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Cited by 103Smoking Behavior and CessationGenetic Associations and EpidemiologySubstance Abuse Treatment and Outcomes

The genetics of tobacco use: methods, findings and policy implications

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Hall, W, Madden, P, Lynskey, M·2002·Tobacco Control
DOI 10.1136/tc.11.2.119PMC PMC1763861
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Abstract

Research on the genetics of smoking has increased our understanding of nicotine dependence, and it is likely to illuminate the mechanisms by which cigarette smoking adversely effects the health of smokers. Given recent advances in molecular biology, including the completion of the draft sequence of the human genome, interest has now turned to identifying gene markers that predict a heightened risk of using tobacco and developing nicotine dependence

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Crossref · 10.1136/tc.11.2.119

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  • Heritability accounts for 50-75% of the risk for nicotine dependence, depending on how dependence is defined and which population is studied.

    “Depending on the parameters used to define dependence, and the population considered, heritability contributes 50–75 % of the risk for dependence (Dokal et al. 1989; Hall et al. 2002; Lessov et al. 2004; Furberg et al. 2010; Nugent et al. 2014; also see chapters entitled Genetics of Smoking Behaviour and Pharmacogenetics of Nicotine and Associated Smoking Behaviors; volume 23).”

    From Nicotine Withdrawal (2015) · cites this paper as Hall et al. 2002

    The Twin studies section says genetic influences play an important role in nicotine dependence, and the Conclusions say dependence is partially under genetic control. But the copy does not give a 50–75% heritability estimate for nicotine dependence; its numerical heritability ranges in Twin studies concern smoking initiation, a different outcome. Pages are not available in the indexed passages. (LLM, conf=0.85)

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4 of the 69 references couldn’t be matched to a known paper.

Research works printed but not linked: 10

  1. Fisher RA. Cigarettes, cancer and statistics. Centennial Review 1958;2:151-66.
  2. Kaprio J, Sarna S, Koskenvuo M, et al. The Finnish twin registry: baseline characteristics. Section II. Helsinki: University of Helsinki Press, 1978.
  3. Long JC, Knowler WC, Hanson RL, et al. Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population. Am J Med Genet 1998;81:216-21.
  4. Reich T, Edenberg HJ, Goate A, et al. Genome-wide search for genes affecting the risk for alcohol dependence. Am J Med Genet 1998;81:207-15.
  5. Vallejo RL, Wilhelm LA, Hoopes D, et al. Genome wide search for genes affecting vulnerability to alcohol dependence in Finnish pedigrees. Am J Human Genet 1998;63:A45.
  6. Ott J. Analysis of human genetic linkage, revised ed. Baltimore: Johns Hopkins University Press, 1991.
  7. Holtzman NA, Marteau TM. Will genetics revolutionise medicine? N Engl J Med 2000;343:141-4.
  8. Holtzman NA, Shapiro D. Genetic testing and public policy. BMJ 1998;316:852-6.
  9. Marteau TM, Croyle RT. Psychological responses to genetic testing. BMJ 1998;316:693-6.
  10. Genewatch UK. Patent on life warning as links between Biotech companies and Japan Tobacco exposed. Access date 13 November 2001. URL: http://www.genewatch.org/press%20 Releases/pr20.htm/

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Authors
Hall, W., Madden, P., & Lynskey, M.
Affiliations
  • The University of Queensland (AU)
  • Washington University in St. Louis (US)
Corresponding author
Hall, W
ORCID
Venue
Tobacco Control
Publisher
BMJ
Published
2002-06
Volume
11
Issue
2
Pages
119-124
ISSN
  • 0964-4563 (ISSN-L)
  • 1468-3318
DOI
10.1136/tc.11.2.119
PMC
PMC1763861
OpenAlex
W2017100051
Cited by
103
References
69
Citations by year
2023: 4 · 2022: 1 · 2021: 1 · 2020: 2 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 5 · 2012: 4
Type
conference abstract
Language
en
Open access
Locations
  • Tobacco Control (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
  • DigitalGeorgetown (Georgetown University Library) (submittedVersion)
Funders
  • National Institutes of Health (DA12854, AA07728)
  • Institute for Molecular Bioscience, University Of Queensland
  • National Institute on Alcohol Abuse and Alcoholism (AA-07728)
  • National Institute on Drug Abuse (R01DA012540, DA12854, DA-12540)
Topics
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords
smoking, nicotine dependence, genetic markers, genetic susceptibility, tobacco control, genetic epidemiology
MeSH terms
Adoption, Health Policy, Humans, Molecular Biology, Tobacco Use Disorder, Twins

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