J., SUTHERLAND, L. R., DEAN SANDHAM, J., FICK, G. H., VERHOEF, M., & MEDDINGS, J. B. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.2.9710092 · Cited by 411 · see citing works

Tight junctions as targets of infectious agents

Guttman, J. A., & Finlay, B. B. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.10.028 · Cited by 398 · see citing works

Microbiology of bacterial translocation in humans

O’Boyle, C. J., MacFie, J., Mitchell, C. J., Johnstone, D., Sagar, P. M., & Sedman, P. C. (1998) · Gut · doi:10.1136/gut.42.1.29 · Cited by 393 · see citing works

Celiac Disease and Nonceliac Gluten Sensitivity

Leonard, M. M., Sapone, A., Catassi, C., & Fasano, A. (2017) · JAMA · doi:10.1001/jama.2017.9730 · Cited by 387 · see citing works

Bacteria Penetrate the Inner Mucus Layer before Inflammation in the Dextran Sulfate Colitis Model

Johansson, M. E. V., Gustafsson, J. K., Sjöberg, K. E., Petersson, J., Holm, L., Sjövall, H., & Hansson, G. C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012238 · Cited by 368 · see citing works

Intestinal Permeability Defects: Is It Time to Treat?

Odenwald, M. A., & Turner, J. R. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.07.001 · Cited by 366 · see citing works

Hormetic Dietary Phytochemicals

Son, T. G., Camandola, S., & Mattson, M. P. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8037-y · Cited by 362 · see citing works

Allogenic Fecal Microbiota Transplantation in Patients With Nonalcoholic Fatty Liver Disease Improves Abnormal Small Intestinal Permeability: A Randomized Control Trial

Craven, L. J., Rahman, A., Parvathy, S. N., Beaton, M. D., Silverman, J. D., Qumosani, K. M., HRAMIAK, I. M., Hegele, R., JOY, T. R., Meddings, J. B., et al. (2020) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000661 · Cited by 346 · see citing works

Enhanced translocation of bacteria across metabolically stressed epithelia is reduced by butyrate†

Lewis, K. J., Lutgendorff, F., Phan, V., Söderholm, J. D., Sherman, P. M., & McKay, D. M. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21177 · Cited by 338 · see citing works

Dietary simple sugars alter microbial ecology in the gut and promote colitis in mice

Khan, S., Waliullah, S., Godfrey, V., Khan, M. A. W., Ramachandran, R. A., Cantarel, B. L., Behrendt, C. L., Peng, L., Hooper, L. V., & Zaki, H. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay6218 · Cited by 322 · see citing works

Goblet cells: multifaceted players in immunity at mucosal surfaces

Knoop, K. A., & Newberry, R. D. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0039-y · Cited by 316 · see citing works

Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology

Rangan, P., Choi, I., Wei, M., Navarrete, G., Guen, E., Brandhorst, S., Enyati, N., Pasia, G., Maesincee, D., Ocon, V., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.019 · Cited by 312 · see citing works

A diet-sensitive commensal Lactobacillus strain Mediates TLR7-dependent systemic autoimmunity

Zegarra-Ruiz, D. F., El Beidaq, A., Iñiguez, A. J., Lubrano Di Ricco, M., Manfredo Vieira, S., Ruff, W. E., Mubiru, D., Fine, R. L., Sterpka, J., Greiling, T. M., et al. (2019) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2018.11.009 · Cited by 308 · see citing works

Role of dietary fiber in the recovery of the human gut microbiome and its metabolome

Tanes, C., Bittinger, K. L., Gao, Y., Friedman, E. S., Nessel, L. A., Paladhi, U. R., Chau, L., Panfen, E., Fischbach, M. A., Braun, J. G., et al. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2020.12.012 · Cited by 306 · see citing works

Quercetin Enhances Intestinal Barrier Function through the Assembly of Zonnula Occludens-2, Occludin, and Claudin-1 and the Expression of Claudin-4 in Caco-2 Cells

Suzuki, T., & Hara, H. (2009) · Journal of Nutrition · doi:10.3945/jn.108.100867 · Cited by 303 · see citing works

Role of melatonin in sleep deprivation‐induced intestinal barrier dysfunction in mice

Gao, T., Wang, Z., Dong, Y., Cao, J., Lin, R., Wang, X., Yu, Z., & Chen, Y. (2019) · Journal of Pineal Research · doi:10.1111/jpi.12574 · Cited by 301 · see citing works

Does the use of antibiotics in early childhood increase the risk of asthma and allergic disease?

