Adolescent voluntary exercise attenuated hippocampal innate immunity responses and depressive-like behaviors following maternal separation stress in male rats

Sadeghi, Mahsa; Peeri, Maghsoud; Hosseini, Mir-Jamal

doi:10.1016/j.physbeh.2016.05.017

Cited by 83Stress Responses and CortisolTryptophan and brain disordersTreatment of Major Depression

Adolescent voluntary exercise attenuated hippocampal innate immunity responses and depressive-like behaviors following maternal separation stress in male rats

Sadeghi, Mahsa, Peeri, Maghsoud, Hosseini, Mir-Jamal·2016·Physiology & Behavior

DOI 10.1016/j.physbeh.2016.05.017

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Abstract

Early life stressful events have detrimental effects on the brain and behavior, which are associated with the development of depression. Immune-inflammatory responses have been reported to contribute in the pathophysiology of depression. Many studies have reported on the beneficial effects of exercise against stress. However, underlying mechanisms through which exercise exerts its effects were poorly studied. Therefore, it applied maternal separation (MS), as a valid animal model of early-life adversity, in rats from postnatal day (PND) 2 to 14 for 180min per day. At PND 28, male Wistar albino rats were subjected to 5 experimental groups; 1) controls 2) MS rats 3) MS rats treated with fluoxetine 5mg/kg to PND 60, 4) MS rats that were subjected to voluntary running wheel (RW) exercise and 5) MS rats that were subjected to mandatory treadmill (TM) exercise until adulthood. At PND 60, depressive-like behaviors were assessed by using forced swimming test (FST), splash test, and sucrose preference test (SPT). Our results revealed that depressive-like behaviors following MS stress were associated with an increase in expression of toll-like receptor 4 (Tlr-4) and its main signaling protein, Myd88, in the hippocampal formation. Also, we found that voluntary (and not mandatory) physical exercise during adolescence is protected against depressant effects of early-life stress at least partly through mitigating the innate immune responses in the hippocampus.

