CoChat
Sign Up
Cited by 29Cardiovascular Function and Risk FactorsCardiovascular Disease and AdiposityDiet, Metabolism, and Disease

Gender-dependent effects of high-fat lard diet on cardiac function in C57Bl/6J mice

Louwe, Mieke C., van der Hoorn, José W.A., van den Berg, Sjoerd A.A., Jukema, J. Wouter, Romijn, Johannes A., Willems van Dijk, Ko, Rensen, Patrick C.N., Smit, Johannes W.A. +1 more·2012·Applied Physiology Nutrition and Metabolism
DOI 10.1139/h11-153
Open this paper in CoChat — free account

Abstract

Increased availability of fatty acids released from insulin-resistant adipose tissue may lead to excess fatty acid uptake in nonadipose organs, including the heart. Accumulation of toxic fatty acid intermediates may affect cardiac function. Our aim was to identify to which extent high-fat diet feeding leads to alterations in cardiac function and whether this depends on gender and (or) duration of high-fat diet feeding. Male and female C57Bl/6J mice (n = 8 per group) of 12 to 16 weeks old were fed a low-fat (10% energy) or high-fat (45% energy) lard diet for 6 or 12 weeks. Plasma lipid levels, echocardiography, and left ventricular pressure-volume relationships were obtained at 2, 1, and 0 weeks before termination, respectively. In both male and female mice, the high-fat diet increased body weight and plasma lipid content. At 10 weeks, significant increases were observed for plasma total cholesterol (males: +44%; females: +86%), phospholipids (+16% and +34%), and triglycerides (+27% and +53%) (all p < 0.001). In male mice, but not in female mice, the high-fat diet significantly affected cardiac function at 12 weeks with increased end-systolic volume (25.4 ± 6.2 vs. 17.0 ± 6.7 µL, p < 0.05), increased end-systolic pressure (72.1 ± 6.9 vs. 63.6 ± 6.9 mm Hg, p < 0.01), and decreased ejection fraction (61.2% ± 4.5% vs. 68.1% ± 3.7%, p < 0.01), indicating reduced systolic function. Multiple linear regression analysis indicated a significant diet-gender interaction for end-systolic volume and ejection fraction. In conclusion, high-fat diet feeding increased body weight and plasma lipid levels in male and in female mice, but resulted in impairment of cardiac function only in males.

Integrity signals

Registry

Crossref · 10.1139/h11-153

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Obesity is closely associated with cardiac disorders, which is assumed to be a consequence of the adaption to an oversupply of high-fat substrates.

    “Obesity is closely associated with cardiac disorders, which is assumed to be a consequence of the adaption to an oversupply of high-fat substrates [262,263].”

    From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [263]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Louwe, M. C., van der Hoorn, J. W. A., van den Berg, S. A. A., Jukema, J. W., Romijn, J. A., Willems van Dijk, K., Rensen, P. C. N., Smit, J. W. A., & Steendijk, P.
Affiliations
  • Leiden University Medical Center (NL)
  • TNO-Metabolic Health Research, Gaubius Laboratory, PO Box 2215, 2333 CK Leiden, the Netherlands.
  • Department of Human Genetics Leiden University Medical Center PO Box 9600, 2300 RC Leiden, the Netherlands.
  • Department of Cardiology Leiden University Medical Center PO Box 9600, 2300 RC Leiden, the Netherlands.
ORCID
Venue
Applied Physiology Nutrition and Metabolism
Publisher
Canadian Science Publishing
Published
2012-04
Volume
37
Issue
2
Pages
214-224
ISSN
  • 1715-5312 (ISSN-L)
  • 1715-5320
DOI
10.1139/h11-153
OpenAlex
W2136828698
Cited by
29
References
41
Citations by year
2026: 1 · 2025: 1 · 2024: 4 · 2023: 1 · 2021: 3 · 2020: 2 · 2018: 2 · 2016: 4 · 2015: 4 · 2014: 6 · 2013: 1
FWCI
2.26
Type
journal article
Language
en
Open access
closed
Licence
www.nrcresearchpress.com/page/about/CorporateTextAndDataMining (tdm)
Locations
  • Applied Physiology, Nutrition, and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Leiden Repository (Leiden University) (submittedVersion)
  • TNO Repository (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
  • Repository hosted by TU Delft Library (TU Delft) (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
high-fat diet, lard, cardiac function, sex differences, systolic function, ejection fraction, end-systolic volume, plasma lipids, triglycerides, cholesterol, phospholipids, fatty acid uptake, insulin resistance, adipose tissue, C57BL/6J mice
MeSH terms
Adipose Tissue, Animals, Cholesterol, Dietary Fats, Echocardiography, Fatty Acids, Nonesterified, Female, Heart, Insulin, Insulin Resistance, Male, Mice, Inbred C57BL, Phospholipids, Sex Factors, Triglycerides, Weight Gain, Leptin, Mice, Diet, High-Fat

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review