The impacts of vorinostat on NADPH oxidase and mitochondrial biogenesis gene expression in the heart of mice model of depression

Depression and cardiac mortality: results from a community-based longitudinal study.

Penninx, B., Beekman, A., Honig, A., Deeg, D., Schoevers, R., van Eijk, J., & van Tilburg, W. V. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.3.221 · Cited by 983 · see citing works

NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

Kuroda, J., Ago, T., Matsushima, S., Zhai, P., Schneider, M. D., & Sadoshima, J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002178107 · Cited by 772 · see citing works

Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress

Lee, H., & Wei, Y. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.09.010 · Cited by 660 · see citing works

NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets

Zhang, Y., Murugesan, P., Huang, K., & Cai, H. “. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0260-8 · Cited by 546 · see citing works

AMPK maintains cellular metabolic homeostasis through regulation of mitochondrial reactive oxygen species

Rabinovitch, R. C., Samborska, B., Faubert, B., Ma, E. H., Gravel, S.-P., Andrzejewski, S., Raissi, T. C., Pause, A., St.-Pierre, J., & Jones, R. G. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.026 · Cited by 543 · see citing works

Prospects: Histone deacetylase inhibitors

Dokmanovic, M., & Marks, P. A. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20532 · Cited by 480 · see citing works

Early maternal deprivation reduces the expression of BDNF and NMDA receptor subunits in rat hippocampus

Roceri, M., Hendriks, W. J. A. J., Racagni, G., Ellenbroek, B. A., & Riva, M. A. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001036 · Cited by 465 · see citing works

Control of Cardiac Growth by Histone Acetylation/Deacetylation

Backs, J., & Olson, E. N. (2006) · Circulation Research · doi:10.1161/01.res.0000197782.21444.8f · Cited by 440 · see citing works

Suppression of Class I and II Histone Deacetylases Blunts Pressure-Overload Cardiac Hypertrophy

Kong, Y., Tannous, P., Lu, G., Berenji, K., Rothermel, B. A., Olson, E. N., & Hill, J. A. (2006) · Circulation · doi:10.1161/circulationaha.106.625467 · Cited by 377 · see citing works

NADPH oxidase-dependent redox signalling in cardiac hypertrophy, remodelling and failure

Murdoch, C. E., Zhang, M., Cave, A. C., & Shah, A. M. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.03.016 · Cited by 343 · see citing works

Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases

Gan, L., & Johnson, J. A. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.12.011 · Cited by 288 · see citing works

Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes

He, X., Kan, H. J., Cai, L., & Ma, Q. (2008) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2008.10.007 · Cited by 249 · see citing works

Depression and Cardiovascular Disorders

Whooley, M. A., & Wong, J. M. (2013) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050212-185526 · Cited by 241 · see citing works

Mitochondrial Biogenesis: A Therapeutic Target for Neurodevelopmental Disorders and Neurodegenerative Diseases

Uittenbogaard, M. N., & Chiaramello, A. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666140305224906 · Cited by 240 · see citing works

Coenzyme Q deficiency triggers mitochondria degradation by mitophagy

Rodríguez-Hernández, Á., Cordero, M. D., Salviati, L., Artuch, R., Pineda, M., Briones, P., Izquierdo, L. G., Cotán, D., Navas, P., & Sánchez-Alcázar, J. A. (2009) · Autophagy · doi:10.4161/auto.5.1.7174 · Cited by 194 · see citing works

Phase II trial of the histone deacetylase inhibitor vorinostat (Zolinza™, suberoylanilide hydroxamic acid, SAHA) in patients with recurrent and/or metastatic head and neck cancer

Blumenschein, G. R., Kies, M. S., Papadimitrakopoulou, V. A., Lu, C., Kumar, A. J., Ricker, J. L., Chiao, J. H., Chen, C., & Frankel, S. R. (2007) · Investigational New Drugs · doi:10.1007/s10637-007-9075-2 · Cited by 167 · see citing works

A mitochondrial bioenergetic basis of depression

Klinedinst, N. J., & Regenold, W. T. (2014) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-014-9584-6 · Cited by 153 · see citing works

Oxytocin mitigated the depressive-like behaviors of maternal separation stress through modulating mitochondrial function and neuroinflammation