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Effects of stress throughout the lifespan on the brain, behaviour and cognition
Lupien, S. J., McEwen, B. S., Gunnar, M. R., & Heim, C. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2639 · Cited by 6,256 · see citing works
Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.
Rice, D., & Barone, S. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108s3511 · Cited by 2,944 · see citing works
Gut–brain axis: How the microbiome influences anxiety and depression
Foster, J. A., & McVey Neufeld, K.-A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.01.005 · Cited by 2,460 · see citing works
From stress to inflammation and major depressive disorder: A social signal transduction theory of depression.
Slavich, G. M., & Irwin, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0035302 · Cited by 2,206 · see citing works
Effects of physical exercise on anxiety, depression, and sensitivity to stress
Salmon, P. (2001) · Clinical Psychology Review · doi:10.1016/s0272-7358(99)00032-x · Cited by 1,363 · see citing works
The ascent of mouse: advances in modelling human depression and anxiety
Cryan, J. F., & Holmes, A. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1825 · Cited by 1,198 · see citing works
Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses
O'Mahony, S. M., Marchesi, J. R., Scully, P., Codling, C., Ceolho, A.-M., Quigley, E. M. M., Cryan, J. F., & Dinan, T. G. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.026 · Cited by 1,069 · see citing works
Stress, sensitive periods and maturational events in adolescent depression
Andersen, S. L., & Teicher, M. H. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.01.004 · Cited by 1,005 · see citing works
The microbiome-gut-brain axis: from bowel to behavior
Cryan, J. F., & O’Mahony, S. M. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01664.x · Cited by 990 · see citing works
The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression
Maes, M., Yirmyia, R., Noraberg, J., Brene, S., Hibbeln, J., Perini, G., Kubera, M., Bob, P., Lerer, B., & Maj, M. (2009) · Metabolic Brain Disease · doi:10.1007/s11011-008-9118-1 · Cited by 894 · see citing works
Seminars in Cell & Developmental Biology
Lee, H., & Kirkwood, A. (2011) · Cited by 692 · see citing works
Environmental Enrichment Reverses the Effects of Maternal Separation on Stress Reactivity
Francis, D. D., Diorio, J., Plotsky, P. M., & Meaney, M. J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-18-07840.2002 · Cited by 663 · see citing works
Depression and anxiety in inflammatory bowel disease: A review of comorbidity and management
Graff, L. A., Walker, J. R., & Bernstein, C. N. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20873 · Cited by 586 · see citing works
Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways
Olson, A. K., Eadie, B. D., Ernst, C., & Christie, B. R. (2006) · Hippocampus · doi:10.1002/hipo.20157 · Cited by 565 · see citing works
Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential
Hanke, M. L., & Kielian, T. (2011) · Clinical Science · doi:10.1042/cs20110164 · Cited by 493 · see citing works
Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: Possible treatments targeting the TLR4 pathway
Lucas, K., & Maes, M. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8425-7 · Cited by 466 · see citing works
Maternal separation as a model of brain-gut axis dysfunction
O’Mahony, S. M., Hyland, N. P., Dinan, T. G., & Cryan, J. F. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2010-9 · Cited by 415 · see citing works
Hippocampal changes associated with early-life adversity and vulnerability to depression
Rao, U., Chen, L.-A., Bidesi, A. S., Shad, M. U., Thomas, M. A., & Hammen, C. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.10.017 · Cited by 383 · see citing works
Environmental enrichment during adolescence reverses the effects of prenatal stress on play behaviour and HPA axis reactivity in rats.
Morley‐Fletcher, S., Rea, M., Maccari, S., & Laviola, G. (2003) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2003.03070.x · Cited by 373 · see citing works
CREB regulation of nucleus accumbens excitability mediates social isolation–induced behavioral deficits
Wallace, D. L., Han, M.-H., Graham, D. L., Green, T. A., Vialou, V., Iñiguez, S. D., Cao, J.-L., Kirk, A., Chakravarty, S., Kumar, A., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2257 · Cited by 342 · see citing works
Forced and voluntary exercise differentially affect brain and behavior
Leasure, J. L., & Jones, M. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.07.041 · Cited by 335 · see citing works
Treadmill running produces both positive and negative physiological adaptations in Sprague-Dawley rats
Moraska, A. F., Terrence Deak, B., Spencer, R. L., Roth, D., & Fleshner, M. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.4.r1321 · Cited by 325 · see citing works
The role of the innate immune system in psychiatric disorders
Jones, K. A., & Thomsen, C. (2013) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.10.002 · Cited by 274 · see citing works
Early maternal separation: a rodent model of depression and a prevailing human condition
Vetulani, J. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71505-6 · Cited by 255 · see citing works
Neurobiology of the development of motivated behaviors in adolescence: A window into a neural systems model
Monique Ernst, D., Romeo, R. D., & Andersen, S. L. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.12.013 · Cited by 236 · see citing works
Microglia-Dependent Alteration of Glutamatergic Synaptic Transmission and Plasticity in the Hippocampus during Peripheral Inflammation
Riazi, K., Galic, M. A., Kentner, A. C., Reid, A. Y., Sharkey, K. A., & Pittman, Q. J. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.4485-14.2015 · Cited by 228 · see citing works
Stress-induced neuroinflammation: role of the toll-like receptor-4 pathway
Gárate, I., Garcia-Bueno, B., Madrigal, J. L. M., Caso, J. R., Alou, L., Gomez-Lus, M. L., Micó, J. A., & Leza, J. C. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.07.005 · Cited by 202 · see citing works
The immunomodulating role of exercise in metabolic disease
Lancaster, G. I., & Febbraio, M. A. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.02.008 · Cited by 193 · see citing works
Maternal separation activates microglial cells and induces an inflammatory response in the hippocampus of male rat pups, independently of hypothalamic and peripheral cytokine levels
Roque, A., Ochoa‐Zarzosa, A., & Torner, L. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.09.017 · Cited by 190 · see citing works
Running is rewarding and antidepressive
Brené, S., Bjørnebekk, A., Åberg, E., Mathé, A. A., Olson, L., & Werme, M. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.05.015 · Cited by 172 · see citing works
Origin and consequences of brain Toll-like receptor 4 pathway stimulation in an experimental model of depression
Gárate, I., García‐Bueno, B., Madrigal, J. L. M., Bravo, L., Berrocoso, E., Caso, J. R., Micó, J. A., & Leza, J. C. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-151 · Cited by 163 · see citing works
Moderate treadmill exercise rescues anxiety and depression-like behavior as well as memory impairment in a rat model of posttraumatic stress disorder
