Cited by 357Nutrition and Health StudiesTrace Elements in HealthIron Metabolism and Disorders

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Micronutrients in health and disease

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Shenkin, A·2006·Postgraduate Medical Journal

DOI 10.1136/pgmj.2006.047670PMC PMC2585731

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Abstract

Micronutrients play a central part in metabolism and in the maintenance of tissue function. An adequate intake therefore is necessary, but provision of excess supplements to people who do not need them may be harmful. Single micronutrient deficiency states are comparatively easily recognised and treated. Subclinical deficiency, often of multiple micronutrients, is more difficult to recognise, and laboratory assessment is often complicated by the acute phase response. Clinical benefit is most likely in those people who are severely depleted and at risk of complications, and is unlikely if this is not the case. There is little evidence for supplements leading to a reduction in the incidence of infections in the elderly population, in coronary artery disease, or in malignant disease. The best evidence for benefit is in critical illness, and in children in developing countries consuming a deficient diet. More clinical trials are required with good clinical outcomes to optimise intake in prevention and treatment of disease.

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Authors: Shenkin, A.
Affiliations: University of Liverpool (GB)
Corresponding author: Shenkin, A
Venue: Postgraduate Medical Journal
Publisher: Oxford University Press (OUP)
Published: 2006-09-01
Volume: 82
Issue: 971
Pages: 559-567
ISSN: 0032-5473 (ISSN-L)
1469-0756
DOI: 10.1136/pgmj.2006.047670
PMC: PMC2585731
OpenAlex: W2112473561
Cited by: 357
References: 99
Citations by year: 2026: 11 · 2025: 36 · 2024: 38 · 2023: 37 · 2022: 36 · 2021: 34 · 2020: 36 · 2019: 21 · 2018: 16 · 2017: 16 · 2016: 13 · 2015: 9 · 2014: 14 · 2013: 6 · 2012: 4
FWCI: 0.81
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: Postgraduate Medical Journal (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords: micronutrients, micronutrient deficiency, subclinical deficiency, micronutrient supplementation, acute phase response, critical illness, infection control, older adults, coronary artery disease, cancer, developing countries, nutritional assessment
MeSH terms: Deficiency Diseases, Diet, Health Status, Humans, Metabolic Diseases, Nutrition Disorders, Nutritional Status, Reference Values, Risk Factors, Socioeconomic Factors, Vitamins, Micronutrients, Dietary Supplements

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