CoChat
Sign Up
Cited by 61Asthma and respiratory diseasesOccupational exposure and asthmaIndoor Air Quality and Microbial Exposure

New-onset asthma and the effect of environment and occupation among farming and nonfarming rural subjects

Open access
Omland, Øyvind, Hjort, Charlotte, Pedersen, Ole Find, Miller, Martin R., Sigsgaard, Torben·2011·Journal of Allergy and Clinical Immunology
DOI 10.1016/j.jaci.2011.06.006
Open this paper in CoChat — free accountOpen PDF

Abstract

Background Many factors, including environmental exposures, have been related to the increase in the prevalence of asthma, but only few have been tested for in longitudinal studies. Objective We studied farming students to determine whether their environment during childhood and as adults was a factor determining subsequent onset of asthma. Methods From 1994 to 1998, new cases of asthma were identified by means of an annual posted questionnaire followed by a telephone interview in a prospective cohort consisting of 1964 farming-school students and 407 nonfarming subjects aged 16 to 26 years. For each case, we selected a control subject from the cohort with no asthma in a case-based design, and all underwent an interview and a clinical examination. Results We found 122 new cases of asthma. In a multiple regression model the odds ratio for new asthma was 3.3 (95% CI, 1.7-6.3) for smoking; 3.4 (95% CI, 1.6-7.0), 2.5 (95% CI, 1.1-5.3), and 7.0 (95% CI, 1.2-41.6) for exposure to swine, dairy production, and welding, respectively; and 11.7 (95% CI, 2.4-56.4) for bronchial hyperresponsiveness at baseline. Being born and raised on a farm significantly reduced the risk odds ratio (0.5 [95% CI, 0.3-0.98]), whereas atopy had no influence. Conclusion Exposure to swine and dairy confinements, welding, smoking, and bronchial hyperresponsiveness are risk factors for nonallergic asthma, and being born and raised on a farm reduces the subsequent risk. These findings support the theory that immune and inflammatory responses can be influenced by environmental exposure to early childhood, reducing the risk of asthma later in life.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.jaci.2011.06.006

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The increased use of antibiotics and changes in dietary patterns in developed countries may lead to alterations in the composition of the intestinal microbiota and a higher risk of bronchial asthma.

    “Also, the increased use of antibiotics and changes in dietary patterns in developed countries, may lead to alterations in the composition of the intestinal microbiota and a higher risk of bronchial asthma [80][81][82] .”

    From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [82]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 2

  1. Svanes C, Omenaas E, Eide GE, Fluge Ø, Glusvik A. Hospitalisation for lung dis- ease in early childhood and asthma symptoms in young adult. Respir Med 1998;92: 1003-9.
  2. Omland Ø, Sigsgaard T, Pedersen OF, Miller MR. Family history of asthma and place of upbringing as determinants for selection into farming [abstract]. Am J Re- spir Crit Care Med 2003;167:A160.

Cited by

Sorted by citations

Related

Authors
Omland, Ø., Hjort, C., Pedersen, O. F., Miller, M. R., & Sigsgaard, T.
Affiliations
  • Aarhus University (DK)
  • Selly Oak Hospital (GB)
Corresponding author
Omland, Øyvind
ORCID
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2011-10
Volume
128
Issue
4
Pages
761-765
ISSN
0091-6749 (ISSN-L)
DOI
10.1016/j.jaci.2011.06.006
OpenAlex
W2055548598
Cited by
61
References
38
Citations by year
2026: 2 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 7 · 2013: 9 · 2012: 7
FWCI
5.65
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Allergy and Clinical Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Sundhed og Sygdom, Det Frie Forskningsråd
  • Helsefonden
  • Medical Research Council
Topics
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
Keywords
new-onset asthma, non-allergic asthma, rural children, environmental exposure, occupational exposure, dairy production, welding, smoking, airway hyperresponsiveness, atopy, farm upbringing, asthma risk factors, immune and inflammatory responses
MeSH terms
Adolescent, Adult, Agriculture, Asthma, Environmental Exposure, Female, Follow-Up Studies, United Kingdom, Humans, Male, Surveys and Questionnaires, Risk Factors, Rural Population, Occupational Exposure

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review