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Cited by 357Nutrition and Health StudiesTrace Elements in HealthIron Metabolism and Disorders

The DOI matches its Crossref record; 97 of the 99 references it cites were found in a registry or an index.

Micronutrients in health and disease

Open access
Shenkin, A·2006·Postgraduate Medical Journal
DOI 10.1136/pgmj.2006.047670PMC PMC2585731
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Abstract

Micronutrients play a central part in metabolism and in the maintenance of tissue function. An adequate intake therefore is necessary, but provision of excess supplements to people who do not need them may be harmful. Single micronutrient deficiency states are comparatively easily recognised and treated. Subclinical deficiency, often of multiple micronutrients, is more difficult to recognise, and laboratory assessment is often complicated by the acute phase response. Clinical benefit is most likely in those people who are severely depleted and at risk of complications, and is unlikely if this is not the case. There is little evidence for supplements leading to a reduction in the incidence of infections in the elderly population, in coronary artery disease, or in malignant disease. The best evidence for benefit is in critical illness, and in children in developing countries consuming a deficient diet. More clinical trials are required with good clinical outcomes to optimise intake in prevention and treatment of disease.

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2 of the 99 references couldn’t be matched to a known paper.

Research works printed but not linked: 11

  1. Food and Nutrition Board IoM, 1998, Dietary reference intakes for thiamin, roboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline
  2. Panel of Dietary Reference Values, Department of Health, 1991, Dietary reference values for food energy and nutrients for the United Kingdom
  3. Food Standards Agency, 2006, Eat well, be well
  4. Hoare, 2004, The national diet and nutrition survey: adults aged 19–64
  5. Finch, 1998, National diet and nutrition survey: people aged 65 and over
  6. Geissler, 2005, Human nutrition
  7. American Institute for Cancer Research, 2003, Vitamin supplements don't help prevent cancer
  8. Mishra, 2005, Selenium supplementation and outcome in septic ICU patients, Clin Chim Acta, 355, S45
  9. Berger, 2005, Selenium supplements reduce the incidence of nosocomial pneumonia after major burns, Clin Nutr, 24, 614
  10. Irlam, 2005, Cochrane Library
  11. Sub Group on Bone health CoMAoFP, 1998, Nutrition and bone health: with particular reference to calcium and vitamin D. Report on health and social subjects no 49

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Metadata

Authors
Shenkin, A.
Affiliations
University of Liverpool (GB)
Corresponding author
Shenkin, A
Venue
Postgraduate Medical Journal
Publisher
Oxford University Press (OUP)
Published
2006-09-01
Volume
82
Issue
971
Pages
559-567
ISSN
  • 0032-5473 (ISSN-L)
  • 1469-0756
DOI
10.1136/pgmj.2006.047670
PMC
PMC2585731
OpenAlex
W2112473561
Cited by
357
References
99
Citations by year
2026: 11 · 2025: 36 · 2024: 38 · 2023: 37 · 2022: 36 · 2021: 34 · 2020: 36 · 2019: 21 · 2018: 16 · 2017: 16 · 2016: 13 · 2015: 9 · 2014: 14 · 2013: 6 · 2012: 4
FWCI
0.81
Type
journal article
Language
en
Open access
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • Postgraduate Medical Journal (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords
micronutrients, micronutrient deficiency, subclinical deficiency, micronutrient supplementation, acute phase response, critical illness, infection control, older adults, coronary artery disease, cancer, developing countries, nutritional assessment
MeSH terms
Deficiency Diseases, Diet, Health Status, Humans, Metabolic Diseases, Nutrition Disorders, Nutritional Status, Reference Values, Risk Factors, Socioeconomic Factors, Vitamins, Micronutrients, Dietary Supplements

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