The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Something old, something new: revisiting natural products in antibiotic drug discovery
Open accessAbstract
Antibiotic discovery is in crisis. Despite a growing need for new drugs resulting from the increasing number of multi-antibiotic-resistant pathogens, there have been only a handful of new antibiotics approved for clinical use in the past 2 decades. Faced with scientific, economic, and regulatory challenges, the pharmaceutical sector seems unable to respond to what has been called an “apocalyptic” threat. Natural products produced by bacteria and fungi are genetically encoded products of natural selection that have been the mainstay sources of the antibiotics in current clinical use. The pharmaceutical industry has largely abandoned these compounds in favor of large libraries of synthetic molecules because of difficulties in identifying new natural product antibiotics scaffolds. Advances in next-generation genome sequencing, bioinformatics, and analytical chemistry are combining to overcome barriers to natural products. Coupled with new strategies in antibiotic discovery, including inhibition of resistance, novel drug combinations, and new targets, natural products are poised for a renaissance to address what is a pressing health care crisis.
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Cites
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Construction of Escherichia coli K‐12 in‐frame, single‐gene knockout mutants: the Keio collection
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Antibiotic resistance-the need for global solutions
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Self-citationBioactive Microbial Metabolites: A Personal View
Bérdy, J. (2005) · The Journal of Antibiotics · doi:10.1038/ja.2005.1 · Cited by 3,170
Drugs for bad bugs: confronting the challenges of antibacterial discovery
Payne, D. J., Gwynn, M. N., Holmes, D. J., & Pompliano, D. L. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2201 · Cited by 2,512
The Genetic Landscape of a Cell
Costanzo, M., Baryshnikova, A., Bellay, J., Kim, Y., Spear, E. D., Sevier, C. S., Ding, H., Koh, J. L. Y., Toufighi, K., Mostafavi, S., et al. (2010) · Science · doi:10.1126/science.1180823 · Cited by 2,162
Three Decades of β-Lactamase Inhibitors
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Sampling the Antibiotic Resistome
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Self-citationMulticomponent therapeutics for networked systems
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Cited by
Natural Products as a Source for Novel Antibiotics
Moloney, M. G. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.05.001 · Cited by 308
Bacterial proteases, untapped antimicrobial drug targets
Culp, E., & Wright, G. D. (2017) · The Journal of Antibiotics · doi:10.1038/ja.2016.138 · Cited by 244
Self-citationNair, V. G., Unnikrishnan, V. K., Muralidharan, N., Venkatathri, B. N. S., Lowrence, R. C., YBRD, R., Narbhavi, D., A, A., N, P., & Nagarajan, S. (2025) · Scientific Reports · doi:10.1038/s41598-025-17404-4 · Cited by 8
Metadata
- Authors
- Wright, G. D.
- Venue
- Canadian Journal of Microbiology
- Publisher
- Canadian Science Publishing
- Published
- 2014-03
- Volume
- 60
- Issue
- 3
- Pages
- 147-154
- ISSN
- 0008-4166 (ISSN-L)
- 1480-3275
- OpenAlex
- W2158696212
- Cited by
- 283
- References
- 9
- FWCI
- 14.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
