Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases
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Oxidative damage contributes to pathogenesis in many neurodegenerative diseases. As the indicator and regulator of oxidative stress, the Nrf2-ARE pathway has been shown dynamic changes and examined for its neuroprotective role in many cases. In this review, we summarize the progress of the Nrf2-ARE pathway in combating toxicity induced from typical misfolded protein aggregates in neurodegenerative diseases, and specifically the effects on the clearance of protein aggregates.
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NFE2L2-dependent gene expression is activated by mild oxidative stress.
“However, this deprives neurons of a useful adaptive response, since NFE2L2-dependent gene expression is activated by mild oxidative stress 82,84,85 .”
From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [84]
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- Authors
- Gan, L., & Johnson, J. A.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Johnson, Jeffrey A.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 1842
- Issue
- 8
- Pages
- 1208-1218
- ISSN
- 0925-4439 (ISSN-L)
- OpenAlex
- W2011199467
- Cited by
- 288
- References
- 166
- Citations by year
- 2026: 13 · 2025: 16 · 2024: 22 · 2023: 24 · 2022: 26 · 2021: 28 · 2020: 19 · 2019: 22 · 2018: 19 · 2017: 35 · 2016: 25 · 2015: 26 · 2014: 13
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Environmental Health Science (ES10042, ES08089)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
- Keywords
- Nrf2/ARE pathway, oxidative stress, neurodegenerative diseases, protein aggregation, misfolded proteins, neuroprotection, protein aggregate clearance, oxidative damage
- MeSH terms
- Animals, Humans, Signal Transduction, Oxidative Stress, Neuroprotective Agents, Neurodegenerative Diseases, NF-E2-Related Factor 2, Antioxidant Response Elements
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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