Droste, J. H. J., Wieringa, M. H., Weyler, J., Nelen, V., Vermeire, P. A., & Bever, H. P. V. (2000) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2000.00939.x · Cited by 288 · see citing works

Gastrointestinal disorders among shift workers

Knutsson, A., & Bøggild, H. (2010) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.2897 · Cited by 286 · see citing works

Bile acids modulate tight junction structure and barrier function of Caco-2 monolayers via EGFR activation

Raimondi, F., Santoro, P., Barone, M. V., Pappacoda, S., Barretta, M. L., Nanayakkara, M., Apicella, C., Capasso, L., & Paludetto, R. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00043.2007 · Cited by 286 · see citing works

Epicutaneous Application of Toll‐like Receptor 7 Agonists Leads to Systemic Autoimmunity in Wild‐Type Mice: A New Model of Systemic Lupus Erythematosus

Yokogawa, M., Takaishi, M., Nakajima, K., Kamijima, R., Fujimoto, C., Kataoka, S., Terada, Y., & Sano, S. (2013) · Arthritis & Rheumatology · doi:10.1002/art.38298 · Cited by 285 · see citing works

Epithelial Barrier Dysfunction: A Unifying Theme to Explain the Pathogenesis of Multiple Organ Dysfunction at the Cellular Level

Fink, M. P., & Delude, R. L. (2005) · Critical Care Clinics · doi:10.1016/j.ccc.2005.01.005 · Cited by 280 · see citing works

Hormesis: A Generalizable and Unifying Hypothesis

Calabrese, E. J., & Baldwin, L. A. (2001) · Critical Reviews in Toxicology · doi:10.1080/20014091111730 · Cited by 273 · see citing works

Protective role of 1,25(OH)2vitamin D3 in the mucosal injury and epithelial barrier disruption in DSS-induced acute colitis in mice

Zhao, H., Zhang, H., Wu, H., Li, H., Liu, L., Guo, J. X., Li, C., Shih, D. Q., & Zhang, X. (2012) · BMC Gastroenterology · doi:10.1186/1471-230x-12-57 · Cited by 272 · see citing works

Pathophysiological Mechanisms of Stress-Induced Intestina Damage

Gareau, M., Silva, M., & Perdue, M. (2008) · Current Molecular Medicine · doi:10.2174/156652408784533760 · Cited by 268 · cited 1× · see citing works

Human Gut-Derived Commensal Bacteria Suppress CNS Inflammatory and Demyelinating Disease

Mangalam, A., Shahi, S. K., Luckey, D., Karau, M., Marietta, E., Luo, N., Choung, R. S., Ju, J., Sompallae, R., Gibson-Corley, K., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.07.031 · Cited by 266 · see citing works

Daily eating patterns and their impact on health and disease

Zarrinpar, A., Chaix, A., & Panda, S. (2016) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/j.tem.2015.11.007 · Cited by 263 · see citing works

Fructose Promotes Leaky Gut, Endotoxemia, and Liver Fibrosis Through Ethanol‐Inducible Cytochrome P450‐2E1–Mediated Oxidative and Nitrative Stress

Cho, Y., Kim, D., Seo, W., Gao, B., Yoo, S., & Song, B. (2019) · Hepatology · doi:10.1002/hep.30652 · Cited by 260 · see citing works

Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus

Llorente, C., Jepsen, P., Inamine, T., Wang, L., Bluemel, S., Wang, H. J., Loomba, R., Bajaj, J. S., Schubert, M. L., Sikaroodi, M., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00796-x · Cited by 257 · see citing works

Disruption of the Circadian Clock in Mice Increases Intestinal Permeability and Promotes Alcohol-Induced Hepatic Pathology and Inflammation

Summa, K. C., Voigt, R. M., Forsyth, C. B., Shaikh, M. W., Cavanaugh, K. E., Tang, Y., Vitaterna, M. H., Song, S., Turek, F. W., & Keshavarzian, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067102 · Cited by 254 · see citing works

Effects of obesity on depression: A role for inflammation and the gut microbiota

Schachter, J., Martel, J., Lin, C.-S., Chang, C., Wu, T.-R., Lu, C., Ko, Y., Lai, H., Ojcius, D. M., & Young, J. D. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.08.026 · Cited by 252 · see citing works

Strategies to improve drug development for sepsis

Fink, M. P., & Warren, H. S. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4368 · Cited by 243 · see citing works

Multicenter Trial of a Combination Probiotic for Children with Gastroenteritis

Freedman, S. B., Williamson-Urquhart, S., Farion, K. J., Gouin, S., Willan, A. R., Poonai, N., Hurley, K. F., Sherman, P. M., Finkelstein, Y., Lee, B. E., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1802597 · Cited by 239 · see citing works

Age-associated Impairment of the Mucus Barrier Function is Associated with Profound Changes in Microbiota and Immunity

Sovran, B., Hugenholtz, F., Elderman, M. E., van Beek, A. A., Graversen, K., Huijskes, M., Boekschoten, M. V., Savelkoul, H. F. J., de Vos, P., Dekker, J. P., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-35228-3 · Cited by 237 · see citing works

Intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease

Uhde, M., Ajamian, M., Caio, G., GIORGIO, R. D., Indart, A. C., Green, P. H., Verna, E. C., Volta, U., & Alaedini, A. (2016) · Gut · doi:10.1136/gutjnl-2016-311964 · Cited by 232 · see citing works

Curcumin improves intestinal barrier function: modulation of intracellular signaling, and organization of tight junctions

Wang, J., Ghosh, S. S., & Ghosh, S. (2017) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00235.2016 · Cited by 225 · see citing works

Antibiotics induced intestinal tight junction barrier dysfunction is associated with microbiota dysbiosis, activated NLRP3 inflammasome and autophagy

Feng, Y., Huang, Y., Wang, Y., Wang, P., Song, H., & Wang, F. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218384 · Cited by 225 · see citing works