Patki, G., Li, L., Allam, F., Solanki, N., Dao, A. T., Alkadhi, K. A., & Salim, S. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.03.016 · Cited by 152 · see citing works
Inflammation and neuronal plasticity: a link between childhood trauma and depression pathogenesis
Cattaneo, A., Macchi, F., Plazzotta, G., Veronica, B., Bocchio-Chiavetto, L., Riva, M. A., & Pariante, C. M. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00040 · Cited by 152 · see citing works
Enduring Deficits in Brain Reward Function after Chronic Social Defeat in Rats: Susceptibility, Resilience, and Antidepressant Response
Der‐Avakian, A., Mazei‐Robison, M. S., Kesby, J. P., Nestler, E. J., & Markou, A. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.01.013 · Cited by 147 · see citing works
Maternal separation induces neuroinflammation and long-lasting emotional alterations in mice
Gracia-Rubio, I., Moscoso-Castro, M., Pozo, O. J., Marcos, J., Nadal, R., & Valverde, O. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.09.003 · Cited by 144 · see citing works
The maternal deprivation animal model revisited.
Marco, E. M., Llorente, R., López-Gallardo, M., Mela, V., Llorente-Berzal, Á., Prada, C., & Viveros, M.-P. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.01.015 · Cited by 132 · see citing works
Co-occurrence of anxiety and depressive-like behaviors following adolescent social isolation in male mice; possible role of nitrergic system
Amiri, S., Haj‐Mirzaian, A., Rahimi-Balaei, M., Razmi, A., Kordjazy, N., Shirzadian, A., Mehr, S. E., Sianati, H., & Dehpour, A. R. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.03.032 · Cited by 128 · see citing works
Toll-like receptor 4: innate immune regulator of neuroimmune and neuroendocrine interactions in stress and major depressive disorder
Liu, J., Buisman-Pijlman, F., & Hutchinson, M. R. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00309 · Cited by 119 · see citing works
Anxiety profile in morphine-dependent and withdrawn rats: Effect of voluntary exercise
Miladi‐Gorji, H., Rashidy‐Pour, A., & Fathollahi, Y. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.08.010 · Cited by 106 · see citing works
Treadmill exercise training augments brain norepinephrine response to familiar and novel stress
Dishman, R. K., Renner, K. J., White-Welkley, J. E., Burke, K. A., & Bunnell, B. N. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00271-9 · Cited by 103 · see citing works
Effects of environmental enrichment and voluntary exercise on neurogenesis, learning and memory, and pattern separation: BDNF as a critical variable?
Bekinschtein, P., Oomen, C., Saksida, L., & Bussey, T. (2011) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2011.07.002 · Cited by 86 · see citing works
Beneficial effects of fluoxetine, reboxetine, venlafaxine, and voluntary running exercise in stressed male rats with anxiety- and depression-like behaviors
Lapmanee, S., Charoenphandhu, J., & Charoenphandhu, N. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.05.018 · Cited by 78 · see citing works
Novel mechanistic insights into treadmill exercise based rescue of social defeat-induced anxiety-like behavior and memory impairment in rats
Patki, G., Solanki, N., Atrooz, F., Ansari, A., Allam, F., Jannise, B., Maturi, J., & Salim, S. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.04.011 · Cited by 67 · see citing works
Repeated predictable stress causes resilience against colitis-induced behavioral changes in mice
Hassan, A. M., Jain, P., Reichmann, F., Mayerhofer, R., Farzi, A., Schuligoi, R., & Holzer, P. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00386 · Cited by 59 · see citing works
Mitochondrial dysfunction bridges negative affective disorders and cardiomyopathy in socially isolated rats: Pros and cons of fluoxetine
Sonei, N., Amiri, S., Jafarian, I., Anoush, M., Rahimi-Balaei, M., Bergen, H., Haj‐Mirzaian, A., & Hosseini, M. (2016) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2016.1149218 · Cited by 59 · see citing works
Exercise improves learning and memory impairments in sleep deprived female rats
Saadati, H., Esmaeili‐Mahani, S., Esmaeilpour, K., Nazeri, M., Mazhari, S., & Sheibani, V. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.10.006 · Cited by 57 · see citing works
Tropisetron attenuated the anxiogenic effects of social isolation by modulating nitrergic system and mitochondrial function
Amiri, S., Amini-Khoei, H., Haj‐Mirzaian, A., Rahimi-Balaei, M., Naserzadeh, P., Dehpour, A. R., Mehr, S. E., & Hosseini, M. (2015) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2015.09.009 · Cited by 53 · see citing works
Simulating the anhedonia symptom of depression in animals
Moreau, J. (2002) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2002.4.4/jlmoreau · Cited by 52 · see citing works
Behavioral despair associated with a mouse model of Crohn's disease: Role of nitric oxide pathway
Heydarpour, P., Rahimian, R., Fakhfouri, G., Khoshkish, S., Fakhraei, N., Salehi-Sadaghiani, M., Wang, H., Abbasi, A., Dehpour, A. R., & Ghia, J. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.08.004 · Cited by 49 · see citing works
Lithium attenuated the depressant and anxiogenic effect of juvenile social stress through mitigating the negative impact of interlukin-1β and nitric oxide on hypothalamic–pituitary–adrenal axis function
Haj-Mirzaian, A., Amiri, S., Kordjazy, N., Momeny, M., Razmi, A., Rahimi-Balaei, M., Amini-Khoei, H., Haj-Mirzaian, A., Marzban, H., Mehr, S. E., et al. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.12.024 · Cited by 46 · see citing works
Synergistic effects of diet and exercise on hippocampal function in chronically stressed mice
Hutton, C. P., Déry, N., Rosa, E., Lemon, J. A., Rollo, C. D., Boreham, D. R., Fahnestock, M., deCatanzaro, D., Wojtowicz, J. M., & Becker, S. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.005 · Cited by 41 · see citing works
Special issue on exercise immunology: Current perspectives on aging, health and extreme performance
Simpson, R. J., & Bosch, J. A. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.03.006 · Cited by 37 · see citing works
Exercise normalizes altered expression of proteins in the ventral hippocampus of rats subjected to maternal separation
Daniels, W. M. U., Marais, L., Stein, D. J., & Russell, V. A. (2011) · Experimental Physiology · doi:10.1113/expphysiol.2011.061176 · Cited by 34 · see citing works
Experiencing neonatal maternal separation increased the seizure threshold in adult male mice: Involvement of the opioid system
Amini-Khoei, H., Amiri, S., Shirzadian, A., Haj‐Mirzaian, A., Alijanpour, S., Rahimi-Balaei, M., Mohammadi‐Asl, A., Hassanipour, M., Mehr, S. E., & Dehpour, A. R. (2015) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2015.08.025 · Cited by 32 · see citing works
Protective effects of exercise in metabolic disorders are mediated by inhibition of mitochondrial-derived sterile inflammation
Peeri, M., & Amiri, S. (2015) · Medical Hypotheses · doi:10.1016/j.mehy.2015.10.026 · Cited by 24 · see citing works
Effects of maternal separation on brain stress systems: Modulation by voluntary exercise in male rats
Campbell, E. J., James, M. H., Hodgson, D. M., & Dayas, C. V. (2013) · TopSCHOLAR (Western Kentucky University) · Cited by 2 · see citing works

