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Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent Individuals
Open accessAbstract
Summary The World Health Organization has declared SARS-CoV-2 virus outbreak a worldwide pandemic. However, there is very limited understanding on the immune responses, especially adaptive immune responses to SARS-CoV-2 infection. Here, we collected blood from COVID-19 patients who have recently become virus-free, and therefore were discharged, and detected SARS-CoV-2-specific humoral and cellular immunity in eight newly discharged patients. Follow-up analysis on another cohort of six patients 2 weeks post discharge also revealed high titers of immunoglobulin G (IgG) antibodies. In all 14 patients tested, 13 displayed serum-neutralizing activities in a pseudotype entry assay. Notably, there was a strong correlation between neutralization antibody titers and the numbers of virus-specific T cells. Our work provides a basis for further analysis of protective immunity to SARS-CoV-2, and understanding the pathogenesis of COVID-19, especially in the severe cases. It also has implications in developing an effective vaccine to SARS-CoV-2 infection.
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Self-citation
Metadata
- Authors
- Ni, L., Ye, F., Cheng, M.-L., Feng, Y., Deng, Y.-Q., Zhao, H., Wei, P., Ge, J., Gou, M., Li, X., Sun, L., Cao, T., Wang, P., Zhou, C., Zhang, R., Liang, P., Guo, H., Wang, X., Qin, C.-F., Chen, F., & Dong, C.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 52
- Issue
- 6
- Pages
- 971-977.e3
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W3021544284
- Cited by
- 1,063
- References
- 7
- FWCI
- 29.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 380 d)
- Funders
- Zhejiang University (2020XGZX014)
- National Natural Science Foundation of China (31991173, 31991170, 31821003)
- Beijing Municipal Science and Technology Commission (Z181100001318007, Z171100000417005, Z181100006318015)
- Tsinghua University
- Ministry of Science and Technology
- National Key Research and Development Program of China (2020YFA0707800, 2016YFC130390, 2016YFC0906200)
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- Ni, L., Ye, F., Cheng, M.-L., Feng, Y., Deng, Y.-Q., Zhao, H., Wei, P., Ge, J., Gou, M., Li, X., Sun, L., Cao, T., Wang, P., Zhou, C., Zhang, R., Liang, P., Guo, H., Wang, X., Qin, C.-F., . . . Dong, C. (2020). Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent Individuals. Immunity. https://doi.org/10.1016/j.immuni.2020.04.023
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