TNFα-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, Akt and NFκB signaling

Amasheh, M., Fromm, A., Krug, S. M., Amasheh, S., Andres, S., Zeitz, M., Fromm, M., & Schulzke, J. (2010) · Journal of Cell Science · doi:10.1242/jcs.070896 · Cited by 224 · see citing works

A novel mechanism for gut barrier dysfunction by dietary fat: epithelial disruption by hydrophobic bile acids

Stenman, L. K., Holma, R., Eggert, A., & Korpela, R. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00267.2012 · Cited by 222 · see citing works

Effect of Gliadin on Permeability of Intestinal Biopsy Explants from Celiac Disease Patients and Patients with Non-Celiac Gluten Sensitivity

Hollon, J. R., Puppa, E. L., Greenwald, B. D., Goldberg, E., Guerrerio, A. L., & Fasano, A. (2015) · Nutrients · doi:10.3390/nu7031565 · Cited by 221 · see citing works

Loss of gut barrier integrity triggers activation of islet-reactive T cells and autoimmune diabetes

Sorini, C., Cosorich, I., Conte, M. L., Giorgi, L. D., Facciotti, F., Lucianò, R., Rocchi, M., Ferrarese, R., Sanvito, F., Canducci, F., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1814558116 · Cited by 220 · see citing works

Circadian Disruption Changes Gut Microbiome Taxa and Functional Gene Composition

Deaver, J. A., Eum, S. Y., & Toborek, M. J. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00737 · Cited by 218 · see citing works

Metabolic and cardiovascular consequences of shift work: The role of circadian disruption and sleep disturbances

Kervezee, L., Kosmadopoulos, A., & Boivin, D. B. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14216 · Cited by 216 · see citing works

<i>Lactobacillus rhamnosus</i> GG versus Placebo for Acute Gastroenteritis in Children

Schnadower, D., Tarr, P. I., Casper, T. C., Gorelick, M. H., Dean, J. M., O’Connell, K. J., Mahajan, P., Levine, A. C., Bhatt, S. R., Roskind, C. G., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1802598 · Cited by 208 · see citing works

The ancestral human diet: what was it and should it be a paradigm for contemporary nutrition?

Eaton, S. B. (2006) · Proceedings of The Nutrition Society · doi:10.1079/pns2005471 · Cited by 201 · see citing works

Gastroenterology Issues in Schizophrenia: Why the Gut Matters

Severance, E. G., Prandovszky, E., Castiglione, J., & Yolken, R. H. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-015-0574-0 · Cited by 196 · see citing works

Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway

He, D. N., Wu, H., Xiang, J., Ruan, X., Peng, P., Ruan, Y., Chen, Y., Wang, Y., Yu, Q., Zhang, H., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13911-x · Cited by 196 · see citing works

Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome

Zhou, Q., Verne, M. L., Fields, J. Z., Lefante, J. J., Basra, S., Salameh, H., & Verne, G. N. (2019) · Gut · doi:10.1136/gutjnl-2017-315136 · Cited by 195 · see citing works

A high-sugar diet rapidly enhances susceptibility to colitis via depletion of luminal short-chain fatty acids in mice

Laffin, M., Fedorak, R., Zalasky, A., Park, H., Gill, A., Agrawal, A., Keshteli, A. H., Hotte, N., & Madsen, K. L. (2019) · Scientific Reports · doi:10.1038/s41598-019-48749-2 · Cited by 193 · see citing works

Tight junctions as targets and effectors of mucosal immune homeostasis

Zuo, L., Kuo, W.-T., & Turner, J. R. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.04.001 · Cited by 191 · see citing works

Plasma Markers of Disrupted Gut Permeability in Severe COVID-19 Patients

Giron, L. B., Dweep, H., Yin, X., Wang, H., Damra, M., Goldman, A. R., Gorman, N., Palmer, C. S., Tang, H., Shaikh, M. W., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.686240 · Cited by 191 · see citing works

Intestinal permeability and inflammation in patients on NSAIDs

Sigthorsson, G., Tibble, J. A., Hayllar, J. S., Menzies, I. S., Macpherson, A. J., Moots, R. J., Scott, D. L., Gumpel, M., & Bjarnason, I. (1998) · Gut · doi:10.1136/gut.43.4.506 · Cited by 190 · see citing works

Age-associated modifications of intestinal permeability and innate immunity in human small intestine.

Man, A., Bertelli, E., Rentini, S., Regoli, M., Briars, G., Marini, M., Watson, A., & Nicoletti, C. (2015) · Clinical science · doi:10.1042/cs20150046 · Cited by 189 · see citing works

Leaky gut biomarkers in depression and suicidal behavior

Ohlsson, L., Gustafsson, A., Lavant, E. H., Suneson, K., Brundin, L., Westrin, Å., Ljunggren, L., & Lindqvist, D. (2018) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12978 · Cited by 181 · see citing works

Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis

Graham, W. V., He, W., Marchiando, A. M., Zha, J., Singh, G., Li, H.-S., Biswas, A., Ong, M. L. D. M., Jiang, Z.-H., Choi, W., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0393-7 · Cited by 176 · see citing works