Amini-Khoei, H., Mohammadi-Asl, A., Amiri, S., Hosseini, M.-J., Momeny, M., Hassanipour, M., Rastegar, M., Haj-Mirzaian, A., Mirzaian, A. H., Sanjarimoghaddam, H., et al. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.02.022 · Cited by 153 · see citing works

Antioxidant and Neuroprotective Effects of Caffeine against Alzheimer’s and Parkinson’s Disease: Insight into the Role of Nrf-2 and A2AR Signaling

Ikram, M. A., Park, T. J., Ali, T., & Kim, M. O. (2020) · Antioxidants · doi:10.3390/antiox9090902 · Cited by 150 · see citing works

The Search for Potent, Small‐Molecule HDACIs in Cancer Treatment: A Decade After Vorinostat

Zagni, C., Floresta, G., Monciino, G., & Rescifina, A. (2017) · Medicinal Research Reviews · doi:10.1002/med.21437 · Cited by 138 · see citing works

Mitochondria and the economy of stress (mal)adaptation

Morava, É., & Kozicz, T. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.02.005 · Cited by 119 · see citing works

Long-term effects of early life stress exposure: Role of epigenetic mechanisms

Silberman, D. M., Acosta, G. B., & Zubilete, M. A. Z. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2015.12.033 · Cited by 104 · see citing works

Overexpression of Adenosine A2A Receptors in Rats: Effects on Depression, Locomotion, and Anxiety

Coelho, J. E., Alves, P., Canas, P. M., Valadas, J. S., Shmidt, T., Batalha, V. L., Ferreira, D. G., Ribeiro, J. A., Bader, M., Cunha, R. A., et al. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00067 · Cited by 102 · see citing works

Reduction in podocyte SIRT1 accelerates kidney injury in aging mice

Chuang, P. Y., Cai, W., Li, X., Fang, L., Xu, J., Yacoub, R., He, J. C., & Lee, K. (2017) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00255.2017 · Cited by 98 · see citing works

Coenzyme Q10 Depletion in Medical and Neuropsychiatric Disorders: Potential Repercussions and Therapeutic Implications

Morris, G., Anderson, G., Berk, M., & Maes, M. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8477-8 · Cited by 96 · see citing works

HDAC Inhibition Suppresses Cardiac Hypertrophy and Fibrosis in DOCA-Salt Hypertensive Rats via Regulation of HDAC6/HDAC8 Enzyme Activity

Kee, H. J., Bae, E. H., Park, S., et al. (2013) · Kidney & Blood Pressure Research · doi:10.1159/000350148 · Cited by 86 · see citing works

Adolescent voluntary exercise attenuated hippocampal innate immunity responses and depressive-like behaviors following maternal separation stress in male rats

Sadeghi, M., Peeri, M., & Hosseini, M.-J. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.05.017 · Cited by 83 · see citing works

Antidepressant activity of vorinostat is associated with amelioration of oxidative stress and inflammation in a corticosterone-induced chronic stress model in mice

Athira, K. V., Madhana, R. M., Indu Chandran, J. S., Lahkar, M., Sinha, S., & Naidu, V. G. M. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.02.009 · Cited by 81 · see citing works

Andrographolide Ameliorates Diabetic Cardiomyopathy in Mice by Blockage of Oxidative Damage and NF‐κB‐Mediated Inflammation

Liang, E., Liu, X., Du, Z., et al. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9086747 · Cited by 80 · see citing works

Protective Role of Antioxidants in Diabetes-Induced Cardiac Dysfunction

Vassort, G., & Turan, B. (2010) · Cardiovascular Toxicology · doi:10.1007/s12012-010-9064-0 · Cited by 75 · see citing works

Epigenetic regulation of vascular NADPH oxidase expression and reactive oxygen species production by histone deacetylase-dependent mechanisms in experimental diabetes

Manea, S., Antonescu, M.-L., Fenyo, I. M., Raicu, M., Simionescu, M., & Manea, A. (2018) · Redox Biology · doi:10.1016/j.redox.2018.03.011 · Cited by 75 · see citing works

Mitochondrial dysfunction bridges negative affective disorders and cardiomyopathy in socially isolated rats: Pros and cons of fluoxetine

Sonei, N., Amiri, S., Jafarian, I., Anoush, M., Rahimi-Balaei, M., Bergen, H., Haj‐Mirzaian, A., & Hosseini, M. (2016) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2016.1149218 · Cited by 59 · see citing works

The histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) alleviates depression-like behavior and normalizes epigenetic changes in the hippocampus during ethanol withdrawal

