Efficacy, safety and palatability of a new broad‐spectrum anthelmintic formulation in dogs
Abstract
The efficacy, safety and palatability of a new flavoured chewable anthelmintic tablet were investigated in dogs. The efficacy, based on worm counts, of a single recommended therapeutic dose (RTD) of 5 mg pyrantel + 20 mg oxantel + 5 mg praziquantel/kg bodyweight was assessed in experimental infections (EI) and natural infections (NI) with Trichuris vulpis , Echinococcus granulosus and Toxocara canis . For T vulpis , the efficacy of the treatment was 99.3 per cent in EI (comparing groups of six treated and six control dogs) and 100 per cent in NI (nine treated and nine control dogs). For E granulosus , the efficacy was more than 99.9 per cent in EI (11 treated and 11 control dogs). For T canis , the efficacy was 94.3 per cent in EI (10 treated and 10 control dogs) and 100 per cent in NI (12 treated and 13 control dogs). In a field study, Ancylostoma caninum (11 dogs) and T canis (11 dogs) faecal egg counts were reduced by more than 99 per cent, and in eight dogs with Dipylidium caninum proglotides in the faeces the efficacy was 100 per cent. The tablets were readily consumed by 56 of 64 (87.5 per cent) privately owned dogs. Safety was assessed in groups of six dogs treated either once with twice the RTD, once with six times the RTD, with twice the RTD on three consecutive days, or untreated. There were no significant differences in blood parameters between the groups, and no abnormal clinical findings. Two dogs treated with six times the RTD vomited, but no vomiting was observed when administration was repeated two days later.
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Good compliance (87.5%) of owned pets treated with oral tablets containing pyrantel/oxantel/praziquantel has been documented.
“good compliance (i.e. 87.5%) of the owned pets treated with oral tablets containing pyrantel/oxantel/praziquantel has been documented [134]”
From Pet roundworms and hookworms: A continuing need for global worming (2012) · cites this paper as [134]
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Pet roundworms and hookworms: A continuing need for global worming
Traversa, D. (2012) · Parasites & Vectors · doi:10.1186/1756-3305-5-91 · Cited by 221 · see citing works
- Authors
- Schmid, K., Rohdich, N., Zschiesche, E., Kok, D. J., & Allan, M. J.
- Affiliations
- Intervet Innovation, Zur Propstei 55270 Schwabenheim Germany
- Clinvet (ZA)
- Venue
- Veterinary Record
- Publisher
- Wiley
- Published
- 2010-10
- Volume
- 167
- Issue
- 17
- Pages
- 647-651
- ISSN
- 0042-4900 (ISSN-L)
- 2042-7670
- OpenAlex
- W2104839991
- Cited by
- 19
- References
- 16
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2022: 2 · 2021: 2 · 2020: 2 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 1 · 2012: 2
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Veterinary Record (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- European Commission
- Topics
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Health Sciences › Medicine › Pathology and Forensic Medicine › Parasitic infections in humans and animals
- Health Sciences › Veterinary › Small Animals › Veterinary Pharmacology and Anesthesia
- Keywords
- anthelmintic efficacy, pyrantel, praziquantel, dogs, Trichuris vulpis, Echinococcus granulosus, Toxocara canis, Ancylostoma caninum, Dipylidium caninum, experimental infection, natural infection, fecal egg count, drug safety, palatability, dose escalation
- MeSH terms
- Animals, Anthelmintics, Dog Diseases, Dogs, Drug Resistance, Drug Therapy, Combination, Feces, Female, Helminthiasis, Animal, Male, Parasite Egg Count, Praziquantel, Pyrantel, Taste, Treatment Outcome
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