The DOI matches its Crossref record; 6 of the 7 references it cites were found in a registry or an index.
‘Long-COVID’: a cross-sectional study of persisting symptoms, biomarker and imaging abnormalities following hospitalisation for COVID-19
Open accessAbstract
Large numbers of people are being discharged from hospital following COVID-19 without assessment of recovery. In 384 patients (mean age 59.9 years; 62% male) followed a median 54 days post discharge, 53% reported persistent breathlessness, 34% cough and 69% fatigue. 14.6% had depression. In those discharged with elevated biomarkers, 30.1% and 9.5% had persistently elevated d-dimer and C reactive protein, respectively. 38% of chest radiographs remained abnormal with 9% deteriorating. Systematic follow-up after hospitalisation with COVID-19 identifies the trajectory of physical and psychological symptom burden, recovery of blood biomarkers and imaging which could be used to inform the need for rehabilitation and/or further investigation.
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“whereas lower rates of depression (15 percent) also have been reported after hospitalization for COVID-19 (8).”
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Citations
Cites
Persistent Symptoms in Patients After Acute COVID-19
Carfì, A., Bernabei, R., Landi, F., & for the Gemelli Against COVID-19 Post-Acute Care Study Group (2020) · JAMA · doi:10.1001/jama.2020.12603 · Cited by 4,561
Halpin, S. J., McIvor, C., Whyatt, G., Adams, A., Harvey, O., McLean, L., Walshaw, C., Kemp, S., Corrado, J., Singh, R., et al. (2021) · Journal of Medical Virology · doi:10.1002/jmv.26368 · Cited by 1,402
Abnormal pulmonary function in COVID-19 patients at time of hospital discharge
Mo, X., Jian, W., Su, Z., Chen, M., Peng, H., Peng, P., Lei, C., Chen, R., Zhong, N., & Li, S. (2020) · European Respiratory Journal · doi:10.1183/13993003.01217-2020 · Cited by 810
Iba, T., Levy, J. H., Levi, M. M., & Thachil, J. V. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14975 · Cited by 610
Hui, D. S. C. (2005) · Thorax · doi:10.1136/thx.2004.030205 · Cited by 525 · cited 1×
“These data are compatible with studies reporting longerterm abnormalities in SARS survivors [6], and initial data emerging from smaller COVID-19 cohorts [1, 7].”
Analysis of thin-section CT in patients with coronavirus disease (COVID-19) after hospital discharge
Wei, J., Yang, H., Lei, P., Fan, B., Qiu, Y., Zeng, B., Yu, P. C., Lv, J., Jian, Y., & Wan, C. (2020) · Journal of X-Ray Science and Technology · doi:10.3233/xst-200685 · Cited by 111 · cited 1×
“Initial reports are emerging of significant on-going symptom burden [1] termed ‘Long-COVID’, and of changes in lung function [2] and imaging [3].”
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More than 50 long-term effects of COVID-19: a systematic review and meta-analysis
Lopez-Leon, S., Wegman-Ostrosky, T., Perelman, C., Sepulveda, R., Rebolledo, P. A., Cuapio, A., & Villapol, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-95565-8 · Cited by 2,757
Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments
Yong, S. J. (2021) · Infectious Diseases · doi:10.1080/23744235.2021.1924397 · Cited by 1,339
Long covid—mechanisms, risk factors, and management
Crook, H., Raza, S., Nowell, J., Young, M., & Edison, P. (2021) · BMJ · doi:10.1136/bmj.n1648 · Cited by 1,655
Short-term and Long-term Rates of Postacute Sequelae of SARS-CoV-2 Infection
Groff, D., Sun, A., Ssentongo, A. E., Ba, D. M., Parsons, N., Poudel, G. R., Lekoubou, A., Oh, J. S., Ericson, J. E., Ssentongo, P., et al. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.28568 · Cited by 1,010
Collaborators, G. B. O. D. L. C., Hanson, S. W., Abbafati, C., Aerts, J. G. J. V., Al‐Aly, Z., Ashbaugh, C., Ballouz, T., Blyuss, O. B., Bobkova, P., Bonsel, G. J., et al. (2022) · JAMA · doi:10.1001/jama.2022.18931 · Cited by 1,015
Metadata
- Authors
- Mandal, S., Barnett, J., Brill, S. E., Brown, J. S., Denneny, E. K., Hare, S. S., Heightman, M., Hillman, T. E., Jacob, J., Jarvis, H. C., Lipman, M. C. I., Naidu, S. B., Nair, A., Porter, J. C., Tomlinson, G. S., & Hurst, J. R.
- Affiliations
- Royal Free London NHS Foundation Trust (GB)
- University College London Hospitals NHS Foundation Trust (GB)
- University College Hospital (GB)
- Corresponding author
- Hurst, John R
- ORCID
- Venue
- Thorax
- Publisher
- BMJ
- Published
- 2020-11-10
- Volume
- 76
- Issue
- 4
- Pages
- 396-398
- ISSN
- 0040-6376 (ISSN-L)
- 1468-3296
- PMC
- PMC7615158
- OpenAlex
- W3101401355
- Cited by
- 864
- References
- 7
- Citations by year
- 2026: 18 · 2025: 50 · 2024: 111 · 2023: 181 · 2022: 263 · 2021: 235 · 2020: 6
- FWCI
- 74.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Thorax (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust (Z/17/Z, 209553, 209553/Z/17/Z)
- National Institute for Health and Care Research
- University College London Hospitals NHS Foundation Trust
- Medical Research Council (MR/N007727/1)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
- Keywords
- long COVID, persistent symptoms, dyspnea, cough, fatigue, depression, D-dimer, C-reactive protein, biomarkers, chest X-ray abnormalities, post-discharge follow-up, rehabilitation
- MeSH terms
- COVID-19, SARS-CoV-2, Cross-Sectional Studies, Diagnostic Imaging, Female, Hospitalization, Humans, Lung, Male, Middle Aged, Severity of Illness Index, Biomarkers, Pandemics
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