Flagged first, then by citations

1 of the 57 references couldn’t be matched to a known paper.

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The effects of early life stress on reward processing
Novick, A. M., Levandowski, M. L., Laumann, L. E., Philip, N. S., Price, L. H., & Tyrka, A. R. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.02.002 · Cited by 192 · see citing works
“Numerous studies of the effects of maternal separation on sucrose preference have reported decreased preference (Amiri et al., 2016; Bolton et al., 2018; Hui et al., 2011; Sadeghi et al., 2016; Shu et al., 2015) or no change in sucrose preference (Matthews et al.”
Background
On the Run for Hippocampal PlasticityPreprint
Cooper, C. P., Moon, H. Y., & van Praag, H. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029736 · Cited by 160 · see citing works
Early life adversity as a risk factor for cognitive impairment and Alzheimer’s disease
Huang, Z., Jordan, J. D., & Zhang, Q. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00355-z · Cited by 92 · see citing works
SiNiSan ameliorates depression-like behavior in rats by enhancing synaptic plasticity via the CaSR-PKC-ERK signaling pathway
Shen, C., Cao, K., Cui, S., Cui, Y., Mo, H., Wen, W., Dong, Z., Lin, H., Bai, S., Yang, L., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109787 · Cited by 71 · see citing works
Progesterone exerts antidepressant-like effect in a mouse model of maternal separation stress through mitigation of neuroinflammatory response and oxidative stress
Nouri, A., Hashemzadeh, F., Soltani, A., Saghaei, E., & Amini-Khoei, H. (2019) · Pharmaceutical Biology · doi:10.1080/13880209.2019.1702704 · Cited by 68 · see citing works
Neuroinflammation, Early-Life Adversity, and Brain Development
Andersen, S. L. (2022) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000325 · Cited by 70 · see citing works
Antidepressant-like Effects of p-Coumaric Acid on LPS-induced Depressive and Inflammatory Changes in Rats
Lee, S., Kim, H.-B., Hwang, E., Kim, E.-S., Kim, S. S., Jeon, T.-D., Song, M.-C., Lee, J.-S., Chung, M.-C., Maeng, S., et al. (2018) · Experimental Neurobiology · doi:10.5607/en.2018.27.3.189 · Cited by 66 · see citing works
Behavioral effects in adolescence and early adulthood in two length models of maternal separation in male rats
Banqueri, M., Méndez, M., & Arias, J. L. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.02.006 · Cited by 62 · see citing works
Voluntary wheel running: a useful rodent model for investigating mechanisms of stress robustness and exercise motivation
Greenwood, B. N., & Fleshner, M. (2019) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2019.02.001 · Cited by 60 · see citing works
Major Depressive Disorder and Gut Microbiota: Role of Physical Exercise
de Souza, P. B., Borba, L. A., de Jesus, L. C., Valverde, A. P., Gil‐Mohapel, J., & Rodrigues, A. L. S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316870 · Cited by 65 · see citing works
Short‐ and long‐term antidepressant effects of ketamine in a rat chronic unpredictable stress model
Jiang, Y., Wang, Y., Sun, X., Lian, B., Sun, H., Wang, G., Du, Z., Li, Q., & Sun, L. (2017) · Brain and Behavior · doi:10.1002/brb3.749 · Cited by 58 · see citing works
Voluntary Exercise During Adolescence Mitigated Negative the Effects of Maternal Separation Stress on the Depressive-Like Behaviors of Adult Male Rats: Role of NMDA Receptors
Masrour, F. F., Peeri, M., Azarbayjani, M. A., & Hosseini, M. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2519-6 · Cited by 58 · see citing works
Music exposure attenuates anxiety- and depression-like behaviors and increases hippocampal spine density in male rats
Papadakakis, A., Sidiropoulou, K., & Panagis, G. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112023 · Cited by 59 · see citing works
Long-term exercise from adolescence to adulthood reduces anxiety- and depression-like behaviors following maternal immune activation in offspring
Rahimi, S., Peeri, M., Azarbayjani, M. A., Anoosheh, L., Ghasemzadeh, E., Khalifeh, N., Noroozi-Mahyari, S., Deravi, S., Saffari-Anaraki, S., Zangeneh, F. H., et al. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113130 · Cited by 54 · see citing works
Transcriptome analysis on maternal separation rats with depression-related manifestations ameliorated by electroacupuncture
Zheng, Y., He, J., Guo, L., Yao, L., Zheng, X., Yang, Z., Xia, Y., Wu, X., Su, Y., Xu, N., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00314 · Cited by 52 · see citing works
Oxytocin and excitation/inhibition balance in social recognition
Lopatina, O. L., Komleva, Y. K., Gorina, Y. V., Olovyannikova, R. Y., Труфанова, Л. В., Hashimoto, T., Takahashi, T., Kikuchi, M., Minabe, Y., Higashida, H., et al. (2018) · Neuropeptides · doi:10.1016/j.npep.2018.09.003 · Cited by 51 · see citing works
Maternal separation in rodents: a journey from gut to brain and nutritional perspectives
Rincel, M., & Darnaudéry, M. (2019) · Proceedings of The Nutrition Society · doi:10.1017/s0029665119000958 · Cited by 50 · see citing works
Effects of chronic fluoxetine treatment on anxiety- and depressive-like behaviors in adolescent rodents – systematic review and meta-analysis
Kryst, J., Majcher‐Maślanka, I., & Chocyk, A. (2022) · Pharmacological Reports · doi:10.1007/s43440-022-00420-w · Cited by 43 · see citing works
Maternal separation induces long-term effects on monoamines and brain-derived neurotrophic factor levels on the frontal cortex, amygdala, and hippocampus: differential effects after a stress challenge
Récamier-Carballo, S., Estrada-Camarena, E. M., & López‐Rubalcava, C. (2017) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000324 · Cited by 41 · see citing works
Interplay between hormones and exercise on hippocampal plasticity across the lifespan
Bettio, L. E. B., Thacker, J. S., Rodgers, S. P., Brocardo, P. S., Christie, B. R., & Gil-Mohapel, J. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165821 · Cited by 40 · see citing works
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Repeated finasteride administration induces depression-like behavior in adult male rats
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Cardiac oxidative stress following maternal separation stress was mitigated following adolescent voluntary exercise in adult male rat
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Tan, X., Zhang, L., Wang, D., Guan, S., Lu, P., Xu, X., & Xu, H. (2021) · Aging · doi:10.18632/aging.203746 · Cited by 33 · see citing works
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Gilak‐Dalasm, M., Peeri, M., & Azarbayjani, M. A. (2021) · Experimental Physiology · doi:10.1113/ep089501 · Cited by 30 · see citing works
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de Oliveira, L. R. S., Machado, F. S. M., Dias, I. R., Magalhães, C. O. D. E., Sousa, R. A. L. D., & Cassilhas, R. C. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07156-z · Cited by 28 · see citing works
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Olayinka, J. N., Akawa, O. B., Ogbu, E. K., Eduviere, A. T., Ozolua, R. I., & Soliman, M. E. S. (2023) · Current Research in Pharmacology and Drug Discovery · doi:10.1016/j.crphar.2023.100161 · Cited by 28 · see citing works
