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Cited by 523Nutrition and Health StudiesNutrition and Health in AgingTrace Elements in Health

RETRACTED: Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects

Chandra, R.K.·1992·The Lancet
DOI 10.1016/0140-6736(92)93151-c
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Abstract

Ageing is associated with impaired immune responses and increased infection-related morbidity. This study assessed the effect of physiological amounts of vitamins and trace elements on immunocompetence and occurrence of infection-related illness. 96 independently living, healthy elderly individuals were randomly assigned to receive nutrient supplementation or placebo. Nutrient status and immunological variables were assessed at baseline and at 12 months, and the frequency of illness due to infection was ascertained. Subjects in the supplement group had higher numbers of certain T-cell subsets and natural killer cells, enhanced proliferation response to mitogen, increased interleukin-2 production, and higher antibody response and natural killer cell activity. These subjects were less likely than those in the placebo group to have illness due to infections (mean [SD] 23 [5] vs 48 [7] days per year, p = 0.002). Supplementation with a modest physiological amount of micronutrients improves immunity and decreases the risk of infection in old age.

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Crossref · 10.1016/0140-6736(92)93151-cThis paper is marked retracted.

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21 of 21 references verified0 citation errors · 0 not checkable

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  • Micronutrient supplementation with higher levels of vitamins C, E and beta-carotene increased the number of various subsets of T-cells, enhanced lymphocyte response to mitogen, increased IL-2 production and NK-cell activity, increased the response to the influenza virus vaccine, and led to fewer days of infection.

    “while micronutrient supplementation with higher levels of vitamins C, E and beta-carotene increased the number of various subsets of T-cells, enhanced lymphocyte response to mitogen, increased IL-2 production and NK-cell activity, increased the response to the influenza virus vaccine, and led to fewer days of infection [118].”

    From Immune function and micronutrient requirements change over the life course (2018) · cites this paper as [118]

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Authors
Chandra, R. K.
Affiliations
Memorial University of Newfoundland (CA)
Corresponding author
Chandra, R.K.
ORCID
Chandra, R.K.
Venue
The Lancet
Publisher
Elsevier BV
Published
1992-11
Volume
340
Issue
8828
Pages
1124-1127
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/0140-6736(92)93151-c
OpenAlex
W2042103706
Cited by
523
References
21
Citations by year
2023: 3 · 2022: 2 · 2021: 11 · 2020: 14 · 2019: 3 · 2018: 1 · 2017: 7 · 2016: 5 · 2015: 8 · 2014: 6 · 2013: 8 · 2012: 10
FWCI
26.61
Type
journal article
Language
en
Status
Retracted
Update notices
retraction (2016-01-20)
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords
vitamin supplementation, trace element supplementation, micronutrients, immune response, older adults, immunosenescence, T cell subsets, natural killer cells, interleukin-2, antibody response
MeSH terms
Aged, Aged, 80 and over, Aging, Double-Blind Method, Female, Humans, Immunocompetence, Infections, Leukocyte Count, Male, Nutritional Status, Reference Values, Trace Elements, Vitamins

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