Chen, W.-Y., Zhang, H., Gatta, E., Glover, E. J., Pandey, S. C., & Lasek, A. W. (2019) · Alcohol · doi:10.1016/j.alcohol.2019.02.005 · Cited by 59 · see citing works

Voluntary Exercise During Adolescence Mitigated Negative the Effects of Maternal Separation Stress on the Depressive-Like Behaviors of Adult Male Rats: Role of NMDA Receptors

Masrour, F. F., Peeri, M., Azarbayjani, M. A., & Hosseini, M. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2519-6 · Cited by 58 · see citing works

Targeting Peroxisome Proliferator Activated Receptor α (PPAR α) for the Prevention of Mitochondrial Impairment and Hypertrophy in Cardiomyocytes

Kar, D., & Bandyopadhyay, A. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000492875 · Cited by 51 · see citing works

Allicin ameliorates obesity comorbid depressive-like behaviors: involvement of the oxidative stress, mitochondrial function, autophagy, insulin resistance and NOX/Nrf2 imbalance in mice

Gao, W., Wang, W., Zhang, J., Deng, P., Hu, J., Yang, J. M., & Deng, Z. (2019) · Metabolic Brain Disease · doi:10.1007/s11011-019-00443-y · Cited by 49 · see citing works

Mitochondrial dysfunction and oxidative damage in the brain of diet-induced obese rats but not in diet-resistant rats

Ma, W., Yuan, L., Yu, H., Xi, Y., & Xiao, R. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.07.018 · Cited by 46 · see citing works

Minocycline attenuates depressive-like behaviors in mice treated with the low dose of intracerebroventricular streptozotocin; the role of mitochondrial function and neuroinflammation

Mozafari, H., Amiri, S., Mehr, S. E., Momeny, M., Amini-Khoei, H., Bijani, S., & Hosseini, M.-J. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05696-w · Cited by 32 · see citing works

SAHA improves depressive symptoms, cognitive impairment and oxidative stress: rise of a new antidepressant class

Ershadi, A. S. B., Amini-Khoei, H., Hosseini, M.-J., & Dehpour, A. R. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03263-8 · Cited by 25 · see citing works

Huoxue Huatan Decoction Ameliorates Myocardial Ischemia/Reperfusion Injury in Hyperlipidemic Rats via PGC-1α–PPARα and PGC-1α–NRF1–mtTFA Pathways

Lin, F., Tan, Y., He, X., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.546825 · Cited by 15 · see citing works

Abstract 10254: HDAC Inhibition Regulates Cardiac Function via Myofilament Acetylation

Eaton, D., Martin, T. G., Kasa, M., et al. (2021) · Circulation · doi:10.1161/circ.144.suppl_1.10254 · Cited by 1 · see citing works

Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook

Lv, L.-Z., Wang, Z.-D., Ren, J.-J., Li, L.-H., Liu, X.-B., Li, J.-L., Zhu, H., Jiang, B., Han, Y.-P., Zhou, X.-M., et al. (2026) · Frontiers in Genetics · doi:10.3389/fgene.2025.1722453 · Cited by 7 · see citing works

Antitumor activity of vorinostat-incorporated nanoparticles against human cholangiocarcinoma cells

Kwak, T. W., Kim, D. H., Jeong, Y., & Kang, D. H. (2015) · Journal of Nanobiotechnology · doi:10.1186/s12951-015-0122-4 · Cited by 46 · see citing works

Molecular and Biological Characteristics of Acquired Vorinostat-Resistant Cutaneous T-Cell Lymphoma Cells.

Zhang, C., Zhang, X., Li, B., et al. (2009) · Blood · doi:10.1182/blood.v114.22.1732.1732 · Cited by 1 · see citing works

In vitro and in vivo histone deacetylase inhibitor therapy with vorinostat and paclitaxel in ovarian cancer models: Does timing matter?

Modesitt, S. C., & Parsons, S. J. (2010) · Gynecologic Oncology · doi:10.1016/j.ygyno.2010.06.030 · Cited by 29 · see citing works

Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo

Hrzenjak, A., Moinfar, F., Kremser, M., et al. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-49 · Cited by 92 · see citing works

The histone deacetylase complex as a drugable target in colorectal cancer.

Mayer, B., Ilmberger, C., Halfter, K., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2015.33.15_suppl.e22200