Sex differences in addiction-relevant behavioral outcomes in rodents following early life stress
Rincón‐Cortés, M. (2023) · Addiction Neuroscience · doi:10.1016/j.addicn.2023.100067 · Cited by 26 · see citing works
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Ershadi, A. S. B., Amini-Khoei, H., Hosseini, M.-J., & Dehpour, A. R. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03263-8 · Cited by 25 · see citing works
Self-citation
Neonatal resource scarcity alters maternal care and impacts offspring core temperature and growth in rats
Shupe, E. A., & Clinton, S. M. (2021) · Developmental Psychobiology · doi:10.1002/dev.22144 · Cited by 24 · see citing works
“The wrong tools for the right job”: a critical meta-analysis of traditional tests to assess behavioural impacts of maternal separation
Stupart, O., Robbins, T. W., & Dalley, J. W. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06275-6 · Cited by 24 · see citing works
Prophylactic effect of physical exercise on Aβ1-40-induced depressive-like behavior and gut dysfunction in mice
Rosa, J. M., Pazini, F. L., Camargo, A., Wolin, I. A. V., Olescowicz, G., Eslabão, L. B., Bruña–Romero, O., Duarte, E. C. W., & Rodrigues, A. L. S. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112791 · Cited by 23 · see citing works
Enduring effects of early-life adversity on reward processes: A systematic review and meta-analysis of animal studies
Duque-Quintero, M., Hooijmans, C. R., Hurowitz, A., Ahmed, A., Barris, B., Homberg, J. R., Hen, R., Harris, A. Z., Balsam, P. D., & Atsak, P. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104849 · Cited by 24 · see citing works
Neurobiology of resilience to early life stress
Torres‐Berrío, A., Bortolami, A., Peña, C. J., & Nestler, E. J. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-025-02158-4 · Cited by 24 · see citing works
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Doreste-Méndez, R., Ríos-Ruiz, E. J., Rivera-López, L. L., Gutierrez, A., & Torres-Reverón, A. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00198 · Cited by 21 · see citing works
Voluntary physical activity increases maternal care and reduces anxiety- and depression-related behaviours during the postpartum period in mice
Naghibi, S., Barzegari, A., Shariatzadeh, M., Vatandoust, M., Ahmadi, M., Mahdinia, E., Neghabi, F., Rajabpour, A., Aleahmad, A. S., Balaghati, F. S., et al. (2022) · Brain Research · doi:10.1016/j.brainres.2022.147880 · Cited by 20 · see citing works
Clozapine attenuates mitochondrial dysfunction, inflammatory gene expression, and behavioral abnormalities in an animal model of schizophrenia
Amiri, S., Dizaji, R., Momeny, M., Gauvin, E., & Hosseini, M. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108503 · Cited by 21 · see citing works
Neuroimmunological effects of early life experiences
Brydges, N. M., & Reddaway, J. (2020) · Brain and Neuroscience Advances · doi:10.1177/2398212820953706 · Cited by 18 · see citing works
Anethole as a promising antidepressant for maternal separation stress in mice by modulating oxidative stress and nitrite imbalance
Rostami-Faradonbeh, N., Amini-Khoei, H., Zarean, E., Bijad, E., & Lorigooini, Z. (2024) · Scientific Reports · doi:10.1038/s41598-024-57959-2 · Cited by 17 · see citing works
Effects of thymoquinone in a rat model of reserpine-induced depression
Kuzay, D., Dileköz, E., & Özer, Ç. (2022) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s2175-97902022e19847 · Cited by 16 · see citing works
Implications of Physical Exercise on Episodic Memory and Anxiety: The Role of the Serotonergic System
Illesca-Matus, R., Ardiles, N. M., Muñoz, F., & Moya, P. R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411372 · Cited by 18 · see citing works
Gene expression signature of antidepressant treatment response/non-response in Flinders Sensitive Line rats subjected to maternal separation
Marchetti, L., Lauria, M., Caberlotto, L., Musazzi, L., Popoli, M., Mathé, A. A., Domenici, E., & Carboni, L. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2019.11.004 · Cited by 17 · see citing works
The Role of Positive Health Behaviors in the Relationship Between Early Life Stress and Migraine
Hammond, N. G., & Colman, I. (2020) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13808 · Cited by 16 · see citing works
Enduring neuroimmunological consequences of developmental experiences: From vulnerability to resilience
Reddaway, J., & Brydges, N. M. (2020) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2020.103567 · Cited by 14 · see citing works
In vitro and in vivo evaluation of taste-masked orodispersible tablets of fluoxetine hydrochloride for the treatment of depression
Marzouk, M. A., Osman, D. A., & Mohamed, O. S. (2021) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2021.1908336 · Cited by 14 · see citing works
Therapeutic Effect of Exercise on Anxiety and Bowel Oxidative Stress in the Maternal Separation Animal Model
Khorjahani, A., Peeri, M., & Azarbayjani, M. A. (2019) · Basic and Clinical Neuroscience Journal · doi:10.32598/bcn.9.10.450 · Cited by 13 · see citing works
Unlocking the epigenome: Stress and exercise induced Bdnf regulation in the prefrontal cortex
Campbell, T. S., Donoghue, K. M., & Roth, T. L. (2024) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2024.107353 · Cited by 11 · see citing works
Antidepressant potential of β-caryophyllene in maternal separation-induced depression-like in mice: A focus on oxidative stress and nitrite levels
Al-Shudifat, A.-E., Qnais, E. Y., Bseiso, Y., Wedyan, M. A., Gammoh, O. S., Alqudah, M., Khaled, A. M. B., & Alqudah, A. M. (2024) · Phytomedicine Plus · doi:10.1016/j.phyplu.2024.100624 · Cited by 11 · see citing works
Early Life Stress-Induced Epigenetic Programming of Hippocampal NPY-Y2 Receptor Gene Expression Changes in Response to Adult Stress
Kocamaz, D., Franzke, C., Gröger, N., Braun, K., & Bock, J. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.936979 · Cited by 11 · see citing works
The effects of minocycline in improving of methamphetamine withdrawal syndrome in male mice
Ghavimi, H., Ershadi, A. S. B., Dastvar, S., & Hosseini, M. (2021) · Drug and Chemical Toxicology · doi:10.1080/01480545.2021.1942484 · Cited by 11 · see citing works
Effects of Maternal Separation on Effort-based Responding for Sucrose Are Associated with c-Fos Expression in the Nucleus Accumbens Core
Gildawie, K. R., Wang, K. L., Budge, K. E., & Byrnes, E. M. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.11.030 · Cited by 8 · see citing works
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Masrour, F. F., Peeri, M., Hosseini, M., & Azarbayjani, M. A. (2018) · Europe PMC (PubMed Central) · Cited by 9 · see citing works
Effect of high-intensity interval training on self-care and anxiety-like behaviors in naive rats
Çalışkan, H., Karakaya, D., Koçak, S., Ömercioğlu, G., & Baştuğ, M. (2024) · Experimental Brain Research · doi:10.1007/s00221-024-06793-z · Cited by 7 · see citing works
