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Cited by 123Coffee research and impactsMuscle metabolism and nutritionExercise and Physiological Responses

The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.

Caffeine and exercise: metabolism and performance.

Graham, Terry E., Rush, James W. E., Soeren, Mary H. van·1994·Canadian Journal of Applied Physiology
DOI 10.1139/h94-010
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Abstract

Caffeine ingestion prior to prolonged exercise delays fatigue. However, the mechanisms involved are very unclear. Caffeine is associated with elevated plasma epinephrine but the metabolic impact of this is uncertain. Glycogen sparing occurs in active muscle, at least in the first few minutes, but studies have generally failed to demonstrate enhanced fat metabolism. The demethylation of caffeine by the hepatic cytochrome P-450 oxygenases begins within minutes and dimethylxanthines (especially paraxanthine) are generated. These compounds appear in the plasma within an hour of caffeine ingestion and may have effects on tissues that have been attributed to caffeine and/or epinephrine. While the most widely supported theory is that caffeine and other methylxanthines are adenosine receptor antagonists, this action alone cannot explain all of the observed responses. Nevertheless, habituation to and withdrawal from caffeine are associated with up and down regulation of adenosine receptors. One study demonstrated marked differences in the effects of caffeine on the plasma concentrations of epinephrine and dimethylxanthines between caffeine users and nonusers. Caffeine is clearly a very active drug that has many effects on humans including increasing exercise endurance. This can be associated with muscle glycogen sparing and elevated plasma epinephrine, but the underlying mechanisms are unknown.

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Crossref · 10.1139/h94-010

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94 of 94 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 94 references

Research works printed but not linked: 25

  1. Berthou F., 1991, Drug Metab. Dispos., 19, 561
  2. Biaggioni I., 1991, J. Pharmaco. Exp. Ther., 258, 588
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Metadata

Authors
Graham, T. E., Rush, J. W. E., & Soeren, M. H. V.
Affiliations
University of Guelph (CA)
Venue
Canadian Journal of Applied Physiology
Publisher
Canadian Science Publishing
Published
1994-06-01
Volume
19
Issue
2
Pages
111-138
ISSN
1066-7814 (ISSN-L)
DOI
10.1139/h94-010
OpenAlex
W2092318720
Cited by
123
References
94
Citations by year
2026: 2 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 8 · 2016: 4 · 2015: 3 · 2014: 7 · 2013: 5 · 2012: 2
FWCI
0.54
Type
journal article
Language
en
Open access
closed
Licence
www.nrcresearchpress.com/page/about/CorporateTextAndDataMining (tdm)
Locations
  • Canadian Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
University of Guelph
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords
caffeine, exercise performance, fatigue, epinephrine, fat metabolism, dimethylxanthines, paraxanthine, adenosine receptor antagonism, caffeine withdrawal
MeSH terms
Caffeine, Catecholamines, Humans, Muscles, Physical Endurance, Exercise, Receptors, Purinergic P1

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