Effects of vitamin D supplementation on intestinal permeability, cathelicidin and disease markers in Crohn's disease: Results from a randomised double‐blind placebo‐controlled study

Raftery, T. C., Martineau, A. R., Greiller, C. L., Ghosh, S. K., McNamara, D. A., Bennett, K., Meddings, J. B., & OʼSullivan, M. (2015) · United European Gastroenterology Journal · doi:10.1177/2050640615572176 · Cited by 175 · see citing works

Intestinal barrier dysfunction as a therapeutic target for cardiovascular disease

Lewis, C., & Taylor, W. R. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00612.2020 · Cited by 174 · see citing works

Stress triggers flare of inflammatory bowel disease in children and adults

Sun, Y., Li, L., Xie, R., Wang, B., Jiang, K., & Cao, H. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00432 · Cited by 171 · see citing works

Effect of caloric restriction on gut permeability, inflammation markers, and fecal microbiota in obese women

Ott, B., Skurk, T., Hastreiter, L., Lagkouvardos, I., Fischer, S., Büttner, J., Kellerer, T., Clavel, T., Rychlik, M., Haller, D., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-12109-9 · Cited by 170 · see citing works

Chronic cigarette smoke exposure induces systemic hypoxia that drives intestinal dysfunction

Fricker, M., Goggins, B. J., Mateer, S. W., Jones, B., Kim, R., Gellatly, S. L., Jarnicki, A., Powell, N., Oliver, B. G. G., Radford‐Smith, G. L., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.94040 · Cited by 169 · see citing works

Rapid barrier restitution in an in vitro model of intestinal epithelial injury.

Moore, R., Carlson, S., & Jl, M. (1989) · PubMed · Cited by 166 · see citing works

Alteration of Gastrointestinal Mucin by Fiber Feeding in Rats

Satchithanandam, S., Vargofcak-Apker, M., Calvert, R. J., Leeds, A., & CASSIDY, M. M. (1990) · Journal of Nutrition · doi:10.1093/jn/120.10.1179 · Cited by 165 · see citing works

Intestinal Permeability Biomarker Zonulin is Elevated in Healthy Aging

Qi, Y., Goel, R., Kim, S., Richards, E. M., Carter, C. S., Pepine, C. J., Raizada, M. K., & Buford, T. W. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.05.018 · Cited by 165 · see citing works

Gut integrity in critical illness

Otani, S., & Coopersmith, C. M. (2019) · Journal of Intensive Care · doi:10.1186/s40560-019-0372-6 · Cited by 165 · see citing works

Hormetic Effects of Phytochemicals on Health and Longevity

Martel, J., Ojcius, D. M., Ko, Y., Ke, P., Wu, C.-Y., Peng, H., & Young, J. D. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.04.001 · Cited by 163 · see citing works

Food without fiber promotes bacterial translocation from the gut.

Spaeth, G., Berg, R. D., Specian, R. D., & Deitch, E. A. (1990) · PubMed · Cited by 160 · see citing works

Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension

Catterson, J. H., Khericha, M., Dyson, M. C., Vincent, A. J., Callard, R., Haveron, S. M., Rajasingam, A., Ahmad, M., & Partridge, L. (2018) · Current Biology · doi:10.1016/j.cub.2018.04.015 · Cited by 154 · see citing works

Stress disrupts intestinal mucus barrier in rats via mucin O-glycosylation shift: prevention by a probiotic treatment

Silva, S. D., Masselot, C. R., Ait-Belgnaoui, A., Mancuso, A., Mercade, M., Salvador–Cartier, C., Gillet, M., Ferrier, L., Loubière, P., Dague, É., et al. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00290.2013 · Cited by 147 · see citing works

Neonatal maternal separation of rat pups results in abnormal cholinergic regulation of epithelial permeability

Gareau, M. G., Jury, J., & Perdue, M. H. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00392.2006 · Cited by 147 · see citing works

Current status of bacterial translocation as a cause of surgical sepsis

MacFie, J. (2004) · British Medical Bulletin · doi:10.1093/bmb/ldh029 · Cited by 145 · see citing works

Probiotic reduces bacterial translocation in type 2 diabetes mellitus: A randomised controlled study

Sato, J., Kanazawa, A., Azuma, K., Ikeda, F., Goto, H., Komiya, K., Kanno, R., Tamura, Y., Asahara, T., Takahashi, T., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-12535-9 · Cited by 145 · see citing works

Regulation of TH17 Cells and Associated Cytokines in Wound Healing, Tissue Regeneration, and Carcinogenesis

Brockmann, L., Giannou, A. D., Gagliani, N., & Huber, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18051033 · Cited by 143 · see citing works

SYSTEMIC INFLAMMATION INCREASES INTESTINAL PERMEABILITY DURING EXPERIMENTAL HUMAN ENDOTOXEMIA

Hietbrink, F., Besselink, M. G., Renooij, W., de Smet, M. D., Draisma, A., van der Hoeven, H., & Pickkers, P. (2009) · Shock · doi:10.1097/shk.0b013e3181a2bcd6 · Cited by 142 · see citing works

NAD ⁺ supplementation rejuvenates aged gut adult stem cells

Igarashi, M., Miura, M., Williams, E., Jaksch, F., Kadowaki, T., Yamauchi, T., & Guarente, L. (2019) · Aging Cell · doi:10.1111/acel.12935 · Cited by 138 · see citing works

Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet-induced systemic inflammation, microglial activation, and reduced neuroplasticity

Jena, P. K., Sheng, L., Di Lucente, J., Jin, L., Maezawa, I., & Wan, Y. Y. (2018) · The FASEB Journal · doi:10.1096/fj.201700984rr · Cited by 134 · see citing works

Intestinal Permeability and IgA Provoke Immune Vasculitis Linked to Cardiovascular Inflammation

Rivas, M. N., Wakita, D., Franklin, M. K., de Carvalho, T. T., Abolhesn, A., Gomez, A. C., Fishbein, M. C., Chen, S., Lehman, T. J. A., Satoh, K., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.05.021 · Cited by 132 · see citing works

Mild Endotoxaemia and the Inflammatory Response Induced by a Marathon Race

Camus, G., Poortmans, J.-R., Nys, M., Deby-Dupont, G. P., Duchateau, J., Deby, C. M. T., & Lamy, M. (1997) · Clinical Science · doi:10.1042/cs0920415 · Cited by 131 · see citing works

Intestinal Bacteria Composition and Translocation of Bacteria in Inflammatory Bowel Disease

Vrakas, S., Mountzouris, K. C., Michalopoulos, G., Karamanolis, G. P., Papatheodoridis, G., Tzathas, C., & Gazouli, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170034 · Cited by 130 · see citing works

Enteric dysbiosis-linked gut barrier disruption triggers early renal injury induced by chronic high salt feeding in mice

Hu, J., Luo, H., Wang, J., Tang, W., Lu, J., Wu, S., Xiong, Z., Yang, G., Chen, Z., Lan, T., et al. (2017) · Experimental &amp; Molecular Medicine · doi:10.1038/emm.2017.122 · Cited by 126 · see citing works

Mechanisms and consequences of gut commensal translocation in chronic diseases

Fine, R. L., Vieira, S. M., Gilmore, M. S., & Kriegel, M. A. (2019) · Gut Microbes · doi:10.1080/19490976.2019.1629236 · Cited by 123 · see citing works

Corticosterone mediates stress‐related increased intestinal permeability in a region‐specific manner

Zheng, G., Wu, S.-P., Hu, Y., Smith, D. E., Wiley, J. W., & Hong, S. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12066 · Cited by 122 · see citing works

Circulatory endotoxin concentration and cytokine profile in response to exertional-heat stress during a multi-stage ultra-marathon competition.

Gill, S. K., Teixeira, A. M., Rama, L. M. P. L., Prestes, J., Rosado, F., Hankey, J., Scheer, V., Hemmings, K., Robson-Ansley, P. J., & Costa, R. J. S. (2015) · PubMed · Cited by 121 · see citing works

Increased Gut Permeability and Bacterial Translocation after Chronic Chlorpyrifos Exposure in Rats

Condette, C. J., Khorsi‐Cauet, H., Morlière, P., Zabijak, L., Reygner, J., Bach, V., & Gay‐Queheillard, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102217 · Cited by 121 · see citing works

The JAK-Inhibitor Tofacitinib Rescues Human Intestinal Epithelial Cells and Colonoids from Cytokine-Induced Barrier Dysfunction

Sayoc-Becerra, A., Krishnan, M., Fan, S., Jimenez, J. L., Hernandez, R., Gibson, K., Preciado, R., Butt, G., & McCole, D. F. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izz266 · Cited by 121 · see citing works

Bacterial translocation: the influence of dietary variables.

Deitch, E. A. (1994) · Gut · doi:10.1136/gut.35.1_suppl.s23 · Cited by 120 · see citing works

Intestinal barrier dysfunction plays an integral role in arthritis pathology and can be targeted to ameliorate disease

Matei, D. E., Menon, M., Alber, D., Smith, A. M., Nedjat-Shokouhi, B., Fasano, A., Magill, L., Duhlin, A., Bitoun, S., Gleizes, A., et al. (2021) · Med · doi:10.1016/j.medj.2021.04.013 · Cited by 119 · see citing works

Relationship between gut microbiota and development of T cell associated disease

Kosiewicz, M. M., Dryden, G. W., Chhabra, A., & Alard, P. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.03.019 · Cited by 118 · see citing works

The Microbiota-Gut-Immune-Glia (MGIG) Axis in Major Depression

Rudzki, L., & Maes, M. H. J. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01961-y · Cited by 114 · see citing works

Food Deprivation and Refeeding Influence Growth, Nutrient Retention and Functional Recovery of Rats

Bozá, J., Moënnoz, D., Vuichoud, J., Jarret, A. R., Weck-Gaudard, D. D., Fritsché, R., Donnet, A., Schiffrin, E. J., Perruisseau, G., & Ballèvre, O. P. (1999) · Journal of Nutrition · doi:10.1093/jn/129.7.1340 · Cited by 112 · see citing works

The Intestinal Epithelial Insulin-Like Growth Factor-1 Receptor Links Glucagon-Like Peptide-2 Action to Gut Barrier Function