Chronic Alcohol Drinking Drives Sex-Specific Differences in Affective Behavior and Medial Prefrontal Cortex Activity in CRF1:Cre:tdTomato Transgenic Rats
Quadir, S. G., Arleth, G., Cone, M. G., High, M. W., Ramage, M. C., Effinger, D. P., Sanchez, M. E., & Herman, M. A. (2023) · eNeuro · doi:10.1523/eneuro.0055-23.2023 · Cited by 6 · see citing works
The impacts of vorinostat on NADPH oxidase and mitochondrial biogenesis gene expression in the heart of mice model of depression
Nasehi, L., Morassaei, B., Ghaffari, M., Sharafi, A., Dehpour, A. R., & Hosseini, M.-J. (2022) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2022-0098 · Cited by 5 · see citing works
Early life stress and the role of environmental and molecular moderators in the ontology of pathological and resilient behavioral phenotypes
Collins, N. J., Campbell, T. S., Donoghue, K. M., Ghosh, U., Smith, J. N., O’Shea, M. C., Nelson, C. M., Bigham, O. K., & Roth, T. L. (2023) · Molecular Psychology Brain Behavior and Society · doi:10.12688/molpsychol.17482.2 · Cited by 5 · see citing works
Voluntary wheel-running exercise improvement of anxiety or depressive symptoms in different models of depression
Shen, H., Li, X., Zhai, J., & Zhang, X. (2024) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2024.1435891 · Cited by 6 · see citing works
Male depression – causes, symptoms, and diagnosis
Talarowska, M. E., Gromniak-Haniecka, E., Rawska, J., & Gałecki, P. (2018) · Neuropsychiatria i Neuropsychologia · doi:10.5114/nan.2018.81250 · Cited by 5 · see citing works
Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook
Lv, L.-Z., Wang, Z.-D., Ren, J.-J., Li, L.-H., Liu, X.-B., Li, J.-L., Zhu, H., Jiang, B., Han, Y.-P., Zhou, X.-M., et al. (2026) · Frontiers in Genetics · doi:10.3389/fgene.2025.1722453 · Cited by 7 · see citing works
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Jazayeri, D., Zanjani, Z., Joekar, S., Alvani, S. R., & Molaei, A. (2022) · Journal of Contemporary Psychotherapy · doi:10.1007/s10879-022-09537-8 · Cited by 4 · see citing works
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momtazbakhsh, M., Fakour, Y., Zarei, A., Daneshpazhooh, M., & Aghapour, E. (2024) · Health Scope · doi:10.5812/healthscope-138659 · Cited by 4 · see citing works
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Takabayashi, K., Kajita, Y., & Mushiake, H. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115617 · Cited by 4 · see citing works
Life-course effects of early life adversity exposure on eating behavior and metabolism
de Lima, R. M. S., Barth, B., Arcego, D. M., Krolow, R., Silveira, P. P., & Dalmaz, C. (2021) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2021.02.003 · Cited by 4 · see citing works
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Mohseni, I., Peeri, M., & Azarbayjani, M. A. (2020) · Journal of Medicinal Plants · doi:10.29252/jmp.1.73.119 · Cited by 4 · see citing works
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Moradi, P., Rahimi‐Madiseh, M., Zerean, E., & Amini-Khoei, H. (2025) · Developmental Neurobiology · doi:10.1002/dneu.70001 · Cited by 3 · see citing works
Glymphatic–meningeal lymphatic system imbalance: a peripheral-to-central inflammatory bridge in perioperative neurocognitive disorders
Wang, H., Wang, X., Liu, N., Wang, H., & Feng, C. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1828809 · Cited by 3 · see citing works
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Sezer, T., Okudan, N., & Belviranlı, M. (2024) · Neuroscience Letters · doi:10.1016/j.neulet.2024.137993 · Cited by 3 · see citing works
Investigation of Pharmacokinetic and Pharmacodynamic Interactions between Citalopram and Duloxetine: An Integrated Analytical, Computational, Behavioral, and Biochemical Approach
Elgawish, M. S., Atta, A. M., Hafeez, S. M., Mageed, S. S. A., Mahmoud, A. M. A., Moustafa, M. A., & Ali, M. A. (2024) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00506 · Cited by 2 · see citing works
Adolescent nonpharmacological interventions for early-life stress and their mechanisms
Li, Y., Shi, D., & Wang, Z. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114580 · Cited by 2 · see citing works
Postnatal Maternal Deprivation Induces Anxious Behaviors, Depressive Behaviors, and Increased Central Inflammation and Oxidative Stress in Adult Rats
Benmhammed, H., Lamtai, M., Bikri, S., Mesfioui, A., Nassiri, A., Mouden, S., & Hassni, A. E. (2024) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2024.00519 · Cited by 2 · see citing works
Voluntary wheel running from early adolescence reduces disease progression, and anxiety- and depression-related symptoms in an adult male mouse model of rheumatoid arthritis
Payamipour, S., Peeri, M., Azarbayjani, M. A., & Masrour, F. F. (2023) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2023.578247 · Cited by 1 · see citing works
Perinatal running training reversed postnatal anxiety and depressive-like behavior and cognitive impairment in mice following prenatal subchronic variable stress
Zhou, L., Wu, Z., Li, Y., Xiao, L., Wang, H., & Wang, G. (2024) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2024.173898 · Cited by 1 · see citing works
Evaluating Dealers’ Satisfaction and Performance Determinants: Insights into Enhancing Operational Efficiency and Business Relationships
R, D. P., & MADHU, K. (2025) · INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT · doi:10.55041/ijsrem51919 · Cited by 1 · see citing works
Behavioral and physiological benefits of alpha-pinene in adult rats experiencing chronic stress: A focus on depression and oxidative stress
Hosseini, S. S., Ghotbeddin, Z., Tabatabaei, S. R. F., & Rahimi, K. (2025) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2025.11.014 · Cited by 1 · see citing works
[Bladder hemangioma after radiotherapy].
Peñalver, C. G., Planet, M. A., López, V. M. C., Gallego, I., del Río, A. A., Alvaro, C. C., & Galvis, O. L. (2003) · PubMed · Cited by 1 · see citing works
“The wrong tools for the right job”: a critical meta-analysis of traditional tests to assess behavioural impacts of early life stressPreprint
Stupart, O., Robbins, T. W., & Dalley, J. W. (2022) · Research Square · doi:10.21203/rs.3.rs-1870443/v1
Early life stress and the role of environmental and molecular moderators in the ontology of pathological and resilient behavioral phenotypes
Collins, N. J., Campbell, T. S., Donoghue, K. M., Ghosh, U., Smith, J. N., O’Shea, M. C., Nelson, C. M., Bigham, O. K., & Roth, T. L. (2022) · Molecular Psychology Brain Behavior and Society · doi:10.12688/molpsychol.17482.1 · Cited by 5 · see citing works
The Effect of Physical Activity on Stress and Inflammation in Mice with Rheumatoid Arthritis
Payamipour, S., Peeri, M., Azarbaijani, M. A., & Masrour, F. F. (2024) · مجله دانشگاه علوم پزشکی اردبیل · doi:10.61186/jarums.24.1.92
Role of the gut-brain axis in early stress-induced emotional vulnerability
Rincel, M. (2017) · theses.fr (ABES) · doi:10.70675/5e8a972cz9ad1z42aezb89cze6474124ef90
Unveiling the mechanisms of comorbidity of aging and depression: a perspective based on early life stress (ELS)
Lin, C., Zhang, S., Li, Q., Qi, Z., & Liu, W. (2026) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2026.07.053

