The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
SARS-CoV-2 seroprevalence and asymptomatic viral carriage in healthcare workers: a cross-sectional study
Open accessAbstract
Objective: To determine the rates of asymptomatic viral carriage and seroprevalence of SARS-CoV-2 antibodies in healthcare workers. Design: A cross-sectional study of asymptomatic healthcare workers undertaken on 24/25 April 2020. Setting: University Hospitals Birmingham NHS Foundation Trust (UHBFT), UK. Participants: 545 asymptomatic healthcare workers were recruited while at work. Participants were invited to participate via the UHBFT social media. Exclusion criteria included current symptoms consistent with COVID-19. No potential participants were excluded. Intervention: Participants volunteered a nasopharyngeal swab and a venous blood sample that were tested for SARS-CoV-2 RNA and anti-SARS-CoV-2 spike glycoprotein antibodies, respectively. Results were interpreted in the context of prior illnesses and the hospital departments in which participants worked. Main outcome measure: Proportion of participants demonstrating infection and positive SARS-CoV-2 serology. Results: The point prevalence of SARS-CoV-2 viral carriage was 2.4% (n=13/545). The overall seroprevalence of SARS-CoV-2 antibodies was 24.4% (n=126/516). Participants who reported prior symptomatic illness had higher seroprevalence (37.5% vs 17.1%, χ 2 =21.1034, p<0.0001) and quantitatively greater antibody responses than those who had remained asymptomatic. Seroprevalence was greatest among those working in housekeeping (34.5%), acute medicine (33.3%) and general internal medicine (30.3%), with lower rates observed in participants working in intensive care (14.8%). BAME (Black, Asian and minority ethnic) ethnicity was associated with a significantly increased risk of seropositivity (OR: 1.92, 95% CI 1.14 to 3.23, p=0.01). Working on the intensive care unit was associated with a significantly lower risk of seropositivity compared with working in other areas of the hospital (OR: 0.28, 95% CI 0.09 to 0.78, p=0.02). Conclusions and relevance: We identify differences in the occupational risk of exposure to SARS-CoV-2 between hospital departments and confirm asymptomatic seroconversion occurs in healthcare workers. Further investigation of these observations is required to inform future infection control and occupational health practices.
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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
Wrapp, D., Wang, N., Corbett, K. S., Goldsmith, J. A., Hsieh, C.-L., Abiona, O., Graham, B. S., & McLellan, J. S. (2020) · Science · doi:10.1126/science.abb2507 · Cited by 8,897
Factors associated with COVID-19-related death using OpenSAFELY
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Detection of SARS-CoV-2 in Different Types of Clinical Specimens
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Antibody Responses to SARS-CoV-2 in Patients With Novel Coronavirus Disease 2019
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Site-specific glycan analysis of the SARS-CoV-2 spike
Watanabe, Y., Allen, J. D., Wrapp, D., McLellan, J. S., & Crispin, M. (2020) · Science · doi:10.1126/science.abb9983 · Cited by 1,548
Self-citationDetection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent Individuals
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Universal Screening for SARS-CoV-2 in Women Admitted for Delivery
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COVID-19: the case for health-care worker screening to prevent hospital transmission
Black, J. R. M., Bailey, C., Przewrocka, J., Dijkstra, K. K., & Swanton, C. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30917-x · Cited by 416
COVID-19: PCR screening of asymptomatic health-care workers at London hospital
Treibel, T. A., Manisty, C., Burton, M., McKnight, Á., Lambourne, J., Augusto, J. B., Couto-Parada, X., Cutino-Moguel, T., Noursadeghi, M., & Moon, J. C. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31100-4 · Cited by 314
First experience of COVID-19 screening of health-care workers in England
Hunter, E., Price, D. A., Murphy, E., van der Loeff, I. S., Baker, K. F., Lendrem, D., Lendrem, C., Schmid, M. L., Pareja-Cebrian, L., Welch, A., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30970-3 · Cited by 306
Cited by
Gómez-Ochoa, S. A., Franco, O. H., Rojas, L. Z., Raguindin, P. F., Roa-Díaz, Z. M., Wyssmann, B. M., Guevara, S. L. R., Echeverría, L. E., Glisic, M., & Muka, T. (2021) · American Journal of Epidemiology · doi:10.1093/aje/kwaa191 · Cited by 785
Martin, C. A., Marshall, C., Patel, P., Goss, C., Jenkins, D. R., Ellwood, C., Barton, L., Price, A., Brunskill, N. J., Khunti, K., et al. (2021) · doi:10.1101/2021.02.11.21251548 · Cited by 104
Zubiri, L., Rosovsky, R. P., Mooradian, M. J., Piper-Vallillo, A. J., Gainor, J. F., Sullivan, R. J., Marte, D., Boland, G. M., Gao, X., Hochberg, E. P., et al. (2021) · The Oncologist · doi:10.1002/onco.13807 · Cited by 19
Metadata
- Authors
- Shields, A., Faustini, S. E., Perez-Toledo, M., Jossi, S., Aldera, E., Allen, J. D., Al-Taei, S., Backhouse, C., Bosworth, A., Dunbar, L. A., Ebanks, D., Emmanuel, B., Garvey, M., Gray, J., Kidd, I. M., McGinnell, G., McLoughlin, D. E., Morley, G., O'Neill, J., Papakonstantinou, D., Pickles, O., Poxon, C., Richter, M., Walker, E. M., Wanigasooriya, K., Watanabe, Y., Whalley, C., Zielinska, A. E., Crispin, M., Wraith, D. C., Beggs, A. D., Cunningham, A. F., Drayson, M. T., & Richter, A. G.
- Venue
- Thorax
- Publisher
- BMJ
- Published
- 2020-09-11
- Volume
- 75
- Issue
- 12
- Pages
- 1089-1094
- ISSN
- 0040-6376 (ISSN-L)
- 1468-3296
- OpenAlex
- W3084708572
- Cited by
- 316
- References
- 18
- FWCI
- 9.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Shields, A., Faustini, S. E., Perez-Toledo, M., Jossi, S., Aldera, E., Allen, J. D., Al-Taei, S., Backhouse, C., Bosworth, A., Dunbar, L. A., Ebanks, D., Emmanuel, B., Garvey, M., Gray, J., Kidd, I. M., McGinnell, G., McLoughlin, D. E., Morley, G., O'Neill, J., . . . Richter, A. G. (2020). SARS-CoV-2 seroprevalence and asymptomatic viral carriage in healthcare workers: a cross-sectional study. Thorax. https://doi.org/10.1136/thoraxjnl-2020-215414
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.