Dong, C. X., Zhao, W. T., Solomon, C. J., Rowland, K., Ackerley, C. A., Robine, S., Holzenberger, M., Gonska, T. Y., & Brubaker, P. L. (2013) · Endocrinology · doi:10.1210/en.2013-1871 · Cited by 109 · see citing works

Acrolein Disrupts Tight Junction Proteins and Causes Endoplasmic Reticulum Stress-Mediated Epithelial Cell Death Leading to Intestinal Barrier Dysfunction and Permeability

Chen, W.-Y., Wang, M., Zhang, J., Barve, S. S., McClain, C. J., & Joshi‐Barve, S. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.08.015 · Cited by 109 · see citing works

Targeting α-7 Nicotinic Acetylcholine Receptor in the Enteric Nervous System

Costantini, T. W., Krzyżaniak, M., Cheadle, G. A., Putnam, J. G., Hageny, A., Lopez, N., Eliceiri, B. P., Bansal, V., & Coimbra, R. S. M. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.04.005 · Cited by 107 · see citing works

Bulk Prevents Bacterial Translocation Induced by the Oral Administration of Total Parenteral Nutrition Solution

Spaeth, G., Specian, R. D., Berg, R. D., et al. (1990) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607190014005442 · Cited by 105 · see citing works

Two phases of aging separated by the Smurf transition as a public path to death

Dambroise, E., Monnier, L., Ruisheng, L., Aguilaniu, H., Joly, J., Tricoire, H., & Rera, M. (2016) · Scientific Reports · doi:10.1038/srep23523 · Cited by 105 · see citing works

Curcumin prevents high-fat diet-induced hepatic steatosis in ApoE−/− mice by improving intestinal barrier function and reducing endotoxin and liver TLR4/NF-κB inflammation

Feng, D., Zou, J., Su, D., Mai, H., Zhang, S., Li, P., & Zheng, X. (2019) · Nutrition & Metabolism · doi:10.1186/s12986-019-0410-3 · Cited by 105 · see citing works

Artificial Sweeteners Disrupt Tight Junctions and Barrier Function in the Intestinal Epithelium through Activation of the Sweet Taste Receptor, T1R3

Shil, A., Olusanya, O., Ghufoor, Z., Forson, B., Marks, J., & Chichger, H. (2020) · Nutrients · doi:10.3390/nu12061862 · Cited by 103 · see citing works

Phytochemicals as Prebiotics and Biological Stress Inducers

Martel, J., Ojcius, D. M., Ko, Y., & Young, J. D. (2020) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2020.02.008 · Cited by 102 · see citing works

Potato Glycoalkaloids Adversely Affect Intestinal Permeability and Aggravate Inflammatory Bowel Disease

Patel, B., Schutte, R. J., Sporns, P., et al. (2002) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200209000-00005 · Cited by 100 · see citing works

Alterations in Intestinal Permeability: The Role of the “Leaky Gut” in Health and Disease

Stewart, A. S., Pratt-Phillips, S. E., & Gonzalez, L. M. (2017) · Journal of Equine Veterinary Science · doi:10.1016/j.jevs.2017.02.009 · Cited by 100 · see citing works

Over-the-counter mouthwash use and risk of pre-diabetes/diabetes

JOSHIPURA, K. J., Muñoz‐Torres, F. J., Morou-Bermúdez, E., & Patel, R. P. (2017) · Nitric Oxide · doi:10.1016/j.niox.2017.09.004 · Cited by 100 · see citing works

Identification of Bacterial DNA in the Peripheral Blood of Patients With Active Psoriasis

Ramírez-Boscá, A., Navarro‐López, V., Martínez‐Andrés, A., Such, J. M., Francés, R., de la Parte, J. H., & Asín‐Llorca, M. (2015) · JAMA Dermatology · doi:10.1001/jamadermatol.2014.5585 · Cited by 99 · see citing works

Dietary fructose induces endotoxemia and hepatic injury in calorically controlled primates

Kavanagh, K., Wylie, A. T., Tucker, K. L., Hamp, T. J., Gharaibeh, R. Z., Fodor, A. A., & Cullen, J. M. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.057331 · Cited by 99 · see citing works

Gut Permeability Might be Improved by Dietary Fiber in Individuals with Nonalcoholic Fatty Liver Disease (NAFLD) Undergoing Weight Reduction

Krawczyk, M. J., Maciejewska, D., Ryterská, K., Czerwińska-Rogowska, M., Jamioł-Milc, D., Skonieczna‐Żydecka, K., Milkiewicz, P., Raszeja‐Wyszomirska, J., & Stachowska, E. (2018) · Nutrients · doi:10.3390/nu10111793 · Cited by 98 · see citing works

Cigarette smoking is associated with intestinal barrier dysfunction in the small intestine but not in the large intestine of mice

Zuo, L., Li, Y., Wang, H., Wu, R., Zhu, W., Zhang, W., Cao, L., Gu, L., Gong, J., Li, N., et al. (2014) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2014.08.008 · Cited by 94 · see citing works

Starvation Compromises Paneth Cells

Hodin, C. M. I. M., Lenaerts, K., Grootjans, J., de Haan, J. J., Hadfoune, M., Verheyen, F., Kiyama, H., Heineman, E., & Buurman, W. A. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.08.030 · Cited by 93 · see citing works