The effect of adolescent treadmill mandatory exercise on symptoms of depression and brain inflammatory responses following maternal separation stress in mature male rats
Zolfaghari, F., Peeri, M., & Hosseini, M. (2018) · DOAJ (DOAJ: Directory of Open Access Journals)
Voluntary Exercise During Adolescence Mitigated Negative the Effects of Maternal Separation Stress on the Depressive-Like Behaviors of Adult Male Rats: Role of NMDA Receptors
Masrour, F. F., Peeri, M., Azarbayjani, M. A., & Hosseini, M. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2519-6 · Cited by 58 · see citing works
Exercise and fluoxetine treatment during adolescence protect against early life stress-induced behavioral abnormalities in adult rats
Zolfaghari, F. S., Pirri, F., Gauvin, E., Peeri, M., & Amiri, S. (2021) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2021.173190 · Cited by 31 · see citing works
Exercise During Adolescence Attenuated Depressive-Like Behaviors and Hippocampal Mitochondrial Dysfunction Following Early Life Stress in Adult Male Rats.
Masrour, F. F., Peeri, M., Hosseini, M., & Azarbayjani, M. A. (2018) · Europe PMC (PubMed Central) · Cited by 9 · see citing works
Running from depression: the antidepressant-like potential of prenatal and pre-pubertal exercise in adolescent FSL rats exposed to an early-life stressor
Whitney, A., Lindeque, J. Z., Kruger, R., & Steyn, S. F. (2023) · Acta Neuropsychiatrica · doi:10.1017/neu.2023.52 · Cited by 7 · see citing works

