Cited by 41Muscle metabolism and nutritionCardiovascular and exercise physiologyDietary Effects on Health

Whole-body fat oxidation increases more by prior exercise than overnight fasting in elite endurance athletes.

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Andersson Hall, Ulrika, Edin, Fredrik, Pedersen, Anders, Madsen, Klavs·2016·Applied Physiology Nutrition and Metabolism

Abstract

The purpose of this study was to compare whole-body fat oxidation kinetics after prior exercise with overnight fasting in elite endurance athletes. Thirteen highly trained athletes (9 men and 4 women; maximal oxygen uptake: 66 ± 1 mL·min(-1)·kg(-1)) performed 3 identical submaximal incremental tests on a cycle ergometer using a cross-over design. A control test (CON) was performed 3 h after a standardized breakfast, a fasting test (FAST) 12 h after a standardized evening meal, and a postexercise test (EXER) after standardized breakfast, endurance exercise, and 2 h fasting recovery. The test consisted of 3 min each at 30%, 40%, 50%, 60%, 70%, and 80% of maximal oxygen uptake and fat oxidation rates were measured through indirect calorimetry. During CON, maximal fat oxidation rate was 0.51 ± 0.04 g·min(-1) compared with 0.69 ± 0.04 g·min(-1) in FAST (P < 0.01), and 0.89 ± 0.05 g·min(-1) in EXER (P < 0.01). Across all intensities, EXER was significantly higher than FAST and FAST was higher than CON (P < 0.01). Blood insulin levels were lower and free fatty acid and cortisol levels were higher at the start of EXER compared with CON and FAST (P < 0.05). Plasma nuclear magnetic resonance-metabolomics showed similar changes in both EXER and FAST, including increased levels of fatty acids and succinate. In conclusion, prior exercise significantly increases whole-body fat oxidation during submaximal exercise compared with overnight fasting. Already high rates of maximal fat oxidation in elite endurance athletes were increased by approximately 75% after prior exercise and fasting recovery.

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Crossref · 10.1139/apnm-2015-0452

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  • A very low rate of fat oxidation is observed during high-intensity exercise.

    “Additionally, a very low rate of fat oxidation is observed during high-intensity exercise (Romijn et al., 1993; Andersson Hall et al., 2016).”

    From Effect of Exercise Training on Fat Loss—Energetic Perspectives and the Role of Improved Adipose Tissue Function and Body Fat Distribution (2021) · cites this paper as Andersson Hall et al., 2016

    The Fat oxidation test section measures fat oxidation up to 80% of VO₂max, but does not characterize its rate at high intensity as very low. The Incremental fat oxidation tests section reports differences among exercise, fasting, and control conditions rather than establishing the claimed low rate; a search for declining or negligible oxidation at higher intensities found no such statement in our copy. (LLM, conf=0.70)

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1 of the 42 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

  1. Coggan, A.R. , and B.D. Williams. 1995. 'Metabolic adaptations to endurance training: substrate metabolism during exercise.' in Hargreaves M (ed.), Exercise Metabolism (Human Kinetics: Champaign, IL).
  2. Gollnick, P.D., and B. Saltin. 1988. 'Fuel for muscular exercise: role of fat.' in E.S.; Terjung Horton, R.L. (ed.), Exercise, Nutrition and Energy metabolism (MacMillan: New York).

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Authors
Andersson Hall, U., Edin, F., Pedersen, A., & Madsen, K.
Affiliations
  • Department of Food and Nutrition, and Sport Science, University of Gothenburg, PO Box 300, 405 30 Gothenburg, Sweden.
  • University of Gothenburg (SE)
  • Aarhus University (DK)
Venue
Applied Physiology Nutrition and Metabolism
Published
2016-04
Volume
41
Issue
4
Pages
430-437
ISSN
  • 1715-5312 (ISSN-L)
  • 1715-5320
OpenAlex
W2218994115
Cited by
41
References
42
Citations by year
2026: 2 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 5 · 2020: 7 · 2019: 5 · 2018: 1 · 2017: 4 · 2016: 1
FWCI
1.07
Type
journal article
Language
en
Open access
Locations
  • Applied Physiology Nutrition and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • TSpace (University of Toronto) (acceptedVersion)
  • Scopus (Elsevier) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
Keywords
prior exercise, overnight fasting, endurance athletes, submaximal exercise, insulin, free fatty acids, cortisol, succinic acid, fatty acids, energy metabolism
MeSH terms
Adipose Tissue, Adult, Bicycling, Blood Glucose, Calorimetry, Indirect, Fasting, Fatty Acids, Nonesterified, Female, Humans, Hydrocortisone, Insulin, Male, Magnetic Resonance Spectroscopy, Oxygen Consumption, Physical Endurance, Exercise, Multivariate Analysis, Linear Models, Cross-Over Studies, Lipid Metabolism, Metabolomics, Athletes, Breakfast

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