A Transient Breach in the Epithelial Barrier Leads to Regulatory T-Cell Generation and Resistance to Experimental Colitis

Boirivant, M., Amendola, A., Butera, A., Sanchez, M., Xu, L., Marinaro, M., Kitani, A., Giacinto, C. D., Strober, W., & Fuss, I. J. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.07.028 · Cited by 91 · see citing works

Stimulating the Central Nervous System to Prevent Intestinal Dysfunction After Traumatic Brain Injury

Bansal, V., Costantini, T. W., Ryu, S. Y., Peterson, C. Y., Loomis, W. H., Putnam, J., Elicieri, B. P., Baird, A., & Coimbra, R. S. M. (2010) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e3181d87373 · Cited by 91 · see citing works

Vasoactive intestinal peptide ameliorates intestinal barrier disruption associated with Citrobacter rodentium -induced colitis

Conlin, V. S., Wu, X., Nguyen, C. P., et al. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90551.2008 · Cited by 91 · see citing works

Man and the Microbiome: A New Theory of Everything?

Butler, M., Cryan, J. F., & Dinan, T. G. (2019) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050718-095432 · Cited by 91 · see citing works

Genetic variation in IBD: progress, clues to pathogenesis and possible clinical utility

Ye, B. D., & McGovern, D. P. B. (2016) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2016.1184972 · Cited by 89 · see citing works

Family history of inflammatory bowel disease among patients with ulcerative colitis: A systematic review and meta-analysis

Childers, R. E., Eluri, S., Vazquez, C., Weise, R. M., Bayless, T. M., & Hutfless, S. M. (2014) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2014.05.008 · Cited by 88 · see citing works

Significant positive association of endotoxemia with histological severity in 237 patients with non‐alcoholic fatty liver disease

Pang, J., Xu, W., Zhang, X., Wong, G. L., Chan, A. W. H., Chan, H., Tse, C., Shu, S. S., Choi, P. C., Chan, H. L., et al. (2017) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14119 · Cited by 88 · see citing works

Role of non-steroidal anti-inflammatory drugs on intestinal permeability and nonalcoholic fatty liver disease

Utzeri, E., & Usai, P. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i22.3954 · Cited by 86 · see citing works

Influence of Fasting on Intestinal Permeability and Disease Activity in Patients with Rheumatoid Arthritis

Sundqvist, T., Lindström, F. D., Magnusson, K., et al. (1982) · Scandinavian Journal of Rheumatology · doi:10.3109/03009748209098111 · Cited by 85 · see citing works

Changes in Intestinal Glucocorticoid Sensitivity in Early Life Shape the Risk of Epithelial Barrier Defect in Maternal-Deprived Rats

Moussaoui, N., Braniste, V., Ait-Belgnaoui, A., Gabanou, M., Sekkal, S., Olier, M., Théodorou, V., Martin, P. G. P., & Houdeau, É. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088382 · Cited by 83 · see citing works

Zonulin transgenic mice show altered gut permeability and increased morbidity/mortality in the DSS colitis model

Sturgeon, C., Lan, J., & Fasano, A. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13343 · Cited by 82 · see citing works

Resveratrol Ameliorates Intestinal Barrier Defects and Inflammation in Colitic Mice and Intestinal Cells

Mayangsari, Y., & Suzuki, T. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b04138 · Cited by 82 · see citing works

Efferent Vagal Nerve Stimulation Attenuates Gut Barrier Injury After Burn: Modulation of Intestinal Occludin Expression

Costantini, T. W., Bansal, V., Peterson, C. Y., Loomis, W. H., Putnam, J. G., Rankin, F., Wolf, P. L., Eliceiri, B. P., Baird, A., & Coimbra, R. S. M. (2010) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e3181dccea0 · Cited by 81 · see citing works

Efficacy of probiotics on anxiety-A meta-analysis of randomized controlled trials

Liu, B., He, Y., Wang, M., Liu, J., Ju, Y., Zhang, Y., Liu, T., Li, L., & Li, Q. (2018) · Depression and Anxiety · doi:10.1002/da.22811 · Cited by 81 · see citing works

Abdominal radiation causes bacterial translocation

Guzman‐Stein, G., Bonsack, M. E., Liberty, J., & Delaney, J. P. (1989) · Journal of Surgical Research · doi:10.1016/0022-4804(89)90211-4 · Cited by 80 · see citing works

Myosin Light Chain Kinase Mediates Intestinal Barrier Disruption following Burn Injury

Chen, C., Wang, P., Su, Q., Wang, S., & Wang, F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034946 · Cited by 79 · see citing works

Impact of Glycemic Control on Risk of Infections in Patients With Type 2 Diabetes: A Population-Based Cohort Study

Mor, A., Dekkers, O. M., Nielsen, J. S., Beck‐Nielsen, H., Sørensen, H. T., & Thomsen, R. W. (2017) · American Journal of Epidemiology · doi:10.1093/aje/kwx049 · Cited by 75 · see citing works

Mechanisms of intestinal tight junctional disruption during infection

O’Hara, J. R., & Ag, B. (2008) · Frontiers in bioscience · doi:10.2741/3206 · Cited by 72 · see citing works