Authors: Sadeghi, M., Peeri, M., & Hosseini, M.-J.
Affiliations: Islamic Azad University, Tehran (IR)
Zanjan University of Medical Sciences (IR)
Corresponding author: Peeri, Maghsoud
ORCID: Peeri, Maghsoud
Hosseini, Mir-Jamal
Venue: Physiology & Behavior
Publisher: Elsevier BV
Published: 2016-09
Volume: 163
Pages: 177-183
ISSN: 0031-9384 (ISSN-L)
DOI: 10.1016/j.physbeh.2016.05.017
OpenAlex: W2351823664
Cited by: 83
References: 57
Citations by year: 2026: 3 · 2025: 5 · 2024: 11 · 2023: 10 · 2022: 13 · 2021: 9 · 2020: 8 · 2019: 11 · 2018: 6 · 2017: 6
FWCI: 4.90
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Physiology & Behavior (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords: maternal separation, early life stress, depression, hippocampus, innate immunity, TLR4, MyD88, fluoxetine, treadmill exercise, depression-like behavior, neuroinflammation
MeSH terms: Age Factors, Animals, Depression, Disease Models, Animal, Exercise Test, Exploratory Behavior, Female, Fluoxetine, Food Preferences, Gene Expression Regulation, Hippocampus, Immunity, Innate, Male, Maternal Deprivation, Motivation, Physical Conditioning, Animal, Pregnancy, Rats, Wistar, Antidepressive Agents, Second-Generation, Toll-Like Receptor 4, Rats

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Adolescent voluntary exercise attenuated hippocampal innate immunity responses and depressive-like behaviors following maternal separation stress in male rats

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