Cited by 1,721Chronic Obstructive Pulmonary Disease (COPD) ResearchHealth Systems, Economic Evaluations, Quality of LifeAsthma and respiratory diseases

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A measure of quality of life for clinical trials in chronic lung disease

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Guyatt, G H, Berman, L B, Townsend, M, Pugsley, S O, Chambers, L W·1987·Thorax

DOI 10.1136/thx.42.10.773PMC PMC460950

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Abstract

Since the relationships between pulmonary function, exercise capacity, and functional state or quality of life are generally weak, a self report questionnaire has been developed to determine the effect of treatment on quality of life in clinical trials. One hundred patients with chronic airflow limitation were asked how their quality of life was affected by their illness, and how important their symptoms and limitations were. The most frequent and important items were used to construct a questionnaire evaluating four dimensions: dyspnoea, fatigue, emotional function, and the patient's feeling of control over the disease (mastery). Reproducibility, tested by repeated administration to patients in a stable condition, was excellent: the coefficient of variation was less than 12% for all four dimensions. Responsiveness (sensitivity to change) was tested by administering the questionnaire to 13 patients before and after optimisation of their drug treatment and to another 28 before and after participation in a respiratory rehabilitation programme. In both cases large, statistically significant improvements in all four dimensions were noted. Changes in questionnaire score were correlated with changes in spirometric values, exercise capacity, and patients' and physicians' global ratings. Thus it has been shown that the questionnaire is precise, valid, and responsive. It can therefore serve as a useful disease specific measure of quality of life for clinical trials.

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Authors: Guyatt, G. H., Berman, L. B., Townsend, M., Pugsley, S. O., & Chambers, L. W.
Affiliations: McMaster University (CA)
ORCID: Guyatt, G H
Chambers, L W
Venue: Thorax
Publisher: BMJ
Published: 1987-10-01
Volume: 42
Issue: 10
Pages: 773-778
ISSN: 0040-6376 (ISSN-L)
DOI: 10.1136/thx.42.10.773
PMC: PMC460950
OpenAlex: W2097667004
Cited by: 1,721
References: 28
Citations by year: 2026: 19 · 2025: 17 · 2024: 32 · 2023: 26 · 2022: 30 · 2021: 34 · 2020: 39 · 2019: 37 · 2018: 30 · 2017: 53 · 2016: 46 · 2015: 54 · 2014: 60 · 2013: 60 · 2012: 59
FWCI: 12.15
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Thorax (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Keywords: quality of life, chronic lung disease, chronic airflow obstruction, self-report questionnaire, dyspnea, fatigue, emotional functioning, reproducibility, responsiveness, pulmonary rehabilitation, spirometry, exercise capacity
MeSH terms: Clinical Trials as Topic, Humans, Lung Diseases, Obstructive, Quality of Life, Surveys and Questionnaires

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A measure of quality of life for clinical trials in chronic lung disease

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