Hormesis in Health and Chronic Diseases

Li, X., Yang, T., & Sun, Z. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.08.007 · Cited by 72 · see citing works

Intestinal Barrier Function and Weight Gain in Malnourished Children Taking Glutamine Supplemented Enteral Formula

Lima, A. Â. M., Brito, L. F. B., Ribeiro, H. B., Martins, M. C. V., Lustosa, A. M. P., Rocha, E. M., Lima, N. L. L., Monte, C. M. G., & Guerrant, R. L. (2004) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200501000-00006 · Cited by 71 · see citing works

Fermented barley and soybean (BS) mixture enhances intestinal barrier function in dextran sulfate sodium (DSS)-induced colitis mouse model

Woo, J. K., Choi, S., Kang, J., Kim, D. E., Hurh, B., Jeon, J.-E., Kim, S. Y., & Oh, S. H. (2016) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-1479-0 · Cited by 71 · see citing works

Mesalamine and azathioprine modulate junctional complexes and restore epithelial barrier function in intestinal inflammation

Khare, V., Krnjic, A., Frick, A., Gmainer, C., Asboth, M., Jimenez, K., Lang, M., Baumgartner, M., Evstatiev, R., & Gasche, C. (2019) · Scientific Reports · doi:10.1038/s41598-019-39401-0 · Cited by 70 · see citing works

Modulation of tight junction integrity by food components

Kosińska, A., & Andlauer, W. (2012) · Food Research International · doi:10.1016/j.foodres.2012.12.038 · Cited by 69 · see citing works

Hydrogen-Rich Saline Regulates Intestinal Barrier Dysfunction, Dysbiosis, and Bacterial Translocation in a Murine Model of Sepsis

Ikeda, M., Shimizu, K., Ogura, H., Kurakawa, T., Umemoto, E., Motooka, D., Nakamura, S., Ichimaru, N., Takeda, K., Takahara, S., et al. (2017) · Shock · doi:10.1097/shk.0000000000001098 · Cited by 69 · see citing works

Gut flora-targeted photobiomodulation therapy improves senile dementia in an Aß-induced Alzheimer’s disease animal model

Chen, Q., Wu, J., Dong, X., Yin, H., Shi, X., Su, S., Che, B., Li, Y., & Yang, J. (2021) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2021.112152 · Cited by 69 · see citing works

Anti-TNF-α antibodies improve intestinal barrier function in Crohn's disease

Noth, R., Stüber, E., Häsler, R., Nikolaus, S., Kühbacher, T., Hampe, J., Bewig, B., Schreiber, S., & Arlt, A. (2012) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2011.10.004 · Cited by 68 · see citing works

Efficacy of probiotics on stress in healthy volunteers: A systematic review and meta-analysis based on randomized controlled trials

Zhang, N., Zhang, Y., Li, M., Wang, W., Liu, Z., Xi, C., Huang, X., Liu, J., Huang, J., Tian, D., et al. (2020) · Brain and Behavior · doi:10.1002/brb3.1699 · Cited by 67 · see citing works

Shift work increases the frequency of duodenal ulcer in<i>H pylori</i>infected workers

Pietroiusti, A., Forlini, A., Magrini, A., Galante, A., Coppeta, L., Gemma, G., Romeo, E., & Bergamaschi, A. (2006) · Occupational and Environmental Medicine · doi:10.1136/oem.2006.027367 · Cited by 65 · see citing works

Do dietary lectins cause disease?

Freed, D. L. J. (1999) · BMJ · doi:10.1136/bmj.318.7190.1023 · Cited by 63 · see citing works

Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis

Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works

Immunopathogenic mechanisms and immunoregulatory therapies in MASLD

He, Y., Chen, Y., Qian, S., van Der Merwe, S., Dhar, D., Brenner, D. A., & Tacke, F. (2025) · Cellular &amp; Molecular Immunology · doi:10.1038/s41423-025-01307-5 · Cited by 81 · see citing works

Gut hormones in microbiota-gut-brain cross-talk

Sun, L.-J., Li, J.-N., & Nie, Y.-Z. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000706 · Cited by 145 · see citing works

Quercetin improves gut dysbiosis in antibiotic-treated mice

Shi, T., Bian, X., Yao, Z., Wang, Y., Gao, W., & Guo, C. (2020) · Food & Function · doi:10.1039/d0fo01439g · Cited by 130 · see citing works

Gut microbiota dysbiosis in rats with LPS-induced liver diseases affected by Aronia melanocarpa polyphenols

Kong, Y., Li, D., & Meng, X. (2023) · Food Science and Technology · doi:10.5327/fst.130622 · Cited by 1 · see citing works

Metagenomic and metabolomic analyses unveil dysbiosis of gut microbiota in chronic heart failure patients

Cui, X., Ye, L., Li, J., Jin, L., Wang, W., Li, S., Bao, M., Wu, S., Li, L., Geng, B., et al. (2018) · Scientific Reports · doi:10.1038/s41598-017-18756-2 · Cited by 373 · see citing works

The potential of human milk oligosaccharides to impact the microbiota-gut-brain axis through modulation of the gut microbiota

Al-Khafaji, A. H., Jepsen, S. D., Christensen, K. R., & Vigsnæs, L. K. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104176 · Cited by 59 · see citing works