Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family
Abstract
To simplify the analysis of asthma susceptibility genes located at human chromosome 5q23-35, we examined congenic mice that differed at the homologous chromosomal segment. We identified a Mendelian trait encoded by T cell and Airway Phenotype Regulator (Tapr). Tapr is genetically distinct from known cytokine genes and controls the development of airway hyperreactivity and T cell production of interleukin 4 (IL-4) and IL-13. Positional cloning identified a gene family that encodes T cell membrane proteins (TIMs); major sequence variants of this gene family (Tim) completely cosegregated with Tapr. The human homolog of TIM-1 is the hepatitis A virus (HAV) receptor, which may explain the inverse relationship between HAV infection and the development of atopy.
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Proteasome-mediated ferritin degradation has been reported.
“Proteasome-mediated ferritin degradation has also been reported (199, 255).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [199]
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- Authors
- McIntire, J. J., Umetsu, S. E., Akbari, O., Potter, M., Kuchroo, V. K., Barsh, G. S., Freeman, G. J., Umetsu, D. T., & DeKruyff, R. H.
- Affiliations
- Stanford University (US)
- National Cancer Institute (US)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- ORCID
- Venue
- Nature Immunology
- Published
- 2001-11-28
- Volume
- 2
- Issue
- 12
- Pages
- 1109-1116
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W1983715014
- Cited by
- 501
- References
- 65
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 16 · 2023: 7 · 2022: 10 · 2021: 15 · 2020: 13 · 2019: 14 · 2018: 12 · 2017: 9 · 2016: 24 · 2015: 16 · 2014: 22 · 2013: 9 · 2012: 21
- FWCI
- 16.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (CA 84500, CA09302, R01CA084500, T32CA009302)
- National Institute of Allergy and Infectious Diseases (AI-24571)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- TIM-1, airway hyperresponsiveness, asthma susceptibility genes, congenic mice, positional cloning, IL-4, IL-13, T cell phenotype, atopy, genetic linkage
- MeSH terms
- Hepatitis A Virus Cellular Receptor 1, Hepatitis A Virus Cellular Receptor 2, Amino Acid Sequence, Animals, Asthma, Cells, Cultured, Chromosome Mapping, Chromosomes, Human, Pair 5, Cloning, Molecular, Multigene Family, T-Lymphocytes, Helper-Inducer, Humans, Membrane Glycoproteins, Membrane Proteins, Mice, Inbred DBA, Molecular Sequence Data, Polymorphism, Genetic, Receptors, Virus, Interleukin-4, Bronchial Hyperreactivity, Sequence Homology, Amino Acid, Interleukin-13, Genetic Predisposition to Disease, Mice
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